Thomas Kurz

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 33

Top Topics

Plasmodium Falciparum

Histone Deacetylase

Top Venues

Pharmaceuticals (Basel, Switzerland)

Journal of medicinal chemistry

ACS infectious diseases

International journal of molecular sciences

This page only lists publications with an associated author ORCID identifier.

Publications

Mona A Abdullaziz, Sana Takada, Boris Illarionov, Lais Pessanha de Carvalho, Yasumitsu Sakamoto, Stefan Höfmann, Talea Knak, Anna-Lene Kiffe-Delf, Flaminia Mazzone, Klaus Pfeffer, Rainer Kalscheuer, Adelbert Bacher, Jana Held, Markus Fischer, Nobutada Tanaka, Thomas Kurz
Reverse N -Substituted Hydroxamic Acid Derivatives of Fosmidomycin Target a Previously Unknown Subpocket of 1-Deoxy-d-xylulose 5-Phosphate Reductoisomerase (DXR). ACS infectious diseases (2024)
Katja Schiedlauske, Alina Deipenbrock, Marc Pflieger, Alexandra Hamacher, Jan Hänsel, Matthias Ulrich Kassack, Thomas Kurz, Nicole E Teusch
Novel Histone Deacetylase (HDAC) Inhibitor Induces Apoptosis and Suppresses Invasion via E-Cadherin Upregulation in Pancreatic Ductal Adenocarcinoma (PDAC). Pharmaceuticals (Basel, Switzerland) 17 (6) (2024)
Mona A Abdullaziz, Sana Takada, Boris Illarionov, Lais Pessanha de Carvalho, Yasumitsu Sakamoto, Stefan Höfmann, Talea Knak, Anna-Lene Kiffe-Delf, Flaminia Mazzone, Klaus Pfeffer, Rainer Kalscheuer, Adelbert Bacher, Jana Held, Markus Fischer, Nobutada Tanaka, Thomas Kurz
Reverse N -Substituted Hydroxamic Acid Derivatives of Fosmidomycin Target a Previously Unknown Subpocket of 1-Deoxy-d-xylulose 5-Phosphate Reductoisomerase (DXR). ACS infectious diseases 10 (5) (2024)
Mona A Abdullaziz, Sana Takada, Boris Illarionov, Lais Pessanha de Carvalho, Yasumitsu Sakamoto, Stefan Höfmann, Talea Knak, Anna-Lene Kiffe-Delf, Flaminia Mazzone, Klaus Pfeffer, Rainer Kalscheuer, Adelbert Bacher, Jana Held, Markus Fischer, Nobutada Tanaka, Thomas Kurz
Reverse N -Substituted Hydroxamic Acid Derivatives of Fosmidomycin Target a Previously Unknown Subpocket of 1-Deoxy-d-xylulose 5-Phosphate Reductoisomerase (DXR). ACS infectious diseases 10 (5) (2024)
Katja Schiedlauske, Alina Deipenbrock, Marc Pflieger, Alexandra Hamacher, Jan Hänsel, Matthias Ulrich Kassack, Thomas Kurz, Nicole E Teusch
Novel Histone Deacetylase (HDAC) Inhibitor Induces Apoptosis and Suppresses Invasion via E-Cadherin Upregulation in Pancreatic Ductal Adenocarcinoma (PDAC). Pharmaceuticals (Basel, Switzerland) 17 (6) (2024)
Eva Hesping, Ming Jang Chua, Marc Pflieger, Yunan Qian, Lilong Dong, Prabhakar Bachu, Ligong Liu, Thomas Kurz, Gillian M Fisher, Tina S Skinner-Adams, Robert C Reid, David P Fairlie, Katherine T Andrews, Alain-Dominique J P Gorse
QSAR Classification Models for Prediction of Hydroxamate Histone Deacetylase Inhibitor Activity against Malaria Parasites. ACS infectious diseases 8 (1) (2022)
Lukas M Bollmann, Alexander J Skerhut, Yodita Asfaha, Nadine Horstick, Helmut Hanenberg, Alexandra Hamacher, Thomas Kurz, Matthias Ulrich Kassack
The Novel Class IIa Selective Histone Deacetylase Inhibitor YAK540 Is Synergistic with Bortezomib in Leukemia Cell Lines. International journal of molecular sciences 23 (21) (2022)
