Thomas Helleday (T Helleday)

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 43

Top Venues

Nature communications

Cells

Cell death & disease

Biomolecules

Stockholms Universitet (PHD)

This page only lists publications with an associated author ORCID identifier.

Education History

Stockholms Universitet

Sweden

PHD

Stockholms Universitet

Sweden

BSC

Stockholms Universitet

Sweden

MSC

Publications

Jianyu Shen, Emilio Guillén Mancina, Shenyu Chen, Theodora Manolakou, Helge Gad, Ulrika Warpman Berglund, Kumar Sanjiv, Thomas Helleday
Mitotic MTH1 inhibitor TH1579 induces PD-L1 expression and inflammatory response through the cGAS-STING pathway. Oncogenesis 13 (1) (2024)
Petra Marttila, Nadilly Bonagas, Christina Chalkiadaki, Hannah Stigsdotter, Korbinian Schelzig, Jianyu Shen, Crystal M Farhat, Amber Hondema, Julian Albers, Elisée Wiita, Azita Rasti, Ulrika Warpman Berglund, Ana Slipicevic, Oliver Mortusewicz, Thomas Helleday
The one-carbon metabolic enzyme MTHFD2 promotes resection and homologous recombination after ionizing radiation. Molecular oncology (2024)
Maria Rita Fabbrizi, Catherine M Nickson, Jonathan R Hughes, Emily A Robinson, Karthik Vaidya, Carlos P Rubbi, Andrzej Kacperek, Helen E Bryant, Thomas Helleday, Jason L Parsons
Targeting OGG1 and PARG radiosensitises head and neck cancer cells to high-LET protons through complex DNA damage persistence. Cell death & disease 15 (2) (2024)
Ning Zhang, Luuk Harbers, Michele Simonetti, Constantin Diekmann, Quentin Verron, Enrico Berrino, Sara E Bellomo, Gabriel Mello da Cunha Longo, Michael Ratz, Niklas Schultz, Firas Tarish, Peng Su, Bo Han, Wanzhong Wang, Sofia Onorato, Dora Grassini, Roberto Ballarino, Silvia Giordano, Qifeng Yang, Anna Sapino, Jonas Frisén, Kanar Alkass, Henrik Druid, Vassilis Roukos, Thomas Helleday, Caterina Marchiò, Magda Bienko, Nicola Crosetto
High clonal diversity and spatial genetic admixture in early prostate cancer and surrounding normal tissue. Nature communications 15 (1) (2024)
Maria Rita Fabbrizi, Catherine M Nickson, Jonathan R Hughes, Emily A Robinson, Karthik Vaidya, Carlos P Rubbi, Andrzej Kacperek, Helen E Bryant, Thomas Helleday, Jason L Parsons
Targeting OGG1 and PARG radiosensitises head and neck cancer cells to high-LET protons through complex DNA damage persistence. Cell death & disease 15 (2) (2024)
Maria Rita Fabbrizi, Catherine M Nickson, Jonathan R Hughes, Emily A Robinson, Karthik Vaidya, Carlos P Rubbi, Andrzej Kacperek, Helen E Bryant, Thomas Helleday, Jason L Parsons
Targeting OGG1 and PARG radiosensitises head and neck cancer cells to high-LET protons through complex DNA damage persistence. Cell death & disease 15 (2) (2024)
Ning Zhang, Luuk Harbers, Michele Simonetti, Constantin Diekmann, Quentin Verron, Enrico Berrino, Sara E Bellomo, Gabriel Mello da Cunha Longo, Michael Ratz, Niklas Schultz, Firas Tarish, Peng Su, Bo Han, Wanzhong Wang, Sofia Onorato, Dora Grassini, Roberto Ballarino, Silvia Giordano, Qifeng Yang, Anna Sapino, Jonas Frisén, Kanar Alkass, Henrik Druid, Vassilis Roukos, Thomas Helleday, Caterina Marchiò, Magda Bienko, Nicola Crosetto
High clonal diversity and spatial genetic admixture in early prostate cancer and surrounding normal tissue. Nature communications 15 (1) (2024)
Jianyu Shen, Emilio Guillén Mancina, Shenyu Chen, Theodora Manolakou, Helge Gad, Ulrika Warpman Berglund, Kumar Sanjiv, Thomas Helleday
