Vamsi K Mootha (Vamsi Mootha)

ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 54

Top Venues

Howard Hughes Medical Institute - Massachusetts General Hospital

Stanford University (BSC)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Howard Hughes Medical Institute - Massachusetts General Hospital

United States

Investigator / Professor :: Molecular Biology

Education History

Stanford University Sep 01 1989 - Jun 15 1993

United States

BSC

Publications

Jeong Hyun Lee, Vishal M Gohil, Pedram Heidari, Jessica L Seidel, Mohammad Zulkifli, Ying Wei, Yuhua Ji, Ali Daneshmand, Umar Mahmood, Andrew T Chan, Vamsi K Mootha, Cenk Ayata
Mechanism of Action and Translational Potential of ( S )-Meclizine in Preemptive Prophylaxis Against Stroke. Stroke (2024)
Anna V Kotrys, Timothy J Durham, Xiaoyan A Guo, Venkata R Vantaku, Sareh Parangi, Vamsi K Mootha
Single-cell analysis reveals context-dependent, cell-level selection of mtDNA. Nature 629 (8011) (2024)
Benjamin E Gewurz, Rui Guo, Matthew Y Lim, Hardik Shah, Joao A Paulo, Yuchen Zhang, Haopeng Yang, Liang Wei Wang, Daniel Strebinger, Nicolas Smith, Meng Li, Merrin Leong, Michael Lutchenkov, Jin-Hua Liang, Zhixuan Li, Yin Wang, Rishi Puri, Ari Melnick, Michael Green, John M Asara, Adonia Papathanassiu, Steven P Gygi, Vamsi K Mootha
Multi-omic Analysis of Human B-cell Activation Reveals a Key Lysosomal BCAT1 Role in mTOR Hyperactivation by B-cell receptor and TLR9. Research square (2024)
Jeong Hyun Lee, Vishal M Gohil, Pedram Heidari, Jessica L Seidel, Mohammad Zulkifli, Ying Wei, Yuhua Ji, Ali Daneshmand, Umar Mahmood, Andrew T Chan, Vamsi K Mootha, Cenk Ayata
Mechanism of Action and Translational Potential of ( S )-Meclizine in Preemptive Prophylaxis Against Stroke. Stroke 55 (5) (2024)
Jeong Hyun Lee, Vishal M Gohil, Pedram Heidari, Jessica L Seidel, Mohammad Zulkifli, Ying Wei, Yuhua Ji, Ali Daneshmand, Umar Mahmood, Andrew T Chan, Vamsi K Mootha, Cenk Ayata
Mechanism of Action and Translational Potential of ( S )-Meclizine in Preemptive Prophylaxis Against Stroke. Stroke 55 (5) (2024)
Tsz-Leung To, Jason G McCoy, Naomi K Ostriker, Lev S Sandler, Carmen A Mannella, Vamsi K Mootha
PMF-seq: a highly scalable screening strategy for linking genetics to mitochondrial bioenergetics. Nature metabolism (2024)
Tsz-Leung To, Jason G McCoy, Naomi K Ostriker, Lev S Sandler, Carmen A Mannella, Vamsi K Mootha
PMF-seq: a highly scalable screening strategy for linking genetics to mitochondrial bioenergetics. Nature metabolism 6 (4) (2024)
Tsz-Leung To, Jason G McCoy, Naomi K Ostriker, Lev S Sandler, Carmen A Mannella, Vamsi K Mootha
PMF-seq: a highly scalable screening strategy for linking genetics to mitochondrial bioenergetics. Nature metabolism 6 (4) (2024)
Tsz-Leung To, Jason G McCoy, Naomi K Ostriker, Lev S Sandler, Carmen A Mannella, Vamsi K Mootha
PMF-seq: a highly scalable screening strategy for linking genetics to mitochondrial bioenergetics. Nature metabolism 6 (4) (2024)
Rahul Gupta, Masahiro Kanai, Timothy J Durham, Kristin Tsuo, Jason G McCoy, Anna V Kotrys, Wei Zhou, Patrick F Chinnery, Konrad J Karczewski, Sarah E Calvo, Benjamin M Neale, Vamsi K Mootha
