Christopher M Dobson

Publication Activity (10 Years)

Years Active: 2017-2021
Publications (10 Years): 25

Top Topics

Cognitive Decline

Top Venues

Science advances

Communications biology

Scientific reports

Nature structural & molecular biology

This page only lists publications with an associated author ORCID identifier.

Publications

Priyanka Joshi, Michele Perni, Ryan Limbocker, Benedetta Mannini, Sam Casford, Sean Chia, Johnny Habchi, Johnathan Labbadia, Christopher M Dobson, Christopher M Dobson
Publisher Correction: Two human metabolites rescue a C. elegans model of Alzheimer's disease via a cytosolic unfolded protein response. Communications biology 4 (1) (2021)
Priyanka Joshi, Michele Perni, Ryan Limbocker, Benedetta Mannini, Sam Casford, Sean Chia, Johnny Habchi, Johnathan Labbadia, Christopher M Dobson, Christopher M Dobson
Two human metabolites rescue a C. elegans model of Alzheimer's disease via a cytosolic unfolded protein response. Communications biology 4 (1) (2021)
Roberta Cascella, Serene W Chen, Alessandra Bigi, José D Camino, Catherine K Xu, Christopher M Dobson, Fabrizio Chiti, Nunilo Cremades, Cristina Cecchi
The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells. Nature communications 12 (1) (2021)
Tessa Sinnige, Karen Stroobants, Christopher M Dobson, Christopher M Dobson
Biophysical studies of protein misfolding and aggregation in in vivo models of Alzheimer's and Parkinson's diseases. Quarterly reviews of biophysics 49 (2020)
Gabriella T Heller, Francesco Antonio Aprile, Thomas C T Michaels, Ryan Limbocker, Michele Perni, Francesco Simone Ruggeri, Benedetta Mannini, Thomas Löhr, Massimiliano Bonomi, Carlo Camilloni, Alfonso De Simone, Isabella C Felli, Roberta Pierattelli, Tuomas P J Knowles, Christopher M Dobson, Christopher M Dobson
Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer's disease. Science advances 6 (45) (2020)
Patrick Flagmeier, Suman De, Thomas C T Michaels, Xiaoting Yang, Alexander J Dear, Cecilia Emanuelsson, Christopher M Dobson, Sara Linse, David Klenerman, Tuomas P J Knowles, Christopher M Dobson
Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation. Nature structural & molecular biology 27 (10) (2020)
Sara Linse, Tom Scheidt, Katja Bernfur, Christopher M Dobson, Christopher M Dobson, Samuel I A Cohen, Eimantas Sileikis, Martin Lundqvist, Fang Qian, Tiernan T O'Malley, Thierry Bussiere, Paul H Weinreb, Catherine K Xu, Georg Meisl, Sean R A Devenish, Tuomas P J Knowles, Oskar Hansson
Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies. Nature structural & molecular biology 27 (12) (2020)
Ryan Limbocker, Benedetta Mannini, Francesco Simone Ruggeri, Roberta Cascella, Catherine K Xu, Michele Perni, Sean Chia, Serene W Chen, Johnny Habchi, Alessandra Bigi, Ryan P Kreiser, Aidan K Wright, J Alex Albright, Tadas Kartanas, Janet R Kumita, Nunilo Cremades, Michael Zasloff, Cristina Cecchi, Tuomas P J Knowles, Fabrizio Chiti, Christopher M Dobson, Christopher M Dobson
Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism. Communications biology 3 (1) (2020)
Matteo Runfola, Alfonso De Simone, Christopher M Dobson, Christopher M Dobson, Giuliana Fusco
The N-terminal Acetylation of α-Synuclein Changes the Affinity for Lipid Membranes but not the Structural Properties of the Bound State. Scientific reports 10 (1) (2020)
Tessa Sinnige, Karen Stroobants, Christopher M Dobson, Christopher M Dobson
Biophysical studies of protein misfolding and aggregation in in vivo models of Alzheimer's and Parkinson's diseases - ERRATUM. Quarterly reviews of biophysics 53 (2020)
Xiaolin Wang, John P Kirkpatrick, Hélène M M Launay, Alfonso de Simone, Daniel Häussinger, Christopher M Dobson, Christopher M Dobson, Lisa D Cabrita, Christopher A Waudby, John Christodoulou
Probing the dynamic stalk region of the ribosome using solution NMR. Scientific reports 9 (1) (2019)
Tom Scheidt, Urszula Łapińska, Janet R Kumita, Carolyn M Sue, David Klenerman, Mark R Wilson, Samuel I A Cohen, Sara Linse, Christopher M Dobson, Christopher M Dobson, Tuomas P J Knowles, Paolo Arosio
Secondary nucleation and elongation occur at different sites on Alzheimer's amyloid-β aggregates. Science advances 5 (4) (2019)
Suman De, David C Wirthensohn, Patrick Flagmeier, Craig Hughes, Francesco A Aprile, Francesco S Ruggeri, Carolyn M Sue, Derya Emin, Zengjie Xia, Juan A Varela, Pietro Sormanni, Franziska Kundel, Tuomas P J Knowles, Christopher M Dobson, Clare Bryant, Christopher M Dobson, David Klenerman
Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms. Nature communications 10 (1) (2019)
Dafni C Delivoria, Sean Chia, Johnny Habchi, Michele Perni, Ilias Matis, Nikoletta Papaevgeniou, Martin Reczko, Niki Chondrogianni, Christopher M Dobson, Christopher M Dobson, Georgios Skretas
Bacterial production and direct functional screening of expanded molecular libraries for discovering inhibitors of protein aggregation. Science advances 5 (10) (2019)
Nabeel Ahmed, