Fabrizio Chiti

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 43

Top Topics

Amyotrophic Lateral Sclerosis

Structural Basis

Binding Protein

Raman Spectroscopy

Top Venues

Journal of the American Chemical Society

Annals of medicine

Translational neurodegeneration

ACS chemical neuroscience

This page only lists publications with an associated author ORCID identifier.

Publications

Tommaso Staderini, Alessandra Bigi, Clément Lagrève, Isabella Marzi, Francesco Bemporad, Fabrizio Chiti
Biophysical characterization of the phase separation of TDP-43 devoid of the C-terminal domain. Cellular & molecular biology letters 29 (1) (2024)
Tommaso Staderini, Alessandra Bigi, Clément Lagrève, Isabella Marzi, Francesco Bemporad, Fabrizio Chiti
Biophysical characterization of the phase separation of TDP-43 devoid of the C-terminal domain. Cellular & molecular biology letters 29 (1) (2024)
Alessandra Bigi, Giulia Fani, Valentina Bessi, Liliana Napolitano, Silvia Bagnoli, Assunta Ingannato, Lorenzo Neri, Roberta Cascella, Paolo Matteini, Sandro Sorbi, Benedetta Nacmias, Cristina Cecchi, Fabrizio Chiti
Putative novel CSF biomarkers of Alzheimer's disease based on the novel concept of generic protein misfolding and proteotoxicity: the PRAMA cohort. Translational neurodegeneration 13 (1) (2024)
Serene W Chen, Joseph D Barritt, Roberta Cascella, Alessandra Bigi, Cristina Cecchi, Martina Banchelli, Angelo Gallo, James A Jarvis, Fabrizio Chiti, Christopher M Dobson, Giuliana Fusco, Alfonso De Simone
Structure-Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates. Journal of the American Chemical Society 146 (15) (2024)
Alessandra Bigi, Giulia Fani, Valentina Bessi, Liliana Napolitano, Silvia Bagnoli, Assunta Ingannato, Lorenzo Neri, Roberta Cascella, Paolo Matteini, Sandro Sorbi, Benedetta Nacmias, Cristina Cecchi, Fabrizio Chiti
Putative novel CSF biomarkers of Alzheimer's disease based on the novel concept of generic protein misfolding and proteotoxicity: the PRAMA cohort. Translational neurodegeneration 13 (1) (2024)
Serene W Chen, Joseph D Barritt, Roberta Cascella, Alessandra Bigi, Cristina Cecchi, Martina Banchelli, Angelo Gallo, James A Jarvis, Fabrizio Chiti, Christopher M Dobson, Giuliana Fusco, Alfonso De Simone
Structure-Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates. Journal of the American Chemical Society 146 (15) (2024)
Stefano Muscat, Silvia Errico, Andrea Danani, Fabrizio Chiti, Gianvito Grasso
Leveraging Machine Learning-Guided Molecular Simulations Coupled with Experimental Data to Decipher Membrane Binding Mechanisms of Aminosterols. Journal of chemical theory and computation (2024)
Serene W Chen, Joseph D Barritt, Roberta Cascella, Alessandra Bigi, Cristina Cecchi, Martina Banchelli, Angelo Gallo, James A Jarvis, Fabrizio Chiti, Christopher M Dobson, Giuliana Fusco, Alfonso De Simone
Structure-Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates. Journal of the American Chemical Society 146 (15) (2024)
Alessandra Bigi, Giulia Fani, Valentina Bessi, Liliana Napolitano, Silvia Bagnoli, Assunta Ingannato, Lorenzo Neri, Roberta Cascella, Paolo Matteini, Sandro Sorbi, Benedetta Nacmias, Cristina Cecchi, Fabrizio Chiti
Putative novel CSF biomarkers of Alzheimer's disease based on the novel concept of generic protein misfolding and proteotoxicity: the PRAMA cohort. Translational neurodegeneration 13 (1) (2024)
Alessandra Bigi, Giulia Fani, Valentina Bessi, Liliana Napolitano, Silvia Bagnoli, Assunta Ingannato, Lorenzo Neri, Roberta Cascella, Paolo Matteini, Sandro Sorbi, Benedetta Nacmias, Cristina Cecchi, Fabrizio Chiti
Putative novel CSF biomarkers of Alzheimer's disease based on the novel concept of generic protein misfolding and proteotoxicity: the PRAMA cohort. Translational neurodegeneration 13 (1) (2024)
