Richard A Young (Richard Young)

ORCID

Publication Activity (10 Years)

Years Active: 2016-2023
Publications (10 Years): 36

Top Venues

Science (New York, N.Y.)

Nature communications

Nature chemical biology

Proceedings of the National Academy of Sciences of the United States of America

Whitehead Institute for Biomedical Research

Yale University (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Whitehead Institute for Biomedical Research

United States

Member

Education History

Yale University

United States

PHD :: Molecular Biophysics and Biochemistry

Indiana University Bloomington

United States

BSC :: Biology

Publications

Megan L Insco, Brian J Abraham, Sara J Dubbury, Ines H Kaltheuner, Sofia Dust, Constance Wu, Kevin Y Chen, David R Liu, Stanislav Bellaousov, Anna M Cox, Benjamin J E Martin, Tongwu Zhang, Calvin Gerald Ludwig, Tania Fabo, Rodsy Modhurima, Dakarai E Esgdaille, Telmo Henriques, Kevin K Brown, Stephen J Chanock, Matthias Geyer, Karen Adelman, Phillip A Sharp, Richard A Young, Paul L Boutz, Leonard I Zon
Oncogenic CDK13 mutations impede nuclear RNA surveillance. Science (New York, N.Y.) 380 (6642) (2023)
Megan L Insco, Brian J Abraham, Sara J Dubbury, Ines H Kaltheuner, Sofia Dust, Constance Wu, Kevin Y Chen, David R Liu, Stanislav Bellaousov, Anna M Cox, Benjamin J E Martin, Tongwu Zhang, Calvin Gerald Ludwig, Tania Fabo, Rodsy Modhurima, Dakarai E Esgdaille, Telmo Henriques, Kevin K Brown, Stephen J Chanock, Matthias Geyer, Karen Adelman, Phillip A Sharp, Richard A Young, Paul L Boutz, Leonard I Zon
Oncogenic CDK13 mutations impede nuclear RNA surveillance. Science (New York, N.Y.) 380 (6642) (2023)
Megan L Insco, Brian J Abraham, Sara J Dubbury, Ines H Kaltheuner, Sofia Dust, Constance Wu, Kevin Y Chen, David R Liu, Stanislav Bellaousov, Anna M Cox, Benjamin J E Martin, Tongwu Zhang, Calvin Gerald Ludwig, Tania Fabo, Rodsy Modhurima, Dakarai E Esgdaille, Telmo Henriques, Kevin K Brown, Stephen J Chanock, Matthias Geyer, Karen Adelman, Phillip A Sharp, Richard A Young, Paul L Boutz, Leonard I Zon
Oncogenic CDK13 mutations impede nuclear RNA surveillance. Science (New York, N.Y.) 380 (6642) (2023)
Megan L Insco, Brian J Abraham, Sara J Dubbury, Ines H Kaltheuner, Sofia Dust, Constance Wu, Kevin Y Chen, David R Liu, Stanislav Bellaousov, Anna M Cox, Benjamin J E Martin, Tongwu Zhang, Calvin Gerald Ludwig, Tania Fabo, Rodsy Modhurima, Dakarai E Esgdaille, Telmo Henriques, Kevin K Brown, Stephen J Chanock, Matthias Geyer, Karen Adelman, Phillip A Sharp, Richard A Young, Paul L Boutz, Leonard I Zon
Oncogenic CDK13 mutations impede nuclear RNA surveillance. Science (New York, N.Y.) 380 (6642) (2023)
Henry R Kilgore, Peter G Mikhael, Kalon J Overholt, Ann Boija, Nancy M Hannett, Catherine Van Dongen, Tong Ihn Lee, Young Tae Chang, Regina Barzilay, Richard A Young
Distinct chemical environments in biomolecular condensates. Nature chemical biology (2023)
Henry R Kilgore, Peter G Mikhael, Kalon J Overholt, Ann Boija, Nancy M Hannett, Catherine Van Dongen, Tong Ihn Lee, Young Tae Chang, Regina Barzilay, Richard A Young
Author Correction: Distinct chemical environments in biomolecular condensates. Nature chemical biology (2023)
