David W Christianson (D W Christianson)

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 55

Top Topics

Idiopathic Pulmonary Fibrosis

Structural Basis

Early Breast Cancer

Top Venues

Journal of medicinal chemistry

Accounts of chemical research

ACS chemical biology

This page only lists publications with an associated author ORCID identifier.

Publications

David W Christianson
Chemical Versatility in Catalysis and Inhibition of the Class IIb Histone Deacetylases. Accounts of chemical research 57 (8) (2024)
Samuel A Eaton, David W Christianson
Structure-Based Engineering of a Sesquiterpene Cyclase to Generate an Alcohol Product: Conversion of epi -Isozizaene Synthase into α-Bisabolol Synthase. Biochemistry (2024)
David W Christianson
Chemical Versatility in Catalysis and Inhibition of the Class IIb Histone Deacetylases. Accounts of chemical research 57 (8) (2024)
Samuel A Eaton, David W Christianson
Structure-Based Engineering of a Sesquiterpene Cyclase to Generate an Alcohol Product: Conversion of epi -Isozizaene Synthase into α-Bisabolol Synthase. Biochemistry 63 (6) (2024)
David W Christianson
Chemical Versatility in Catalysis and Inhibition of the Class IIb Histone Deacetylases. Accounts of chemical research (2024)
David W Christianson
Chemical Versatility in Catalysis and Inhibition of the Class IIb Histone Deacetylases. Accounts of chemical research 57 (8) (2024)
David W Christianson
Chemical Versatility in Catalysis and Inhibition of the Class IIb Histone Deacetylases. Accounts of chemical research 57 (8) (2024)
Samuel A Eaton, David W Christianson
Structure-Based Engineering of a Sesquiterpene Cyclase to Generate an Alcohol Product: Conversion of epi -Isozizaene Synthase into α-Bisabolol Synthase. Biochemistry 63 (6) (2024)
Samuel A Eaton, David W Christianson
Structure-Based Engineering of a Sesquiterpene Cyclase to Generate an Alcohol Product: Conversion of epi -Isozizaene Synthase into α-Bisabolol Synthase. Biochemistry 63 (6) (2024)
David W Christianson
Chemical Versatility in Catalysis and Inhibition of the Class IIb Histone Deacetylases. Accounts of chemical research 57 (8) (2024)
Samuel A Eaton, David W Christianson
Structure-Based Engineering of a Sesquiterpene Cyclase to Generate an Alcohol Product: Conversion of epi -Isozizaene Synthase into α-Bisabolol Synthase. Biochemistry 63 (6) (2024)
Paris R Watson, Suchetana Gupta, Parisa Hosseinzadeh, Benjamin P Brown, David Baker, David W Christianson
Macrocyclic Octapeptide Binding and Inferences on Protein Substrate Binding to Histone Deacetylase 6. ACS chemical biology (2023)
Paris R Watson, David W Christianson
Structure and Function of Kdac1, a Class II Deacetylase from the Multidrug-Resistant Pathogen Acinetobacter baumannii . Biochemistry (2023)
Paris R Watson, Juana Goulart Stollmaier, David W Christianson
Crystal Structure of Histone Deacetylase 6 Complexed with ( R )-Lipoic Acid, an Essential Cofactor in Central Carbon Metabolism. bioRxiv : the preprint server for biology (2023)
Samuel A Eaton, David W Christianson
Reprogramming the Cyclization Cascade of epi -Isozizaene Synthase to Generate Alternative Terpene Products. Biochemistry (2023)
Beate König, Paris R Watson, Nina Reßing, Abigail D Cragin, Linda Schäker-Hübner, David W Christianson, Finn K Hansen
Difluoromethyl-1,3,4-oxadiazoles Are Selective, Mechanism-Based, and Essentially Irreversible Inhibitors of Histone Deacetylase 6 . Journal of medicinal chemistry (2023)
