David T Scadden (Giulia Schiroli)

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 26

Top Topics

Acute Myeloid Leukemia

Diffusion Weighted

Top Venues

Nature communications

Science signaling

This page only lists publications with an associated author ORCID identifier.

Publications

Asim Saha, Rahul Palchaudhuri, Leanne Lanieri, Sharon Hyzy, Megan J Riddle, Jamie Panthera, Cindy R Eide, Jakub Tolar, Angela Panoskaltsis-Mortari, Lev Gorfinkel, Victor Tkachev, Ulrike Gerdemann, Francesca Alvarez Calderon, Elisa Rojas Palato, Margaret L MacMillan, John E Wagner, Leslie S Kean, Mark J Osborn, Hans-Peter Kiem, David T Scadden, Lisa M Olson, Bruce R Blazar
Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate-conditioned Fanconi anemia mice. Blood 143 (21) (2024)
Asim Saha, Rahul Palchaudhuri, Leanne Lanieri, Sharon Hyzy, Megan J Riddle, Jamie Panthera, Cindy R Eide, Jakub Tolar, Angela Panoskaltsis-Mortari, Lev Gorfinkel, Victor Tkachev, Ulrike Gerdemann, Francesca Alvarez Calderon, Elisa Rojas Palato, Margaret L MacMillan, John E Wagner, Leslie S Kean, Mark Osborn, Hans-Peter Kiem, David T Scadden, Lisa M Olson, Bruce R Blazar
Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate conditioned Fanconi anemia mice. Blood (2024)
Asim Saha, Rahul Palchaudhuri, Leanne Lanieri, Sharon Hyzy, Megan J Riddle, Jamie Panthera, Cindy R Eide, Jakub Tolar, Angela Panoskaltsis-Mortari, Lev Gorfinkel, Victor Tkachev, Ulrike Gerdemann, Francesca Alvarez Calderon, Elisa Rojas Palato, Margaret L MacMillan, John E Wagner, Leslie S Kean, Mark Osborn, Hans-Peter Kiem, David T Scadden, Lisa M Olson, Bruce R Blazar
Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate conditioned Fanconi anemia mice. Blood (2024)
David T Scadden, Vinay Kartha, Fabiana M Duarte, Trine A Kristiansen, Christina Mayerhofer, Rojesh Shrestha, Andrew Scott Earl, Yan Hu, Tristan Tay, Catherine Rhee, Jason D Buenrostro, David T Scadden
Cell of origin epigenetic priming determines susceptibility to Tet2 mutation. Nature communications 15 (1) (2024)
David T Scadden, Vinay Kartha, Fabiana M Duarte, Trine A Kristiansen, Christina Mayerhofer, Rojesh Shrestha, Andrew Scott Earl, Yan Hu, Tristan Tay, Catherine Rhee, Jason D Buenrostro, David T Scadden
Cell of origin epigenetic priming determines susceptibility to Tet2 mutation. Nature communications 15 (1) (2024)
Asim Saha, Rahul Palchaudhuri, Leanne Lanieri, Sharon Hyzy, Megan J Riddle, Jamie Panthera, Cindy R Eide, Jakub Tolar, Angela Panoskaltsis-Mortari, Lev Gorfinkel, Victor Tkachev, Ulrike Gerdemann, Francesca Alvarez Calderon, Elisa Rojas Palato, Margaret L MacMillan, John E Wagner, Leslie S Kean, Mark Osborn, Hans-Peter Kiem, David T Scadden, Lisa M Olson, Bruce R Blazar
Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate conditioned Fanconi anemia mice. Blood (2024)
Asim Saha, Rahul Palchaudhuri, Leanne Lanieri, Sharon Hyzy, Megan J Riddle, Jamie Panthera, Cindy R Eide, Jakub Tolar, Angela Panoskaltsis-Mortari, Lev Gorfinkel, Victor Tkachev, Ulrike Gerdemann, Francesca Alvarez Calderon, Elisa Rojas Palato, Margaret L MacMillan, John E Wagner, Leslie S Kean, Mark J Osborn, Hans-Peter Kiem, David T Scadden, Lisa M Olson, Bruce R Blazar
Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate-conditioned Fanconi anemia mice. Blood 143 (21) (2024)
David T Scadden, Vinay Kartha, Fabiana M Duarte, Trine A Kristiansen, Christina Mayerhofer, Rojesh Shrestha, Andrew Scott Earl, Yan Hu, Tristan Tay, Catherine Rhee, Jason D Buenrostro, David T Scadden
Cell of origin epigenetic priming determines susceptibility to Tet2 mutation. Nature communications 15 (1) (2024)
