John M Asara (John Asara)

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 36

Top Topics

Tyrosine Kinase

Gas Chromatography Mass Spectrometry

Peripheral Nerve

Top Venues

Science (New York, N.Y.)

Science translational medicine

Research square

Proceedings of the National Academy of Sciences of the United States of America

This page only lists publications with an associated author ORCID identifier.

Publications

Umakant Sahu, Elodie Villa, Colleen R Reczek, Zibo Zhao, Brendan P O'Hara, Michael D Torno, Rohan Mishra, William D Shannon, John M Asara, Peng Gao, Ali Shilatifard, Navdeep S Chandel, Issam Ben-Sahra
Pyrimidines maintain mitochondrial pyruvate oxidation to support de novo lipogenesis. Science (New York, N.Y.) 383 (6690) (2024)
Prashanth Thevkar Nagesh, Yeonhee Cho, Yuan Zhuang, Mrigya Babuta, Marti Ortega-Ribera, Radhika Joshi, Veronika Lelakova, Arman Patel, Aditi Ashish Datta, Viliam Brezani, Yun-Cheng Hsieh, Adriana Ramos, Jeeval Mehta, Christopher J Copeland, Eleni Kanata, Zhenghui Gordon Jiang, Ioannis S Vlachos, John M Asara, null null, Gyongyi Szabo
In vivo Bruton's tyrosine kinase inhibition attenuates alcohol-associated liver disease by regulating CD84-mediated granulopoiesis. Science translational medicine 16 (759) (2024)
Benjamin E Gewurz, Rui Guo, Matthew Y Lim, Hardik Shah, Joao A Paulo, Yuchen Zhang, Haopeng Yang, Liang Wei Wang, Daniel Strebinger, Nicolas Smith, Meng Li, Merrin Leong, Michael Lutchenkov, Jin-Hua Liang, Zhixuan Li, Yin Wang, Rishi Puri, Ari Melnick, Michael Green, John M Asara, Adonia Papathanassiu, Steven P Gygi, Vamsi K Mootha
Multi-omic Analysis of Human B-cell Activation Reveals a Key Lysosomal BCAT1 Role in mTOR Hyperactivation by B-cell receptor and TLR9. Research square (2024)
Qiuhua Yang, Yongfeng Cai, Qian Ma, Albert Xiong, Peishan Xu, Zhidan Zhang, Jiean Xu, Yaqi Zhou, Zhiping Liu, Dingwei Zhao, John M Asara, Wei Li, Huidong Shi, Ruth B Caldwell, Akrit Sodhi, Yuqing Huo
Inactivation of adenosine receptor 2A suppresses endothelial-to-mesenchymal transition and inhibits subretinal fibrosis in mice. Science translational medicine 16 (737) (2024)
Umakant Sahu, Elodie Villa, Colleen R Reczek, Zibo Zhao, Brendan P O'Hara, Michael D Torno, Rohan Mishra, William D Shannon, John M Asara, Peng Gao, Ali Shilatifard, Navdeep S Chandel, Issam Ben-Sahra
Pyrimidines maintain mitochondrial pyruvate oxidation to support de novo lipogenesis. Science (New York, N.Y.) 383 (6690) (2024)
Bridget A Tripp, Simon T Dillon, Min Yuan, John M Asara, Sarinnapha M Vasunilashorn, Tamara G Fong, Sharon K Inouye, Long H Ngo, Marcantonio Er, Zhongcong Xie, Libermann Ta, Hasan H Otu
Integrated Multi-Omics Analysis of Cerebrospinal Fluid in Postoperative Delirium. Biomolecules 14 (8) (2024)
Mehrdad Zarei, Omid Hajihassani, Jonathan J Hue, Alexander W Loftus, Hallie J Graor, Faith Nakazzi, Parnian Naji, Christina S Boutros, Vinayak Uppin, Ali Vaziri-Gohar, Akram Shalaby, John M Asara, Luke D Rothermel, Jonathan R Brody, Jordan M Winter
IDH1 inhibition potentiates chemotherapy efficacy in pancreatic cancer. Cancer research (2024)
Bridget A Tripp, Simon T Dillon, Min Yuan, John M Asara, Sarinnapha M Vasunilashorn, Tamara G Fong, Sharon K Inouye, Long H Ngo, Marcantonio Er, Zhongcong Xie, Libermann Ta, Hasan H Otu
Integrated Multi-Omics Analysis of Cerebrospinal Fluid in Postoperative Delirium. Biomolecules 14 (8) (2024)
