Paul E Brennan (Paul Brennan)

ORCID

Publication Activity (10 Years)

Years Active: 2015-2023
Publications (10 Years): 29

Top Venues

Journal of medicinal chemistry

Angewandte Chemie (International ed. in English)

ChemMedChem

ACS chemical biology

University of Oxford

University of California Berkeley (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Oxford Aug 01 2018

United Kingdom

Professor of Medicinal Chemistry :: Nuffield Department of Medicine

University of Oxford Sep 01 2015

United Kingdom

Head of Chemistry :: Alzheimer's Research UK Oxford Drug Discovery Institute

University of Oxford Aug 01 2011

United Kingdom

Principal Investigator :: Structural Genomics Constortium

University of Oxford Aug 01 2013 - Jul 31 2018

United Kingdom

Associate Professor of Medicinal Chemistry :: Nuffield Department of Medicine

Pfizer Global Research and Development Sandwich Jun 01 2005 - Jul 01 2011

United Kingdom

Senior Principal Scientist :: Medicinal Chemistry

Amgen Inc May 01 2003 - Mar 01 2005

United States

Senior Scientist :: Discovery Chemistry

Education History

University of California Berkeley Sep 01 1995 - Apr 03 2000

United States

PHD :: Chemistry

University of California Davis Sep 01 1991 - Jun 01 1995

United States

BSC :: Chemistry

Publications

Milan M Fowkes, Linda Troeberg, Paul E Brennan, Tonia L Vincent, Morten Meldal, Ngee H Lim
Development of Selective ADAMTS-5 Peptide Substrates to Monitor Proteinase Activity. Journal of medicinal chemistry 66 (5) (2023)
Milan M Fowkes, Linda Troeberg, Paul E Brennan, Tonia L Vincent, Morten Meldal, Ngee H Lim
Development of Selective ADAMTS-5 Peptide Substrates to Monitor Proteinase Activity. Journal of medicinal chemistry 66 (5) (2023)
Milan M Fowkes, Linda Troeberg, Paul E Brennan, Tonia L Vincent, Morten Meldal, Ngee H Lim
Development of Selective ADAMTS-5 Peptide Substrates to Monitor Proteinase Activity. Journal of medicinal chemistry 66 (5) (2023)
Milan M Fowkes, Linda Troeberg, Paul E Brennan, Tonia L Vincent, Morten Meldal, Ngee H Lim
Development of Selective ADAMTS-5 Peptide Substrates to Monitor Proteinase Activity. Journal of medicinal chemistry 66 (5) (2023)
Milan M Fowkes, Linda Troeberg, Paul E Brennan, Tonia L Vincent, Morten Meldal, Ngee H Lim
Development of Selective ADAMTS-5 Peptide Substrates to Monitor Proteinase Activity. Journal of medicinal chemistry 66 (5) (2023)
Elisabeth M Rothweiler, Paul E Brennan, Kilian V M Huber
Covalent fragment-based ligand screening approaches for identification of novel ubiquitin proteasome system modulators. Biological chemistry 403 (4) (2022)
Arne W Mould, Noura Al-Juffali, Annette von Delft, Paul E Brennan, Elizabeth M Tunbridge
Kalirin as a Novel Treatment Target for Cognitive Dysfunction in Schizophrenia. CNS drugs 36 (1) (2021)
Robert B A Quinlan, Paul E Brennan
Chemogenomics for drug discovery: clinical molecules from open access chemical probes. RSC chemical biology 2 (3) (2021)