David T Scadden, Vinay Kartha, Fabiana M Duarte, Trine A Kristiansen, Christina Mayerhofer, Rojesh Shrestha, Andrew Scott Earl, Yan Hu, Tristan Tay, Catherine Rhee, Jason D Buenrostro, David T Scadden
Cell of origin epigenetic priming determines susceptibility to Tet2 mutation. Nature communications 15 (1) (2024)
Asim Saha, Rahul Palchaudhuri, Leanne Lanieri, Sharon Hyzy, Megan J Riddle, Jamie Panthera, Cindy R Eide, Jakub Tolar, Angela Panoskaltsis-Mortari, Lev Gorfinkel, Victor Tkachev, Ulrike Gerdemann, Francesca Alvarez Calderon, Elisa Rojas Palato, Margaret L MacMillan, John E Wagner, Leslie S Kean, Mark Osborn, Hans-Peter Kiem, David T Scadden, Lisa M Olson, Bruce R Blazar
Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate conditioned Fanconi anemia mice. Blood (2024)
Asim Saha, Rahul Palchaudhuri, Leanne Lanieri, Sharon Hyzy, Megan J Riddle, Jamie Panthera, Cindy R Eide, Jakub Tolar, Angela Panoskaltsis-Mortari, Lev Gorfinkel, Victor Tkachev, Ulrike Gerdemann, Francesca Alvarez Calderon, Elisa Rojas Palato, Margaret L MacMillan, John E Wagner, Leslie S Kean, Mark Osborn, Hans-Peter Kiem, David T Scadden, Lisa M Olson, Bruce R Blazar
Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate conditioned Fanconi anemia mice. Blood (2024)
Asim Saha, Rahul Palchaudhuri, Leanne Lanieri, Sharon Hyzy, Megan J Riddle, Jamie Panthera, Cindy R Eide, Jakub Tolar, Angela Panoskaltsis-Mortari, Lev Gorfinkel, Victor Tkachev, Ulrike Gerdemann, Francesca Alvarez Calderon, Elisa Rojas Palato, Margaret L MacMillan, John E Wagner, Leslie S Kean, Mark J Osborn, Hans-Peter Kiem, David T Scadden, Lisa M Olson, Bruce R Blazar
Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate-conditioned Fanconi anemia mice. Blood 143 (21) (2024)
Asim Saha, Rahul Palchaudhuri, Leanne Lanieri, Sharon Hyzy, Megan J Riddle, Jamie Panthera, Cindy R Eide, Jakub Tolar, Angela Panoskaltsis-Mortari, Lev Gorfinkel, Victor Tkachev, Ulrike Gerdemann, Francesca Alvarez Calderon, Elisa Rojas Palato, Margaret L MacMillan, John E Wagner, Leslie S Kean, Mark J Osborn, Hans-Peter Kiem, David T Scadden, Lisa M Olson, Bruce R Blazar
Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate-conditioned Fanconi anemia mice. Blood 143 (21) (2024)
Peter Grant Miller, Adam S Sperling, Christina Mayerhofer, Marie McConkey, Jana Maria Ellegast, Carmen Da Silva, Drew Nathaniel Cohen, Chuqi Wang, Azeem Sharda, Ni Yan, Subha Saha, Cameron Schluter, Ilexa Ashley Schechter, Mikołaj Słabicki, Brittany Sandoval, Josephine Kahn, Steffen Boettcher, Christopher J Gibson, David T Scadden, Kimberly Stegmaier, Shruti Bhatt, R Coleman Lindsley, Benjamin L Ebert
PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy. Blood (2023)
Youmna S Kfoury, Fei Ji, Esha Jain, Michael C Mazzola, David T Scadden, Ani Papazian, Francois Emile Mercier, David Brian Sykes, Anna Kiem, Mark A Randolph, Omar I Abdel-Wahab, Laura Maria Calvi, Ruslan Sadreyev, David T Scadden
The bone marrow stroma in human myelodysplastic syndrome reveals alterations that regulate disease progression. Blood advances (2023)
Catherine Rhee, Elizabeth W Scadden, Lai Ping Wong, David T Scadden, Michael C Mazzola, Phillip L Chea, Hiroki Kato, Friedrich F Hoyer, Meeta Mistry, Bum-Kyu Lee, Jonghwan Kim, Matthias Nahrendorf, Michael K Mansour, David Brian Sykes, Ruslan Sadreyev, David T Scadden
Limited plasticity of monocyte fate and function associated with epigenetic scripting at the level of progenitors. Blood (2023)
Karin Gustafsson, Catherine Rhee, Vanessa Frodermann, Elizabeth W Scadden, Dan Li, Yoshiko Iwamoto, Rahul Palchaudhuri, Sharon Hyzy, Anthony Boitano, Matthias Nahrendorf, David T Scadden