Umakant Sahu, Elodie Villa, Colleen R Reczek, Zibo Zhao, Brendan P O'Hara, Michael D Torno, Rohan Mishra, William D Shannon, John M Asara, Peng Gao, Ali Shilatifard, Navdeep S Chandel, Issam Ben-Sahra
Pyrimidines maintain mitochondrial pyruvate oxidation to support de novo lipogenesis. Science (New York, N.Y.) 383 (6690) (2024)
Umakant Sahu, Elodie Villa, Colleen R Reczek, Zibo Zhao, Brendan P O'Hara, Michael D Torno, Rohan Mishra, William D Shannon, John M Asara, Peng Gao, Ali Shilatifard, Navdeep S Chandel, Issam Ben-Sahra
Pyrimidines maintain mitochondrial pyruvate oxidation to support de novo lipogenesis. Science (New York, N.Y.) 383 (6690) (2024)
Qiuhua Yang, Yongfeng Cai, Qian Ma, Albert Xiong, Peishan Xu, Zhidan Zhang, Jiean Xu, Yaqi Zhou, Zhiping Liu, Dingwei Zhao, John M Asara, Wei Li, Huidong Shi, Ruth B Caldwell, Akrit Sodhi, Yuqing Huo
Inactivation of adenosine receptor 2A suppresses endothelial-to-mesenchymal transition and inhibits subretinal fibrosis in mice. Science translational medicine 16 (737) (2024)
Umakant Sahu, Elodie Villa, Colleen R Reczek, Zibo Zhao, Brendan P O'Hara, Michael D Torno, Rohan Mishra, William D Shannon, John M Asara, Peng Gao, Ali Shilatifard, Navdeep S Chandel, Issam Ben-Sahra
Pyrimidines maintain mitochondrial pyruvate oxidation to support de novo lipogenesis. Science (New York, N.Y.) 383 (6690) (2024)
Qiuhua Yang, Yongfeng Cai, Qian Ma, Albert Xiong, Peishan Xu, Zhidan Zhang, Jiean Xu, Yaqi Zhou, Zhiping Liu, Dingwei Zhao, John M Asara, Wei Li, Huidong Shi, Ruth B Caldwell, Akrit Sodhi, Yuqing Huo
Inactivation of adenosine receptor 2A suppresses endothelial-to-mesenchymal transition and inhibits subretinal fibrosis in mice. Science translational medicine 16 (737) (2024)
Benjamin E Gewurz, Rui Guo, Matthew Y Lim, Hardik Shah, Joao A Paulo, Yuchen Zhang, Haopeng Yang, Liang Wei Wang, Daniel Strebinger, Nicolas Smith, Meng Li, Merrin Leong, Michael Lutchenkov, Jin-Hua Liang, Zhixuan Li, Yin Wang, Rishi Puri, Ari Melnick, Michael Green, John M Asara, Adonia Papathanassiu, Steven P Gygi, Vamsi K Mootha
Multi-omic Analysis of Human B-cell Activation Reveals a Key Lysosomal BCAT1 Role in mTOR Hyperactivation by B-cell receptor and TLR9. Research square (2024)
Benjamin E Gewurz, Rui Guo, Matthew Y Lim, Hardik Shah, Joao A Paulo, Yuchen Zhang, Haopeng Yang, Liang Wei Wang, Daniel Strebinger, Nicolas Smith, Meng Li, Merrin Leong, Michael Lutchenkov, Jin-Hua Liang, Zhixuan Li, Yin Wang, Rishi Puri, Ari Melnick, Michael Green, John M Asara, Adonia Papathanassiu, Steven P Gygi, Vamsi K Mootha
Multi-omic Analysis of Human B-cell Activation Reveals a Key Lysosomal BCAT1 Role in mTOR Hyperactivation by B-cell receptor and TLR9. Research square (2024)
Qiuhua Yang, Yongfeng Cai, Qian Ma, Albert Xiong, Peishan Xu, Zhidan Zhang, Jiean Xu, Yaqi Zhou, Zhiping Liu, Dingwei Zhao, John M Asara, Wei Li, Huidong Shi, Ruth B Caldwell, Akrit Sodhi, Yuqing Huo
Inactivation of adenosine receptor 2A suppresses endothelial-to-mesenchymal transition and inhibits subretinal fibrosis in mice. Science translational medicine 16 (737) (2024)
Zoe N Loh, Mu-En Wang, Changxin Wan, John M Asara, Zhicheng Ji, Ming Chen
Nuclear PTEN Regulates Thymidylate Biosynthesis in Human Prostate Cancer Cell Lines. Metabolites 13 (8) (2023)
