Hidde L Ploegh (Hidde Ploegh)

ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 57

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

Nature communications

ACS chemical biology

Journal of immunology (Baltimore, Md. : 1950)

Boston Children's Hospital

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Boston Children's Hospital Nov 01 2016

United States

Research Associate, Member of the Faculty :: Program in Cellular and Molecular Medicine

Publications

Xiaomeng Han, Xiaotang Lu, Peter H Li, Shuohong Wang, Richard Schalek, Yaron Meirovitch, Zudi Lin, Jason Adhinarta, Karl D Murray, Leah M MacNiven, Daniel Raimund Berger, Yuelong Wu, Tao Fang, Elif Sevde Meral, Shadnan Asraf, Hidde L Ploegh, Hanspeter Pfister, Donglai Wei, Viren Jain, James S Trimmer, Jeff William Lichtman
Multiplexed volumetric CLEM enabled by scFvs provides insights into the cytology of cerebellar cortex. Nature communications 15 (1) (2024)
Xiaomeng Han, Xiaotang Lu, Peter H Li, Shuohong Wang, Richard Schalek, Yaron Meirovitch, Zudi Lin, Jason Adhinarta, Karl D Murray, Leah M MacNiven, Daniel Raimund Berger, Yuelong Wu, Tao Fang, Elif Sevde Meral, Shadnan Asraf, Hidde L Ploegh, Hanspeter Pfister, Donglai Wei, Viren Jain, James S Trimmer, Jeff William Lichtman
Multiplexed volumetric CLEM enabled by scFvs provides insights into the cytology of cerebellar cortex. Nature communications 15 (1) (2024)
Elisha R Verhaar, Willemijn J C van Keizerswaard, Anouk Knoflook, Thomas Balligand, Hidde L Ploegh
Nanobody-based CAR NK cells for possible immunotherapy of MICA + tumors. PNAS nexus 3 (5) (2024)
Hidde L Ploegh, Xin Liu, Camille Le Gall, Ryan Alexander, Ella Borgman, Thomas Balligand
Bi-specific antibody engagers for cancer immunotherapy. Research square (2024)
Elisha R Verhaar, Willemijn J C van Keizerswaard, Anouk Knoflook, Thomas Balligand, Hidde L Ploegh
Nanobody-based CAR NK cells for possible immunotherapy of MICA + tumors. PNAS nexus 3 (5) (2024)
Xiaomeng Han, Xiaotang Lu, Peter H Li, Shuohong Wang, Richard Schalek, Yaron Meirovitch, Zudi Lin, Jason Adhinarta, Karl D Murray, Leah M MacNiven, Daniel Raimund Berger, Yuelong Wu, Tao Fang, Elif Sevde Meral, Shadnan Asraf, Hidde L Ploegh, Hanspeter Pfister, Donglai Wei, Viren Jain, James S Trimmer, Jeff William Lichtman
Multiplexed volumetric CLEM enabled by scFvs provides insights into the cytology of cerebellar cortex. Nature communications 15 (1) (2024)
Elisha R Verhaar, Willemijn J C van Keizerswaard, Anouk Knoflook, Thomas Balligand, Hidde L Ploegh
Nanobody-based CAR NK cells for possible immunotherapy of MICA + tumors. PNAS nexus 3 (5) (2024)
Hidde L Ploegh, Xin Liu, Camille Le Gall, Ryan Alexander, Ella Borgman, Thomas Balligand
Bi-specific antibody engagers for cancer immunotherapy. Research square (2024)
Xiaomeng Han, Xiaotang Lu, Peter H Li, Shuohong Wang, Richard Schalek, Yaron Meirovitch, Zudi Lin, Jason Adhinarta, Karl D Murray, Leah M MacNiven, Daniel Raimund Berger, Yuelong Wu, Tao Fang, Elif Sevde Meral, Shadnan Asraf, Hidde L Ploegh, Hanspeter Pfister, Donglai Wei, Viren Jain, James S Trimmer, Jeff William Lichtman
