Sarel Jacob Fleishman (Sarel J Fleishman, S J Fleishman)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 52

Top Venues

Nature communications

Journal of the American Chemical Society

Proceedings of the National Academy of Sciences of the United States of America

Protein science : a publication of the Protein Society

Weizmann Institute of Science

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Weizmann Institute of Science Sep 01 2011

Israel

Assistant Professor :: Department of Biomolecular Sciences

Howard Hughes Medical Institute - University of Washington Oct 01 2006 - Aug 31 2011

United States

Postdoctoral Fellow :: Biochemistry

Publications

Rosalie Lipsh-Sokolik, Sarel Jacob Fleishman
Addressing epistasis in the design of protein function. Proceedings of the National Academy of Sciences of the United States of America 121 (34) (2024)
Rosalie Lipsh-Sokolik, Sarel Jacob Fleishman
Addressing epistasis in the design of protein function. Proceedings of the National Academy of Sciences of the United States of America 121 (34) (2024)
Dina Listov, Casper A Goverde, Bruno E Correia, Sarel Jacob Fleishman
Opportunities and challenges in design and optimization of protein function. Nature reviews. Molecular cell biology 25 (8) (2024)
Jonathan Yaacov Weinstein, Chandamita Saikia, Izhar Karbat, Adi Goldenzweig, Eitan Reuveny, Sarel Jacob Fleishman
One-shot design elevates functional expression levels of a voltage-gated potassium channel. Protein science : a publication of the Protein Society 33 (6) (2024)
Dina Listov, Casper A Goverde, Bruno E Correia, Sarel Jacob Fleishman
Opportunities and challenges in design and optimization of protein function. Nature reviews. Molecular cell biology (2024)
Dina Listov, Casper A Goverde, Bruno E Correia, Sarel Jacob Fleishman
Opportunities and challenges in design and optimization of protein function. Nature reviews. Molecular cell biology (2024)
Jonathan Yaacov Weinstein, Chandamita Saikia, Izhar Karbat, Adi Goldenzweig, Eitan Reuveny, Sarel Jacob Fleishman
One-shot design elevates functional expression levels of a voltage-gated potassium channel. Protein science : a publication of the Protein Society 33 (6) (2024)
Rosalie Lipsh-Sokolik, Sarel Jacob Fleishman
Addressing epistasis in the design of protein function. Proceedings of the National Academy of Sciences of the United States of America 121 (34) (2024)
Dina Listov, Casper A Goverde, Bruno E Correia, Sarel Jacob Fleishman
Opportunities and challenges in design and optimization of protein function. Nature reviews. Molecular cell biology 25 (8) (2024)
Shlomo Yakir Hoch, Ravit Netzer, Jonathan Yaacov Weinstein, Lucas Krauss, Karen Hakeny, Sarel Jacob Fleishman
GGAssembler: Precise and economical design and synthesis of combinatorial mutation libraries. Protein science : a publication of the Protein Society 33 (10) (2024)
Iris D Zelnik, Beatriz Mestre, Jonathan Yaacov Weinstein, Tamir Dingjan, Stav Izrailov, Shifra Ben-Dor, Sarel Jacob Fleishman, Anthony H Futerman
Computational design and molecular dynamics simulations suggest the mode of substrate binding in ceramide synthases. Nature communications 14 (1) (2023)
Ariel Tennenhouse, Lev Khmelnitsky, Razi Khalaila, Noa Yeshaya, Ashish Noronha, Moshit Lindzen, Emily K Makowski, Ira Zaretsky, Yael Fridmann Sirkis, Yael Galon-Wolfenson, Peter M Tessier, Jakub Abramson, Yosef Yarden, Deborah Fass, Sarel Jacob Fleishman
Computational optimization of antibody humanness and stability by systematic energy-based ranking. Nature biomedical engineering (2023)
Iris D Zelnik, Beatriz Mestre, Jonathan Yaacov Weinstein, Tamir Dingjan, Stav Izrailov, Shifra Ben-Dor, Sarel Jacob Fleishman, Anthony H Futerman
Computational design and molecular dynamics simulations suggest the mode of substrate binding in ceramide synthases. Nature communications 14 (1) (2023)