Tao Zhang, Daichao Xu, Elijah Trefts, Mingming Lv, Hiroyuki Inuzuka, Guobin Song, Min Liu, Jianlin Lu, Jianping Liu, Chen Chu, Min Wang, Huibing Wang, Huyan Meng, Hui Liu, Yuan Zhuang, Xingxing Xie, Fabin Dang, Dongxian Guan, Yuqin Men, Shuwen Jiang, Cong Jiang, Xiaoming Dai, Jing Liu, Zhen Wang, Peiqiang Yan, Jingchao Wang, Zhenbo Tu, Mrigya Babuta, Emily C Erickson, Alissandra L Hillis, Christian C Dibble, John M Asara, Gyongyi Szabo, Piotr Sicinski, Ji Miao, Yu-Ru Lee, Lifeng Pan, Reuben J Shaw, Junying Yuan, Wenyi Wei
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. Science (New York, N.Y.) 380 (6652) (2023)
Kathryn M Lemberg, Eunus S Ali, Marcela Krecmerova, Joanna Marie H Aguilar, Jesse Alt, Diane E Peters, Liang Zhao, Ying Wu, Naziba Nuha, John M Asara, Verena Staedtke, Christine A Pratilas, Pavel Majer, Rana Rais, Issam Ben-Sahra, Barbara S Slusher
Pro-905, a novel purine antimetabolite, combines with glutamine amidotransferase inhibition to suppress growth of malignant peripheral nerve sheath tumor. Molecular cancer therapeutics (2023)
Benjamin D Stein, John R Ferrarone, Eric E Gardner, Jae Won Chang, David Wu, Pablo E Hollstein, Roger J Liang, Min Yuan, Qiuying Chen, John S Coukos, Miriam Sindelar, Bryan Ngo, Steven S Gross, Reuben J Shaw, Chen Zhang, John M Asara, Raymond E Moellering, Harold Varmus, Lewis C Cantley
LKB1-dependent regulation of TPI1 creates a divergent metabolic liability between human and mouse lung adenocarcinoma. Cancer discovery (2023)
Qiuhua Yang, Emily Huo, Yongfeng Cai, Zhidan Zhang, Charles Dong, John M Asara, Qingqing Wei
PFKFB3-Mediated Glycolysis Boosts Fibroblast Activation and Subsequent Kidney Fibrosis. Cells 12 (16) (2023)
Tao Zhang, Daichao Xu, Elijah Trefts, Mingming Lv, Hiroyuki Inuzuka, Guobin Song, Min Liu, Jianlin Lu, Jianping Liu, Chen Chu, Min Wang, Huibing Wang, Huyan Meng, Hui Liu, Yuan Zhuang, Xingxing Xie, Fabin Dang, Dongxian Guan, Yuqin Men, Shuwen Jiang, Cong Jiang, Xiaoming Dai, Jing Liu, Zhen Wang, Peiqiang Yan, Jingchao Wang, Zhenbo Tu, Mrigya Babuta, Emily C Erickson, Alissandra L Hillis, Christian C Dibble, John M Asara, Gyongyi Szabo, Piotr Sicinski, Ji Miao, Yu-Ru Lee, Lifeng Pan, Reuben J Shaw, Junying Yuan, Wenyi Wei
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. Science (New York, N.Y.) 380 (6652) (2023)
Tao Zhang, Daichao Xu, Elijah Trefts, Mingming Lv, Hiroyuki Inuzuka, Guobin Song, Min Liu, Jianlin Lu, Jianping Liu, Chen Chu, Min Wang, Huibing Wang, Huyan Meng, Hui Liu, Yuan Zhuang, Xingxing Xie, Fabin Dang, Dongxian Guan, Yuqin Men, Shuwen Jiang, Cong Jiang, Xiaoming Dai, Jing Liu, Zhen Wang, Peiqiang Yan, Jingchao Wang, Zhenbo Tu, Mrigya Babuta, Emily C Erickson, Alissandra L Hillis, Christian C Dibble, John M Asara, Gyongyi Szabo, Piotr Sicinski, Ji Miao, Yu-Ru Lee, Lifeng Pan, Reuben J Shaw, Junying Yuan, Wenyi Wei
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. Science (New York, N.Y.) 380 (6652) (2023)
Long He, Jennifer E Endress, Sungyun Cho, Zhongchi Li, Yuxiang Zheng, John M Asara, John Blenis
Suppression of nuclear GSK3 signaling promotes serine/one-carbon metabolism and confers metabolic vulnerability in lung cancer cells. Science advances 8 (20) (2022)
Patrick Jouandin, Zvonimir Marelja, Yung-Hsin Shih, Andrey A Parkhitko, Miriam Dambowsky, John M Asara, Ivan Nemazanyy, Christian C Dibble, Matias Simons, Norbert Perrimon
Lysosomal cystine mobilization shapes the response of TORC1 and tissue growth to fasting. Science (New York, N.Y.) 375 (6582) (2022)