Author Correction: Nuclear genetic control of mtDNA copy number and heteroplasmy in humans. Nature (2024)
Jeong Hyun Lee, Vishal M Gohil, Pedram Heidari, Jessica L Seidel, Mohammad Zulkifli, Ying Wei, Yuhua Ji, Ali Daneshmand, Umar Mahmood, Andrew T Chan, Vamsi K Mootha, Cenk Ayata
Mechanism of Action and Translational Potential of ( S )-Meclizine in Preemptive Prophylaxis Against Stroke. Stroke (2024)
Anna V Kotrys, Timothy J Durham, Xiaoyan A Guo, Venkata R Vantaku, Sareh Parangi, Vamsi K Mootha
Single-cell analysis reveals context-dependent, cell-level selection of mtDNA. Nature 629 (8011) (2024)
Anna V Kotrys, Timothy J Durham, Xiaoyan A Guo, Venkata R Vantaku, Sareh Parangi, Vamsi K Mootha
Single-cell analysis reveals context-dependent, cell-level selection of mtDNA. Nature 629 (8011) (2024)
Benjamin E Gewurz, Rui Guo, Matthew Y Lim, Hardik Shah, Joao A Paulo, Yuchen Zhang, Haopeng Yang, Liang Wei Wang, Daniel Strebinger, Nicolas Smith, Meng Li, Merrin Leong, Michael Lutchenkov, Jin-Hua Liang, Zhixuan Li, Yin Wang, Rishi Puri, Ari Melnick, Michael Green, John M Asara, Adonia Papathanassiu, Steven P Gygi, Vamsi K Mootha
Multi-omic Analysis of Human B-cell Activation Reveals a Key Lysosomal BCAT1 Role in mTOR Hyperactivation by B-cell receptor and TLR9. Research square (2024)
Benjamin E Gewurz, Rui Guo, Matthew Y Lim, Hardik Shah, Joao A Paulo, Yuchen Zhang, Haopeng Yang, Liang Wei Wang, Daniel Strebinger, Nicolas Smith, Meng Li, Merrin Leong, Michael Lutchenkov, Jin-Hua Liang, Zhixuan Li, Yin Wang, Rishi Puri, Ari Melnick, Michael Green, John M Asara, Adonia Papathanassiu, Steven P Gygi, Vamsi K Mootha
Multi-omic Analysis of Human B-cell Activation Reveals a Key Lysosomal BCAT1 Role in mTOR Hyperactivation by B-cell receptor and TLR9. Research square (2024)
Anna V Kotrys, Timothy J Durham, Xiaoyan A Guo, Venkata R Vantaku, Sareh Parangi, Vamsi K Mootha
Single-cell analysis reveals context-dependent, cell-level selection of mtDNA. Nature 629 (8011) (2024)
Tsz-Leung To, Jason G McCoy, Naomi K Ostriker, Lev S Sandler, Carmen A Mannella, Vamsi K Mootha
PMF-seq: a highly scalable screening strategy for linking genetics to mitochondrial bioenergetics. Nature metabolism 6 (4) (2024)
Jeong Hyun Lee, Vishal M Gohil, Pedram Heidari, Jessica L Seidel, Mohammad Zulkifli, Ying Wei, Yuhua Ji, Ali Daneshmand, Umar Mahmood, Andrew T Chan, Vamsi K Mootha, Cenk Ayata
Mechanism of Action and Translational Potential of ( S )-Meclizine in Preemptive Prophylaxis Against Stroke. Stroke 55 (5) (2024)
Jeong Hyun Lee, Vishal M Gohil, Pedram Heidari, Jessica L Seidel, Mohammad Zulkifli, Ying Wei, Yuhua Ji, Ali Daneshmand, Umar Mahmood, Andrew T Chan, Vamsi K Mootha, Cenk Ayata
Mechanism of Action and Translational Potential of ( S )-Meclizine in Preemptive Prophylaxis Against Stroke. Stroke 55 (5) (2024)
Anna V Kotrys, Timothy J Durham, Xiaoyan A Guo, Venkata R Vantaku, Sareh Parangi, Vamsi K Mootha
Single-cell analysis reveals context-dependent, cell-level selection of mtDNA. Nature (2024)