Serene W Chen, Joseph D Barritt, Roberta Cascella, Alessandra Bigi, Cristina Cecchi, Martina Banchelli, Angelo Gallo, James A Jarvis, Fabrizio Chiti, Christopher M Dobson, Giuliana Fusco, Alfonso De Simone
Structure-Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates. Journal of the American Chemical Society 146 (15) (2024)
Serene W Chen, Joseph D Barritt, Roberta Cascella, Alessandra Bigi, Cristina Cecchi, Martina Banchelli, Angelo Gallo, James A Jarvis, Fabrizio Chiti, Christopher M Dobson, Giuliana Fusco, Alfonso De Simone
Structure-Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates. Journal of the American Chemical Society (2024)
Tommaso Staderini, Alessandra Bigi, Clément Lagrève, Isabella Marzi, Francesco Bemporad, Fabrizio Chiti
Biophysical characterization of the phase separation of TDP-43 devoid of the C-terminal domain. Cellular & molecular biology letters 29 (1) (2024)
Serene W Chen, Joseph D Barritt, Roberta Cascella, Alessandra Bigi, Cristina Cecchi, Martina Banchelli, Angelo Gallo, James A Jarvis, Fabrizio Chiti, Christopher M Dobson, Giuliana Fusco, Alfonso De Simone
Structure-Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates. Journal of the American Chemical Society 146 (15) (2024)
Ryan Limbocker, Nunilo Cremades, Roberta Cascella, Peter M Tessier, Christopher M Dobson, Fabrizio Chiti
Characterization of Pairs of Toxic and Nontoxic Misfolded Protein Oligomers Elucidates the Structural Determinants of Oligomer Toxicity in Protein Misfolding Diseases. Accounts of chemical research (2023)
Silvia Errico, Giacomo Lucchesi, Davide Odino, Enass Youssef Osman, Roberta Cascella, Lorenzo Neri, Claudia Capitini, Martino Calamai, Francesco Bemporad, Cristina Cecchi, William A Kinney, Denise Barbut, Annalisa Relini, Claudio Canale, Gabriella Caminati, Ryan Limbocker, Christopher M Dobson, Michael Zasloff, Fabrizio Chiti
Quantitative Attribution of the Protective Effects of Aminosterols against Protein Aggregates to Their Chemical Structures and Ability to Modulate Biological Membranes. Journal of medicinal chemistry (2023)
Roberta Cascella, Martina Banchelli, Seyyed Abolghasem Ghadami, Diletta Ami, Maria Cristina Gagliani, Alessandra Bigi, Tommaso Staderini, Davide Tampellini, Katia Cortese, Cristina Cecchi, Antonino Natalello, Hadi Adibi, Paolo Matteini, Fabrizio Chiti
An in situ and in vitro investigation of cytoplasmic TDP-43 inclusions reveals the absence of a clear amyloid signature. Annals of medicine 55 (1) (2022)
Roberta Cascella, Martina Banchelli, Seyyed Abolghasem Ghadami, Diletta Ami, Maria Cristina Gagliani, Alessandra Bigi, Tommaso Staderini, Davide Tampellini, Katia Cortese, Cristina Cecchi, Antonino Natalello, Hadi Adibi, Paolo Matteini, Fabrizio Chiti
An in situ and in vitro investigation of cytoplasmic TDP-43 inclusions reveals the absence of a clear amyloid signature. Annals of medicine 55 (1) (2022)
Roberta Cascella, Martina Banchelli, Seyyed Abolghasem Ghadami, Diletta Ami, Maria Cristina Gagliani, Alessandra Bigi, Tommaso Staderini, Davide Tampellini, Katia Cortese, Cristina Cecchi, Antonino Natalello, Hadi Adibi, Paolo Matteini, Fabrizio Chiti
An in situ and in vitro investigation of cytoplasmic TDP-43 inclusions reveals the absence of a clear amyloid signature. Annals of medicine 55 (1) (2022)
Roberta Cascella, Alessandra Bigi, Dylan Giorgino Riffert, Maria Cristina Gagliani, Emilio Ermini, Matteo Moretti, Katia Cortese, Cristina Cecchi, Fabrizio Chiti
A quantitative biology approach correlates neuronal toxicity with the largest inclusions of TDP-43. Science advances 8 (30) (2022)
Giulia Fani, Chiara Ester La Torre, Roberta Cascella, Cristina Cecchi, Michele Vendruscolo, Fabrizio Chiti
