Michele Perni

Publication Activity (10 Years)

Years Active: 2018-2023
Publications (10 Years): 24

Top Topics

Cognitive Decline

Protein Protein

Top Venues

ACS chemical neuroscience

Communications biology

ACS chemical biology

Science advances

This page only lists publications with an associated author ORCID identifier.

Publications

Priyanka Joshi, Sean Chia, Xiaoting Yang, Michele Perni, Justus M Gabriel, Marshall Gilmer, Ryan Limbocker, Johnny Habchi, Christopher M Dobson
Combinations of Vitamin A and Vitamin E Metabolites Confer Resilience against Amyloid-β Aggregation. ACS chemical neuroscience 14 (4) (2023)
Priyanka Joshi, Sean Chia, Xiaoting Yang, Michele Perni, Justus M Gabriel, Marshall Gilmer, Ryan Limbocker, Johnny Habchi, Christopher M Dobson
Combinations of Vitamin A and Vitamin E Metabolites Confer Resilience against Amyloid-β Aggregation. ACS chemical neuroscience (2023)
Priyanka Joshi, Sean Chia, Xiaoting Yang, Michele Perni, Justus M Gabriel, Marshall Gilmer, Ryan Limbocker, Johnny Habchi, Christopher M Dobson
Combinations of Vitamin A and Vitamin E Metabolites Confer Resilience against Amyloid-β Aggregation. ACS chemical neuroscience 14 (4) (2023)
Priyanka Joshi, Sean Chia, Xiaoting Yang, Michele Perni, Justus M Gabriel, Marshall Gilmer, Ryan Limbocker, Johnny Habchi, Christopher M Dobson
Combinations of Vitamin A and Vitamin E Metabolites Confer Resilience against Amyloid-β Aggregation. ACS chemical neuroscience 14 (4) (2023)
Priyanka Joshi, Sean Chia, Xiaoting Yang, Michele Perni, Justus M Gabriel, Marshall Gilmer, Ryan Limbocker, Johnny Habchi, Christopher M Dobson
Combinations of Vitamin A and Vitamin E Metabolites Confer Resilience against Amyloid-β Aggregation. ACS chemical neuroscience 14 (4) (2023)
Priyanka Joshi, Sean Chia, Xiaoting Yang, Michele Perni, Justus M Gabriel, Marshall Gilmer, Ryan Limbocker, Johnny Habchi, Christopher M Dobson
Combinations of Vitamin A and Vitamin E Metabolites Confer Resilience against Amyloid-β Aggregation. ACS chemical neuroscience 14 (4) (2023)
Priyanka Joshi, Sean Chia, Xiaoting Yang, Michele Perni, Justus M Gabriel, Marshall Gilmer, Ryan Limbocker, Johnny Habchi, Christopher M Dobson
Combinations of Vitamin A and Vitamin E Metabolites Confer Resilience against Amyloid-β Aggregation. ACS chemical neuroscience 14 (4) (2023)
Priyanka Joshi, Michele Perni, Ryan Limbocker, Benedetta Mannini, Sam Casford, Sean Chia, Johnny Habchi, Johnathan Labbadia, Christopher M Dobson, Christopher M Dobson
Publisher Correction: Two human metabolites rescue a C. elegans model of Alzheimer's disease via a cytosolic unfolded protein response. Communications biology 4 (1) (2021)
Priyanka Joshi, Michele Perni, Ryan Limbocker, Benedetta Mannini, Sam Casford, Sean Chia, Johnny Habchi, Johnathan Labbadia, Christopher M Dobson, Christopher M Dobson
Two human metabolites rescue a C. elegans model of Alzheimer's disease via a cytosolic unfolded protein response. Communications biology 4 (1) (2021)
Massimiliano Runfola, Michele Perni, Xiaoting Yang, Maria Marchese, Andrea Bacci, Serena Mero, Filippo M Santorelli, Beatrice Polini, Grazia Chiellini, Daniela Giuliani, Antonietta Vilella, Martina Bodria, Eleonora Daini, Eleonora Vandini, Simon Rudge, Sheraz Gul, Michale O J Wakelam, Christopher M Dobson, Simona Rapposelli
Identification of a Thyroid Hormone Derivative as a Pleiotropic Agent for the Treatment of Alzheimer's Disease. Pharmaceuticals (Basel, Switzerland) 14 (12) (2021)
Rodrigo Cataldi, Sean Chia, Katarina Pisani, Francesco Simone Ruggeri, Catherine K Xu, Tomas Šneideris, Michele Perni, Sunehera Sarwat, Priyanka Joshi, Janet R Kumita, Sara Linse, Johnny Habchi, Tuomas P J Knowles, Benedetta Mannini, Christopher M Dobson, Christopher M Dobson
Publisher Correction: A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers. Communications biology 4 (1) (2021)
Rodrigo Cataldi, Sean Chia, Katarina Pisani, Francesco Simone Ruggeri, Catherine K Xu, Tomas Šneideris, Michele Perni, Sunehera Sarwat, Priyanka Joshi, Janet R Kumita, Sara Linse, Johnny Habchi, Tuomas P J Knowles, Benedetta Mannini, Christopher M Dobson, Christopher M Dobson
A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers. Communications biology 4 (1) (2021)
Urszula Nowicka, Piotr Chroscicki, Karen Stroobants, Maria Sladowska, Michal Turek, Barbara Uszczynska-Ratajczak, Rishika Kundra, Tomasz Goral, Michele Perni, Christopher M Dobson, Christopher M Dobson, Agnieszka Chacinska
Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins. eLife 10 (2021)