Ki Back Chu, Hae-Ahm Lee, Marc Pflieger, Fabian Fischer, Yodita Asfaha, Leandro A Alves Avelar, Alexander Skerhut, Matthias U Kassack, Finn K Hansen, Andrea Schöler, Thomas Kurz, Min-Jeong Kim, Eun-Kyung Moon, Fu-Shi Quan
Antiproliferation and Antiencystation Effect of Class II Histone Deacetylase Inhibitors on Acanthamoeba castellanii . ACS infectious diseases 8 (2) (2022)
Aaron Burmeister, Alexa Stephan, Leandro A Alves Avelar, Melanie R Müller, Andrea Seiwert, Stefan Höfmann, Fabian Fischer, Hector Torres-Gomez, Michèle Janine Hoffmann, Guenter Niegisch, Felix Bremmer, Patrick Petzsch, Karl Köhrer, Peter Albers, Thomas Kurz, Margaretha A Skowron, Daniel Nettersheim
Establishment and Evaluation of Dual HDAC/BET Inhibitors as Therapeutic Options for Germ Cell Tumors and Other Urological Malignancies. Molecular cancer therapeutics 21 (11) (2022)
Alexander Berger, Talea Knak, Anna-Lene Kiffe-Delf, Korana Mudrovcic, Vinayak Singh, Mathew Njoroge, Bjoern Bengt Burckhardt, Mohanraj Gopalswamy, Beate Lungerich, Lutz Ackermann, Holger Gohlke, Kelly Chibale, Rainer Kalscheuer, Thomas Kurz
Total Synthesis of the Antimycobacterial Natural Product Chlorflavonin and Analogs via a Late-Stage Ruthenium(II)-Catalyzed ortho -C(sp 2 )-H-Hydroxylation. Pharmaceuticals (Basel, Switzerland) 15 (8) (2022)
Talea Knak, Mona A Abdullaziz, Stefan Höfmann, Leandro A Alves Avelar, Saskia Klein, Matthew J Martin, Markus Fischer, Nobutada Tanaka, Thomas Kurz
Over 40 Years of Fosmidomycin Drug Research: A Comprehensive Review and Future Opportunities. Pharmaceuticals (Basel, Switzerland) 15 (12) (2022)
Markéta Zajíčková, Lukáš Prchal, Ivan Vokřál, Linh Thuy Nguyen, Thomas Kurz, Robin B Gasser, Klára Bednářová, Magdalena Mičundová, Beate Lungerich, Oliver Michel, Lenka Skálová
Assessing the Anthelmintic Candidates BLK127 and HBK4 for Their Efficacy on Haemonchus contortus Adults and Eggs, and Their Hepatotoxicity and Biotransformation. Pharmaceutics 14 (4) (2022)
Talea Knak, Mona A Abdullaziz, Stefan Höfmann, Leandro A Alves Avelar, Saskia Klein, Matthew J Martin, Markus Fischer, Nobutada Tanaka, Thomas Kurz
Over 40 Years of Fosmidomycin Drug Research: A Comprehensive Review and Future Opportunities. Pharmaceuticals (Basel, Switzerland) 15 (12) (2022)
Talea Knak, Mona A Abdullaziz, Stefan Höfmann, Leandro A Alves Avelar, Saskia Klein, Matthew J Martin, Markus Fischer, Nobutada Tanaka, Thomas Kurz
Over 40 Years of Fosmidomycin Drug Research: A Comprehensive Review and Future Opportunities. Pharmaceuticals (Basel, Switzerland) 15 (12) (2022)
Sanil Bhatia, Lukas Spanier, David Bickel, Niklas Dienstbier, Vitalij Woloschin, Melina Vogt, Henrik Pols, Beate Lungerich, Jens Reiners, Narges Aghaallaei, Daniela Diedrich, Benedikt Frieg, Julian Schliehe-Diecks, Bertan Bopp, Franziska Lang, Mohanraj Gopalswamy, Jennifer Loschwitz, Baubak Bajoghli, Julia Skokowa, Arndt Borkhardt, Julia Hauer, Finn K Hansen, Sander H J Smits, Joachim Jose, Holger Gohlke, Thomas Kurz
Development of a First-in-Class Small-Molecule Inhibitor of the C-Terminal Hsp90 Dimerization. ACS central science 8 (5) (2022)
