Richard O Hynes

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 22

Top Venues

Cancer research

Proceedings of the National Academy of Sciences of the United States of America

Cancers

PNAS nexus

Massachusetts Institute of Technology

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Massachusetts Institute of Technology

United States

Professor of Biology :: Biology/Koch Institute

Publications

Ryan Kanai, Emily Norton, Patrick Stern, Richard O Hynes, Janine S A Warren
Identification of a Gene Signature That Predicts Dependence upon YAP/TAZ-TEAD. Cancers 16 (5) (2024)
Ryan Kanai, Emily Norton, Patrick Stern, Richard O Hynes, Janine S A Warren
Identification of a Gene Signature That Predicts Dependence upon YAP/TAZ-TEAD. Cancers 16 (5) (2024)
Ryan Kanai, Emily Norton, Patrick Stern, Richard O Hynes, Janine S A Warren
Identification of a Gene Signature That Predicts Dependence upon YAP/TAZ-TEAD. Cancers 16 (5) (2024)
Noor Jailkhani, Karl R Clauser, Howard H Mak, Steffen Rickelt, Chenxi Tian, Charles A Whittaker, Kenneth K Tanabe, Stephen R Purdy, Steven A Carr, Richard O Hynes
Proteomic profiling of extracellular matrix components from patient metastases identifies consistently elevated proteins for developing nanobodies that target primary tumors and metastases. Cancer research (2023)
Emi A Lutz, Noor Jailkhani, Noor Momin, Ying Huang, Allison Sheen, Byong H Kang, Karl Dane Wittrup, Richard O Hynes
Intratumoral nanobody-IL-2 fusions that bind the tumor extracellular matrix suppress solid tumor growth in mice. PNAS nexus 1 (5) (2022)
Emi A Lutz, Noor Jailkhani, Noor Momin, Ying Huang, Allison Sheen, Byong H Kang, Karl Dane Wittrup, Richard O Hynes
Intratumoral nanobody-IL-2 fusions that bind the tumor extracellular matrix suppress solid tumor growth in mice. PNAS nexus 1 (5) (2022)
Noor Momin, Joseph R Palmeri, Emi A Lutz, Noor Jailkhani, Howard Mak, Anthony Tabet, Magnolia M Chinn, Byong Ha Kang, Virginia Spanoudaki, Richard O Hynes, Karl Dane Wittrup
Maximizing response to intratumoral immunotherapy in mice by tuning local retention. Nature communications 13 (1) (2022)
Chenxi Tian, Ying Huang, Karl R Clauser, Steffen Rickelt, Allison N Lau, Steven A Carr, Matthew G Vander Heiden, Richard O Hynes
Suppression of pancreatic ductal adenocarcinoma growth and metastasis by fibrillar collagens produced selectively by tumor cells. Nature communications 12 (1) (2021)
Steffen Rickelt, Azfar Neyaz, Charlene Condon, Charles A Whittaker, Blair A Jobe, Martin S Taylor, Genevieve Abbruzzese, Anthony R Mattia, Lawrence Zukerberg, Stuti G Shroff, Ömer H Yilmaz, Osman Yılmaz, Elizabeth Y Wu, Won-Tak Choi, Blair A Jobe, Robert D Odze, Deepa T Patil, Vikram Deshpande, Richard O Hynes
Agrin loss in Barrett's esophagus-related neoplasia and its utility as a diagnostic and predictive biomarker. Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
Chenxi Tian, Daniel Öhlund, Steffen Rickelt, Tommy Lidström, Ying Huang, Liangliang Hao, Renee T Zhao, Oskar Franklin, Sangeeta N Bhatia, David A Tuveson, Richard O Hynes
Cancer Cell-Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal Adenocarcinoma. Cancer research 80 (7) (2020)
Jess D Hebert, Chenxi Tian, Janine S A Warren, Steffen Rickelt, Genevieve Abbruzzese, Xiaotie Liu, Richard O Hynes
The scaffold protein IQGAP1 is crucial for extravasation and metastasis. Scientific reports 10 (1) (2020)
Jess D Hebert, Samuel A Myers, Alexandra Naba, Genevieve Abbruzzese, Janine S A Warren, Steven A Carr, Richard O Hynes
Proteomic Profiling of the ECM of Xenograft Breast Cancer Metastases in Different Organs Reveals Distinct Metastatic Niches. Cancer research 80 (7) (2020)