Rahul Gupta, Masahiro Kanai, Timothy J Durham, Kristin Tsuo, Jason G McCoy, Patrick F Chinnery, Konrad J Karczewski, Sarah E Calvo, Benjamin M Neale, Vamsi K Mootha
Nuclear genetic control of mtDNA copy number and heteroplasmy in humans. medRxiv : the preprint server for health sciences (2023)
Robert S Rogers, Hong Wang, Timothy J Durham, Jonathan A Stefely, Norah A Owiti, Andrew L Markhard, Lev Sandler, Tsz-Leung To, Vamsi K Mootha
Hypoxia extends lifespan and neurological function in a mouse model of aging. PLoS biology 21 (5) (2023)
Owen S Skinner, Joan Blanco-Fernández, Russell P Goodman, Akinori Kawakami, Hongying Shen, Lajos V Kemény, Lena Joesch-Cohen, Matthew G Rees, Jennifer A Roth, David E Fisher, Vamsi K Mootha, Alexis A Jourdain
Salvage of ribose from uridine or RNA supports glycolysis in nutrient-limited conditions. Nature metabolism (2023)
Owen S Skinner, Joan Blanco-Fernández, Russell P Goodman, Akinori Kawakami, Hongying Shen, Lajos V Kemény, Lena Joesch-Cohen, Matthew G Rees, Jennifer A Roth, David E Fisher, Vamsi K Mootha, Alexis A Jourdain
Salvage of ribose from uridine or RNA supports glycolysis in nutrient-limited conditions. Nature metabolism (2023)
Raj K Gopal, Venkata R Vantaku, Apekshya Panda, Bryn Reimer, Sneha Rath, Tsz-Leung To, Adam S Fisch, Murat Cetinbas, Maia Livneh, Michael J Calcaterra, Benjamin J Gigliotti, Kerry A Pierce, Andrew T Chan, Dora Dias-Santagata, Peter M Sadow, Lori J Wirth, Gilbert H Daniels, Ruslan I Sadreyev, Sarah E Calvo, Sareh Parangi, Vamsi K Mootha
Effectors enabling adaptation to mitochondrial complex I loss in Hurthle cell carcinoma. Cancer discovery (2023)
Rahul Gupta, Masahiro Kanai, Timothy J Durham, Kristin Tsuo, Jason G McCoy, Patrick F Chinnery, Konrad J Karczewski, Sarah E Calvo, Benjamin M Neale, Vamsi K Mootha
Nuclear genetic control of mtDNA copy number and heteroplasmy in humans. medRxiv : the preprint server for health sciences (2023)
Rahul Gupta, Masahiro Kanai, Timothy J Durham, Kristin Tsuo, Jason G McCoy, Anna V Kotrys, Wei Zhou, Patrick F Chinnery, Konrad J Karczewski, Sarah E Calvo, Benjamin M Neale, Vamsi K Mootha
Nuclear genetic control of mtDNA copy number and heteroplasmy in humans. Nature (2023)
Rahul Gupta, Masahiro Kanai, Timothy J Durham, Kristin Tsuo, Jason G McCoy, Patrick F Chinnery, Konrad J Karczewski, Sarah E Calvo, Benjamin M Neale, Vamsi K Mootha
Nuclear genetic control of mtDNA copy number and heteroplasmy in humans. medRxiv : the preprint server for health sciences (2023)
Rahul Gupta, Masahiro Kanai, Timothy J Durham, Kristin Tsuo, Jason G McCoy, Patrick F Chinnery, Konrad J Karczewski, Sarah E Calvo, Benjamin M Neale, Vamsi K Mootha
Nuclear genetic control of mtDNA copy number and heteroplasmy in humans. medRxiv : the preprint server for health sciences (2023)
Rahul Gupta, Masahiro Kanai, Timothy J Durham, Kristin Tsuo, Jason G McCoy, Patrick F Chinnery, Konrad J Karczewski, Sarah E Calvo, Benjamin M Neale, Vamsi K Mootha
Nuclear genetic control of mtDNA copy number and heteroplasmy in humans. medRxiv : the preprint server for health sciences (2023)
Rebecca D Ganetzky, Andrew L Markhard, Irene Yee, Sheila Clever, Alan Cahill, Hardik Shah, Zenon Grabarek, Tsz-Leung To, Vamsi K Mootha