Megan L Insco, Brian J Abraham, Sara J Dubbury, Ines H Kaltheuner, Sofia Dust, Constance Wu, Kevin Y Chen, David R Liu, Stanislav Bellaousov, Anna M Cox, Benjamin J E Martin, Tongwu Zhang, Calvin Gerald Ludwig, Tania Fabo, Rodsy Modhurima, Dakarai E Esgdaille, Telmo Henriques, Kevin K Brown, Stephen J Chanock, Matthias Geyer, Karen Adelman, Phillip A Sharp, Richard A Young, Paul L Boutz, Leonard I Zon
Oncogenic CDK13 mutations impede nuclear RNA surveillance. Science (New York, N.Y.) 380 (6642) (2023)
Megan L Insco, Brian J Abraham, Sara J Dubbury, Ines H Kaltheuner, Sofia Dust, Constance Wu, Kevin Y Chen, David R Liu, Stanislav Bellaousov, Anna M Cox, Benjamin J E Martin, Tongwu Zhang, Calvin Gerald Ludwig, Tania Fabo, Rodsy Modhurima, Dakarai E Esgdaille, Telmo Henriques, Kevin K Brown, Stephen J Chanock, Matthias Geyer, Karen Adelman, Phillip A Sharp, Richard A Young, Paul L Boutz, Leonard I Zon
Oncogenic CDK13 mutations impede nuclear RNA surveillance. Science (New York, N.Y.) 380 (6642) (2023)
Megan L Insco, Brian J Abraham, Sara J Dubbury, Ines H Kaltheuner, Sofia Dust, Constance Wu, Kevin Y Chen, David R Liu, Stanislav Bellaousov, Anna M Cox, Benjamin J E Martin, Tongwu Zhang, Calvin Gerald Ludwig, Tania Fabo, Rodsy Modhurima, Dakarai E Esgdaille, Telmo Henriques, Kevin K Brown, Stephen J Chanock, Matthias Geyer, Karen Adelman, Phillip A Sharp, Richard A Young, Paul L Boutz, Leonard I Zon
Oncogenic CDK13 mutations impede nuclear RNA surveillance. Science (New York, N.Y.) 380 (6642) (2023)
Yao Yao, Jessica Fong Ng, Woojun Daniel Park, Mehmet K Samur, Eugenio Morelli, Jessica Encinas, Zuzana Chyra, Lian Xu, Sanika Derebail, Charles B Epstein, Behnam Nabet, Marta Chesi, Nathanael S Gray, Richard A Young, Nicholas Kwiatkowski, Constantine S Mitsiades, Kenneth C Anderson, Charles Y Lin, Nikhil C Munshi, Mariateresa Fulciniti
CDK7 controls E2F- and MYC-driven proliferative and metabolic vulnerabilities in multiple myeloma. Blood (2023)
Megan L Insco, Brian J Abraham, Sara J Dubbury, Ines H Kaltheuner, Sofia Dust, Constance Wu, Kevin Y Chen, David R Liu, Stanislav Bellaousov, Anna M Cox, Benjamin J E Martin, Tongwu Zhang, Calvin Gerald Ludwig, Tania Fabo, Rodsy Modhurima, Dakarai E Esgdaille, Telmo Henriques, Kevin K Brown, Stephen J Chanock, Matthias Geyer, Karen Adelman, Phillip A Sharp, Richard A Young, Paul L Boutz, Leonard I Zon
Oncogenic CDK13 mutations impede nuclear RNA surveillance. Science (New York, N.Y.) 380 (6642) (2023)
Henry R Kilgore, Richard A Young
Learning the chemical grammar of biomolecular condensates. Nature chemical biology 18 (12) (2022)
Eugenio Morelli, Mariateresa Fulciniti, Mehmet K Samur, Caroline Fidalgo Ribeiro, Leon Wert-Lamas, Jonathan E Henninger, Annamaria Gulla, Anil Aktas Samur, Katia Todoerti, Srikanth Talluri, Woojun Daniel Park, Cinzia Federico, Francesca Scionti, Nicola Amodio, Giada Bianchi, Megan Johnstone, Na Liu, Doriana Gramegna, Domenico Maisano, Nicola Antonino Russo, Charles Y Lin, Yu-Tzu Tai, Antonino Neri, Dharminder Chauhan, Teru Hideshima, Masood A Shammas, Pierfrancesco Tassone, Sergei Gryaznov, Richard A Young, Kenneth C Anderson, Carl D Novina, Massimo Loda, Nikhil C Munshi
A MIR17HG-derived Long Noncoding RNA Provides an Essential Chromatin Scaffold for Protein Interaction and Myeloma Growth. Blood (2022)