Patricia Gomez de Santos, Ivan Mateljak, Manh Dat Hoang, Sarel Jacob Fleishman, Frank Hollmann, Miguel Alcalde
Repertoire of Computationally Designed Peroxygenases for Enantiodivergent C-H Oxyfunctionalization Reactions. Journal of the American Chemical Society 145 (6) (2023)
Patricia Gomez de Santos, Ivan Mateljak, Manh Dat Hoang, Sarel Jacob Fleishman, Frank Hollmann, Miguel Alcalde
Repertoire of Computationally Designed Peroxygenases for Enantiodivergent C-H Oxyfunctionalization Reactions. Journal of the American Chemical Society 145 (6) (2023)
Iris D Zelnik, Beatriz Mestre, Jonathan Yaacov Weinstein, Tamir Dingjan, Stav Izrailov, Shifra Ben-Dor, Sarel Jacob Fleishman, Anthony H Futerman
Computational design and molecular dynamics simulations suggest the mode of substrate binding in ceramide synthases. Nature communications 14 (1) (2023)
Jonathan Yaacov Weinstein, Carlos Martí-Gómez, Rosalie Lipsh-Sokolik, Shlomo Yakir Hoch, Demian Liebermann, Reinat Nevo, Haim Weissman, Ekaterina Petrovich-Kopitman, David Margulies, Dmitry N Ivankov, David M McCandlish, Sarel Jacob Fleishman
Designed active-site library reveals thousands of functional GFP variants. Nature communications 14 (1) (2023)
Rosalie Lipsh-Sokolik, Olga Khersonsky, Sybrin P Schröder, Casper de Boer, Shlomo Yakir Hoch, Gideon J Davies, Herman S Overkleeft, Sarel Jacob Fleishman
Combinatorial assembly and design of enzymes. Science (New York, N.Y.) 379 (6628) (2023)
Patricia Gomez de Santos, Ivan Mateljak, Manh Dat Hoang, Sarel Jacob Fleishman, Frank Hollmann, Miguel Alcalde
Repertoire of Computationally Designed Peroxygenases for Enantiodivergent C-H Oxyfunctionalization Reactions. Journal of the American Chemical Society 145 (6) (2023)
Jonathan Yaacov Weinstein, Carlos Martí-Gómez, Rosalie Lipsh-Sokolik, Shlomo Yakir Hoch, Demian Liebermann, Reinat Nevo, Haim Weissman, Ekaterina Petrovich-Kopitman, David Margulies, Dmitry N Ivankov, David M McCandlish, Sarel Jacob Fleishman
Designed active-site library reveals thousands of functional GFP variants. Nature communications 14 (1) (2023)
Gerard Duart, Assaf Elazar, Jonathan Yaacov Weinstein, Laura Gadea-Salom, Juan Ortiz-Mateu, Sarel Jacob Fleishman, Ismael Mingarro, Luis Martinez-Gil
Computational design of BclxL inhibitors that target transmembrane domain interactions. Proceedings of the National Academy of Sciences of the United States of America 120 (11) (2023)
Iris D Zelnik, Beatriz Mestre, Jonathan Yaacov Weinstein, Tamir Dingjan, Stav Izrailov, Shifra Ben-Dor, Sarel Jacob Fleishman, Anthony H Futerman
Computational design and molecular dynamics simulations suggest the mode of substrate binding in ceramide synthases. Nature communications 14 (1) (2023)
Patricia Gomez de Santos, Ivan Mateljak, Manh Dat Hoang, Sarel Jacob Fleishman, Frank Hollmann, Miguel Alcalde
Repertoire of Computationally Designed Peroxygenases for Enantiodivergent C-H Oxyfunctionalization Reactions. Journal of the American Chemical Society 145 (6) (2023)
Patricia Gomez de Santos, Ivan Mateljak, Manh Dat Hoang, Sarel Jacob Fleishman, Frank Hollmann, Miguel Alcalde
Repertoire of Computationally Designed Peroxygenases for Enantiodivergent C-H Oxyfunctionalization Reactions. Journal of the American Chemical Society (2023)
Patricia Gomez de Santos, Ivan Mateljak, Manh Dat Hoang, Sarel Jacob Fleishman, Frank Hollmann, Miguel Alcalde
Repertoire of Computationally Designed Peroxygenases for Enantiodivergent C-H Oxyfunctionalization Reactions. Journal of the American Chemical Society 145 (6) (2023)
Sarka Pokorna, Olga Khersonsky, Rosalie Lipsh-Sokolik, Adi Goldenzweig, Rebekka Nielsen, Yacov Ashani, Yoav Peleg, Tamar Unger, Shira Albeck, Orly Dym, Asa Tirosh, Rana Tarayra, Michaël Hocquemiller, Ralph Laufer, Shifra Ben-Dor, Israel Silman, Joel L Sussman, Sarel Jacob Fleishman, Anthony H Futerman