Multiplexed volumetric CLEM enabled by scFvs provides insights into the cytology of cerebellar cortex. Nature communications 15 (1) (2024)
Hidde L Ploegh, Xin Liu, Camille Le Gall, Ryan Alexander, Ella Borgman, Thomas Balligand
Bi-specific antibody engagers for cancer immunotherapy. Research square (2024)
Xiaomeng Han, Peter H Li, Shuohong Wang, Morgan Sanchez, Sneha Aggarwal, Tim Blakely, Richard L Schalek, Yaron Meirovitch, Zudi Lin, Daniel Berger, Yuelong Wu, Fatima Aly, Sylvie Bay, Benoît Delatour, Pierre LaFaye, Hanspeter Pfister, Donglai Wei, Viren Jain, Hidde L Ploegh, Jeff William Lichtman
A large-scale volumetric correlated light and electron microscopy study localizes Alzheimer's disease-related molecules in the hippocampus. bioRxiv : the preprint server for biology (2023)
Jin Gan, Adán Pinto-Fernández, Dennis Flierman, Jimmy J L L Akkermans, Darragh P O'Brien, Helene Greenwood, Hannah Claire Scott, Günter Fritz, Klaus-Peter Knobeloch, Jacques Neefjes, Hans van Dam, Huib Ovaa, Hidde L Ploegh, Benedikt Mathias Kessler, Paul P Geurink, Aysegul Sapmaz
USP16 is an ISG15 cross-reactive deubiquitinase that targets pro-ISG15 and ISGylated proteins involved in metabolism. Proceedings of the National Academy of Sciences of the United States of America 120 (50) (2023)
Xin Liu, Thomas Balligand, Claire Carpenet, Hidde L Ploegh
An armed anti-immunoglobulin light chain nanobody protects mice against influenza A and B infections. Science immunology 8 (84) (2023)
Yoon Ho Lee, Himadri Medhi, Xin Liu, In Han Ha, Ki Tae Nam, Hidde L Ploegh
Selective Targeting of Nanobody-Modified Gold Nanoparticles to Distinct Cell Types. ACS applied materials & interfaces (2023)
Xiaomeng Han, Xiaotang Lu, Peter H Li, Shuohong Wang, Richard L Schalek, Yaron Meirovitch, Zudi Lin, Jason Adhinarta, Daniel Raimund Berger, Yuelong Wu, Tao Fang, Elif Sevde Meral, Shadnan Asraf, Hidde L Ploegh, Hanspeter Pfister, Donglai Wei, Viren Jain, James S Trimmer, Jeff William Lichtman
Multiplexed Volumetric CLEM enabled by antibody derivatives provides new insights into the cytology of the mouse cerebellar cortex. bioRxiv : the preprint server for biology (2023)
Jeff William Lichtman, Xiaomeng Han, Xiaotang Lu, Peter Li, Shuohong Wang, Richard Schalek, Yaron Meirovitch, Zudi Lin, Jason Adhinarta, Daniel Berger, Yuelong Wu, Tao Fang, Elif Sevde Meral, Shadnan Asraf, Hidde L Ploegh, Hanspeter Pfister, Donglai Wei, Viren Jain, James S Trimmer
Multiplexed volumetric CLEM enabled by antibody derivatives provides new insights into the cytology of the mouse cerebellar cortex. Research square (2023)
Timothy A Bates, Mila Trank-Greene, Xammy Huu Nguyenla, Aidan Anastas, Ilaria R Merutka, Shandee D Dixon, Anthony Shumate, Abigail R Groncki, Matthew A H Parson, Eric Barklis, John E Burke, Ujwal Shinde, Hidde L Ploegh, Fikadu G Tafesse
ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6 specific nanobody restricts M. tuberculosis growth in macrophages. bioRxiv : the preprint server for biology (2023)
Djenet Bousbaine, Laura I Fisch, Mariya London, Preksha Bhagchandani, Tiago Rezende de Castro, Mark Mimee, Scott W Olesen, Bernardo Sgarbi Reis, Libusha Kelly, Juliana Bortolatto, Mathilde Poyet, Ross W Cheloha, John Sidney, Jingjing Ling, Aaron Gupta, Timothy K Lu, Alessandro Sette, Eric John Alm, James J Moon, Gabriel D Victora, Daniel Mucida, Hidde L Ploegh, Angelina M Bilate
