Stephen H Hughes

ORCID

Publication Activity (10 Years)

Years Active: 2019-2024
Publications (10 Years): 35

Top Venues

ACS infectious diseases

mBio

PLoS pathogens

Viruses

National Cancer Institute

This page only lists publications with an associated author ORCID identifier.

Affiliation History

National Cancer Institute May 01 1984

United States

Lab Chief :: HIV DRP

Publications

Lulu Yu, Vladimir Majerciak, Alexei Lobanov, Sameer Mirza, Vimla Band, Haibin Liu, Maggie Cam, Stephen H Hughes, Douglas R Lowy, Zhi-Ming Zheng
HPV oncogenes expressed from only one of multiple integrated HPV DNA copies drive clonal cell expansion in cervical cancer. mBio 15 (5) (2024)
Lulu Yu, Vladimir Majerciak, Alexei Lobanov, Sameer Mirza, Vimla Band, Haibin Liu, Maggie Cam, Stephen H Hughes, Douglas R Lowy, Zhi-Ming Zheng
HPV oncogenes expressed from only one of multiple integrated HPV DNA copies drive clonal cell expansion in cervical cancer. mBio (2024)
Pankaj S Mahajan, Steven J Smith, Min Li, Robert Craigie, Stephen H Hughes, Xue Zhi Zhao, Terrence R Burke
N -Substituted Bicyclic Carbamoyl Pyridones: Integrase Strand Transfer Inhibitors that Potently Inhibit Drug-Resistant HIV-1 Integrase Mutants. ACS infectious diseases 10 (3) (2024)
Lulu Yu, Vladimir Majerciak, Alexei Lobanov, Sameer Mirza, Vimla Band, Haibin Liu, Maggie Cam, Stephen H Hughes, Douglas R Lowy, Zhi-Ming Zheng
HPV oncogenes expressed from only one of multiple integrated HPV DNA copies drive clonal cell expansion in cervical cancer. mBio (2024)
Pankaj S Mahajan, Steven J Smith, Min Li, Robert Craigie, Stephen H Hughes, Xue Zhi Zhao, Terrence R Burke
N -Substituted Bicyclic Carbamoyl Pyridones: Integrase Strand Transfer Inhibitors that Potently Inhibit Drug-Resistant HIV-1 Integrase Mutants. ACS infectious diseases 10 (3) (2024)
Pankaj S Mahajan, Steven J Smith, Min Li, Robert Craigie, Stephen H Hughes, Xue Zhi Zhao, Terrence R Burke
N -Substituted Bicyclic Carbamoyl Pyridones: Integrase Strand Transfer Inhibitors that Potently Inhibit Drug-Resistant HIV-1 Integrase Mutants. ACS infectious diseases 10 (3) (2024)
Pankaj S Mahajan, Steven J Smith, Min Li, Robert Craigie, Stephen H Hughes, Xue Zhi Zhao, Terrence R Burke
N -Substituted Bicyclic Carbamoyl Pyridones: Integrase Strand Transfer Inhibitors that Potently Inhibit Drug-Resistant HIV-1 Integrase Mutants. ACS infectious diseases 10 (3) (2024)
Lulu Yu, Vladimir Majerciak, Alexei Lobanov, Sameer Mirza, Vimla Band, Haibin Liu, Maggie Cam, Stephen H Hughes, Douglas R Lowy, Zhi-Ming Zheng
HPV oncogenes expressed from only one of multiple integrated HPV DNA copies drive clonal cell expansion in cervical cancer. mBio 15 (5) (2024)
Lulu Yu, Vladimir Majerciak, Alexei Lobanov, Sameer Mirza, Vimla Band, Haibin Liu, Maggie Cam, Stephen H Hughes, Douglas R Lowy, Zhi-Ming Zheng
HPV oncogenes expressed from only one of multiple integrated HPV DNA copies drive clonal cell expansion in cervical cancer. mBio 15 (5) (2024)
Pankaj S Mahajan, Steven J Smith, Min Li, Robert Craigie, Stephen H Hughes, Xue Zhi Zhao, Terrence R Burke
N -Substituted Bicyclic Carbamoyl Pyridones: Integrase Strand Transfer Inhibitors that Potently Inhibit Drug-Resistant HIV-1 Integrase Mutants. ACS infectious diseases 10 (3) (2024)
Pankaj S Mahajan, Steven J Smith, Min Li, Robert Craigie, Stephen H Hughes, Xue Zhi Zhao, Terrence R Burke
N -Substituted Bicyclic Carbamoyl Pyridones: Integrase Strand Transfer Inhibitors that Potently Inhibit Drug-Resistant HIV-1 Integrase Mutants. ACS infectious diseases (2024)
Liguo Zhang, Punam Bisht, Anthony Flamier, M Inmaculada Barrasa, Max Friesen, Alexsia Richards, Stephen H Hughes, Rudolf Jaenisch