Clearing and replacing tissue-resident myeloid cells with an anti-CD45-antibody-drug conjugate. Blood advances (2023)
Francois Emile Mercier, Jiantao Shi, David Brian Sykes, Toshihiko Oki, Maja Jankovic, Cheuk-Him Man, Youmna S Kfoury, Elizabeth Miller, Shutao He, Alexander Zhu, Radovan Vasic, John G Doench, Alexandre Orthwein, Franziska Michor, David T Scadden
In vivo genome-wide CRISPR screening in murine acute myeloid leukemia uncovers microenvironmental dependencies. Blood advances 6 (17) (2022)
Johannes Elferich, David T Scadden, David T Scadden, Nikolaus Grigorieff
Defocus Corrected Large Area Cryo-EM (DeCo-LACE) for label-free detection of molecules across entire cell sections. eLife 11 (2022)
Cameron S McAlpine, Máté G Kiss, Faris M Zuraikat, David Cheek, David T Scadden, Hajera Amatullah, Pacific Huynh, Mehreen Z Bhatti, Lai-Ping Wong, Abi G Yates, Wolfram C Poller, John E Mindur, Christopher T Chan, Henrike Janssen, Jeffrey Downey, Sumnima Singh, Ruslan I Sadreyev, Matthias Nahrendorf, Kate L Jeffrey, David T Scadden, Kamila Naxerova, Marie-Pierre St-Onge, Filip K Swirski
Sleep exerts lasting effects on hematopoietic stem cell function and diversity. The Journal of experimental medicine 219 (11) (2022)
Veerle W Daniels, Jason J Zoeller, Nick van Gastel, Kelley E McQueeney, Salma Parvin, Danielle S Potter, Geoffrey G Fell, Vinícius G Ferreira, Binyam Yilma, Rajat Gupta, Johan K E Spetz, Patrick D Bhola, Jennifer E Endress, Isaac S Harris, Emanuel Carrilho, Kristopher A Sarosiek, David T Scadden, Joan S Brugge, Anthony G Letai
Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3 mimetics. Science signaling 14 (686) (2021)
Toshihiko Oki, Francois Mercier, Hiroki Kato, Yookyung Jung, Thomas O McDonald, Joel A Spencer, Michael C Mazzola, Nick van Gastel, Charles P Lin, Franziska Michor, Toshio Kitamura, David T Scadden
Imaging dynamic mTORC1 pathway activity in vivo reveals marked shifts that support time-specific inhibitor therapy in AML. Nature communications 12 (1) (2021)
Cheuk Him Man, Francois Emile Mercier, Nian Liu, Wentao Dong, Gregory Stephanopoulos, Li Jiang, Yookyung Jung, Charles P Lin, Anskar Yh Leung, David T Scadden
Proton export alkalinizes intracellular pH and reprograms carbon metabolism to drive hematopoietic progenitor growth. Blood (2021)
Nisarg J Shah, Alexander J Najibi, Ting-Yu Shih, Angelo S Mao, Azeem Sharda, David T Scadden, David J Mooney
A biomaterial-based vaccine eliciting durable tumour-specific responses against acute myeloid leukaemia. Nature biomedical engineering 4 (1) (2020)
Camilla Engblom, Christina Pfirschke, Rapolas Zilionis, Janaina Da Silva Martins, Stijn A Bos, Gabriel Courties, Steffen Rickelt, Nicolas Severe, Ninib Baryawno, Julien Faget, Virginia Savova, David Zemmour, Jaclyn Kline, Marie Siwicki, Christopher S Garris, Ferdinando Pucci, Hsin-Wei Liao, Yi-Jang Lin, Andita Newton, Omar K Yaghi, Yoshiko Iwamoto, Benoit Tricot, Gregory R Wojtkiewicz, Matthias Nahrendorf, Virna Cortez-Retamozo, Etienne Meylan, Richard O Hynes, Marie B Demay, Allon M Klein, Miriam A Bredella, David T Scadden, Ralph Weissleder, Mikaël J Pittet
Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils. Science (New York, N.Y.) 358 (6367) (2018)
David T Scadden, Samuele Ferrari, Anthony Conway, Aurélien Jacob, Valentina Capo, Luisa Albano, Tiziana Plati, Maria C Castiello, Francesca Sanvito, Andrew R Gennery, Chiara Bovolenta, Rahul Palchaudhuri, David T Scadden, Michael C Holmes, Anna Villa, Giovanni Sitia, Angelo Lombardo, Pietro Genovese, Luigi Naldini
Preclinical modeling highlights the therapeutic potential of hematopoietic stem cell gene editing for correction of SCID-X1. Science translational medicine 9 (411) (2018)