Laura Sinatra, Anja Vogelmann, Florian Friedrich, Margarita A Tararina, Emilia Neuwirt, Arianna Colcerasa, Philipp König, Lara Toy, Talha Z Yesiloglu, Sebastian Hilscher, Lena Gaitzsch, Niklas Papenkordt, Shiyang Zhai, Lin Zhang, Christophe Romier, Oliver Einsle, Wolfgang Sippl, Mike Schutkowski, Olaf Gross, Gerd Bendas, David W Christianson, Finn K Hansen, Manfred Jung, Matthias Schiedel
Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation. Journal of medicinal chemistry (2023)
Margarita A Tararina, Danielle A Yee, Yi Tang, David W Christianson
Structure of the Repurposed Fungal Terpene Cyclase FlvF Implicated in the C-N Bond-Forming Reaction of Flavunoidine Biosynthesis. Biochemistry 61 (18) (2022)
Daniel Herp, Johannes Ridinger, Dina Robaa, Stephen A Shinsky, Karin Schmidtkunz, Talha Z Yesiloglu, Theresa Bayer, Raphael R Steimbach, Corey J Herbst-Gervasoni, Annika Merz, Christophe Romier, Peter Sehr, Nikolas Gunkel, Aubry K Miller, David W Christianson, Ina Oehme, Wolfgang Sippl, Manfred Jung
First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement. Chembiochem : a European journal of chemical biology 23 (14) (2022)
Nina Reßing, Julian Schliehe-Diecks, Paris R Watson, Melf Sönnichsen, Abigail D Cragin, Andrea Schöler, Jing Yang, Linda Schäker-Hübner, Arndt Borkhardt, David W Christianson, Sanil Bhatia, Finn K Hansen
Development of Fluorinated Peptoid-Based Histone Deacetylase (HDAC) Inhibitors for Therapy-Resistant Acute Leukemia. Journal of medicinal chemistry 65 (22) (2022)
Samuel A Eaton, Trey A Ronnebaum, Benjamin W Roose, David W Christianson
Structural Basis of Substrate Promiscuity and Catalysis by the Reverse Prenyltransferase N -Dimethylallyl-l-tryptophan Synthase from Fusarium fujikuroi . Biochemistry 61 (18) (2022)
Paris R Watson, Ping Bai, Changning Wang, Abigail D Cragin, Jacob M Hooker, David W Christianson
Aromatic Ring Fluorination Patterns Modulate Inhibitory Potency of Fluorophenylhydroxamates Complexed with Histone Deacetylase 6. Biochemistry 61 (18) (2022)
Raphael R Steimbach, Corey J Herbst-Gervasoni, Severin Lechner, Tracy Murray Stewart, Glynis Klinke, Johannes Ridinger, Magalie N E Géraldy, Gergely Tihanyi, Jackson R Foley, Ulrike Uhrig, Bernhard Kuster, Gernot Poschet, Robert A Casero, Guillaume Médard, Ina Oehme, David W Christianson, Nikolas Gunkel, Aubry K Miller
Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout. Journal of the American Chemical Society 144 (41) (2022)
Jacque L Faylo, Trevor van Eeuwen, Kushol Gupta, Kenji Murakami, David W Christianson
Transient Prenyltransferase-Cyclase Association in Fusicoccadiene Synthase, an Assembly-Line Terpene Synthase. Biochemistry 61 (21) (2022)
Trey A Ronnebaum, Samuel A Eaton, Emily A E Brackhahn, David W Christianson
Engineering the Prenyltransferase Domain of a Bifunctional Assembly-Line Terpene Synthase. Biochemistry 60 (42) (2021)
Olasunkanmi O Olaoye, Paris R Watson, Nabanita Nawar, Mulu Geletu, Abootaleb Sedighi, Shazreh Bukhari, Yasir S Raouf, Pimyupa Manaswiyoungkul, Fettah Erdogan, Ayah Abdeldayem, Aaron D Cabral, Muhammad Murtaza Hassan, Krimo Toutah, Andrew E Shouksmith, Justyna M Gawel, Johan Israelian, Tudor B Radu, Niyati Kachhiyapatel, Elvin D de Araujo, David W Christianson, Patrick Thomas Gunning
Unique Molecular Interaction with the Histone Deacetylase 6 Catalytic Tunnel: Crystallographic and Biological Characterization of a Model Chemotype. Journal of medicinal chemistry 64 (5) (2021)
Jacque L Faylo, Trey A Ronnebaum, David W Christianson
Assembly-Line Catalysis in Bifunctional Terpene Synthases. Accounts of chemical research 54 (20) (2021)
Jacque L Faylo, Trevor Van Eeuwen, Hee Jong Kim, Jose J Gorbea Colón, Benjamin A Garcia, Kenji Murakami, David W Christianson