LINE1-Mediated Reverse Transcription and Genomic Integration of SARS-CoV-2 mRNA Detected in Virus-Infected but Not in Viral mRNA-Transfected Cells. Viruses 15 (3) (2023)
Pankaj S Mahajan, Steven J Smith, Stephen H Hughes, Xue Zhi Zhao, Terrence R Burke
A Practical Approach to Bicyclic Carbamoyl Pyridones with Application to the Synthesis of HIV-1 Integrase Strand Transfer Inhibitors. Molecules (Basel, Switzerland) 28 (3) (2023)
Liguo Zhang, Punam Bisht, Anthony Flamier, M Inmaculada Barrasa, Max Friesen, Alexsia Richards, Stephen H Hughes, Rudolf Jaenisch
LINE1-Mediated Reverse Transcription and Genomic Integration of SARS-CoV-2 mRNA Detected in Virus-Infected but Not in Viral mRNA-Transfected Cells. Viruses 15 (3) (2023)
Pankaj S Mahajan, Steven J Smith, Stephen H Hughes, Xue Zhi Zhao, Terrence R Burke
A Practical Approach to Bicyclic Carbamoyl Pyridones with Application to the Synthesis of HIV-1 Integrase Strand Transfer Inhibitors. Molecules (Basel, Switzerland) 28 (3) (2023)
Pankaj S Mahajan, Steven J Smith, Stephen H Hughes, Xue Zhi Zhao, Terrence R Burke
A Practical Approach to Bicyclic Carbamoyl Pyridones with Application to the Synthesis of HIV-1 Integrase Strand Transfer Inhibitors. Molecules (Basel, Switzerland) 28 (3) (2023)
Min Li, Dario Oliveira Passos, Zelin Shan, Steven J Smith, Qinfang Sun, Avik Biswas, Indrani Choudhuri, Timothy S Strutzenberg, Allan Haldane, Nanjie Deng, Zhaoyang Li, Xue Zhi Zhao, Lorenzo Briganti, Mamuka Kvaratskhelia, Terrence R Burke, Ronald M Levy, Stephen H Hughes, Robert Craigie, Dmitry Lyumkis
Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants. Science advances 9 (29) (2023)
Liguo Zhang, Punam Bisht, Anthony Flamier, M Inmaculada Barrasa, Max Friesen, Alexsia Richards, Stephen H Hughes, Rudolf Jaenisch
LINE1-Mediated Reverse Transcription and Genomic Integration of SARS-CoV-2 mRNA Detected in Virus-Infected but Not in Viral mRNA-Transfected Cells. Viruses 15 (3) (2023)
Shuang Guo, Brian T Luke, Amy R Henry, Samuel Darko, Leah D Brandt, Ling Su, David Sun, Daria Wells, Kevin W Joseph, Dimiter Demirov, Elias K Halvas, Daniel C Douek, Xiaolin Wu, John W Mellors, Stephen H Hughes
HIV infected CD4+ T cell clones are more stable than uninfected clones during long-term antiretroviral therapy. PLoS pathogens 18 (8) (2022)
Michal S Barski, Teresa Vanzo, Xue Zhi Zhao, Steven J Smith, Allison Ballandras-Colas, Nora B Cronin, Valerie E Pye, Stephen H Hughes, Terrence R Burke, Peter Cherepanov, Goedele N Maertens
Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures. Nature communications 12 (1) (2021)
Lulu Yu, Vladimir Majerciak, Xiang-Yang Xue, Aayushi Uberoi, Alexei Lobanov, Xiongfong Chen, Margaret C Cam, Stephen H Hughes, Paul F Lambert, Zhi-Ming Zheng
Mouse papillomavirus type 1 (MmuPV1) DNA is frequently integrated in benign tumors by microhomology-mediated end-joining. PLoS pathogens 17 (8) (2021)
Michael J Bale, Mary Grace Katusiime, Daria Wells, Xiaolin Wu, Jonathan Spindler, Elias K Halvas, Joshua C Cyktor, Ann Wiegand, Wei Shao, Mark F Cotton, Stephen H Hughes, John W Mellors, John M Coffin, Gert U Van Zyl, Mary F Kearney
Early Emergence and Long-Term Persistence of HIV-Infected T-Cell Clones in Children. mBio 12 (2) (2021)
Liguo Zhang, Alexsia Richards, M Inmaculada Barrasa, Stephen H Hughes, Richard A Young, Rudolf Jaenisch
Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues. Proceedings of the National Academy of Sciences of the United States of America 118 (21) (2021)
Steven J Smith, Andrea Ferris, Xue Zhi Zhao, Gary Pauly, Joel P Schneider, Terrence R Burke, Stephen H Hughes
INSTIs and NNRTIs Potently Inhibit HIV-1 Polypurine Tract Mutants in a Single Round Infection Assay. Viruses 13 (12) (2021)
Liguo Zhang, Alexsia Richards, M Inmaculada Barrasa, Stephen H Hughes, Richard A Young, Rudolf Jaenisch
Response to Parry et al.: Strong evidence for genomic integration of SARS-CoV-2 sequences and expression in patient tissues. Proceedings of the National Academy of Sciences of the United States of America 118 (33) (2021)
John M Coffin, Michael J Bale, Daria Wells, Shuang Guo, Brian Luke, Jennifer M Zerbato, Michele D Sobolewski, Twan Sia, Wei Shao, Xiaolin Wu, Frank Maldarelli, Mary F Kearney, John W Mellors, Stephen H Hughes
Integration in oncogenes plays only a minor role in determining the in vivo distribution of HIV integration sites before or during suppressive antiretroviral therapy. PLoS pathogens 17 (4) (2021)
Paul L Boyer, Catherine A Rehm, Michael C Sneller, JoAnn Mican, Margaret R Caplan, Robin Dewar, Andrea L Ferris, Patrick Clark, Adam Johnson, Frank Maldarelli, Stephen H Hughes
A Combination of Amino Acid Mutations Leads to Resistance to Multiple Nucleoside Analogs in Reverse Transcriptases from HIV-1 Subtypes B and C. Antimicrobial agents and chemotherapy (2021)
Steven J Smith, Xue Zhi Zhao, Dario Oliveira Passos, Valerie E Pye, Peter Cherepanov, Dmitry Lyumkis, Terrence R Burke, Stephen H Hughes
HIV-1 Integrase Inhibitors with Modifications That Affect Their Potencies against Drug Resistant Integrase Mutants. ACS infectious diseases 7 (6) (2021)
John W Mellors, Shuang Guo, Asma Naqvi, Leah D Brandt, Ling Su, Zhonghe Sun, Kevin W Joseph, Dimiter Demirov, Elias K Halvas, Donna Butcher, Beth Scott, Aaron Hamilton, Marintha Heil, Baktiar O Karim, Xiaolin Wu, Stephen H Hughes
Insertional activation of STAT3 and LCK by HIV-1 proviruses in T cell lymphomas. Science advances 7 (42) (2021)
Michal S Barski, Teresa Vanzo, Xue Zhi Zhao, Steven J Smith, Allison Ballandras-Colas, Nora B Cronin, Valerie E Pye, Stephen H Hughes, Terrence R Burke, Peter Cherepanov, Goedele N Maertens
Publisher Correction: Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures. Nature communications 12 (1) (2021)
Liguo Zhang, Alexsia Richards, M Inmaculada Barrasa, Stephen H Hughes, Richard A Young, Rudolf Jaenisch
Reply to Briggs et al.: Genomic integration and expression of SARS-CoV-2 sequences can explain prolonged or recurrent viral RNA detection. Proceedings of the National Academy of Sciences of the United States of America 118 (44) (2021)
Steven J Smith, Gary T Pauly, Katharine Hewlett, Joel P Schneider, Stephen H Hughes
Structure-based non-nucleoside inhibitor design: Developing inhibitors that are effective against resistant mutants. Chemical biology & drug design 97 (1) (2020)
Steven J Smith, Xue Zhi Zhao, Dario Oliveira Passos, Dmitry Lyumkis, Terrence R Burke, Stephen H Hughes
HIV-1 Integrase Inhibitors That Are Active against Drug-Resistant Integrase Mutants. Antimicrobial agents and chemotherapy 64 (9) (2020)
Nirali N Shah, Haiying Qin, Bonnie Yates, Ling Su, Haneen Shalabi, Mark Raffeld, Mark A Ahlman, Maryalice Stetler-Stevenson, Constance M Yuan, Shuang Guo, Siyuan Liu, Stephen H Hughes, Terry J Fry, Xiaolin Wu
Clonal expansion of CAR T cells harboring lentivector integration in the CBL gene following anti-CD22 CAR T-cell therapy. Blood advances 3 (15) (2020)
Andrea L Ferris, David W Wells, Shuang Guo, Gregory Q Del Prete, Adrienne E Swanstrom, John M Coffin, Xiaolin Wu, Jeffrey D Lifson, Stephen H Hughes
Clonal expansion of SIV-infected cells in macaques on antiretroviral therapy is similar to that of HIV-infected cells in humans. PLoS pathogens 15 (7) (2019)

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Publication Activity (10 Years)

Top Topics

Top Venues

Stephen H Hughes