Andrey A Parkhitko, Lin Wang, Elizabeth Filine, Patrick Jouandin, Dmitry Leshchiner, Richard Binari, John M Asara, Joshua D Rabinowitz, Norbert Perrimon
A genetic model of methionine restriction extends Drosophila health- and lifespan. Proceedings of the National Academy of Sciences of the United States of America 118 (40) (2021)
Julie Agopian, Quentin Da Costa, Quang Vo Nguyen, Giulia Scorrano, Paraskevi Kousteridou, Min Yuan, Rabie Chelbi, Armelle Goubard, Remy Castellano, Julien Maurizio, Cristina Teodosio, Paulo De Sepulveda, John M Asara, Alberto Orfao, Olivier Hermine, Patrice Dubreuil, Fabienne Brenet
GlcNAc is a mast-cell chromatin-remodeling oncometabolite that promotes systemic mastocytosis aggressiveness. Blood 138 (17) (2021)
Ji Wang, Harilaos Filippakis, Thomas Hougard, Heng Du, Chenyang Ye, Heng-Jia Liu, Long Zhang, Khadijah Hindi, Shefali Bagwe, Julie Nijmeh, John M Asara, Wei Shi, Souheil El-Chemaly, Elizabeth P Henske, Hilaire C Lam
Interleukin-6 mediates PSAT1 expression and serine metabolism in TSC2-deficient cells. Proceedings of the National Academy of Sciences of the United States of America 118 (39) (2021)
Nicholas D Nguyen, Meifang Yu, Vinit Y Reddy, Ariana C Acevedo-Diaz, Enzo C Mesarick, Joseph Abi Jaoude, Min Yuan, John M Asara, Cullen M Taniguchi
Comparative Untargeted Metabolomic Profiling of Induced Mitochondrial Fusion in Pancreatic Cancer. Metabolites 11 (9) (2021)
Chien-Min Hung, Portia S Lombardo, Nazma Malik, Sonja N Brun, Kristina Hellberg, Jeanine L Van Nostrand, Daniel Garcia, Joshua Baumgart, Ken Diffenderfer, John M Asara, Reuben J Shaw
AMPK/ULK1-mediated phosphorylation of Parkin ACT domain mediates an early step in mitophagy. Science advances 7 (15) (2021)
Hong-Wen Tang, Jui-Hsia Weng, Wen Xing Lee, Yanhui Hu, Lei Gu, Sungyun Cho, Gina Lee, Richard Binari, Cathleen Li, Min En Cheng, Ah-Ram Kim, Jun Xu, Zhangfei Shen, Chiwei Xu, John M Asara, John Blenis, Norbert Perrimon
mTORC1-chaperonin CCT signaling regulates m6A RNA methylation to suppress autophagy. Proceedings of the National Academy of Sciences of the United States of America 118 (10) (2021)
Andrii Kovalenko, Andres Sanin, Kosmas Kosmas, Long Zhang, Ji Wang, Elie W Akl, Krinio Giannikou, Clemens K Probst, Thomas R Hougard, Ryan W Rue, Vera P Krymskaya, John M Asara, Hilaire C Lam, David J Kwiatkowski, Elizabeth P Henske, Harilaos Filippakis
Therapeutic Targeting of DGKA-Mediated Macropinocytosis Leads to Phospholipid Reprogramming in Tuberous Sclerosis Complex. Cancer research 81 (8) (2021)
Laura Strauss, Mohamed A A Mahmoud, Jessica D Weaver, Natalia M Tijaro-Ovalle, Anthos Christofides, Qi Wang, Rinku Pal, Min Yuan, John M Asara, Nikolaos Patsoukis, Vassiliki A Boussiotis
Targeted deletion of PD-1 in myeloid cells induces antitumor immunity. Science immunology 5 (43) (2020)
He Huang, Min Yuan, Phillip M Seitzer, Susan Ludwigsen, John M Asara
IsoSearch: An Untargeted and Unbiased Metabolite and Lipid Isotopomer Tracing Strategy from HR-LC-MS/MS Datasets. Methods and protocols 3 (3) (2020)
Gerta Hoxhaj, Issam Ben-Sahra, Sophie E Lockwood, Rebecca C Timson, Vanessa Byles, Graham T Henning, Peng Gao, Laura M Selfors, John M Asara, Brendan D Manning
Direct stimulation of NADP+ synthesis through Akt-mediated phosphorylation of NAD kinase. Science (New York, N.Y.) 363 (6431) (2019)
Min Yuan, Susanne B Breitkopf, John M Asara
Serial-omics characterization of equine urine. PloS one 12 (10) (2017)