Alessandra Dall'Agnese, Jesse M Platt, Ming M Zheng, Max Friesen, Giuseppe Dall'Agnese, Alyssa M Blaise, Jessica Brooke Spinelli, Jonathan E Henninger, Erin N Tevonian, Nancy M Hannett, Charalampos Lazaris, Hannah K Drescher, Lea M Bartsch, Henry R Kilgore, Rudolf Jaenisch, Linda G Griffith, Ibrahim I Cisse, Jacob F Jeppesen, Tong Ihn Lee, Richard A Young
The dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance. Nature communications 13 (1) (2022)
Austin Hsu, Qiming Duan, Daniel S Day, Xin Luo, Sarah McMahon, Yu Huang, Zachary B Feldman, Zhen Jiang, Tinghu Zhang, Yanke Liang, Michael Alexanian, Arun Padmanabhan, Jonathan D Brown, Charles Y Lin, Nathanael S Gray, Richard A Young, Benoit G Bruneau, Saptarsi M Haldar
Targeting transcription in heart failure via CDK7/12/13 inhibition. Nature communications 13 (1) (2022)
Marlies P Rossmann, Karen Hoi, Victoria Chan, Brian J Abraham, Song Yang, James P Mullahoo, Malvina Papanastasiou, Ying Wang, Ilaria Elia, Julie R Perlin, Elliott J Hagedorn, Sara Hetzel, Raha Weigert, Sejal Vyas, Partha P Nag, Lucas B Sullivan, Curtis R Warren, Bilguujin Dorjsuren, Eugenia Custo Greig, Isaac Adatto, Chad A Cowan, Stuart L Schreiber, Richard A Young, Alexander Meissner, Marcia C Haigis, Siegfried Hekimi, Steven A Carr, Leonard I Zon
Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis. Science (New York, N.Y.) 372 (6543) (2021)
Mark W Zimmerman, Adam D Durbin, Shuning He, Felix Oppel, Hui Shi, Ting Tao, Zhaodong Li, Alla Berezovskaya, Yu Liu, Jinghui Zhang, Richard A Young, Brian J Abraham, A Thomas Look
Retinoic acid rewires the adrenergic core regulatory circuitry of childhood neuroblastoma. Science advances 7 (43) (2021)
Liguo Zhang, Alexsia Richards, M Inmaculada Barrasa, Stephen H Hughes, Richard A Young, Rudolf Jaenisch
Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues. Proceedings of the National Academy of Sciences of the United States of America 118 (21) (2021)
Liguo Zhang, Alexsia Richards, M Inmaculada Barrasa, Stephen H Hughes, Richard A Young, Rudolf Jaenisch
Response to Parry et al.: Strong evidence for genomic integration of SARS-CoV-2 sequences and expression in patient tissues. Proceedings of the National Academy of Sciences of the United States of America 118 (33) (2021)
Liguo Zhang, Alexsia Richards, M Inmaculada Barrasa, Stephen H Hughes, Richard A Young, Rudolf Jaenisch
Reply to Briggs et al.: Genomic integration and expression of SARS-CoV-2 sequences can explain prolonged or recurrent viral RNA detection. Proceedings of the National Academy of Sciences of the United States of America 118 (44) (2021)
Jessica Reddy, Marcos A S Fonseca, Rosario I Corona, Robbin Nameki, Felipe Segato Dezem, Isaac A Klein, Heidi Chang, Daniele Chaves-Moreira, Lena K Afeyan, Tathiane Maistro Malta, Xianzhi Lin, Forough Abbasi, Alba Font-Tello, Thais S Sabedot, Paloma Cejas, Norma Rodríguez-Malavé, Ji-Heui Seo, De-Chen Lin, Ursula Matulonis, Beth Y Karlan, Simon A Gayther, Bogdan Pasaniuc, Alexander Gusev, Houtan Noushmehr, Henry W Long, Matthew L Freedman, Ronny Drapkin, Richard A Young, Brian J Abraham, Kate Lawrenson
Predicting master transcription factors from pan-cancer expression data. Science advances 7 (48) (2021)
Gerd A Blobel, Douglas R Higgs, Jennifer A Mitchell, Dimple Notani, Richard A Young
Testing the super-enhancer concept. Nature reviews. Genetics 22 (12) (2021)
