Philippe Sarret

ORCID

Publication Activity (10 Years)

Years Active: 2019-2024
Publications (10 Years): 31

Top Venues

Journal of medicinal chemistry

International journal of molecular sciences

ACS pharmacology & translational science

Science advances

Université de Sherbrooke

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Université de Sherbrooke

Canada

Full professor :: Pharmacology & Physiology

Publications

Jolien De Neve, Émile Breault, Santo Previti, Esaü Vangeloven, Bobbi Loranger, Magali Chartier, Rebecca Brouillette, Annik Lanoie, Brian J Holleran, Jean-Michel Longpré, Louis Gendron, Dirk Tourwé, Philippe Sarret, Steven Ballet
Design, Synthesis, and In Vitro Characterization of Proteolytically-Stable Opioid-Neurotensin Hybrid Peptidomimetics. ACS pharmacology & translational science 7 (9) (2024)
Michael Desgagné, Antoine Désilets, Sára Ferková, Matthieu Lepage, Olivier Perreault, Alexandre Joushomme, Gabriel Lemieux, Walid Guerrab, Ulrike Froehlich, Christian Comeau, Philippe Sarret, Richard Leduc, Pierre-Luc Boudreault
Rational In Silico Design of Selective TMPRSS6 Peptidomimetic Inhibitors via Exploitation of the S2 Subpocket. Journal of medicinal chemistry (2024)
Michael Desgagné, Antoine Désilets, Sára Ferková, Matthieu Lepage, Olivier Perreault, Alexandre Joushomme, Gabriel Lemieux, Walid Guerrab, Ulrike Froehlich, Christian Comeau, Philippe Sarret, Richard Leduc, Pierre-Luc Boudreault
Rational In Silico Design of Selective TMPRSS6 Peptidomimetic Inhibitors via Exploitation of the S2 Subpocket. Journal of medicinal chemistry 67 (15) (2024)
Emmeran Le Moal, Yuguo Liu, Jasmin Collerette-Tremblay, Simon Dumontier, Paul Fabre, Thomas Molina, Junio Dort, Zakaria Orfi, Nicolas Denault, Joël Boutin, Joris Michaud, Hugo Giguère, Alexandre Desroches, Kien Trân, Benjamin Ellezam, François Vézina, Sonia Bedard, Catherine Raynaud, Frédéric Balg, Philippe Sarret, Pierre-Luc Boudreault, Michelle S Scott, Jean-Bernard Denault, Eric Marsault, Jérôme N Feige, Mannix Auger-Messier, Nicolas A Dumont, C Florian Bentzinger
Apelin stimulation of the vascular skeletal muscle stem cell niche enhances endogenous repair in dystrophic mice. Science translational medicine 16 (739) (2024)
Emmeran Le Moal, Yuguo Liu, Jasmin Collerette-Tremblay, Simon Dumontier, Paul Fabre, Thomas Molina, Junio Dort, Zakaria Orfi, Nicolas Denault, Joël Boutin, Joris Michaud, Hugo Giguère, Alexandre Desroches, Kien Trân, Benjamin Ellezam, François Vézina, Sonia Bedard, Catherine Raynaud, Frédéric Balg, Philippe Sarret, Pierre-Luc Boudreault, Michelle S Scott, Jean-Bernard Denault, Eric Marsault, Jérôme N Feige, Mannix Auger-Messier, Nicolas A Dumont, C Florian Bentzinger
Apelin stimulation of the vascular skeletal muscle stem cell niche enhances endogenous repair in dystrophic mice. Science translational medicine 16 (739) (2024)
Michael Desgagné, Antoine Désilets, Sára Ferková, Matthieu Lepage, Olivier Perreault, Alexandre Joushomme, Gabriel Lemieux, Walid Guerrab, Ulrike Froehlich, Christian Comeau, Philippe Sarret, Richard Leduc, Pierre-Luc Boudreault
Rational In Silico Design of Selective TMPRSS6 Peptidomimetic Inhibitors via Exploitation of the S2 Subpocket. Journal of medicinal chemistry 67 (15) (2024)
