Roberta Cascella

Scopus Author ID ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 29

Top Topics

Oxidative Stress

Protein Protein

Spinal Cord Injury

Top Venues

Journal of the American Chemical Society

Annals of medicine

International journal of molecular sciences

Oxidative medicine and cellular longevity

This page only lists publications with an associated author ORCID identifier.

Publications

Serene W Chen, Joseph D Barritt, Roberta Cascella, Alessandra Bigi, Cristina Cecchi, Martina Banchelli, Angelo Gallo, James A Jarvis, Fabrizio Chiti, Christopher M Dobson, Giuliana Fusco, Alfonso De Simone
Structure-Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates. Journal of the American Chemical Society 146 (15) (2024)
Serene W Chen, Joseph D Barritt, Roberta Cascella, Alessandra Bigi, Cristina Cecchi, Martina Banchelli, Angelo Gallo, James A Jarvis, Fabrizio Chiti, Christopher M Dobson, Giuliana Fusco, Alfonso De Simone
Structure-Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates. Journal of the American Chemical Society 146 (15) (2024)
Serene W Chen, Joseph D Barritt, Roberta Cascella, Alessandra Bigi, Cristina Cecchi, Martina Banchelli, Angelo Gallo, James A Jarvis, Fabrizio Chiti, Christopher M Dobson, Giuliana Fusco, Alfonso De Simone
Structure-Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates. Journal of the American Chemical Society 146 (15) (2024)
Serene W Chen, Joseph D Barritt, Roberta Cascella, Alessandra Bigi, Cristina Cecchi, Martina Banchelli, Angelo Gallo, James A Jarvis, Fabrizio Chiti, Christopher M Dobson, Giuliana Fusco, Alfonso De Simone
Structure-Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates. Journal of the American Chemical Society 146 (15) (2024)
Serene W Chen, Joseph D Barritt, Roberta Cascella, Alessandra Bigi, Cristina Cecchi, Martina Banchelli, Angelo Gallo, James A Jarvis, Fabrizio Chiti, Christopher M Dobson, Giuliana Fusco, Alfonso De Simone
Structure-Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates. Journal of the American Chemical Society (2024)
Serene W Chen, Joseph D Barritt, Roberta Cascella, Alessandra Bigi, Cristina Cecchi, Martina Banchelli, Angelo Gallo, James A Jarvis, Fabrizio Chiti, Christopher M Dobson, Giuliana Fusco, Alfonso De Simone
Structure-Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates. Journal of the American Chemical Society 146 (15) (2024)
Alessandra Bigi, Eva Lombardo, Roberta Cascella, Cristina Cecchi
The Toxicity of Protein Aggregates: New Insights into the Mechanisms. International journal of molecular sciences 24 (9) (2023)
Alessandra Bigi, Eva Lombardo, Roberta Cascella, Cristina Cecchi
The Toxicity of Protein Aggregates: New Insights into the Mechanisms. International journal of molecular sciences 24 (9) (2023)
Ryan Limbocker, Nunilo Cremades, Roberta Cascella, Peter M Tessier, Christopher M Dobson, Fabrizio Chiti
Characterization of Pairs of Toxic and Nontoxic Misfolded Protein Oligomers Elucidates the Structural Determinants of Oligomer Toxicity in Protein Misfolding Diseases. Accounts of chemical research (2023)
Silvia Errico, Giacomo Lucchesi, Davide Odino, Enass Youssef Osman, Roberta Cascella, Lorenzo Neri, Claudia Capitini, Martino Calamai, Francesco Bemporad, Cristina Cecchi, William A Kinney, Denise Barbut, Annalisa Relini, Claudio Canale, Gabriella Caminati, Ryan Limbocker, Christopher M Dobson, Michael Zasloff, Fabrizio Chiti
Quantitative Attribution of the Protective Effects of Aminosterols against Protein Aggregates to Their Chemical Structures and Ability to Modulate Biological Membranes. Journal of medicinal chemistry (2023)
Roberta Cascella, Martina Banchelli, Seyyed Abolghasem Ghadami, Diletta Ami, Maria Cristina Gagliani, Alessandra Bigi, Tommaso Staderini, Davide Tampellini, Katia Cortese, Cristina Cecchi, Antonino Natalello, Hadi Adibi, Paolo Matteini, Fabrizio Chiti
An in situ and in vitro investigation of cytoplasmic TDP-43 inclusions reveals the absence of a clear amyloid signature. Annals of medicine 55 (1) (2022)
Roberta Cascella, Martina Banchelli, Seyyed Abolghasem Ghadami, Diletta Ami, Maria Cristina Gagliani, Alessandra Bigi, Tommaso Staderini, Davide Tampellini, Katia Cortese, Cristina Cecchi, Antonino Natalello, Hadi Adibi, Paolo Matteini, Fabrizio Chiti
An in situ and in vitro investigation of cytoplasmic TDP-43 inclusions reveals the absence of a clear amyloid signature. Annals of medicine 55 (1) (2022)
Roberta Cascella, Martina Banchelli, Seyyed Abolghasem Ghadami, Diletta Ami, Maria Cristina Gagliani, Alessandra Bigi, Tommaso Staderini, Davide Tampellini, Katia Cortese, Cristina Cecchi, Antonino Natalello, Hadi Adibi, Paolo Matteini, Fabrizio Chiti