Structural insight on assembly-line catalysis in terpene biosynthesis. Nature communications 12 (1) (2021)
Parisa Hosseinzadeh, Paris R Watson, Timothy W Craven, Xinting Li, Stephen Rettie, Fátima Pardo-Avila, Asim K Bera, Vikram Khipple Mulligan, Peilong Lu, Alexander S Ford, Brian D Weitzner, Lance J Stewart, Adam P Moyer, Maddalena Di Piazza, Joshua G Whalen, Per Jr Greisen, David W Christianson, Julien S Baker
Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites. Nature communications 12 (1) (2021)
Giuseppe Campiani, Caterina Cavella, Jeremy D Osko, Margherita Brindisi, Nicola Relitti, Simone Brogi, A Prasanth Saraswati, Stefano Federico, Giulia Chemi, Samuele Maramai, Gabriele Carullo, Benedikt Jaeger, Alfonso Carleo, Rosaria Benedetti, Federica Sarno, Stefania Lamponi, Paola Rottoli, Elena Bargagli, Carlo Bertucci, Daniele Tedesco, Daniel Herp, Johanna Senger, Giovina Ruberti, Fulvio Saccoccia, Simona Saponara, Beatrice Gorelli, Massimo Valoti, Breandán N Kennedy, Husvinee Sundaramurthi, Stefania Butini, Manfred Jung, Katy M Roach, Lucia Altucci, Peter Bradding, David W Christianson, Sandra Gemma, Antje Prasse
Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors. Journal of medicinal chemistry 64 (14) (2021)
Corey J Herbst-Gervasoni, David W Christianson
X-ray Crystallographic Snapshots of Substrate Binding in the Active Site of Histone Deacetylase 10. Biochemistry 60 (4) (2021)
Jeremy D Osko, David W Christianson
Binding of inhibitors to active-site mutants of CD1, the enigmatic catalytic domain of histone deacetylase 6. Acta crystallographica. Section F, Structural biology communications 76 (Pt 9) (2020)
P N Blank, Austen A Barnett, T A Ronnebaum, K E Alderfer, B N Gillott, David W Christianson, J A Himmelberger
Structural studies of geranylgeranylglyceryl phosphate synthase, a prenyltransferase found in thermophilic Euryarchaeota. Acta crystallographica. Section D, Structural biology 76 (Pt 6) (2020)
Trey A Ronnebaum, Sarah M Gardner, David W Christianson
An Aromatic Cluster in the Active Site of epi-Isozizaene Synthase Is an Electrostatic Toggle for Divergent Terpene Cyclization Pathways. Biochemistry 59 (50) (2020)
Corey J Herbst-Gervasoni, Raphael R Steimbach, Michael Morgen, Aubry K Miller, David W Christianson
Structural Basis for the Selective Inhibition of HDAC10, the Cytosolic Polyamine Deacetylase. ACS chemical biology 15 (8) (2020)
Nina Reßing, Melf Sönnichsen, Jeremy D Osko, Andrea Schöler, Julian Schliehe-Diecks, Alexander Skerhut, Arndt Borkhardt, Julia Hauer, Matthias U Kassack, David W Christianson, Sanil Bhatia, Finn K Hansen
Multicomponent Synthesis, Binding Mode, and Structure-Activity Relationship of Selective Histone Deacetylase 6 (HDAC6) Inhibitors with Bifurcated Capping Groups. Journal of medicinal chemistry 63 (18) (2020)
Benjamin W Roose, David W Christianson
Structural Basis of Tryptophan Reverse N-Prenylation Catalyzed by CymD. Biochemistry 58 (30) (2019)
Patrick N Blank, Stephen A Shinsky, David W Christianson
Structure of Sesquisabinene Synthase 1, a Terpenoid Cyclase That Generates a Strained [3.1.0] Bridged-Bicyclic Product. ACS chemical biology 14 (5) (2019)
Katherine R Welker Leng, Carol Ann Castañeda, Christophe Decroos, Barira Islam, Shozeb M Haider, David W Christianson, Carol A Fierke
Phosphorylation of Histone Deacetylase 8: Structural and Mechanistic Analysis of the Phosphomimetic S39E Mutant. Biochemistry 58 (45) (2019)
Jeremy D Osko, Nicholas J Porter, Poli Adi Narayana Reddy, You-Cai Xiao, Johanna Rokka, Manfred Jung, Jacob M Hooker, Joseph M Salvino, David W Christianson