Design of a stable human acid-β-glucosidase: towards improved Gaucher disease therapy and mutation classification. The FEBS journal (2023)
Jonathan Yaacov Weinstein, Carlos Martí-Gómez, Rosalie Lipsh-Sokolik, Shlomo Yakir Hoch, Demian Liebermann, Reinat Nevo, Haim Weissman, Ekaterina Petrovich-Kopitman, David Margulies, Dmitry N Ivankov, David M McCandlish, Sarel Jacob Fleishman
Designed active-site library reveals thousands of functional GFP variants. Nature communications 14 (1) (2023)
Gerard Duart, Assaf Elazar, Jonathan Yaacov Weinstein, Laura Gadea-Salom, Juan Ortiz-Mateu, Sarel Jacob Fleishman, Ismael Mingarro, Luis Martinez-Gil
Computational design of BclxL inhibitors that target transmembrane domain interactions. Proceedings of the National Academy of Sciences of the United States of America 120 (11) (2023)
Iris D Zelnik, Beatriz Mestre, Jonathan Yaacov Weinstein, Tamir Dingjan, Stav Izrailov, Shifra Ben-Dor, Sarel Jacob Fleishman, Anthony H Futerman
Computational design and molecular dynamics simulations suggest the mode of substrate binding in ceramide synthases. Nature communications 14 (1) (2023)
Rosalie Lipsh-Sokolik, Olga Khersonsky, Sybrin P Schröder, Casper de Boer, Shlomo Yakir Hoch, Gideon J Davies, Herman S Overkleeft, Sarel Jacob Fleishman
Combinatorial assembly and design of enzymes. Science (New York, N.Y.) 379 (6628) (2023)
Patricia Gomez de Santos, Ivan Mateljak, Manh Dat Hoang, Sarel Jacob Fleishman, Frank Hollmann, Miguel Alcalde
Repertoire of Computationally Designed Peroxygenases for Enantiodivergent C-H Oxyfunctionalization Reactions. Journal of the American Chemical Society 145 (6) (2023)
Gerard Duart, Assaf Elazar, Jonathan Yaacov Weinstein, Laura Gadea-Salom, Juan Ortiz-Mateu, Sarel Jacob Fleishman, Ismael Mingarro, Luis Martinez-Gil
Computational design of BclxL inhibitors that target transmembrane domain interactions. Proceedings of the National Academy of Sciences of the United States of America 120 (11) (2023)
Rosalie Lipsh-Sokolik, Olga Khersonsky, Sybrin P Schröder, Casper de Boer, Shlomo Yakir Hoch, Gideon J Davies, Herman S Overkleeft, Sarel Jacob Fleishman
Combinatorial assembly and design of enzymes. Science (New York, N.Y.) 379 (6628) (2023)
Rosalie Lipsh-Sokolik, Olga Khersonsky, Sybrin P Schröder, Casper de Boer, Shlomo Yakir Hoch, Gideon J Davies, Herman S Overkleeft, Sarel Jacob Fleishman
Combinatorial assembly and design of enzymes. Science (New York, N.Y.) 379 (6628) (2023)
Fanindra Kumar Deshmukh, Gili Ben-Nissan, Maya A Olshina, Maria G Füzesi-Levi, Caley Polkinghorn, Galina Arkind, Yegor Leushkin, Irit Fainer, Sarel Jacob Fleishman, Dan S Tawfik, Michal Sharon
Allosteric regulation of the 20S proteasome by the Catalytic Core Regulators (CCRs) family. Nature communications 14 (1) (2023)
Iris D Zelnik, Beatriz Mestre, Jonathan Yaacov Weinstein, Tamir Dingjan, Stav Izrailov, Shifra Ben-Dor, Sarel Jacob Fleishman, Anthony H Futerman
Computational design and molecular dynamics simulations suggest the mode of substrate binding in ceramide synthases. Nature communications 14 (1) (2023)
Shiran Barber-Zucker, Ivan Mateljak, Moshe Goldsmith, Meital Kupervaser, Miguel Alcalde, Sarel Jacob Fleishman
Designed High-Redox Potential Laccases Exhibit High Functional Diversity. ACS catalysis 12 (21) (2022)
Assaf Elazar, Nicholas J Chandler, Ashleigh S Davey, Jonathan Y Weinstein, Julie V Nguyen, Raphael Trenker, Ryan S Cross, Misty R Jenkins, Melissa J Call, Matthew E Call, Sarel Jacob Fleishman
De novo-designed transmembrane domains tune engineered receptor functions. eLife 11 (2022)
Dina Listov, Rosalie Lipsh-Sokolik, Stéphane Rosset, Che Yang, Bruno E Correia, Sarel Jacob Fleishman