Mitotic MTH1 inhibitor TH1579 induces PD-L1 expression and inflammatory response through the cGAS-STING pathway. Oncogenesis 13 (1) (2024)
Maria Rita Fabbrizi, Catherine M Nickson, Jonathan R Hughes, Emily A Robinson, Karthik Vaidya, Carlos P Rubbi, Andrzej Kacperek, Helen E Bryant, Thomas Helleday, Jason L Parsons
Targeting OGG1 and PARG radiosensitises head and neck cancer cells to high-LET protons through complex DNA damage persistence. Cell death & disease 15 (2) (2024)
Ning Zhang, Luuk Harbers, Michele Simonetti, Constantin Diekmann, Quentin Verron, Enrico Berrino, Sara E Bellomo, Gabriel Mello da Cunha Longo, Michael Ratz, Niklas Schultz, Firas Tarish, Peng Su, Bo Han, Wanzhong Wang, Sofia Onorato, Dora Grassini, Roberto Ballarino, Silvia Giordano, Qifeng Yang, Anna Sapino, Jonas Frisén, Kanar Alkass, Henrik Druid, Vassilis Roukos, Thomas Helleday, Caterina Marchiò, Magda Bienko, Nicola Crosetto
High clonal diversity and spatial genetic admixture in early prostate cancer and surrounding normal tissue. Nature communications 15 (1) (2024)
Emma R Scaletti, Judith E Unterlass, Ingrid Almlöf, Tobias Koolmeister, Karl S Vallin, Despina Kapsitidou, Viktoriia Tsuber, Thomas Helleday, Pål Stenmark, Ann-Sofie Jemth
Kinetic and structural characterization of NUDT15 and NUDT18 as catalysts of isoprene pyrophosphate hydrolysis. The FEBS journal (2024)
Lloyd Tanner, A B Single, Ravi Kiran Varma Bhongir, Moritz Heusel, Tirthankar Mohanty, C A Q Karlsson, Lang Pan, C-M Clausson, J Bergwik, K Wang, C K Andersson, R M Oommen, J S Erjefält, Johan Malmstöm, O Wallner, I Boldogh, Thomas Helleday, C Kalderén, Arne Egesten
Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model. Nature communications 14 (1) (2023)
Melanie Walter, Florian Mayr, Bishoy M F Hanna, Victoria Cookson, Oliver Mortusewicz, Thomas Helleday, Patrick Herr
NUDT22 promotes cancer growth through pyrimidine salvage. Oncogene (2023)
Lloyd Tanner, A B Single, Ravi Kiran Varma Bhongir, Moritz Heusel, Tirthankar Mohanty, C A Q Karlsson, Lang Pan, C-M Clausson, J Bergwik, K Wang, C K Andersson, R M Oommen, J S Erjefält, Johan Malmstöm, O Wallner, I Boldogh, Thomas Helleday, C Kalderén, Arne Egesten
Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model. Nature communications 14 (1) (2023)
Lloyd Tanner, A B Single, Ravi Kiran Varma Bhongir, Moritz Heusel, Tirthankar Mohanty, C A Q Karlsson, Lang Pan, C-M Clausson, J Bergwik, K Wang, C K Andersson, R M Oommen, J S Erjefält, Johan Malmstöm, O Wallner, I Boldogh, Thomas Helleday, C Kalderén, Arne Egesten
Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model. Nature communications 14 (1) (2023)
Louise Ramos, Martin Henriksson, Thomas Helleday, Alanna C Green
Targeting MTHFD2 to exploit cancer-specific metabolism and the DNA damage response. Cancer research (2023)
Lloyd Tanner, A B Single, Ravi Kiran Varma Bhongir, Moritz Heusel, Tirthankar Mohanty, C A Q Karlsson, Lang Pan, C-M Clausson, J Bergwik, K Wang, C K Andersson, R M Oommen, J S Erjefält, Johan Malmstöm, O Wallner, I Boldogh, Thomas Helleday, C Kalderén, Arne Egesten
Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model. Nature communications 14 (1) (2023)
Alanna C Green, Petra Marttila, Nicole Kiweler, Christina Chalkiadaki, Elisée Wiita, Victoria Cookson, Antoine Lesur, Kim Eiden, François Bernardin, Karl S A Vallin, Sanjay Borhade, Maeve Long, Elahe Kamali Ghahe, Julio J Jiménez-Alonso, Ann-Sofie Jemth, Olga Loseva, Oliver Mortusewicz, Marianne Meyers, Elodie Viry, Annika I Johansson, Ondrej Hodek, Evert Homan, Nadilly Bonagas, Louise Ramos, Lars Sandberg, Morten Frödin, Etienne Moussay, Ana Slipicevic, Elisabeth Letellier, Jérôme Paggetti, Claus Storgaard Sørensen, Thomas Helleday, Martin Henriksson, Johannes Meiser
Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells. Nature metabolism (2023)
Sofia Henriksson, José Manuel Calderón-Montaño, Daniel Solvie, Ulrika Warpman Berglund, Thomas Helleday
Overexpressed c-Myc Sensitizes Cells to TH1579, a Mitotic Arrest and Oxidative DNA Damage Inducer. Biomolecules 12 (12) (2022)
Marlinde L van den Boogaard, Rurika Oka, Anne Hakkert, Linda Schild, Marli E Ebus, Michael R van Gerven, Danny A Zwijnenburg, Piet Molenaar, Lieke L Hoyng, M Emmy M Dolman, Anke H W Essing, Bianca Koopmans, Thomas Helleday, Jarno Drost, Ruben van Boxtel, Rogier Versteeg, Jan Koster, Jan J Molenaar
Defects in 8-oxo-guanine repair pathway cause high frequency of C > A substitutions in neuroblastoma. Proceedings of the National Academy of Sciences of the United States of America 118 (36) (2022)
Thomas Helleday
Polθ inhibitors unchained. Nature cancer 2 (6) (2022)
Mohammad Mobashir, S Pauliina Turunen, Mohammad Asrar Izhari, Ibraheem Mohammed Ashankyty, Thomas Helleday, Kaisa Lehti
An Approach for Systems-Level Understanding of Prostate Cancer from High-Throughput Data Integration to Pathway Modeling and Simulation. Cells 11 (24) (2022)
Mohammad Mobashir, S Pauliina Turunen, Mohammad Asrar Izhari, Ibraheem Mohammed Ashankyty, Thomas Helleday, Kaisa Lehti
An Approach for Systems-Level Understanding of Prostate Cancer from High-Throughput Data Integration to Pathway Modeling and Simulation. Cells 11 (24) (2022)
Maurice Michel, Carlos Benítez-Buelga, Patricia A Calvo, Bishoy M F Hanna, Oliver Mortusewicz, Geoffrey Masuyer, Jonathan R Davies, Olov Wallner, Kumar Sanjiv, Julian J Albers, Sergio Castañeda-Zegarra, Ann-Sofie Jemth, Torkild Visnes, Ana Sastre-Perona, Akhilesh N Danda, Evert J Homan, Karthick Marimuthu, Zhao Zhenjun, Celestine N Chi, Antonio Sarno, Elisée Wiita, Catharina von Nicolai, Anna J Komor, Varshni Rajagopal, Sarah Müller, Emily C Hank, Marek Varga, Emma R Scaletti, Monica Pandey, Stella Karsten, Hanne Haslene-Hox, Simon Loevenich, Petra Marttila, Azita Rasti, Kirill Mamonov, Florian Ortis, Fritz Schömberg, Olga Loseva, Josephine Stewart, Nicholas D'Arcy-Evans, Tobias Koolmeister, Martin Henriksson, Dana Michel, Ana de Ory, Lucia Acero, Oriol Calvete, Martin Scobie, Christian Hertweck, Ivan Vilotijevic, Christina Kalderén, Ana Osorio, Rosario Perona, Alexandra Stolz, Pål Stenmark, Ulrika Warpman Berglund, Miguel de Vega, Thomas Helleday
Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function. Science (New York, N.Y.) 376 (6600) (2022)
Sofia Henriksson, José Manuel Calderón-Montaño, Daniel Solvie, Ulrika Warpman Berglund, Thomas Helleday
Overexpressed c-Myc Sensitizes Cells to TH1579, a Mitotic Arrest and Oxidative DNA Damage Inducer. Biomolecules 12 (12) (2022)
Thomas Helleday, Sean G Rudd
Targeting the DNA damage response and repair in cancer through nucleotide metabolism. Molecular oncology 16 (21) (2022)
Mohammad Mobashir, S Pauliina Turunen, Mohammad Asrar Izhari, Ibraheem Mohammed Ashankyty, Thomas Helleday, Kaisa Lehti
An Approach for Systems-Level Understanding of Prostate Cancer from High-Throughput Data Integration to Pathway Modeling and Simulation. Cells 11 (24) (2022)