A conserved Bacteroidetes antigen induces anti-inflammatory intestinal T lymphocytes. Science (New York, N.Y.) 377 (6606) (2022)
Novalia Pishesha, Thibault J Harmand, Hidde L Ploegh
A guide to antigen processing and presentation. Nature reviews. Immunology 22 (12) (2022)
Lea-Marie Jenster, Karl-Elmar Lange, Sabine Normann, Anja Vom Hemdt, Jennifer Deborah Wuerth, Lisa D J Schiffelers, Yonas M Tesfamariam, Florian N Gohr, Laura Klein, Ines H Kaltheuner, Stefan Ebner, Dorothee Johanna Lapp, Jacob Mayer, Jonas Moecking, Hidde L Ploegh, Eicke Latz, Rüdiger Klein, Matthias Geyer, Beate Mareike Kümmerer, Florian Ingo Schmidt
P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection. The Journal of experimental medicine 220 (1) (2022)
Novalia Pishesha, Thibault Harmand, Claire Carpenet, Xin Liu, Atul Bhan, Ashraful Islam, Renate van den Doel, William Pinney, Hidde L Ploegh
Targeted delivery of an anti-inflammatory corticosteroid to Ly6C/G-positive cells abates severity of influenza A symptoms. Proceedings of the National Academy of Sciences of the United States of America 119 (43) (2022)
Sai Luo, Jun Zhang, Alex J B Kreutzberger, Amanda Eaton, Robert J Edwards, Chang-Bin Jing, Hai-Qiang Dai, Gregory D Sempowski, Kenneth Cronin, Robert Parks, Adam Yongxin Ye, Katayoun Mansouri, Maggie Barr, Novalia Pishesha, Aimee Chapdelaine Williams, Lucas Vieira Francisco, Anand Saminathan, Hanqin Peng, Himanshu Batra, Lorenza Bellusci, Surender Khurana, S Munir Alam, David C Montefiori, Kevin O Saunders, Ming Tian, Hidde L Ploegh, Tomas Kirchhausen, Bing Chen, Barton F Haynes, Frederick W Alt
An antibody from single human V H -rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion. Science immunology 7 (76) (2022)
Ross W Cheloha, Fabian A Fischer, Thomas J Gardella, Hidde L Ploegh
Activation of a G protein-coupled receptor through indirect antibody-mediated tethering of ligands. RSC chemical biology 2 (6) (2021)
Thibault J Harmand, Ashraful Islam, Novalia Pishesha, Hidde L Ploegh
Nanobodies as in vivo, non-invasive, imaging agents. RSC chemical biology 2 (3) (2021)
Ashraful Islam, Novalia Pishesha, Thibault J Harmand, Hailey Heston, Andrew W Woodham, Ross W Cheloha, Djenet Bousbaine, Mohammad Rashidian, Hidde L Ploegh
Converting an Anti-Mouse CD4 Monoclonal Antibody into an scFv Positron Emission Tomography Imaging Agent for Longitudinal Monitoring of CD4+ T Cells. Journal of immunology (Baltimore, Md. : 1950) 207 (5) (2021)
Novalia Pishesha, Thibault J Harmand, Paul W Rothlauf, Patrique Praest, Ryan K Alexander, Renate van den Doel, Mariel J Liebeskind, Maria A Vakaki, Nicholas McCaul, Charlotte Wijne, Elisha Verhaar, William Pinney, Hailey Heston, Louis-Marie Bloyet, Marjorie Cornejo Pontelli, Ma Xenia G Ilagan, Robert Jan Lebbink, William J Buchser, Emmanuel J H J Wiertz, Sean P J Whelan, Hidde L Ploegh
A class II MHC-targeted vaccine elicits immunity against SARS-CoV-2 and its variants. Proceedings of the National Academy of Sciences of the United States of America 118 (44) (2021)