Congenital Hypermetabolism and Uncoupled Oxidative Phosphorylation. The New England journal of medicine 387 (15) (2022)
Xiaojian Shi, Bryn Reimer, Hardik Shah, Tsz-Leung To, Katie Byrne, Luanna Summer, Sarah E Calvo, Olga Goldberger, John G Doench, Vamsi K Mootha, Hongying Shen
Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS. Nature communications 13 (1) (2022)
Zhonghao Wang, Rui Guo, Stephen J Trudeau, Emma Wolinsky, Tslil Ast, Jin Hua Liang, Chang Jiang, Yijie Ma, Mingxiang Teng, Vamsi K Mootha, Benjamin E Gewurz
CYB561A3 is the key lysosomal iron reductase required for Burkitt B-cell growth and survival. Blood 138 (22) (2022)
Kristen M Laricchia, Nicole J Lake, Nicholas A Watts, Megan Shand, Andrea Haessly, Laura Gauthier, David Benjamin, Eric Banks, Jose Soto, Kiran V Garimella, James Emery, null null, Michael J Bamshad, Daniel G MacArthur, Grace Tiao, Monkol Lek, Vamsi K Mootha, Sarah E Calvo
Mitochondrial DNA variation across 56,434 individuals in gnomAD. Genome research 32 (3) (2022)
Andrew L Markhard, Jason G McCoy, Tsz-Leung To, Vamsi K Mootha
A genetically encoded system for oxygen generation in living cells. Proceedings of the National Academy of Sciences of the United States of America 119 (43) (2022)
Beverly Y Mok, Anna V Kotrys, Aditya Raguram, Tony P Huang, Vamsi K Mootha, David R Liu
CRISPR-free base editors with enhanced activity and expanded targeting scope in mitochondrial and nuclear DNA. Nature biotechnology 40 (9) (2022)
Rahul Gupta, Konrad J Karczewski, Daniel P Howrigan, Benjamin M Neale, Vamsi K Mootha
Human genetic analyses of organelles highlight the nucleus in age-related trait heritability. eLife 10 (2021)
Tslil Ast, Vamsi K Mootha
Oxygen and mammalian cell culture: are we repeating the experiment of Dr. Ox? Nature metabolism 1 (9) (2021)
Manjunatha Shivaraju, Udbhav K Chitta, Robert M H Grange, Isha H Jain, Diane E Capen, Lan Liao, Jianming Xu, Fumito Ichinose, Warren M Zapol, Vamsi K Mootha, Jayaraj Rajagopal
Airway stem cells sense hypoxia and differentiate into protective solitary neuroendocrine cells. Science (New York, N.Y.) 371 (6524) (2021)
Markus Ruetz, Gregory C Campanello, Meredith Purchal, Hongying Shen, Liam McDevitt, Harsha Gouda, Shoko Wakabayashi, Junhao Zhu, Eric J Rubin, Kurt Warncke, Vamsi K Mootha, Markos Koutmos, Ruma Banerjee
Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair. Science (New York, N.Y.) 366 (6465) (2020)
Eran Mick, Denis V Titov, Owen S Skinner, Rohit Sharma, Alexis A Jourdain, Vamsi K Mootha
Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell. eLife 9 (2020)
Melissa J S MacEwen, Andrew L Markhard, Mert Bozbeyoglu, Forrest Bradford, Olga Goldberger, Vamsi K Mootha, Yasemin Sancak
Evolutionary divergence reveals the molecular basis of EMRE dependence of the human MCU. Life science alliance 3 (10) (2020)
Russell P Goodman, Andrew L Markhard, Hardik Shah, Rohit Sharma, Owen S Skinner, Andrew T Chan, Amy Deik, Anupam Patgiri, Yu-Han H Hsu, Ricard Masia, Hye Lim Noh, Sujin Suk, Olga Goldberger, Joel N Hirschhorn, Gary Yellen, Jason K Kim, Vamsi K Mootha