Misfolded protein oligomers induce an increase of intracellular Ca 2+ causing an escalation of reactive oxidative species. Cellular and molecular life sciences : CMLS 79 (9) (2022)
Ryan P Kreiser, Aidan K Wright, Liam R Sasser, Dillon J Rinauro, Justus M Gabriel, Claire M Hsu, Jorge A Hurtado, Tristan L McKenzie, Silvia Errico, J Alex Albright, Lance Richardson, Victor A Jaffett, Dawn E Riegner, Lam T Nguyen, Kathleen LeForte, Michael Zasloff, Jared E Hollows, Fabrizio Chiti, Christopher M Dobson, Ryan Limbocker
A Brain-Permeable Aminosterol Regulates Cell Membranes to Mitigate the Toxicity of Diverse Pore-Forming Agents. ACS chemical neuroscience 13 (8) (2022)
Tommaso Staderini, Alessandra Bigi, Daniele Mongiello, Cristina Cecchi, Fabrizio Chiti
Biophysical characterization of full-length TAR DNA-binding protein (TDP-43) phase separation. Protein science : a publication of the Protein Society 31 (12) (2022)
Matteo Moretti, Isabella Marzi, Cristina Cantarutti, Mirella Vivoli Vega, Walter Mandaliti, Maria Chiara Mimmi, Francesco Bemporad, Alessandra Corazza, Fabrizio Chiti
Conversion of the Native N-Terminal Domain of TDP-43 into a Monomeric Alternative Fold with Lower Aggregation Propensity. Molecules (Basel, Switzerland) 27 (13) (2022)
Alessandra Bigi, Roberta Cascella, Giulia Fani, Caterina Bernacchioni, Francesca Cencetti, Paola Bruni, Fabrizio Chiti, Chiara Donati, Cristina Cecchi
Sphingosine 1-phosphate attenuates neuronal dysfunction induced by amyloid-β oligomers through endocytic internalization of NMDA receptors. The FEBS journal (2022)
Roberta Cascella, Martina Banchelli, Seyyed Abolghasem Ghadami, Diletta Ami, Maria Cristina Gagliani, Alessandra Bigi, Tommaso Staderini, Davide Tampellini, Katia Cortese, Cristina Cecchi, Antonino Natalello, Hadi Adibi, Paolo Matteini, Fabrizio Chiti
An in situ and in vitro investigation of cytoplasmic TDP-43 inclusions reveals the absence of a clear amyloid signature. Annals of medicine 55 (1) (2022)
Alessandra Bigi, Roberta Cascella, Fabrizio Chiti, Cristina Cecchi
Amyloid fibrils act as a reservoir of soluble oligomers, the main culprits in protein deposition diseases. BioEssays : news and reviews in molecular, cellular and developmental biology 44 (11) (2022)
Roberta Cascella, Martina Banchelli, Seyyed Abolghasem Ghadami, Diletta Ami, Maria Cristina Gagliani, Alessandra Bigi, Tommaso Staderini, Davide Tampellini, Katia Cortese, Cristina Cecchi, Antonino Natalello, Hadi Adibi, Paolo Matteini, Fabrizio Chiti
An in situ and in vitro investigation of cytoplasmic TDP-43 inclusions reveals the absence of a clear amyloid signature. Annals of medicine 55 (1) (2022)
Giulia Fani, Benedetta Mannini, Giulia Vecchi, Roberta Cascella, Cristina Cecchi, Christopher M Dobson, Christopher M Dobson, Fabrizio Chiti
Aβ Oligomers Dysregulate Calcium Homeostasis by Mechanosensitive Activation of AMPA and NMDA Receptors. ACS chemical neuroscience 12 (4) (2021)
Ryan Limbocker, Silvia Errico, Denise Barbut, Tuomas P J Knowles, Christopher M Dobson, Fabrizio Chiti, Michael Zasloff
Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic. Natural product reports (2021)
Roberta Cascella, Serene W Chen, Alessandra Bigi, José D Camino, Catherine K Xu, Christopher M Dobson, Fabrizio Chiti, Nunilo Cremades, Cristina Cecchi
The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells. Nature communications 12 (1) (2021)
Silvia Errico, Hassan Ramshini, Claudia Capitini, Claudio Canale, Martina Spaziano, Denise Barbut, Martino Calamai, Michael Zasloff, Reinier Oropesa-Nuñez, Christopher M Dobson, Fabrizio Chiti
Quantitative Measurement of the Affinity of Toxic and Nontoxic Misfolded Protein Oligomers for Lipid Bilayers and of its Modulation by Lipid Composition and Trodusquemine. ACS chemical neuroscience 12 (17) (2021)