Assessing and enhancing foldability in designed proteins. Protein science : a publication of the Protein Society 31 (9) (2022)
Adva Mechaly, Eran Diamant, Ron Alkalay, Alon Ben David, Eyal Dor, Amram Torgeman, Ada Barnea, Meni Girshengorn, Lilach Levin, Eyal Epstein, Ariel Tennenhouse, Sarel Jacob Fleishman, Ran Zichel, Ohad Mazor
Highly Specific Monoclonal Antibody Targeting the Botulinum Neurotoxin Type E Exposed SNAP-25 Neoepitope. Antibodies (Basel, Switzerland) 11 (1) (2022)
Olga Khersonsky, Sarel Jacob Fleishman
What Have We Learned from Design of Function in Large Proteins? Biodesign research 2022 (2022)
Shiran Barber-Zucker, Vladimir Mindel, Eva Garcia-Ruiz, Jonathan J Weinstein, Miguel Alcalde, Sarel Jacob Fleishman
Stable and Functionally Diverse Versatile Peroxidases Designed Directly from Sequences. Journal of the American Chemical Society 144 (8) (2022)
Vanessa Vongsouthi, Jason H Whitfield, Petr Unichenko, Joshua A Mitchell, Björn Breithausen, Olga Khersonsky, Leon Kremers, Harald Janovjak, Hiromu Monai, Hajime Hirase, Sarel Jacob Fleishman, Christian Henneberger, Colin J Jackson
A Rationally and Computationally Designed Fluorescent Biosensor for d-Serine. ACS sensors 6 (11) (2021)
Chelsey M VanDrisse, Rosalie Lipsh-Sokolik, Olga Khersonsky, Sarel Jacob Fleishman, Dianne K Newman
Computationally designed pyocyanin demethylase acts synergistically with tobramycin to kill recalcitrant Pseudomonas aeruginosa biofilms. Proceedings of the National Academy of Sciences of the United States of America 118 (12) (2021)
Rosalie Lipsh-Sokolik, Dina Listov, Sarel Jacob Fleishman
The AbDesign computational pipeline for modular backbone assembly and design of binders and enzymes. Protein science : a publication of the Protein Society 30 (1) (2020)
Shira Warszawski, Aliza Borenstein Katz, Rosalie Lipsh-Sokolik, Lev Khmelnitsky, Gili Ben-Nissan, Gabriel Javitt, Orly Dym, Tamar Unger, Orli Knop, Shira Albeck, Ron Diskin, Deborah Fass, Michal Sharon, Sarel Jacob Fleishman
Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces. PLoS computational biology 15 (8) (2019)
Shira Warszawski, Elya Dekel, Ivan Campeotto, Jennifer M Marshall, Katherine E Wright, Oliver Lyth, Orli Knop, Neta Regev-Rudzki, Matthew K Higgins, Simon J Draper, Jake Baum, Sarel Jacob Fleishman
Design of a basigin-mimicking inhibitor targeting the malaria invasion protein RH5. Proteins 88 (1) (2019)
Jonathan Yaacov Weinstein, Assaf Elazar, Sarel Jacob Fleishman
A lipophilicity-based energy function for membrane-protein modelling and design. PLoS computational biology 15 (8) (2019)
Ravit Netzer, Dina Listov, Rosalie Lipsh, Orly Dym, Shira Albeck, Orli Knop, Colin Kleanthous, Sarel Jacob Fleishman
Ultrahigh specificity in a network of computationally designed protein-interaction pairs. Nature communications 9 (1) (2018)
Raisa Kantaev, Inbal Riven, Adi Goldenzweig, Yoav Barak, Orly Dym, Yoav Peleg, Shira Albeck, Sarel Jacob Fleishman, Gilad Haran
Manipulating the Folding Landscape of a Multidomain Protein. The journal of physical chemistry. B 122 (49) (2018)
Jelena Cveticanin, Ravit Netzer, Galina Arkind, Sarel Jacob Fleishman, Amnon Horovitz, Michal Sharon
Estimating Interprotein Pairwise Interaction Energies in Cell Lysates from a Single Native Mass Spectrum. Analytical chemistry 90 (17) (2018)
Gideon Lapidoth, Olga Khersonsky, Rosalie Lipsh, Orly Dym, Shira Albeck, Shelly Rogotner, Sarel Jacob Fleishman
Highly active enzymes by automated combinatorial backbone assembly and sequence design. Nature communications 9 (1) (2018)

Sarel Jacob Fleishman.css-eqlu8i{font-size:small;padding-left:4px;} (Sarel J Fleishman, S J Fleishman)

Publication Activity (10 Years)

Top Topics

Top Venues

Sarel Jacob Fleishman (Sarel J Fleishman, S J Fleishman)