Alessandra Bigi

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2019-2024
Publications (10 Years): 23

Top Venues

Journal of the American Chemical Society

Annals of medicine

International journal of molecular sciences

Cellular and molecular life sciences : CMLS

Università degli Studi di Firenze

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Università degli Studi di Firenze

Italy

Postdoctoral Fellow

Publications

Serene W Chen, Joseph D Barritt, Roberta Cascella, Alessandra Bigi, Cristina Cecchi, Martina Banchelli, Angelo Gallo, James A Jarvis, Fabrizio Chiti, Christopher M Dobson, Giuliana Fusco, Alfonso De Simone
Structure-Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates. Journal of the American Chemical Society 146 (15) (2024)
Serene W Chen, Joseph D Barritt, Roberta Cascella, Alessandra Bigi, Cristina Cecchi, Martina Banchelli, Angelo Gallo, James A Jarvis, Fabrizio Chiti, Christopher M Dobson, Giuliana Fusco, Alfonso De Simone
Structure-Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates. Journal of the American Chemical Society 146 (15) (2024)
Serene W Chen, Joseph D Barritt, Roberta Cascella, Alessandra Bigi, Cristina Cecchi, Martina Banchelli, Angelo Gallo, James A Jarvis, Fabrizio Chiti, Christopher M Dobson, Giuliana Fusco, Alfonso De Simone
Structure-Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates. Journal of the American Chemical Society 146 (15) (2024)
Serene W Chen, Joseph D Barritt, Roberta Cascella, Alessandra Bigi, Cristina Cecchi, Martina Banchelli, Angelo Gallo, James A Jarvis, Fabrizio Chiti, Christopher M Dobson, Giuliana Fusco, Alfonso De Simone
Structure-Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates. Journal of the American Chemical Society 146 (15) (2024)
Serene W Chen, Joseph D Barritt, Roberta Cascella, Alessandra Bigi, Cristina Cecchi, Martina Banchelli, Angelo Gallo, James A Jarvis, Fabrizio Chiti, Christopher M Dobson, Giuliana Fusco, Alfonso De Simone
Structure-Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates. Journal of the American Chemical Society (2024)
Serene W Chen, Joseph D Barritt, Roberta Cascella, Alessandra Bigi, Cristina Cecchi, Martina Banchelli, Angelo Gallo, James A Jarvis, Fabrizio Chiti, Christopher M Dobson, Giuliana Fusco, Alfonso De Simone
Structure-Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates. Journal of the American Chemical Society 146 (15) (2024)
Alessandra Bigi, Eva Lombardo, Roberta Cascella, Cristina Cecchi
The Toxicity of Protein Aggregates: New Insights into the Mechanisms. International journal of molecular sciences 24 (9) (2023)
Alessandra Bigi, Eva Lombardo, Roberta Cascella, Cristina Cecchi
The Toxicity of Protein Aggregates: New Insights into the Mechanisms. International journal of molecular sciences 24 (9) (2023)
Roberta Cascella, Martina Banchelli, Seyyed Abolghasem Ghadami, Diletta Ami, Maria Cristina Gagliani, Alessandra Bigi, Tommaso Staderini, Davide Tampellini, Katia Cortese, Cristina Cecchi, Antonino Natalello, Hadi Adibi, Paolo Matteini, Fabrizio Chiti
An in situ and in vitro investigation of cytoplasmic TDP-43 inclusions reveals the absence of a clear amyloid signature. Annals of medicine 55 (1) (2022)
Roberta Cascella, Martina Banchelli, Seyyed Abolghasem Ghadami, Diletta Ami, Maria Cristina Gagliani, Alessandra Bigi, Tommaso Staderini, Davide Tampellini, Katia Cortese, Cristina Cecchi, Antonino Natalello, Hadi Adibi, Paolo Matteini, Fabrizio Chiti
An in situ and in vitro investigation of cytoplasmic TDP-43 inclusions reveals the absence of a clear amyloid signature. Annals of medicine 55 (1) (2022)
Roberta Cascella, Martina Banchelli, Seyyed Abolghasem Ghadami, Diletta Ami, Maria Cristina Gagliani, Alessandra Bigi, Tommaso Staderini, Davide Tampellini, Katia Cortese, Cristina Cecchi, Antonino Natalello, Hadi Adibi, Paolo Matteini, Fabrizio Chiti