Novalia Pishesha, Thibault Harmand, Liyan Y Smeding, Weiyi Ma, Leif S Ludwig, Robine Janssen, Ashraful Islam, Yushu J Xie, Tao Fang, Nicholas McCaul, William Pinney, Harun R Sugito, Martin A Rossotti, Gualberto Gonzalez-Sapienza, Hidde L Ploegh
Induction of antigen-specific tolerance by nanobody-antigen adducts that target class-II major histocompatibility complexes. Nature biomedical engineering 5 (11) (2021)
Jae-Hyeok Choi, Lip Ket Chin, Bo Mee Woo, Younghoon Song, Min Jeong Seol, Yoontaik Hong, Ai-Qun Liu, Seongsoo Jang, Hidde L Ploegh, Hyungsoon Im, Dongyoung Lee
Hydrogel-Based Stamping Technology for Solution-Free Blood Cell Staining. ACS applied materials & interfaces 13 (19) (2021)
Alexander R Loftis, Genwei Zhang, Coralie M Backlund, Anthony J Quartararo, Novalia Pishesha, Cameron C Hanna, Carly K Schissel, Daniel Garafola, Andrei Loas, R John Collier, Hidde L Ploegh, Darrell J Irvine, Bradley L Pentelute
An in vivo selection-derived d-peptide for engineering erythrocyte-binding antigens that promote immune tolerance. Proceedings of the National Academy of Sciences of the United States of America 118 (34) (2021)
Hidde L Ploegh
A giant ubiquitin ligase. Nature chemical biology 17 (10) (2021)
Thibault J Harmand, Novalia Pishesha, Fabian B H Rehm, Weiyi Ma, William B Pinney, Yushu J Xie, Hidde L Ploegh
Asparaginyl Ligase-Catalyzed One-Step Cell Surface Modification of Red Blood Cells. ACS chemical biology 16 (7) (2021)
Timo W M De Groof, Nick D Bergkamp, Raimond Heukers, Truc Giap, Maarten P Bebelman, Richard Goeij-de Haas, Sander R Piersma, Connie R Jimenez, K Christopher Garcia, Hidde L Ploegh, Marco Siderius, Martine J Smit
Selective targeting of ligand-dependent and -independent signaling by GPCR conformation-specific anti-US28 intrabodies. Nature communications 12 (1) (2021)
Yu Kato, Thiago M Steiner, Hae-Young Park, Rohan O Hitchcock, Ali Zaid, Jyh Liang Hor, Sapna Devi, Gayle M Davey, David Vremec, Kirsteen M Tullett, Peck Szee Tan, Fatma Ahmet, Scott N Mueller, Sylvie Alonso, David Mathew Tarlinton, Hidde L Ploegh, Tsuneyasu Kaisho, Lynette Beattie, Jonathan H Manton, Daniel Fernandez-Ruiz, Ken Shortman, Mireille H Lahoud, William R Heath, Irina Caminschi
Display of Native Antigen on cDC1 That Have Spatial Access to Both T and B Cells Underlies Efficient Humoral Vaccination. Journal of immunology (Baltimore, Md. : 1950) 205 (7) (2020)
Ross W Cheloha, Fabian A Fischer, Andrew W Woodham, Eileen Daley, Naomi Suminski, Thomas J Gardella, Hidde L Ploegh
Improved GPCR ligands from nanobody tethering. Nature communications 11 (1) (2020)
Sarah A Nordeen, Kasper Røjkjær Andersen, Kevin E Knockenhauer, Jessica R Ingram, Hidde L Ploegh, Thomas U Schwartz
A nanobody suite for yeast scaffold nucleoporins provides details of the nuclear pore complex structure. Nature communications 11 (1) (2020)
Andrew W Woodham, Stad H Zeigler, Ella L Zeyang, Stephen C Kolifrath, Ross W Cheloha, Mohammad Rashidian, Rodolfo J Chaparro, Ronald D Seidel, Scott J Garforth, Jason L Dearling, Maia Mesyngier, Phaneendra K Duddempudi, Alan B Packard, Steven C Almo, Hidde L Ploegh
In vivo detection of antigen-specific CD8+ T cells by immuno-positron emission tomography. Nature methods 17 (10) (2020)