Talea Knak, Mona A Abdullaziz, Stefan Höfmann, Leandro A Alves Avelar, Saskia Klein, Matthew J Martin, Markus Fischer, Nobutada Tanaka, Thomas Kurz
Over 40 Years of Fosmidomycin Drug Research: A Comprehensive Review and Future Opportunities. Pharmaceuticals (Basel, Switzerland) 15 (12) (2022)
Fabian Fischer, Leandro A Alves Avelar, Laoise Murray, Thomas Kurz
Designing HDAC-PROTACs: lessons learned so far. Future medicinal chemistry 14 (3) (2021)
Tanja C Knaab, Jana Held, Bjoern B Burckhardt, Kelly Rubiano, John Okombo, Tomas Yeo, Sachel Mok, Anne-Catrin Uhlemann, Beate Lungerich, Christoph Fischli, Lais Pessanha De Carvalho, Benjamin Mordmüller, Sergio Wittlin, David A Fidock, Thomas Kurz
3-Hydroxy-propanamidines, a New Class of Orally Active Antimalarials Targeting Plasmodium falciparum. Journal of medicinal chemistry 64 (6) (2021)
Marc Pflieger, Melf Sönnichsen, Nadine Horstick-Muche, Jing Yang, Julian Schliehe-Diecks, Andrea Schöler, Arndt Borkhardt, Alexandra Hamacher, Matthias U Kassack, Finn K Hansen, Sanil Bhatia, Thomas Kurz
Oxa Analogues of Nexturastat A Demonstrate Improved HDAC6 Selectivity and Superior Antileukaemia Activity. ChemMedChem 16 (11) (2021)
Aya C Taki, Abdul Jabbar, Thomas Kurz, Beate Lungerich, Guangxu Ma, Joseph J Byrne, Marc Pflieger, Yodita Asfaha, Fabian Fischer, Bill C H Chang, Robin B Gasser, Robin B Gasser
Three Small Molecule Entities (MPK18, MPK334 and YAK308) with Activity against Haemonchus contortus In Vitro. Molecules (Basel, Switzerland) 26 (9) (2021)
Annabelle Friedrich, Ann-Sophie Assmann, Lena Schumacher, Jana V Stuijvenberg, Matthias Ulrich Kassack, Wolfgang A Schulz, Wynand P Roos, Finn K Hansen, Marc Pflieger, Thomas Kurz, Gerhard Fritz
In Vitro Assessment of the Genotoxic Hazard of Novel Hydroxamic Acid- and Benzamide-Type Histone Deacetylase Inhibitors (HDACi). International journal of molecular sciences 21 (13) (2020)
Ana J Rodrigues Moita, Jan J Bandolik, Finn K Hansen, Thomas Kurz, Alexandra Hamacher, Matthias Ulrich Kassack
Priming with HDAC Inhibitors Sensitizes Ovarian Cancer Cells to Treatment with Cisplatin and HSP90 Inhibitors. International journal of molecular sciences 21 (21) (2020)
Viktoria Krieger, Alexandra Hamacher, Fangyuan Cao, Katharina Stenzel, Christoph G W Gertzen, Linda Schäker-Hübner, Thomas Kurz, Holger Gohlke, Frank J Dekker, Matthias U Kassack, Finn K Hansen
Synthesis of Peptoid-Based Class I-Selective Histone Deacetylase Inhibitors with Chemosensitizing Properties. Journal of medicinal chemistry 62 (24) (2019)
Michael Leven, Jana Held, Sandra Duffy, Leandro A Alves Avelar, Stephan Meister, Michael Delves, David Plouffe, Krystina Kuna, Serena Tschan, Vicky M Avery, Elizabeth A Winzeler, Benjamin Mordmüller, Thomas Kurz
8-Aminoquinolines with an Aminoxyalkyl Side Chain Exert in vitro Dual-Stage Antiplasmodial Activity. ChemMedChem 14 (4) (2019)
Sanil Bhatia, Viktoria Krieger, Michael Groll, Jeremy D Osko, Nina Reßing, Heinz Ahlert, Arndt Borkhardt, Thomas Kurz, David W Christianson, Julia Hauer, Finn K Hansen
Discovery of the First-in-Class Dual Histone Deacetylase-Proteasome Inhibitor. Journal of medicinal chemistry 61 (22) (2018)