Susanne Müller, Suzanne Ackloo, Arij Al Chawaf, Bissan Al-Lazikani, Albert Antolin, Jonathan B Baell, Hartmut Beck, Shaunna Beedie, Ulrich A K Betz, Gustavo Arruda Bezerra, Paul E Brennan, David Brown, Peter J Brown, Alex N Bullock, Adrian J Carter, Apirat Chaikuad, Mathilde Chaineau, Alessio Ciulli, Ian Collins, Jan Dreher, David Drewry, Kristina Edfeldt, Aled M Edwards, Ursula Egner, Stephen V Frye, Stephen M Fuchs, Matthew D Hall, Ingo V Hartung, Alexander Hillisch, Stephen H Hitchcock, Evert Homan, Natarajan Kannan, James R Kiefer, Stefan Knapp, Milka Kostic, Stefan Kubicek, Andrew R Leach, Sven Lindemann, Brian D Marsden, Hisanori Matsui, Jordan L Meier, Daniel Merk, Maurice Michel, Maxwell Robert Morgan, Anke Mueller-Fahrnow, Dafydd R Owen, Benjamin G Perry, Saul H Rosenberg, Kumar Singh Saikatendu, Matthieu Schapira, Cora Scholten, Sujata Sharma, Anton Simeonov, Michael Sundström, Giulio Superti-Furga, Matthew H Todd, Claudia Tredup, Masoud Vedadi, Frank von Delft, Timothy M Willson, Georg E Winter, Paul Workman, Cheryl H Arrowsmith
Target 2035 - update on the quest for a probe for every protein. RSC medicinal chemistry 13 (1) (2021)
Sabrina R Mackinnon, Tobias Krojer, William R Foster, Laura Diaz-Saez, Manshu Tang, Kilian V M Huber, Frank von Delft, Kent Lai, Paul E Brennan, Gustavo Arruda Bezerra, Wyatt W Yue
Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia. ACS chemical biology 16 (4) (2021)
Janine L Gray, Frank von Delft, Paul E Brennan
Targeting the Small GTPase Superfamily through Their Regulatory Proteins. Angewandte Chemie (International ed. in English) 59 (16) (2020)
Raysa Khan Tareque, Storm Hassell-Hart, Tobias Krojer, Anthony Bradley, Srikannathasan Velupillai, Romain Talon, Michael Fairhead, Iain J Day, Kamlesh Bala, Robert Felix, Paul D Kemmitt, Paul E Brennan, Frank von Delft, Laura Díaz Sáez, Kilian V M Huber, John Spencer
Deliberately Losing Control of C-H Activation Processes in the Design of Small-Molecule-Fragment Arrays Targeting Peroxisomal Metabolism. ChemMedChem 15 (24) (2020)
Stephane De Cesco, John B Davis, Paul E Brennan
TargetDB: A target information aggregation tool and tractability predictor. PloS one 15 (9) (2020)
Lucia Cottone, Adam P Cribbs, Garima Khandelwal, Graham Wells, Lorena Ligammari, Martin Philpott, Anthony Tumber, Patrick Lombard, Edward S Hookway, Tamas Szommer, Catrine Johansson, Paul E Brennan, Nischalan Pillay, Richard G Jenner, Udo Oppermann, Adrienne M Flanagan
Inhibition of Histone H3K27 Demethylases Inactivates Brachyury (TBXT) and Promotes Chordoma Cell Death. Cancer research 80 (20) (2020)
Luyi Huang, Hui Li, Linli Li, Lu Niu, Raina Seupel, Chengyong Wu, Wei Cheng, Chong Chen, Bisen Ding, Paul E Brennan, Sheng-Yong Yang
Discovery of Pyrrolo[3,2- d]pyrimidin-4-one Derivatives as a New Class of Potent and Cell-Active Inhibitors of P300/CBP-Associated Factor Bromodomain. Journal of medicinal chemistry 62 (9) (2019)
Yan Xiong, Holger Greschik, Catrine Johansson, Ludwig Seifert, Johannes Bacher, Kwang-Su Park, Nicolas Babault, Michael Martini, Vincent Fagan, Fengling Li, Irene Chau, Thomas Christott, David Dilworth, Dalia Barsyte-Lovejoy, Masoud Vedadi, Cheryl H Arrowsmith, Paul E Brennan, Oleg Fedorov, Manfred Jung, Gillian Farnie, Jing Liu, Udo Oppermann, Roland Schüle, Jian Jin
Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1). Journal of medicinal chemistry 62 (20) (2019)