Yushu Joy Xie, Michael Dougan, Jessica R Ingram, Novalia Pishesha, Tao Fang, Noor Momin, Hidde L Ploegh
Improved Antitumor Efficacy of Chimeric Antigen Receptor T Cells that Secrete Single-Domain Antibody Fragments. Cancer immunology research 8 (4) (2020)
Noor Jailkhani, Jessica R Ingram, Mohammad Rashidian, Steffen Rickelt, Chenxi Tian, Howard Mak, Zhigang Jiang, Hidde L Ploegh, Richard O Hynes
Noninvasive imaging of tumor progression, metastasis, and fibrosis using a nanobody targeting the extracellular matrix. Proceedings of the National Academy of Sciences of the United States of America 116 (28) (2019)
Ross W Cheloha, Zeyang Li, Djenet Bousbaine, Andrew W Woodham, Priscillia Perrin, Jana Volarić, Hidde L Ploegh
Internalization of Influenza Virus and Cell Surface Proteins Monitored by Site-Specific Conjugation of Protease-Sensitive Probes. ACS chemical biology 14 (8) (2019)
Fabian B H Rehm, Thibault J Harmand, Kuok Yap, Thomas Durek, David J Craik, Hidde L Ploegh
Site-Specific Sequential Protein Labeling Catalyzed by a Single Recombinant Ligase. Journal of the American Chemical Society 141 (43) (2019)
Ross W Cheloha, Andrew W Woodham, Djenet Bousbaine, Tong Wang, Shi Liu, John Sidney, Alessandro Sette, Samuel H Gellman, Hidde L Ploegh
Recognition of Class II MHC Peptide Ligands That Contain β-Amino Acids. Journal of immunology (Baltimore, Md. : 1950) 203 (6) (2019)
Jordan A Krall, Ferenc Reinhardt, Oblaise A Mercury, Diwakar R Pattabiraman, Mary W Brooks, Michael Dougan, Arthur W Lambert, Brian Bierie, Hidde L Ploegh, Stephanie K Dougan, Robert A Weinberg
The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy. Science translational medicine 10 (436) (2019)
Mohammad Rashidian, Martin W LaFleur, Vincent L Verschoor, Anushka Dongre, Yun Zhang, Thao H Nguyen, Stephen Kolifrath, Amir R Aref, Christie J Lau, Cloud P Paweletz, Xia Bu, Gordon J Freeman, M Inmaculada Barrasa, Robert A Weinberg, Arlene H Sharpe, Hidde L Ploegh
Immuno-PET identifies the myeloid compartment as a key contributor to the outcome of the antitumor response under PD-1 blockade. Proceedings of the National Academy of Sciences of the United States of America 116 (34) (2019)
Yushu Joy Xie, Michael Dougan, Noor Jailkhani, Jessica Ingram, Tao Fang, Laura Kummer, Noor Momin, Novalia Pishesha, Steffen Rickelt, Richard O Hynes, Hidde L Ploegh
Nanobody-based CAR T cells that target the tumor microenvironment inhibit the growth of solid tumors in immunocompetent mice. Proceedings of the National Academy of Sciences of the United States of America 116 (16) (2019)
Tao Fang, Ran Li, Zeyang Li, Julia Cho, Jonathan S Guzman, Roger Dale Kamm, Hidde L Ploegh
Remodeling of the Tumor Microenvironment by a Chemokine/Anti-PD-L1 Nanobody Fusion Protein. Molecular pharmaceutics 16 (6) (2019)
Jessica R Ingram, Olga S Blomberg, Mohammad Rashidian, Lestat Ali, Scott Garforth, Elena Fedorov, Alexander A Fedorov, Jeffrey B Bonanno, Camille Le Gall, Stephanie Crowley, Camilo Espinosa, Tamara Biary, Edmund J Keliher, Ralph Weissleder, Steven C Almo, Stephanie K Dougan, Hidde L Ploegh, Michael Dougan