Gabriella T Heller, Francesco Antonio Aprile, Thomas C T Michaels, Ryan Limbocker, Michele Perni, Francesco Simone Ruggeri, Benedetta Mannini, Thomas Löhr, Massimiliano Bonomi, Carlo Camilloni, Alfonso De Simone, Isabella C Felli, Roberta Pierattelli, Tuomas P J Knowles, Christopher M Dobson, Christopher M Dobson
Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer's disease. Science advances 6 (45) (2020)
Francesco Antonio Aprile, Pietro Sormanni, Marina Podpolny, Shianne Chhangur, Lisa-Maria Needham, Francesco Simone Ruggeri, Michele Perni, Ryan Limbocker, Gabriella T Heller, Tomas Sneideris, Tom Scheidt, Benedetta Mannini, Johnny Habchi, Steven F Lee, Patricia C Salinas, Tuomas P J Knowles, Christopher M Dobson, Christopher M Dobson
Rational design of a conformation-specific antibody for the quantification of Aβ oligomers. Proceedings of the National Academy of Sciences of the United States of America 117 (24) (2020)
Ryan Limbocker, Benedetta Mannini, Francesco Simone Ruggeri, Roberta Cascella, Catherine K Xu, Michele Perni, Sean Chia, Serene W Chen, Johnny Habchi, Alessandra Bigi, Ryan P Kreiser, Aidan K Wright, J Alex Albright, Tadas Kartanas, Janet R Kumita, Nunilo Cremades, Michael Zasloff, Cristina Cecchi, Tuomas P J Knowles, Fabrizio Chiti, Christopher M Dobson, Christopher M Dobson
Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism. Communications biology 3 (1) (2020)
Romain F Laine, Tessa Sinnige, Kai Yu Ma, Amanda J Haack, Chetan Poudel, Peter Gaida, Nathan Curry, Michele Perni, Ellen A A Nollen, Christopher M Dobson, Christopher M Dobson, Gabriele S Kaminski Schierle, Clemens F Kaminski
Fast Fluorescence Lifetime Imaging Reveals the Aggregation Processes of α-Synuclein and Polyglutamine in Aging Caenorhabditis elegans. ACS chemical biology 14 (7) (2019)
Roberta Cascella, Michele Perni, Serene W Chen, Giuliana Fusco, Cristina Cecchi, Christopher M Dobson, Fabrizio Chiti, Christopher M Dobson, Alfonso De Simone
Probing the Origin of the Toxicity of Oligomeric Aggregates of α-Synuclein with Antibodies. ACS chemical biology 14 (6) (2019)
Ryan Limbocker, Sean Chia, Francesco S Ruggeri, Michele Perni, Roberta Cascella, Gabriella T Heller, Georg Meisl, Benedetta Mannini, Johnny Habchi, Thomas C T Michaels, Pavan K Challa, Minkoo Ahn, Samuel T Casford, Nilumi Fernando, Catherine K Xu, Nina D Kloss, Samuel I A Cohen, Janet R Kumita, Cristina Cecchi, Michael Zasloff, Sara Linse, Tuomas P J Knowles, Fabrizio Chiti, Michele Vendruscolo, Christopher M Dobson
Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes. Nature communications 10 (1) (2019)
Dafni C Delivoria, Sean Chia, Johnny Habchi, Michele Perni, Ilias Matis, Nikoletta Papaevgeniou, Martin Reczko, Niki Chondrogianni, Christopher M Dobson, Christopher M Dobson, Georgios Skretas
Bacterial production and direct functional screening of expanded molecular libraries for discovering inhibitors of protein aggregation. Science advances 5 (10) (2019)
Giulia Faravelli, Sara Raimondi, Loredana Marchese, Frederick A Partridge, Cristina Soria, P Patrizia Mangione, Diana Canetti, Michele Perni, Francesco A Aprile, Irene Zorzoli, Elia Di Schiavi, David A Lomas, Vittorio Bellotti, David B Sattelle, Sofia Giorgetti
C. elegans expressing D76N β2-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis. Scientific reports 9 (1) (2019)
Michele Perni, Patrick Flagmeier, Ryan Limbocker, Roberta Cascella, Francesco Antonio Aprile, Céline Galvagnion, Gabriella T Heller, Georg Meisl, Serene W Chen, Janet R Kumita, Pavan Kumar Challa, Julius B Kirkegaard, Samuel I A Cohen, Benedetta Mannini, Denise Barbut, Ellen A A Nollen, Cristina Cecchi, Nunilo Cremades, Tuomas P J Knowles, Fabrizio Chiti, Michael Zasloff, Christopher M Dobson, Christopher M Dobson
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine. ACS chemical biology 13 (8) (2018)
Giuliana Fusco, Serene W Chen, Philip T F Williamson, Roberta Cascella, Michele Perni, James A Jarvis, Cristina Cecchi, Michele Vendruscolo, Fabrizio Chiti, Nunilo Cremades, Liming Ying, Christopher M Dobson, Alfonso De Simone
Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers. Science (New York, N.Y.) 358 (6369) (2018)
Benedetta Mannini, Johnny Habchi, Sean Chia, Francesco S Ruggeri, Michele Perni, Tuomas P J Knowles, Christopher M Dobson, Christopher M Dobson
Stabilization and Characterization of Cytotoxic Aβ40 Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions. ACS chemical neuroscience 9 (12) (2018)