Michael Desgagné, Antoine Désilets, Sára Ferková, Matthieu Lepage, Olivier Perreault, Alexandre Joushomme, Gabriel Lemieux, Walid Guerrab, Ulrike Froehlich, Christian Comeau, Philippe Sarret, Richard Leduc, Pierre-Luc Boudreault
Rational In Silico Design of Selective TMPRSS6 Peptidomimetic Inhibitors via Exploitation of the S2 Subpocket. Journal of medicinal chemistry 67 (15) (2024)
Dany Dion, Christophe Noll, Mélanie Fortin, Lounès Haroune, Sabrina Saibi, Philippe Sarret, André C Carpentier
Plasma endocannabinoids are independently associated with the metabolic function of white adipose tissue. The Journal of clinical endocrinology and metabolism (2024)
Michael Desgagné, Antoine Désilets, Sára Ferková, Matthieu Lepage, Olivier Perreault, Alexandre Joushomme, Gabriel Lemieux, Walid Guerrab, Ulrike Froehlich, Christian Comeau, Philippe Sarret, Richard Leduc, Pierre-Luc Boudreault
Rational In Silico Design of Selective TMPRSS6 Peptidomimetic Inhibitors via Exploitation of the S2 Subpocket. Journal of medicinal chemistry 67 (15) (2024)
Léa Théroux, Robin Van Den Hauwe, Kien Trân, Justin Fournier, Michael Desgagné, Nathan Meneboo, Alexis Lavallée, Ulrike Fröhlich, Jérôme Côté, Charlie Hollanders, Jean-Michel Longpré, Alexandre Murza, Eric Marsault, Philippe Sarret, Pierre-Luc Boudreault, Steven Ballet
Signaling Modulation via Minimal C-Terminal Modifications of Apelin-13. ACS pharmacology & translational science 6 (2) (2023)
Sára Ferková, Ulrike Froehlich, Marie-Edith Nepveu-Traversy, Alexandre Murza, Taha Azad, Michel Grandbois, Philippe Sarret, Pierre Lavigne, Pierre-Luc Boudreault
Comparative Analysis of Cyclization Techniques in Stapled Peptides: Structural Insights into Protein-Protein Interactions in a SARS-CoV-2 Spike RBD/hACE2 Model System. International journal of molecular sciences 25 (1) (2023)
Sára Ferková, Ulrike Froehlich, Marie-Edith Nepveu-Traversy, Alexandre Murza, Taha Azad, Michel Grandbois, Philippe Sarret, Pierre Lavigne, Pierre-Luc Boudreault
Comparative Analysis of Cyclization Techniques in Stapled Peptides: Structural Insights into Protein-Protein Interactions in a SARS-CoV-2 Spike RBD/hACE2 Model System. International journal of molecular sciences 25 (1) (2023)
Léa Théroux, Robin Van Den Hauwe, Kien Trân, Justin Fournier, Michael Desgagné, Nathan Meneboo, Alexis Lavallée, Ulrike Fröhlich, Jérôme Côté, Charlie Hollanders, Jean-Michel Longpré, Alexandre Murza, Eric Marsault, Philippe Sarret, Pierre-Luc Boudreault, Steven Ballet
Signaling Modulation via Minimal C-Terminal Modifications of Apelin-13. ACS pharmacology & translational science 6 (2) (2023)
Sára Ferková, Ulrike Froehlich, Marie-Edith Nepveu-Traversy, Alexandre Murza, Taha Azad, Michel Grandbois, Philippe Sarret, Pierre Lavigne, Pierre-Luc Boudreault
Comparative Analysis of Cyclization Techniques in Stapled Peptides: Structural Insights into Protein-Protein Interactions in a SARS-CoV-2 Spike RBD/hACE2 Model System. International journal of molecular sciences 25 (1) (2023)
Sára Ferková, Ulrike Froehlich, Marie-Edith Nepveu-Traversy, Alexandre Murza, Taha Azad, Michel Grandbois, Philippe Sarret, Pierre Lavigne, Pierre-Luc Boudreault