David C Benjamin, Joon Ho Kang, Bashar Hamza, Emily M King, Janine S A Warren, Scott R Manalis, Richard O Hynes
YAP Enhances Tumor Cell Dissemination by Promoting Intravascular Motility and Reentry into Systemic Circulation. Cancer research 80 (18) (2020)
Noor Jailkhani, Jessica R Ingram, Mohammad Rashidian, Steffen Rickelt, Chenxi Tian, Howard Mak, Zhigang Jiang, Hidde L Ploegh, Richard O Hynes
Noninvasive imaging of tumor progression, metastasis, and fibrosis using a nanobody targeting the extracellular matrix. Proceedings of the National Academy of Sciences of the United States of America 116 (28) (2019)
Steffen Rickelt, Charlene Condon, Miyeko D Mana, Charlie Whittaker, Christina Pfirschke, Jatin Roper, Deepa T Patil, Ian Brown, Anthony R Mattia, Lawrence Zukerberg, Qing Zhao, Runjan Chetty, Gregory Y Lauwers, Azfar Neyaz, Lieve G J Leijssen, Katherine Boylan, Omer H Yilmaz, Vikram Deshpande, Richard O Hynes
Agrin in the Muscularis Mucosa Serves as a Biomarker Distinguishing Hyperplastic Polyps from Sessile Serrated Lesions. Clinical cancer research : an official journal of the American Association for Cancer Research 26 (6) (2019)
Yushu Joy Xie, Michael Dougan, Noor Jailkhani, Jessica Ingram, Tao Fang, Laura Kummer, Noor Momin, Novalia Pishesha, Steffen Rickelt, Richard O Hynes, Hidde L Ploegh
Nanobody-based CAR T cells that target the tumor microenvironment inhibit the growth of solid tumors in immunocompetent mice. Proceedings of the National Academy of Sciences of the United States of America 116 (16) (2019)
Chenxi Tian, Karl R Clauser, Daniel Öhlund, Steffen Rickelt, Ying Huang, Mala Gupta, D R Mani, Steven A Carr, David A Tuveson, Richard O Hynes
Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and stromal cells. Proceedings of the National Academy of Sciences of the United States of America 116 (39) (2019)
Camilla Engblom, Christina Pfirschke, Rapolas Zilionis, Janaina Da Silva Martins, Stijn A Bos, Gabriel Courties, Steffen Rickelt, Nicolas Severe, Ninib Baryawno, Julien Faget, Virginia Savova, David Zemmour, Jaclyn Kline, Marie Siwicki, Christopher S Garris, Ferdinando Pucci, Hsin-Wei Liao, Yi-Jang Lin, Andita Newton, Omar K Yaghi, Yoshiko Iwamoto, Benoit Tricot, Gregory R Wojtkiewicz, Matthias Nahrendorf, Virna Cortez-Retamozo, Etienne Meylan, Richard O Hynes, Marie B Demay, Allon M Klein, Miriam A Bredella, David T Scadden, Ralph Weissleder, Mikaël J Pittet
Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils. Science (New York, N.Y.) 358 (6367) (2018)
Janine S A Warren, Yuxuan Xiao, Emily Norton, Zhi-Gang Jiang, Genevieve M Gerhard, Simrin Kooner, Janine S A Warren, Richard O Hynes
SRC tyrosine kinase activates the YAP/TAZ axis and thereby drives tumor growth and metastasis. The Journal of biological chemistry 294 (7) (2018)
Patrick A Murphy, Vincent L Butty, Paul L Boutz, Shahinoor Begum, Amy L Kimble, Phillip A Sharp, Christopher B Burge, Richard O Hynes
Alternative RNA splicing in the endothelium mediated in part by Rbfox2 regulates the arterial response to low flow. eLife 7 (2018)
David C Benjamin, Richard O Hynes
Intravital imaging of metastasis in adult Zebrafish. BMC cancer 17 (1) (2017)
Byron H Kwan, Eric F Zhu, Alice Tzeng, Harun R Sugito, Ahmed A Eltahir, Botong Ma, Mary K Delaney, Patrick A Murphy, Monique J Kauke, Alessandro Angelini, Noor Momin, Naveen K Mehta, Alecia M Maragh, Richard O Hynes, Glenn Dranoff, Jennifer R Cochran, Karl Dane Wittrup
Integrin-targeted cancer immunotherapy elicits protective adaptive immune responses. The Journal of experimental medicine 214 (6) (2017)

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Publication Activity (10 Years)

Top Topics

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Richard O Hynes