An in situ and in vitro investigation of cytoplasmic TDP-43 inclusions reveals the absence of a clear amyloid signature. Annals of medicine 55 (1) (2022)
Roberta Cascella, Alessandra Bigi, Dylan Giorgino Riffert, Maria Cristina Gagliani, Emilio Ermini, Matteo Moretti, Katia Cortese, Cristina Cecchi, Fabrizio Chiti
A quantitative biology approach correlates neuronal toxicity with the largest inclusions of TDP-43. Science advances 8 (30) (2022)
Roberta Cascella, Alessandra Bigi, Nunilo Cremades, Cristina Cecchi
Effects of oligomer toxicity, fibril toxicity and fibril spreading in synucleinopathies. Cellular and molecular life sciences : CMLS 79 (3) (2022)
Alessandra Bigi, Roberta Cascella, Giulia Fani, Caterina Bernacchioni, Francesca Cencetti, Paola Bruni, Fabrizio Chiti, Chiara Donati, Cristina Cecchi
Sphingosine 1-phosphate attenuates neuronal dysfunction induced by amyloid-β oligomers through endocytic internalization of NMDA receptors. The FEBS journal (2022)
Roberta Cascella, Martina Banchelli, Seyyed Abolghasem Ghadami, Diletta Ami, Maria Cristina Gagliani, Alessandra Bigi, Tommaso Staderini, Davide Tampellini, Katia Cortese, Cristina Cecchi, Antonino Natalello, Hadi Adibi, Paolo Matteini, Fabrizio Chiti
An in situ and in vitro investigation of cytoplasmic TDP-43 inclusions reveals the absence of a clear amyloid signature. Annals of medicine 55 (1) (2022)
Alessandra Bigi, Roberta Cascella, Fabrizio Chiti, Cristina Cecchi
Amyloid fibrils act as a reservoir of soluble oligomers, the main culprits in protein deposition diseases. BioEssays : news and reviews in molecular, cellular and developmental biology 44 (11) (2022)
Roberta Cascella, Martina Banchelli, Seyyed Abolghasem Ghadami, Diletta Ami, Maria Cristina Gagliani, Alessandra Bigi, Tommaso Staderini, Davide Tampellini, Katia Cortese, Cristina Cecchi, Antonino Natalello, Hadi Adibi, Paolo Matteini, Fabrizio Chiti
An in situ and in vitro investigation of cytoplasmic TDP-43 inclusions reveals the absence of a clear amyloid signature. Annals of medicine 55 (1) (2022)
Roberta Cascella, Cristina Cecchi
Calcium Dyshomeostasis in Alzheimer's Disease Pathogenesis. International journal of molecular sciences 22 (9) (2021)
Roberta Cascella, Serene W Chen, Alessandra Bigi, José D Camino, Catherine K Xu, Christopher M Dobson, Fabrizio Chiti, Nunilo Cremades, Cristina Cecchi
The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells. Nature communications 12 (1) (2021)
Alessandra Bigi, Emilio Ermini, Serene W Chen, Roberta Cascella, Cristina Cecchi
Exploring the Release of Toxic Oligomers from α-Synuclein Fibrils with Antibodies and STED Microscopy. Life (Basel, Switzerland) 11 (5) (2021)
Giovanna Cenini, Ana Lloret, Roberta Cascella
Oxidative Stress and Mitochondrial Damage in Neurodegenerative Diseases: From Molecular Mechanisms to Targeted Therapies. Oxidative medicine and cellular longevity 2020 (2020)
Martina Banchelli, Roberta Cascella, Cristiano D'Andrea, Leszek Cabaj, Iacopo Osticioli, Daniele Ciofini, Mai Suan Li, Krzysztof Skupień, Marella de Angelis, Salvatore Siano, Cristina Cecchi, Roberto Pini, Giovanni La Penna, Fabrizio Chiti, Paolo Matteini
Nanoscopic insights into the surface conformation of neurotoxic amyloid β oligomers. RSC advances 10 (37) (2020)
Ryan Limbocker, Benedetta Mannini, Francesco Simone Ruggeri, Roberta Cascella, Catherine K Xu, Michele Perni, Sean Chia, Serene W Chen, Johnny Habchi, Alessandra Bigi, Ryan P Kreiser, Aidan K Wright, J Alex Albright, Tadas Kartanas, Janet R Kumita, Nunilo Cremades, Michael Zasloff, Cristina Cecchi, Tuomas P J Knowles, Fabrizio Chiti, Christopher M Dobson, Christopher M Dobson
Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism. Communications biology 3 (1) (2020)
Annika Höhn, Antonella Tramutola, Roberta Cascella
Proteostasis Failure in Neurodegenerative Diseases: Focus on Oxidative Stress. Oxidative medicine and cellular longevity 2020 (2020)
Giovanna Cenini, Ana Lloret, Roberta Cascella
Oxidative Stress in Neurodegenerative Diseases: From a Mitochondrial Point of View. Oxidative medicine and cellular longevity 2019 (2019)
Roberta Cascella, Giulia Fani, Alessandra Bigi, Fabrizio Chiti, Cristina Cecchi
Partial Failure of Proteostasis Systems Counteracting TDP-43 Aggregates in Neurodegenerative Diseases. International journal of molecular sciences 20 (15) (2019)
Giuliana Fusco, Serene W Chen, Philip T F Williamson, Roberta Cascella, Michele Perni, James A Jarvis, Cristina Cecchi, Michele Vendruscolo, Fabrizio Chiti, Nunilo Cremades, Liming Ying, Christopher M Dobson, Alfonso De Simone
Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers. Science (New York, N.Y.) 358 (6369) (2018)