Comparative Analysis of Cyclization Techniques in Stapled Peptides: Structural Insights into Protein-Protein Interactions in a SARS-CoV-2 Spike RBD/hACE2 Model System. International journal of molecular sciences 25 (1) (2023)
Kien Tran, Xavier Sainsily, Jérôme Côté, David Coquerel, Pierre Couvineau, Sabrina Saibi, Lounès Haroune, Élie Besserer-Offroy, Joël Flynn-Robitaille, Martin Resua Rojas, Alexandre Murza, Jean-Michel Longpré, Mannix Auger-Messier, Olivier Lesur, Michel Bouvier, Eric Marsault, Pierre-Luc Boudreault, Philippe Sarret
Size-Reduced Macrocyclic Analogues of [Pyr 1 ]-apelin-13 Showing Negative Gα 12 Bias Still Produce Prolonged Cardiac Effects. Journal of medicinal chemistry 65 (1) (2022)
Santo Previti, Michael Desgagné, Dirk Tourwé, Florine Cavelier, Philippe Sarret, Steven Ballet
Opening the amino acid toolbox for peptide-based NTS2-selective ligands as promising lead compounds for pain management. Journal of peptide science : an official publication of the European Peptide Society (2022)
Yang Yue, Lier Liu, Li-Jie Wu, Yiran Wu, Ling Wang, Fei Li, Junlin Liu, Gye-Won Han, Bo Chen, Xi Lin, Rebecca L Brouillette, Émile Breault, Jean-Michel Longpré, Songting Shi, Hui Lei, Philippe Sarret, Raymond C Stevens, Michael A Hanson, Tingting Wu
Structural insight into apelin receptor-G protein stoichiometry. Nature structural & molecular biology 29 (7) (2022)
Magali Chartier, Michael Desgagné, Marc Sousbie, Jérôme Côté, Jean-Michel Longpré, Eric Marsault, Philippe Sarret
Design, Structural Optimization, and Characterization of the First Selective Macrocyclic Neurotensin Receptor Type 2 Non-opioid Analgesic. Journal of medicinal chemistry 64 (4) (2021)
Nairie Michaelian, Anastasiia Sadybekov, Élie Besserer-Offroy, Gye Won Han, Harini Krishnamurthy, Beata A Zamlynny, Andreas Verras, Phieng Siliphaivanh, Jeremy Presland, Kerrie B Spencer, Stephen M Soisson, Petr Popov, Philippe Sarret, Vsevolod Katritch, Vadim Cherezov
Structural insights on ligand recognition at the human leukotriene B4 receptor 1. Nature communications 12 (1) (2021)
Kien Trân, Robin Van Den Hauwe, Xavier Sainsily, Pierre Couvineau, Jérôme Côté, Louise Simard, Marco Echevarria, Alexandre Murza, Alexandra Serre, Léa Théroux, Sabrina Saibi, Lounès Haroune, Jean-Michel Longpré, Olivier Lesur, Mannix Auger-Messier, Claude Spino, Michel Bouvier, Philippe Sarret, Steven Ballet, Eric Marsault
Constraining the Side Chain of C-Terminal Amino Acids in Apelin-13 Greatly Increases Affinity, Modulates Signaling, and Improves the Pharmacokinetic Profile. Journal of medicinal chemistry 64 (9) (2021)
Maxime Fougère, Cornelis Immanuel van der Zouwen, Joël Boutin, Kloé Neszvecsko, Philippe Sarret, Dimitri Ryczko
Optogenetic stimulation of glutamatergic neurons in the cuneiform nucleus controls locomotion in a mouse model of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America 118 (43) (2021)
Christian Comeau, Benjamin Ries, Thomas Stadelmann, Jacob Tremblay, Sylvain Poulet, Ulrike Fröhlich, Jérôme Côté, Pierre-Luc Boudreault, Rabeb Mouna Derbali, Philippe Sarret, Michel Grandbois, Grégoire Leclair, Sereina Riniker, Eric Marsault
Modulation of the Passive Permeability of Semipeptidic Macrocycles: N- and C-Methylations Fine-Tune Conformation and Properties. Journal of medicinal chemistry 64 (9) (2021)
