Alfonso De Simone

ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 27

Top Venues

Journal of the American Chemical Society

ACS applied materials & interfaces

JACS Au

ACS chemical biology

Imperial College London

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Imperial College London

United Kingdom

Reader and Research Group Leader :: Life Sciences

Publications

Alessandra Esposito, Linda Leone, Alfonso De Simone, Giuliana Fusco, Flavia Nastri, Angelina Lombardi
Catalytic Nanomaterials by Conjugation of an Artificial Heme-Peroxidase to Amyloid Fibrils. ACS applied materials & interfaces 16 (34) (2024)
Alessandra Esposito, Linda Leone, Alfonso De Simone, Giuliana Fusco, Flavia Nastri, Angelina Lombardi
Catalytic Nanomaterials by Conjugation of an Artificial Heme-Peroxidase to Amyloid Fibrils. ACS applied materials & interfaces (2024)
Serene W Chen, Joseph D Barritt, Roberta Cascella, Alessandra Bigi, Cristina Cecchi, Martina Banchelli, Angelo Gallo, James A Jarvis, Fabrizio Chiti, Christopher M Dobson, Giuliana Fusco, Alfonso De Simone
Structure-Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates. Journal of the American Chemical Society 146 (15) (2024)
Alessandra Esposito, Linda Leone, Alfonso De Simone, Giuliana Fusco, Flavia Nastri, Angelina Lombardi
Catalytic Nanomaterials by Conjugation of an Artificial Heme-Peroxidase to Amyloid Fibrils. ACS applied materials & interfaces 16 (34) (2024)
Serene W Chen, Joseph D Barritt, Roberta Cascella, Alessandra Bigi, Cristina Cecchi, Martina Banchelli, Angelo Gallo, James A Jarvis, Fabrizio Chiti, Christopher M Dobson, Giuliana Fusco, Alfonso De Simone
Structure-Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates. Journal of the American Chemical Society 146 (15) (2024)
Ana Florencia Vega-Benedetti, Clara Porcedda, Tommaso Ercoli, Giuliana Fusco, Chiara Burgaletto, Rita Pillai, Maria Francesca Palmas, Anna Flavia Cantone, Fabrizio Angius, Paolo Solla, Alfonso De Simone, Giuseppina Cantarella, Cesarina Giallongo, Valeria Sogos, Giovanni Defazio, Anna R Carta
Immune responses to oligomeric α-synuclein in Parkinson's disease peripheral blood mononuclear cells. Journal of neurology (2024)
Serene W Chen, Joseph D Barritt, Roberta Cascella, Alessandra Bigi, Cristina Cecchi, Martina Banchelli, Angelo Gallo, James A Jarvis, Fabrizio Chiti, Christopher M Dobson, Giuliana Fusco, Alfonso De Simone
Structure-Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates. Journal of the American Chemical Society 146 (15) (2024)
Alessandra Esposito, Linda Leone, Alfonso De Simone, Giuliana Fusco, Flavia Nastri, Angelina Lombardi
Catalytic Nanomaterials by Conjugation of an Artificial Heme-Peroxidase to Amyloid Fibrils. ACS applied materials & interfaces 16 (34) (2024)
Angelo Gallo, Silvia Mansueto, Alessandro Emendato, Giuliana Fusco, Alfonso De Simone
α-Synuclein and Mitochondria: Probing the Dynamics of Disordered Membrane-protein Regions Using Solid-State Nuclear Magnetic Resonance. JACS Au 4 (6) (2024)
Serene W Chen, Joseph D Barritt, Roberta Cascella, Alessandra Bigi, Cristina Cecchi, Martina Banchelli, Angelo Gallo, James A Jarvis, Fabrizio Chiti, Christopher M Dobson, Giuliana Fusco, Alfonso De Simone
Structure-Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates. Journal of the American Chemical Society 146 (15) (2024)
Serene W Chen, Joseph D Barritt, Roberta Cascella, Alessandra Bigi, Cristina Cecchi, Martina Banchelli, Angelo Gallo, James A Jarvis, Fabrizio Chiti, Christopher M Dobson, Giuliana Fusco, Alfonso De Simone
Structure-Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates. Journal of the American Chemical Society (2024)
Angelo Gallo, Silvia Mansueto, Alessandro Emendato, Giuliana Fusco, Alfonso De Simone
α-Synuclein and Mitochondria: Probing the Dynamics of Disordered Membrane-protein Regions Using Solid-State Nuclear Magnetic Resonance. JACS Au 4 (6) (2024)
Serene W Chen, Joseph D Barritt, Roberta Cascella, Alessandra Bigi, Cristina Cecchi, Martina Banchelli, Angelo Gallo, James A Jarvis, Fabrizio Chiti, Christopher M Dobson, Giuliana Fusco, Alfonso De Simone