Efrat Resnick, Anthony Bradley, Jinrui Gan, Alice Douangamath, Tobias Krojer, Ritika Sethi, Paul P Geurink, Anthony Aimon, Gabriel Amitai, Dom Bellini, James Bennett, Michael Fairhead, Oleg Fedorov, Ronen Gabizon, Jin Gan, Jingxu Guo, Alexander Plotnikov, Nava Reznik, Gian Filippo Ruda, Laura Díaz-Sáez, Verena M Straub, Tamas Szommer, Srikannathasan Velupillai, Daniel Zaidman, Yanling Zhang, Alun R Coker, Christopher G Dowson, Haim M Barr, Chu Wang, Kilian V M Huber, Paul E Brennan, Huib Ovaa, Frank von Delft, Nir London
Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. Journal of the American Chemical Society 141 (22) (2019)
Vincent Fagan, Catrine Johansson, Carina Gileadi, Octovia Monteiro, James E Dunford, Reshma Nibhani, Martin Philpott, Jessica Malzahn, Graham Wells, Ruth Faram, Adam P Cribbs, Nadia Halidi, Fengling Li, Irene Chau, Holger Greschik, Srikannathasan Velupillai, Abdellah Allali-Hassani, James Bennett, Thomas Christott, Charline Giroud, Andrew M Lewis, Kilian V M Huber, Nick Athanasou, Chas Bountra, Manfred Jung, Roland Schüle, Masoud Vedadi, Cheryl H Arrowsmith, Yan Xiong, Jian Jin, Oleg Fedorov, Gillian Farnie, Paul E Brennan, Udo Oppermann
A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function. Journal of medicinal chemistry 62 (20) (2019)
Miranda Wright, Carolina Martínez-Lamenca, Joseph E Leenaerts, Paul E Brennan, Andres A Trabanco, Daniel Oehlrich
Bench-Stable Transfer Reagent Facilitates the Generation of Trifluoromethyl-sulfonimidamides. The Journal of organic chemistry 83 (16) (2018)
Saleta Vazquez-Rodriguez, Miranda Wright, Catherine M Rogers, Adam P Cribbs, Srikannathasan Velupillai, Martin Philpott, Henry Lee, James E Dunford, Kilian V M Huber, Matthew B Robers, James D Vasta, Marie-Laetitia Thezenas, Sarah Bonham, Benedikt Mathias Kessler, James Bennett, Oleg Fedorov, Florence Raynaud, Adam Donovan, Julian Blagg, Vassilios Bavetsias, Udo Oppermann, Chas Bountra, Akane Kawamura, Paul E Brennan
Design, Synthesis and Characterization of Covalent KDM5 Inhibitors. Angewandte Chemie (International ed. in English) 58 (2) (2018)
David Heidenreich, Moses Moustakim, Jurema Schmidt, Daniel Merk, Paul E Brennan, Oleg Fedorov, Apirat Chaikuad, Stefan Knapp
Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL). Journal of medicinal chemistry 61 (23) (2018)
Melissa D'Ascenzio, Kathryn M Pugh, Rebecca Konietzny, Georgina Berridge, Cynthia Tallant, Shaima Hashem, Octovia Monteiro, Jason R Thomas, Markus Schirle, Stefan Knapp, Brian Marsden, Oleg Fedorov, Chas Bountra, Benedikt M Kessler, Paul E Brennan
An Activity-Based Probe Targeting Non-Catalytic, Highly Conserved Amino Acid Residues within Bromodomains. Angewandte Chemie (International ed. in English) 58 (4) (2018)
Moses Moustakim, Thomas Christott, Octovia P Monteiro, James Bennett, Charline Giroud, Jennifer Ward, Catherine M Rogers, Paul Smith, Ioanna Panagakou, Laura Díaz-Sáez, Suet Ling Felce, Vicki Gamble, Carina Gileadi, Nadia Halidi, David Heidenreich, Apirat Chaikuad, Stefan Knapp, Kilian V M Huber, Gillian Farnie, Jag Heer, Nenad Manevski, Gennady Poda, Rima Al-Awar, Darren J Dixon, Paul E Brennan, Oleg Fedorov
Discovery of an MLLT1/3 YEATS Domain Chemical Probe. Angewandte Chemie (International ed. in English) 57 (50) (2018)
David Bowkett, Romain Talon, Cynthia Tallant, Chris Schofield, Frank von Delft, Stefan Knapp, Gordon Bruton, Paul E Brennan
Identifying Small-Molecule Binding Sites for Epigenetic Proteins at Domain-Domain Interfaces. ChemMedChem 13 (10) (2018)