An in situ and in vitro investigation of cytoplasmic TDP-43 inclusions reveals the absence of a clear amyloid signature. Annals of medicine 55 (1) (2022)
Roberta Cascella, Alessandra Bigi, Dylan Giorgino Riffert, Maria Cristina Gagliani, Emilio Ermini, Matteo Moretti, Katia Cortese, Cristina Cecchi, Fabrizio Chiti
A quantitative biology approach correlates neuronal toxicity with the largest inclusions of TDP-43. Science advances 8 (30) (2022)
Roberta Cascella, Alessandra Bigi, Nunilo Cremades, Cristina Cecchi
Effects of oligomer toxicity, fibril toxicity and fibril spreading in synucleinopathies. Cellular and molecular life sciences : CMLS 79 (3) (2022)
Tommaso Staderini, Alessandra Bigi, Daniele Mongiello, Cristina Cecchi, Fabrizio Chiti
Biophysical characterization of full-length TAR DNA-binding protein (TDP-43) phase separation. Protein science : a publication of the Protein Society 31 (12) (2022)
Alessandra Bigi, Roberta Cascella, Giulia Fani, Caterina Bernacchioni, Francesca Cencetti, Paola Bruni, Fabrizio Chiti, Chiara Donati, Cristina Cecchi
Sphingosine 1-phosphate attenuates neuronal dysfunction induced by amyloid-β oligomers through endocytic internalization of NMDA receptors. The FEBS journal (2022)
Roberta Cascella, Martina Banchelli, Seyyed Abolghasem Ghadami, Diletta Ami, Maria Cristina Gagliani, Alessandra Bigi, Tommaso Staderini, Davide Tampellini, Katia Cortese, Cristina Cecchi, Antonino Natalello, Hadi Adibi, Paolo Matteini, Fabrizio Chiti
An in situ and in vitro investigation of cytoplasmic TDP-43 inclusions reveals the absence of a clear amyloid signature. Annals of medicine 55 (1) (2022)
Alessandra Bigi, Roberta Cascella, Fabrizio Chiti, Cristina Cecchi
Amyloid fibrils act as a reservoir of soluble oligomers, the main culprits in protein deposition diseases. BioEssays : news and reviews in molecular, cellular and developmental biology 44 (11) (2022)
Roberta Cascella, Martina Banchelli, Seyyed Abolghasem Ghadami, Diletta Ami, Maria Cristina Gagliani, Alessandra Bigi, Tommaso Staderini, Davide Tampellini, Katia Cortese, Cristina Cecchi, Antonino Natalello, Hadi Adibi, Paolo Matteini, Fabrizio Chiti
An in situ and in vitro investigation of cytoplasmic TDP-43 inclusions reveals the absence of a clear amyloid signature. Annals of medicine 55 (1) (2022)
Roberta Cascella, Serene W Chen, Alessandra Bigi, José D Camino, Catherine K Xu, Christopher M Dobson, Fabrizio Chiti, Nunilo Cremades, Cristina Cecchi
The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells. Nature communications 12 (1) (2021)
Alessandra Bigi, Emilio Ermini, Serene W Chen, Roberta Cascella, Cristina Cecchi
Exploring the Release of Toxic Oligomers from α-Synuclein Fibrils with Antibodies and STED Microscopy. Life (Basel, Switzerland) 11 (5) (2021)
Ryan Limbocker, Benedetta Mannini, Francesco Simone Ruggeri, Roberta Cascella, Catherine K Xu, Michele Perni, Sean Chia, Serene W Chen, Johnny Habchi, Alessandra Bigi, Ryan P Kreiser, Aidan K Wright, J Alex Albright, Tadas Kartanas, Janet R Kumita, Nunilo Cremades, Michael Zasloff, Cristina Cecchi, Tuomas P J Knowles, Fabrizio Chiti, Christopher M Dobson, Christopher M Dobson
Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism. Communications biology 3 (1) (2020)
Roberta Cascella, Giulia Fani, Alessandra Bigi, Fabrizio Chiti, Cristina Cecchi
Partial Failure of Proteostasis Systems Counteracting TDP-43 Aggregates in Neurodegenerative Diseases. International journal of molecular sciences 20 (15) (2019)
Hassan Ramshini, Reza Tayebee, Alessandra Bigi, Francesco Bemporad, Cristina Cecchi, Fabrizio Chiti
Identification of Novel 1,3,5-Triphenylbenzene Derivative Compounds as Inhibitors of Hen Lysozyme Amyloid Fibril Formation. International journal of molecular sciences 20 (22) (2019)

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Publication Activity (10 Years)

Top Topics

Top Venues

Alessandra Bigi