Anti-CTLA-4 therapy requires an Fc domain for efficacy. Proceedings of the National Academy of Sciences of the United States of America 115 (15) (2018)
Soohyun Kwon, Joao N Duarte, Zeyang Li, Jingjing J Ling, Olivier Cheneval, Thomas Durek, Christina I Schroeder, David J Craik, Hidde L Ploegh
Targeted Delivery of Cyclotides via Conjugation to a Nanobody. ACS chemical biology 13 (10) (2018)
Chih-Hang Anthony Tang, Shiun Chang, Adrienne W Paton, James C Paton, Dmitry I Gabrilovich, Hidde L Ploegh, Juan R Del Valle, Chih-Chi Andrew Hu
Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization. The Journal of cell biology 217 (5) (2018)
Thibault J Harmand, Djenet Bousbaine, Alix I Chan, Xiaohong Zhang, David R Liu, James P Tam, Hidde L Ploegh
One-Pot Dual Labeling of IgG 1 and Preparation of C-to-C Fusion Proteins Through a Combination of Sortase A and Butelase 1. Bioconjugate chemistry 29 (10) (2018)
Matthias C Truttmann, David Pincus, Hidde L Ploegh
Chaperone AMPylation modulates aggregation and toxicity of neurodegenerative disease-associated polypeptides. Proceedings of the National Academy of Sciences of the United States of America 115 (22) (2018)
Leo Hanke, Florian Ingo Schmidt, Kevin E Knockenhauer, Benjamin Morin, Sean Pj Whelan, Thomas U Schwartz, Hidde L Ploegh
Vesicular stomatitis virus N protein-specific single-domain antibody fragments inhibit replication. EMBO reports 18 (6) (2017)
Qin Wu, Hidde L Ploegh, Matthias C Truttmann
Hepta-Mutant Staphylococcus aureus Sortase A (SrtA7m) as a Tool for in Vivo Protein Labeling in Caenorhabditis elegans. ACS chemical biology 12 (3) (2017)
Neelkanth M Bardhan, Priyank V Kumar, Zeyang Li, Hidde L Ploegh, Jeffrey C Grossman, Angela M Belcher, Guan-Yu Chen
Enhanced Cell Capture on Functionalized Graphene Oxide Nanosheets through Oxygen Clustering. ACS nano 11 (2) (2017)
Mohammad Rashidian, Jessica R Ingram, Michael L Dougan, Anushka Dongre, Katherine A Whang, Camille LeGall, Juan J Cragnolini, Brian Bierie, Monica Gostissa, James Gorman, Gijsbert M Grotenbreg, Atul Bhan, Robert A Weinberg, Hidde L Ploegh
Predicting the response to CTLA-4 blockade by longitudinal noninvasive monitoring of CD8 T cells. The Journal of experimental medicine 214 (8) (2017)
Tao Fang, Catharina H M J Van Elssen, Joao N Duarte, Jonathan S Guzman, Jasdave S Chahal, Jingjing Ling, Hidde L Ploegh
Targeted antigen delivery by an anti-class II MHC VHH elicits focused αMUC1(Tn) immunity. Chemical science 8 (8) (2017)
Joao N Duarte, Juan J Cragnolini, Lee Kim Swee, Angelina M Bilate, Justin Bader, Jessica R Ingram, Ali Rashidfarrokhi, Tao Fang, Ariën Schiepers, Leo Hanke, Hidde L Ploegh
Generation of Immunity against Pathogens via Single-Domain Antibody-Antigen Constructs. Journal of immunology (Baltimore, Md. : 1950) 197 (12) (2016)
Julia von Rohrscheidt, Elisabetta Petrozziello, Jelena Nedjic, Christine Federle, Lena Krzyzak, Hidde L Ploegh, Satoshi Ishido, Alexander Steinkasserer, Ludger Klein
Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83. The Journal of experimental medicine 213 (9) (2016)

Hidde L Ploegh.css-eqlu8i{font-size:small;padding-left:4px;} (Hidde Ploegh)

Publication Activity (10 Years)

Top Topics

Top Venues

Hidde L Ploegh (Hidde Ploegh)