Isaac A Klein, Ann Boija, Lena K Afeyan, Susana Wilson Hawken, Mengyang Fan, Alessandra Dall'Agnese, Ozgur Oksuz, Jonathan E Henninger, Krishna Shrinivas, Benjamin R Sabari, Ido Sagi, Victoria E Clark, Jesse M Platt, Mrityunjoy Kar, Patrick M McCall, Alicia V Zamudio, John C Manteiga, Eliot L Coffey, Charles H Li, Nancy M Hannett, Yang Eric Guo, Tim-Michael Decker, Tong Ihn Lee, Tinghu Zhang, Jing-Ke Weng, Dylan J Taatjes, Arup K Chakraborty, Phillip A Sharp, Young Tae Chang, Anthony A Hyman, Nathanael S Gray, Richard A Young
Partitioning of cancer therapeutics in nuclear condensates. Science (New York, N.Y.) 368 (6497) (2020)
Kaveh Daneshvar, M Behfar Ardehali, Isaac A Klein, Fu-Kai Hsieh, Arcadia J Kratkiewicz, Amin Mahpour, Sabrina O L Cancelliere, Chan Zhou, Brett M Cook, Wenyang Li, Joshua V Pondick, Sweta K Gupta, Sean P Moran, Richard A Young, Robert E Kingston, Alan C Mullen
lncRNA DIGIT and BRD3 protein form phase-separated condensates to regulate endoderm differentiation. Nature cell biology 22 (10) (2020)
Avik Choudhuri, Eirini Trompouki, Brian J Abraham, Leandro M Colli, Kian Hong Kock, William Mallard, Min-Lee Yang, Divya S Vinjamur, Alireza Ghamari, Audrey Sporrij, Karen Hoi, Barbara Hummel, Sonja Boatman, Victoria Chan, Sierra Tseng, Satish K Nandakumar, Song Yang, Asher Lichtig, Michael Superdock, Seraj N Grimes, Teresa V Bowman, Yi Zhou, Shinichiro Takahashi, Roby Joehanes, Alan B Cantor, Daniel E Bauer, Santhi K Ganesh, John Rinn, Paul S Albert, Martha L Bulyk, Stephen J Chanock, Richard A Young, Leonard I Zon
Common variants in signaling transcription-factor-binding sites drive phenotypic variability in red blood cell traits. Nature genetics 52 (12) (2020)
Charles H Li, Eliot L Coffey, Alessandra Dall'Agnese, Nancy M Hannett, Xin Tang, Jonathan E Henninger, Jesse M Platt, Ozgur Oksuz, Alicia V Zamudio, Lena K Afeyan, Jurian Schuijers, X Shawn Liu, Styliani Markoulaki, Tenzin Lungjangwa, Gary LeRoy, Devon S Svoboda, Emile Wogram, Tong Ihn Lee, Rudolf Jaenisch, Richard A Young
MeCP2 links heterochromatin condensates and neurodevelopmental disease. Nature 586 (7829) (2020)
Lu Wang, Tze King Tan, Adam D Durbin, Mark W Zimmerman, Brian J Abraham, Shi Hao Tan, Phuong Cao Thi Ngoc, Nina Weichert-Leahey, Koshi Akahane, Lee N Lawton, Jo Lynne Rokita, John M Maris, Richard A Young, A Thomas Look, Takaomi Sanda
ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry. Nature communications 10 (1) (2019)
Malgorzata Krajewska, Ruben Dries, Andrew V Grassetti, Sofia Dust, Yang Gao, Hao Huang, Bandana Sharma, Daniel S Day, Nicholas Kwiatkowski, Monica Pomaville, Oliver Dodd, Edmond Chipumuro, Tinghu Zhang, Arno L Greenleaf, Guo-Cheng Yuan, Nathanael S Gray, Richard A Young, Matthias Geyer, Scott A Gerber, Rani E George
CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation. Nature communications 10 (1) (2019)
Adam D Durbin, Mark W Zimmerman, Neekesh V Dharia, Brian J Abraham, Amanda Balboni Iniguez, Nina Weichert-Leahey, Shuning He, John M Krill-Burger, David E Root, Francisca Vazquez, Aviad Tsherniak, William C Hahn, Todd R Golub, Richard A Young, A Thomas Look, Kimberly Stegmaier
Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry. Nature genetics 50 (9) (2018)