Marc-André Dansereau, Élora Midavaine, Valérie Bégin-Lavallée, Mounir Belkouch, Nicolas Beaudet, Jean-Michel Longpré, Stéphane Mélik-Parsadaniantz, Philippe Sarret
Mechanistic insights into the role of the chemokine CCL2/CCR2 axis in dorsal root ganglia to peripheral inflammation and pain hypersensitivity. Journal of neuroinflammation 18 (1) (2021)
Mélissa Girard, Steve Dagenais Bellefeuille, Émilie Eiselt, Rebecca L Brouillette, Morgane Placet, Guillaume Arguin, Jean-Michel Longpré, Philippe Sarret, Fernand-Pierre Gendron
The P2Y6 receptor signals through Gαq /Ca2+ /PKCα and Gα13 /ROCK pathways to drive the formation of membrane protrusions and dictate cell migration. Journal of cellular physiology 235 (12) (2020)
Kien Trân, Alexandre Murza, Xavier Sainsily, Eugénie Delile, Pierre Couvineau, Jérôme Côté, David Coquerel, Maude Peloquin, Mannix Auger-Messier, Michel Bouvier, Olivier Lesur, Philippe Sarret, Eric Marsault
Structure-Activity Relationship and Bioactivity of Short Analogues of ELABELA as Agonists of the Apelin Receptor. Journal of medicinal chemistry 64 (1) (2020)
Simon Gonzalez, Maria Dumitrascuta, Emilie Eiselt, Stevany Louis, Linda Kunze, Annalisa Blasiol, Mélanie Vivancos, Santo Previti, Elke Dewolf, Charlotte Martin, Dirk Tourwé, Florine Cavelier, Louis Gendron, Philippe Sarret, Mariana Spetea, Steven Ballet
Optimized Opioid-Neurotensin Multitarget Peptides: From Design to Structure-Activity Relationship Studies. Journal of medicinal chemistry 63 (21) (2020)
Émilie Eiselt, Valérie Otis, Karine Belleville, Gaoqiang Yang, Alain Larocque, Anthony Régina, Michel Demeule, Philippe Sarret, Louis Gendron
Use of a Noninvasive Brain-Penetrating Peptide-Drug Conjugate Strategy to Improve the Delivery of Opioid Pain Relief Medications to the Brain. The Journal of pharmacology and experimental therapeutics 374 (1) (2020)
Emilie Eiselt, Simon Gonzalez, Charlotte Martin, Magali Chartier, Cecilia Betti, Jean-Michel Longpré, Florine Cavelier, Dirk Tourwé, Louis Gendron, Steven Ballet, Philippe Sarret
Neurotensin Analogues Containing Cyclic Surrogates of Tyrosine at Position 11 Improve NTS2 Selectivity Leading to Analgesia without Hypotension and Hypothermia. ACS chemical neuroscience 10 (11) (2019)
Aleksandra Luginina, Anastasiia Gusach, Egor Marin, Alexey V Mishin, Rebecca L Brouillette, Petr Popov, Anna Shiriaeva, Élie Besserer-Offroy, Jean-Michel Longpré, Elizaveta Lyapina, Andrii Ishchenko, Nilkanth Patel, Vitaly Polovinkin, Nadezhda Safronova, Andrey Bogorodskiy, Evelina Edelweiss, Hao Hu, Uwe Weierstall, Wei Liu, Alexander Batyuk, Valentin Gordeliy, Gye Won Han, Philippe Sarret, Vsevolod Katritch, Valentin I Borshchevskiy, Vadim Cherezov
Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs. Science advances 5 (10) (2019)
Tobias Claff, Jing Yu, Véronique Blais, Nilkanth Patel, Charlotte Martin, Li-Jie Wu, Gye Won Han, Brian J Holleran, Olivier Van der Poorten, Kate L White, Michael A Hanson, Philippe Sarret, Louis Gendron, Vadim Cherezov, Vsevolod Katritch, Steven Ballet, Zhi-Jie Liu, Christa Elisabeth Müller, Raymond C Stevens
Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists. Science advances 5 (11) (2019)

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Publication Activity (10 Years)

Top Topics

Top Venues

Philippe Sarret