Structure-Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates. Journal of the American Chemical Society 146 (15) (2024)
Silvia Mansueto, Giuliana Fusco, Alfonso De Simone
α-Synuclein and biological membranes: the danger of loving too much. Chemical communications (Cambridge, England) (2023)
Guowei Qi, Michail D Vrettas, Carmen Biancaniello, Maximo Sanz-Hernandez, Conor T Cafolla, John W R Morgan, Yifei Wang, Alfonso De Simone, David J Wales
Enhancing Biomolecular Simulations with Hybrid Potentials Incorporating NMR Data. Journal of chemical theory and computation (2022)
Maria Francesca Palmas, Michela Etzi, Augusta Pisanu, Chiara Camoglio, Claudia Sagheddu, Michele Santoni, Maria Francesca Manchinu, Mauro Pala, Giuliana Fusco, Alfonso De Simone, Luca Picci, Giovanna Mulas, Saturnino Spiga, Maria Scherma, Paola Fadda, Marco Pistis, Nicola Simola, Ezio Carboni, Anna R Carta
The Intranigral Infusion of Human-Alpha Synuclein Oligomers Induces a Cognitive Impairment in Rats Associated with Changes in Neuronal Firing and Neuroinflammation in the Anterior Cingulate Cortex. Cells 11 (17) (2022)
Nicole Balasco, Luciana Esposito, Alfonso De Simone, Luigi Vitagliano
Local Backbone Geometry Plays a Critical Role in Determining Conformational Preferences of Amino Acid Residues in Proteins. Biomolecules 12 (9) (2022)
Daniel K Weber, U Venkateswara Reddy, Songlin Wang, Erik K Larsen, Tata Gopinath, Martin B Gustavsson, Razvan L Cornea, David Dt Thomas, Alfonso De Simone, Gianluigi Veglia
Structural basis for allosteric control of the SERCA-Phospholamban membrane complex by Ca2+ and phosphorylation. eLife 10 (2021)
Wing K Man, Bogachan Tahirbegi, Michail D Vrettas, Swapan Preet, Liming Ying, Christopher M Dobson, Alfonso De Simone, Giuliana Fusco
The docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition. Nature communications 12 (1) (2021)
Máximo Sanz-Hernández, Alfonso De Simone
Backbone NMR assignments of the C-terminal domain of the human prion protein and its disease-associated T183A variant. Biomolecular NMR assignments 15 (1) (2021)
Maximo Sanz-Hernandez, Joseph D Barritt, Jens Sobek, Simone Hornemann, Adriano Aguzzi, Alfonso De Simone
Mechanism of misfolding of the human prion protein revealed by a pathological mutation. Proceedings of the National Academy of Sciences of the United States of America 118 (12) (2021)
Carlos Navarro-Paya, Maximo Sanz-Hernandez, Alfonso De Simone
In Silico Study of the Mechanism of Binding of the N-Terminal Region of α Synuclein to Synaptic-Like Membranes. Life (Basel, Switzerland) 10 (6) (2020)
Gabriella T Heller, Francesco Antonio Aprile, Thomas C T Michaels, Ryan Limbocker, Michele Perni, Francesco Simone Ruggeri, Benedetta Mannini, Thomas Löhr, Massimiliano Bonomi, Carlo Camilloni, Alfonso De Simone, Isabella C Felli, Roberta Pierattelli, Tuomas P J Knowles, Christopher M Dobson, Christopher M Dobson
Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer's disease. Science advances 6 (45) (2020)
Mirella Vivoli Vega, Roberta Cascella, Serene W Chen, Giuliana Fusco, Alfonso De Simone, Christopher M Dobson, Cristina Cecchi, Fabrizio Chiti
The Toxicity of Misfolded Protein Oligomers Is Independent of Their Secondary Structure. ACS chemical biology 14 (7) (2019)
Roberta Cascella, Michele Perni, Serene W Chen, Giuliana Fusco, Cristina Cecchi, Christopher M Dobson, Fabrizio Chiti, Christopher M Dobson, Alfonso De Simone
Probing the Origin of the Toxicity of Oligomeric Aggregates of α-Synuclein with Antibodies. ACS chemical biology 14 (6) (2019)
Giuliana Fusco, Serene W Chen, Philip T F Williamson, Roberta Cascella, Michele Perni, James A Jarvis, Cristina Cecchi, Michele Vendruscolo, Fabrizio Chiti, Nunilo Cremades, Liming Ying, Christopher M Dobson, Alfonso De Simone
Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers. Science (New York, N.Y.) 358 (6369) (2018)
Giuliana Fusco, Maximo Sanz-Hernandez, Francesco Simone Ruggeri, Christopher M Dobson, Christopher M Dobson, Alfonso De Simone
Molecular determinants of the interaction of EGCG with ordered and disordered proteins. Biopolymers 109 (10) (2018)

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Publication Activity (10 Years)

Top Topics

Top Venues

Alfonso De Simone