Sofia Henriksson, José Manuel Calderón-Montaño, Daniel Solvie, Ulrika Warpman Berglund, Thomas Helleday
Overexpressed c-Myc Sensitizes Cells to TH1579, a Mitotic Arrest and Oxidative DNA Damage Inducer. Biomolecules 12 (12) (2022)
Andrew Erickson, Mengxiao He, Emelie Berglund, Maja Marklund, Reza Mirzazadeh, Niklas Schultz, Linda Kvastad, Alma Andersson, Ludvig Bergenstråhle, Joseph Bergenstråhle, Ludvig Larsson, Leire Alonso Galicia, Alia Shamikh, Elisa Basmaci, Teresita Díaz De Ståhl, Timothy Rajakumar, Dimitrios Doultsinos, Kim Thrane, Andrew L Ji, Paul A Khavari, Firaz Tarish, Anna Tanoglidi, Jonas Maaskola, Richard Colling, Tuomas Mirtti, Freddie C Hamdy, Dan J Woodcock, Thomas Helleday, Ian Geoffrey Mills, Alastair D Lamb, Joakim Lundeberg
Spatially resolved clonal copy number alterations in benign and malignant tissue. Nature 608 (7922) (2022)
Sofia Henriksson, José Manuel Calderón-Montaño, Daniel Solvie, Ulrika Warpman Berglund, Thomas Helleday
Overexpressed c-Myc Sensitizes Cells to TH1579, a Mitotic Arrest and Oxidative DNA Damage Inducer. Biomolecules 12 (12) (2022)
Maja Marklund, Niklas Schultz, Stefanie Friedrich, Emelie Berglund, Firas Tarish, Anna Tanoglidi, Yao Liu, Ludvig Bergenstråhle, Andrew Erickson, Thomas Helleday, Alastair D Lamb, Erik L L Sonnhammer, Joakim Lundeberg
Spatio-temporal analysis of prostate tumors in situ suggests pre-existence of treatment-resistant clones. Nature communications 13 (1) (2022)
Nadilly Bonagas, Nina M S Gustafsson, Martin Henriksson, Petra Marttila, Robert Gustafsson, Elisée Wiita, Sanjay Borhade, Alanna C Green, Karl S A Vallin, Antonio Sarno, Richard Svensson, Camilla Göktürk, Therese Pham, Ann-Sofie Jemth, Olga Loseva, Victoria Cookson, Nicole Kiweler, Lars Sandberg, Azita Rasti, Judith E Unterlass, Martin Haraldsson, Yasmin Andersson, Emma R Scaletti, Christoffer Bengtsson, Cynthia B J Paulin, Kumar Sanjiv, Eldar Abdurakhmanov, Linda Pudelko, Ben Kunz, Matthieu Desroses, Petar Iliev, Katarina Färnegårdh, Andreas Krämer, Neeraj Garg, Maurice Michel, Sara Häggblad, Malin Jarvius, Christina Kalderén, Amanda Bögedahl Jensen, Ingrid Almlöf, Stella Karsten, Si Min Zhang, Maria Häggblad, Anders Eriksson, Jianping Liu, Björn Glinghammar, Natalia Nekhotiaeva, Fredrik Klingegård, Tobias Koolmeister, Ulf Martens, Sabin Llona-Minguez, Ruth Moulson, Helena Nordström, Vendela Parrow, Leif Dahllund, Birger Sjöberg, Irene L Vargas, Duy Duc Vo, Johan Wannberg, Stefan Knapp, Hans E Krokan, Per I Arvidsson, Martin Scobie, Johannes Meiser, Pål Stenmark, Ulrika Warpman Berglund, Evert J Homan, Thomas Helleday
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress. Nature cancer 3 (2) (2022)
Sophie T Williams, Greg Wells, Samantha Conroy, Hannah Gagg, Richard Allen, Ola Rominiyi, Thomas Helleday, Katie Hullock, Catherine E W Pennington, Juha K Rantala, Spencer James Collis, Sarah J Danson
Precision oncology using ex vivo technology: a step towards individualised cancer care? Expert reviews in molecular medicine 24 (2022)
Mohammad Mobashir, S Pauliina Turunen, Mohammad Asrar Izhari, Ibraheem Mohammed Ashankyty, Thomas Helleday, Kaisa Lehti
An Approach for Systems-Level Understanding of Prostate Cancer from High-Throughput Data Integration to Pathway Modeling and Simulation. Cells 11 (24) (2022)
Stella Karsten, Roland Fiskesund, Xing-Mei Zhang, Petra Marttila, Kumar Sanjiv, Therese Pham, Azita Rasti, Lars Bräutigam, Ingrid Almlöf, Maritha Marcusson-Ståhl, Carolina Sandman, Björn Platzack, Robert A Harris, Christina Kalderén, Karin Cederbrant, Thomas Helleday, Ulrika Warpman Berglund
MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells. Cell death and differentiation (2021)
Christine Hansel, Julian Hlouschek, Kexu Xiang, Margarita Melnikova, Juergen Thomale, Thomas Helleday, Verena Jendrossek, Johann Matschke
Adaptation to Chronic-Cycling Hypoxia Renders Cancer Cells Resistant to MTH1-Inhibitor Treatment Which Can Be Counteracted by Glutathione Depletion. Cells 10 (11) (2021)
Sean G Rudd, Nikolaos Tsesmetzis, Kumar Sanjiv, Cynthia Bj Paulin, Lakshmi Sandhow, Juliane Kutzner, Ida Hed Myrberg, Sarah S Bunten, Hanna Axelsson, Si Min Zhang, Azita Rasti, Petri Mäkelä, Si'Ana A Coggins, Sijia Tao, Sharda Suman, Rui M Branca, Georgios Mermelekas, Elisée Wiita, Sun Lee, Julian Walfridsson, Raymond F Schinazi, Baek Kim, Janne Lehtiö, Georgios Z Rassidakis, Katja Pokrovskaja Tamm, Ulrika Warpman-Berglund, Mats Heyman, Dan Grandér, Sören Lehmann, Thomas Lundbäck, Hong Qian, Jan-Inge Henter, Michaela Arndt, Thomas Helleday, Nikolas Herold
Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy. EMBO molecular medicine 12 (3) (2020)
Ann-Sofie Jemth, Emma Scaletti, Megan Carter, Thomas Helleday, Pål Stenmark
Crystal Structure and Substrate Specificity of the 8-oxo-dGTP Hydrolase NUDT1 from Arabidopsis thaliana. Biochemistry 58 (7) (2019)
Torkild Visnes, Armando Cázares-Körner, Wenjing Hao, Olov Wallner, Geoffrey Masuyer, Olga Loseva, Oliver Mortusewicz, Elisée Wiita, Antonio Sarno, Aleksandr Manoilov, Juan Astorga Wells, Ann-Sofie Jemth, Lang Pan, Kumar Sanjiv, Stella Karsten, Camilla Gokturk, Maurice Grube, Evert J Homan, Bishoy M F Hanna, Cynthia B J Paulin, Therese Pham, Azita Rasti, Ulrika Warpman Berglund, Catharina von Nicolai, Carlos Benitez-Buelga, Tobias Koolmeister, Dag Ivanic, Petar Iliev, Martin Scobie, Hans E Krokan, Pawel Baranczewski, Per Artursson, Mikael Altun, Annika Jenmalm Jensen, Christina Kalderén, Xueqing Ba, Roman A Zubarev, Pål Stenmark, Istvan Boldogh, Thomas Helleday
Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation. Science (New York, N.Y.) 362 (6416) (2019)
Hongwei Liao, Fang Ji, Thomas Helleday, Songmin Ying
Mechanisms for stalled replication fork stabilization: new targets for synthetic lethality strategies in cancer treatments. EMBO reports 19 (9) (2018)
Mohit Narwal, Ann-Sofie Jemth, Robert Gustafsson, Ingrid Almlöf, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark
Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity. Biochemistry 57 (5) (2018)
Pilar Mur, Ann-Sofie Jemth, Luka Bevc, Nuno Amaral, Matilde Navarro, Rafael Valdés-Mas, Tirso Pons, Gemma Aiza, Miguel Urioste, Alfonso Valencia, Conxi Lazaro Garcia, Victor Moreno, Xose S Puente, Pål Stenmark, Ulrika Warpman-Berglund, Gabriel Capellá Munar, Thomas Helleday, Laura Valle
Germline variation in the oxidative DNA repair genes NUDT1 and OGG1 is not associated with hereditary colorectal cancer or polyposis. Human mutation 39 (9) (2018)
Sabin Llona-Minguez, Artin Ghassemian, Pawel Baranczewski, Matthieu Desroses, Tobias Koolmeister, Per Artursson, Martin Scobie, Thomas Helleday
Structure-metabolism-relationships in the microsomal clearance of piperazin-1-ylpyridazines. MedChemComm 8 (7) (2017)

Thomas Helleday.css-eqlu8i{font-size:small;padding-left:4px;} (T Helleday)

Publication Activity (10 Years)

Top Topics

Top Venues

Thomas Helleday (T Helleday)