Hepatic NADH reductive stress underlies common variation in metabolic traits. Nature 583 (7814) (2020)
Anupam Patgiri, Owen S Skinner, Yusuke Miyazaki, Grigorij Schleifer, Eizo Marutani, Hardik Shah, Rohit Sharma, Russell P Goodman, Tsz-Leung To, Xiaoyan Robert Bao, Fumito Ichinose, Warren M Zapol, Vamsi K Mootha
An engineered enzyme that targets circulating lactate to alleviate intracellular NADH:NAD+ imbalance. Nature biotechnology 38 (3) (2020)
Melissa A Walker, Caleb A Lareau, Leif S Ludwig, Amel Karaa, Vijay G Sankaran, Aviv Regev, Vamsi K Mootha
Purifying Selection against Pathogenic Mitochondrial DNA in Human T Cells. The New England journal of medicine 383 (16) (2020)
Yan Wang, Alexis A Reyes, Ji She, Nam X Nguyen, Vamsi K Mootha, Xiao-Chen Bai, Youxing Jiang
Structural insights into the Ca2+-dependent gating of the human mitochondrial calcium uniporter. eLife 9 (2020)
Sagnika Ghosh, Writoban Basu Ball, Travis R Madaris, Subramanya Srikantan, Muniswamy Madesh, Vamsi K Mootha, Vishal M Gohil
An essential role for cardiolipin in the stability and function of the mitochondrial calcium uniporter. Proceedings of the National Academy of Sciences of the United States of America 117 (28) (2020)
Nicole J Lake, Luke E Formosa, David Arthur Stroud, Michael T Ryan, Sarah E Calvo, Vamsi K Mootha, Bharti Morar, Peter G Procopis, John Chrisodoulou, Alison G Compton, David R Thorburn
A patient with homozygous nonsense variants in two Leigh syndrome disease genes: Distinguishing a dual diagnosis from a hypomorphic protein-truncating variant. Human mutation 40 (7) (2019)
Victoria Hung, Stephanie S Lam, Namrata D Udeshi, Tanya Svinkina, Gaelen Guzman, Vamsi K Mootha, Steven A Carr, Alice Y Ting
Correction: Proteomic mapping of cytosol-facing outer mitochondrial and ER membranes in living human cells by proximity biotinylation. eLife 8 (2019)
Michael W Gray, Vamsi K Mootha
Evolutionary mitochondrial biology in titisee. IUBMB life 70 (12) (2018)
Victoria Hung, Stephanie S Lam, Namrata D Udeshi, Tanya Svinkina, Gaelen Guzman, Vamsi K Mootha, Steven A Carr, Alice Y Ting
Proteomic mapping of cytosol-facing outer mitochondrial and ER membranes in living human cells by proximity biotinylation. eLife 6 (2017)
Sarah E Calvo, Olivier Julien, Karl R Clauser, Hongying Shen, Kimberli J Kamer, James A Wells, Vamsi K Mootha
Comparative Analysis of Mitochondrial N-Termini from Mouse, Human, and Yeast. Molecular & cellular proteomics : MCP 16 (4) (2017)
Kimberli J Kamer, Zenon Grabarek, Vamsi K Mootha
High-affinity cooperative Ca2+ binding by MICU1-MICU2 serves as an on-off switch for the uniporter. EMBO reports 18 (8) (2017)
Xiaoyan Robert Bao, Shao-En Ong, Olga Goldberger, Jun Peng, Rohit Sharma, Dawn A Thompson, Scott B Vafai, Andrew G Cox, Eizo Marutani, Fumito Ichinose, Wolfram Goessling, Aviv Regev, Steven A Carr, Clary B Clish, Vamsi K Mootha
Mitochondrial dysfunction remodels one-carbon metabolism in human cells. eLife 5 (2016)

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Publication Activity (10 Years)

Top Topics

Top Venues

Vamsi K Mootha (Vamsi Mootha)