Aline Kaletsch, Maria Pinkerneil, Michèle Janine Hoffmann, Ananda Ayyappan Jaguva Vasudevan, Chenyin Wang, Finn K Hansen, Constanze Wiek, Helmut Hanenberg, Christoph G W Gertzen, Holger Gohlke, Matthias Ulrich Kassack, Thomas Kurz, Wolfgang A Schulz, Guenter Niegisch
Effects of novel HDAC inhibitors on urothelial carcinoma cells. Clinical epigenetics 10 (1) (2018)
Nicholas J Porter, Jeremy D Osko, Daniela Diedrich, Thomas Kurz, Jacob M Hooker, Finn K Hansen, David W Christianson
Histone Deacetylase 6-Selective Inhibitors and the Influence of Capping Groups on Hydroxamate-Zinc Denticity. Journal of medicinal chemistry 61 (17) (2018)
Sanil Bhatia, Daniela Diedrich, Benedikt Frieg, Heinz Ahlert, Stefan Stein, Bertan Bopp, Franziska Lang, Tao Zang, Tobias Kröger, Thomas Ernst, Gesine Kögler, Andreas Krieg, Steffen Lüdeke, Hana Kunkel, Ana J Rodrigues Moita, Matthias U Kassack, Viktoria Marquardt, Friederike V Opitz, Marina Oldenburg, Marc Remke, Florian Babor, Manuel Grez, Andreas Hochhaus, Arndt Borkhardt, Georg Groth, Luitgard Nagel-Steger, Joachim Jose, Thomas Kurz, Holger Gohlke, Finn K Hansen, Julia Hauer
Targeting HSP90 dimerization via the C terminus is effective in imatinib-resistant CML and lacks the heat shock response. Blood 132 (3) (2018)
Leandro A Alves Avelar, Jana Held, Jessica A Engel, Parichat Sureechatchaiyan, Finn K Hansen, Alexandra Hamacher, Matthias U Kassack, Benjamin Mordmüller, Katherine T Andrews, Thomas Kurz
Design and Synthesis of Novel Anti-Plasmodial Histone Deacetylase Inhibitors Containing an Alkoxyamide Connecting Unit. Archiv der Pharmazie 350 (3-4) (2017)
Michael Leven, Tanja C Knaab, Jana Held, Sandra Duffy, Stephan Meister, Christoph Fischli, Diane Meitzner, Ursula Lehmann, Beate Lungerich, Krystina Kuna, Petra Stahlke, Michael J Delves, Mirko Buchholz, Elizabeth A Winzeler, Vicky M Avery, Benjamin Mordmüller, Sergio Wittlin, Thomas Kurz
3-Hydroxy-N'-arylidenepropanehydrazonamides with Halo-Substituted Phenanthrene Scaffolds Cure P. berghei Infected Mice When Administered Perorally. Journal of medicinal chemistry 60 (14) (2017)
Katharina Stenzel, Alokta Chakrabarti, Jelena Melesina, Finn K Hansen, Julien Lancelot, Simon Herkenhöhner, Beate Lungerich, Martin Marek, Christophe Romier, Raymond J Pierce, Wolfgang Sippl, Manfred Jung, Thomas Kurz
Isophthalic Acid-Based HDAC Inhibitors as Potent Inhibitors of HDAC8 from Schistosoma mansoni. Archiv der Pharmazie 350 (8) (2017)
Katharina Stenzel, Alexandra Hamacher, Finn K Hansen, Christoph G W Gertzen, Johanna Senger, Viktoria Marquardt, Linda Marek, Martin Marek, Christophe Romier, Marc Remke, Manfred Jung, Holger Gohlke, Matthias U Kassack, Thomas Kurz
Alkoxyurea-Based Histone Deacetylase Inhibitors Increase Cisplatin Potency in Chemoresistant Cancer Cell Lines. Journal of medicinal chemistry 60 (13) (2017)
Viktoria Krieger, Alexandra Hamacher, Christoph G W Gertzen, Johanna Senger, Martijn R H Zwinderman, Martin Marek, Christophe Romier, Frank J Dekker, Thomas Kurz, Manfred Jung, Holger Gohlke, Matthias U Kassack, Finn K Hansen
Design, Multicomponent Synthesis, and Anticancer Activity of a Focused Histone Deacetylase (HDAC) Inhibitor Library with Peptoid-Based Cap Groups. Journal of medicinal chemistry 60 (13) (2017)