Seyyed Abolghasem Ghadami, Sean Chia, Francesco Simone Ruggeri, Georg Meisl, Francesco Bemporad, Johnny Habchi, Roberta Cascella, Christopher M Dobson, Christopher M Dobson, Tuomas P J Knowles, Fabrizio Chiti
Transthyretin Inhibits Primary and Secondary Nucleations of Amyloid-β Peptide Aggregation and Reduces the Toxicity of Its Oligomers. Biomacromolecules 21 (3) (2020)
Elham Rezvani Boroujeni, Seyed Masoud Hosseini, Giulia Fani, Cristina Cecchi, Fabrizio Chiti
Soluble Prion Peptide 107-120 Protects Neuroblastoma SH-SY5Y Cells against Oligomers Associated with Alzheimer's Disease. International journal of molecular sciences 21 (19) (2020)
Denisa Jazaj, Seyyed Abolghasem Ghadami, Francesco Bemporad, Fabrizio Chiti
Probing conformational changes of monomeric transthyretin with second derivative fluorescence. Scientific reports 9 (1) (2019)
Benedetta Mannini, Giulia Vecchi, Adahir Labrador-Garrido, Bertrand Fabre, Giulia Fani, Jaime M Franco, Kathryn Lilley, David Pozo, Christopher M Dobson, Fabrizio Chiti, Christopher M Dobson, Cintia Roodveldt
Differential Interactome and Innate Immune Response Activation of Two Structurally Distinct Misfolded Protein Oligomers. ACS chemical neuroscience 10 (8) (2019)
Mirella Vivoli Vega, Roberta Cascella, Serene W Chen, Giuliana Fusco, Alfonso De Simone, Christopher M Dobson, Cristina Cecchi, Fabrizio Chiti
The Toxicity of Misfolded Protein Oligomers Is Independent of Their Secondary Structure. ACS chemical biology 14 (7) (2019)
Roberta Cascella, Michele Perni, Serene W Chen, Giuliana Fusco, Cristina Cecchi, Christopher M Dobson, Fabrizio Chiti, Christopher M Dobson, Alfonso De Simone
Probing the Origin of the Toxicity of Oligomeric Aggregates of α-Synuclein with Antibodies. ACS chemical biology 14 (6) (2019)
Ryan Limbocker, Sean Chia, Francesco S Ruggeri, Michele Perni, Roberta Cascella, Gabriella T Heller, Georg Meisl, Benedetta Mannini, Johnny Habchi, Thomas C T Michaels, Pavan K Challa, Minkoo Ahn, Samuel T Casford, Nilumi Fernando, Catherine K Xu, Nina D Kloss, Samuel I A Cohen, Janet R Kumita, Cristina Cecchi, Michael Zasloff, Sara Linse, Tuomas P J Knowles, Fabrizio Chiti, Michele Vendruscolo, Christopher M Dobson
Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes. Nature communications 10 (1) (2019)
Edoardo Del Poggetto, Angelo Toto, Chiara Aloise, Francesco Di Piro, Ludovica Gori, Francesco Malatesta, Stefano Gianni, Fabrizio Chiti, Francesco Bemporad
Stability of an aggregation-prone partially folded state of human profilin-1 correlates with aggregation propensity. The Journal of biological chemistry 293 (26) (2018)
Michele Perni, Patrick Flagmeier, Ryan Limbocker, Roberta Cascella, Francesco Antonio Aprile, Céline Galvagnion, Gabriella T Heller, Georg Meisl, Serene W Chen, Janet R Kumita, Pavan Kumar Challa, Julius B Kirkegaard, Samuel I A Cohen, Benedetta Mannini, Denise Barbut, Ellen A A Nollen, Cristina Cecchi, Nunilo Cremades, Tuomas P J Knowles, Fabrizio Chiti, Michael Zasloff, Christopher M Dobson, Christopher M Dobson
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine. ACS chemical biology 13 (8) (2018)
Giuliana Fusco, Serene W Chen, Philip T F Williamson, Roberta Cascella, Michele Perni, James A Jarvis, Cristina Cecchi, Michele Vendruscolo, Fabrizio Chiti, Nunilo Cremades, Liming Ying, Christopher M Dobson, Alfonso De Simone
Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers. Science (New York, N.Y.) 358 (6369) (2018)
Cristiano D'Andrea, Antonino Foti, Maximilien Cottat, Martina Banchelli, Fabrizio Chiti, Francesco Barreca, Claudio Canale, Marella de Angelis, Annalisa Relini, Onofrio M Maragò, Roberto Pini, Fabrizio Chiti, Pietro Giuseppe Gucciardi, Paolo Matteini
Nanoscale Discrimination between Toxic and Nontoxic Protein Misfolded Oligomers with Tip-Enhanced Raman Spectroscopy. Small (Weinheim an der Bergstrasse, Germany) 14 (36) (2018)