Benjamin R Sabari, Alessandra Dall'Agnese, Ann Boija, Isaac A Klein, Eliot L Coffey, Krishna Shrinivas, Brian J Abraham, Nancy M Hannett, Alicia V Zamudio, John C Manteiga, Charles H Li, Yang E Guo, Daniel S Day, Jurian Schuijers, Eliza Vasile, Sohail Malik, Denes Hnisz, Tong Ihn Lee, Ibrahim I Cisse, Robert G Roeder, Phillip A Sharp, Arup K Chakraborty, Richard A Young
Coactivator condensation at super-enhancers links phase separation and gene control. Science (New York, N.Y.) 361 (6400) (2018)
Brian J Abraham, Denes Hnisz, Abraham S Weintraub, Nicholas Kwiatkowski, Charles H Li, Zhaodong Li, Nina Weichert-Leahey, Sunniyat Rahman, Yu Liu, Julia Etchin, Benshang Li, Shuhong Shen, Tong Ihn Lee, Jinghui Zhang, A Thomas Look, Marc R Mansour, Richard A Young
Small genomic insertions form enhancers that misregulate oncogenes. Nature communications 8 (2017)
Paola A Betancur, Brian J Abraham, Ying Y Yiu, Stephen B Willingham, Farnaz Khameneh, Mark Zarnegar, Angera H Kuo, Kelly McKenna, Yoko Kojima, Nicholas J Leeper, Po Ho, Phung Gip, Tomek Swigut, Richard I Sherwood, Michael F Clarke, George Somlo, Richard A Young, Irving L Weissman
A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer. Nature communications 8 (2017)
Calla M Olson, Baishan Jiang, Michael A Erb, Yanke Liang, Zainab M Doctor, Zinan Z Zhang, Tinghu Zhang, Nicholas Kwiatkowski, Myriam Boukhali, Jennifer L Green, Wilhelm Haas, Tyzoon Nomanbhoy, Eric S Fischer, Richard A Young, James E Bradner, Georg E Winter, Nathanael S Gray
Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation. Nature chemical biology 14 (2) (2017)
Akdes Serin Harmancı, Mark W Youngblood, Victoria E Clark, Süleyman Coşkun, Octavian Henegariu, Daniel Duran, E Zeynep Erson-Omay, Leon D Kaulen, Tong Ihn Lee, Brian J Abraham, Matthias Simon, Boris Krischek, Marco Timmer, Roland Goldbrunner, S Bülent Omay, Jacob Baranoski, Burçin Baran, Geneive Carrión-Grant, Hanwen Bai, Ketu Mishra-Gorur, Johannes Schramm, Jennifer Moliterno, Alexander O Vortmeyer, Kaya Bilgüvar, Katsuhito Yasuno, Richard A Young, Murat Günel
Integrated genomic analyses of de novo pathways underlying atypical meningiomas. Nature communications 8 (2017)
Victoria E Clark, Akdes Serin Harmancı, Hanwen Bai, Mark W Youngblood, Tong Ihn Lee, Jacob F Baranoski, A Gulhan Ercan-Sencicek, Brian J Abraham, Abraham S Weintraub, Denes Hnisz, Matthias Simon, Boris Krischek, E Zeynep Erson-Omay, Octavian Henegariu, Geneive Carrión-Grant, Ketu Mishra-Gorur, Daniel Durán, Johanna E Goldmann, Johannes Schramm, Roland Goldbrunner, Joseph M Piepmeier, Alexander O Vortmeyer, Jennifer Moliterno Günel, Kaya Bilgüvar, Katsuhito Yasuno, Richard A Young, Murat Günel
Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas. Nature genetics 48 (10) (2016)
Tinghu Zhang, Nicholas Kwiatkowski, Calla M Olson, Sarah E Dixon-Clarke, Brian J Abraham, Ann K Greifenberg, Scott B Ficarro, Jonathan M Elkins, Yanke Liang, Nancy M Hannett, Theresa Manz, Mingfeng Hao, Bartlomiej Bartkowiak, Arno L Greenleaf, Jarrod A Marto, Matthias Geyer, Alex N Bullock, Richard A Young, Nathanael S Gray
Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors. Nature chemical biology 12 (10) (2016)

Richard A Young.css-eqlu8i{font-size:small;padding-left:4px;} (Richard Young)

Publication Activity (10 Years)

Top Topics

Top Venues

Richard A Young (Richard Young)