Exploring Structural Determinants of Inhibitor Affinity and Selectivity in Complexes with Histone Deacetylase 6. Journal of medicinal chemistry 63 (1) (2019)
Katharina Vögerl, Nghia Ong, Johanna Senger, Daniel Herp, Karin Schmidtkunz, Martin Marek, Martin Müller, Karin Bartel, Tajith Baba Shaik, Nicholas J Porter, Dina Robaa, David W Christianson, Christophe Romier, Wolfgang Sippl, Manfred Jung, Franz Bracher
Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors. Journal of medicinal chemistry 62 (3) (2019)
Jeremy D Osko, David W Christianson
Structural Basis of Catalysis and Inhibition of HDAC6 CD1, the Enigmatic Catalytic Domain of Histone Deacetylase 6. Biochemistry 58 (49) (2019)
Corey J Herbst-Gervasoni, David W Christianson
Binding of N8-Acetylspermidine Analogues to Histone Deacetylase 10 Reveals Molecular Strategies for Blocking Polyamine Deacetylation. Biochemistry 58 (49) (2019)
Jeremy D Osko, Benjamin W Roose, Stephen A Shinsky, David W Christianson
Structure and Function of the Acetylpolyamine Amidohydrolase from the Deep Earth Halophile Marinobacter subterrani. Biochemistry 58 (36) (2019)
Sanil Bhatia, Viktoria Krieger, Michael Groll, Jeremy D Osko, Nina Reßing, Heinz Ahlert, Arndt Borkhardt, Thomas Kurz, David W Christianson, Julia Hauer, Finn K Hansen
Discovery of the First-in-Class Dual Histone Deacetylase-Proteasome Inhibitor. Journal of medicinal chemistry 61 (22) (2018)
Marcel K W Mackwitz, Alexandra Hamacher, Jeremy D Osko, Jana Held, Andrea Schöler, David W Christianson, Matthias U Kassack, Finn K Hansen
Multicomponent Synthesis and Binding Mode of Imidazo[1,2- a]pyridine-Capped Selective HDAC6 Inhibitors. Organic letters 20 (11) (2018)
Patrick N Blank, Travis A Pemberton, Jeng-Yeong Chow, C Dale Poulter, David W Christianson
Crystal Structure of Cucumene Synthase, a Terpenoid Cyclase That Generates a Linear Triquinane Sesquiterpene. Biochemistry 57 (44) (2018)
Stephen A Shinsky, David W Christianson
Polyamine Deacetylase Structure and Catalysis: Prokaryotic Acetylpolyamine Amidohydrolase and Eukaryotic HDAC10. Biochemistry 57 (22) (2018)
Nicholas J Porter, Jeremy D Osko, Daniela Diedrich, Thomas Kurz, Jacob M Hooker, Finn K Hansen, David W Christianson
Histone Deacetylase 6-Selective Inhibitors and the Influence of Capping Groups on Hydroxamate-Zinc Denticity. Journal of medicinal chemistry 61 (17) (2018)
David W Christianson
Correction to Structural and Chemical Biology of Terpenoid Cyclases. Chemical reviews 118 (24) (2018)
Nicholas J Porter, Florence F Wagner, David W Christianson
Entropy as a Driver of Selectivity for Inhibitor Binding to Histone Deacetylase 6. Biochemistry 57 (26) (2018)
Patrick N Blank, Golda H Barrow, Wayne K W Chou, Lian Duan, David E Cane, David W Christianson
Substitution of Aromatic Residues with Polar Residues in the Active Site Pocket of epi-Isozizaene Synthase Leads to the Generation of New Cyclic Sesquiterpenes. Biochemistry 56 (43) (2017)
David W Christianson
Structural and Chemical Biology of Terpenoid Cyclases. Chemical reviews 117 (17) (2017)
Nicholas J Porter, David W Christianson
Binding of the Microbial Cyclic Tetrapeptide Trapoxin A to the Class I Histone Deacetylase HDAC8. ACS chemical biology 12 (9) (2017)
Travis A Pemberton, Mengbin Chen, Golda G Harris, Wayne K W Chou, Lian Duan, Mustafa Köksal, Alex S Genshaft, David E Cane, David W Christianson
Exploring the Influence of Domain Architecture on the Catalytic Function of Diterpene Synthases. Biochemistry 56 (14) (2017)