Julia C Meier, Cynthia Tallant, Oleg Fedorov, Hanna Witwicka, Sung-Yong Hwang, Ruud G van Stiphout, Jean-Philippe Lambert, Catherine Rogers, Clarence Yapp, Brian S Gerstenberger, Vita Fedele, Pavel Savitsky, David Heidenreich, Danette L Daniels, Dafydd R Owen, Paul V Fish, Niall M Igoe, Elliott D Bayle, Bernard Haendler, Udo C T Oppermann, Francesca Buffa, Paul E Brennan, Susanne Müller, Anne Claude Gingras, Paul R Odgren, Mark J Birnbaum, Stefan Knapp
Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation. ACS chemical biology 12 (10) (2017)
Niall Igoe, Elliott D Bayle, Cynthia Tallant, Oleg Fedorov, Julia C Meier, Pavel Savitsky, Catherine Rogers, Yannick Morias, Sarah Scholze, Helen Boyd, Danen Cunoosamy, David M Andrews, Anne Cheasty, Paul E Brennan, Susanne Müller, Stefan Knapp, Paul V Fish
Design of a Chemical Probe for the Bromodomain and Plant Homeodomain Finger-Containing (BRPF) Family of Proteins. Journal of medicinal chemistry 60 (16) (2017)
Philip A Gerken, Jamie R Wolstenhulme, Anthony Tumber, Stephanie B Hatch, Yijia Zhang, Susanne Müller, Shane A Chandler, Barbara Mair, Fengling Li, Sebastian M B Nijman, Rebecca Konietzny, Tamas Szommer, Clarence Yapp, Oleg Fedorov, Justin L P Benesch, Masoud Vedadi, Benedikt M Kessler, Akane Kawamura, Paul E Brennan, Martin D Smith
Discovery of a Highly Selective Cell-Active Inhibitor of the Histone Lysine Demethylases KDM2/7. Angewandte Chemie (International ed. in English) 56 (49) (2017)
Moses Moustakim, Peter G K Clark, Laura Trulli, Angel L Fuentes de Arriba, Matthias T Ehebauer, Apirat Chaikuad, Emma J Murphy, Jacqui Mendez-Johnson, Danette Daniels, Chun-Feng D Hou, Yu-Hui Lin, John R Walker, Raymond Hui, Hongbing Yang, Lucy Dorrell, Catherine M Rogers, Octovia P Monteiro, Oleg Fedorov, Kilian V M Huber, Stefan Knapp, Jag Heer, Darren J Dixon, Paul E Brennan
Discovery of a PCAF Bromodomain Chemical Probe. Angewandte Chemie (International ed. in English) 56 (3) (2016)
Sarah Picaud, Katharina Leonards, Jean-Philippe Lambert, Oliver Dovey, Christopher Wells, Oleg Fedorov, Octovia Monteiro, Takao Fujisawa, Chen-Yi Wang, Hannah Lingard, Cynthia Tallant, Nikzad Nikbin, Lucie Guetzoyan, Richard Ingham, Steven V Ley, Paul E Brennan, Susanne Müller, Anastasia Samsonova, Anne-Claude Gingras, Juerg Schwaller, George S Vassiliou, Stefan Knapp, Panagis Filippakopoulos
Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia. Science advances 2 (10) (2016)
Oleg Fedorov, Josefina Castex, Cynthia Tallant, Dafydd R Owen, Sarah Martin, Matteo Aldeghi, Octovia Monteiro, Panagis Filippakopoulos, Sarah Picaud, John D Trzupek, Brian S Gerstenberger, Chas Bountra, Dominica Willmann, Christopher Wells, Martin Philpott, Catherine Rogers, Philip C Biggin, Paul E Brennan, Mark E Bunnage, Roland Schüle, Thomas Günther, Stefan Knapp, Susanne Müller
Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance. Science advances 1 (10) (2015)
Oakley B Cox, Tobias Krojer, Patrick Collins, Octovia Monteiro, Romain Talon, Anthony Bradley, Oleg Fedorov, Jahangir Amin, Brian D Marsden, John Spencer, Frank von Delft, Paul E Brennan
A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain. Chemical science 7 (3) (2015)

Paul E Brennan.css-eqlu8i{font-size:small;padding-left:4px;} (Paul Brennan)

Publication Activity (10 Years)

Top Topics

Top Venues

Paul E Brennan (Paul Brennan)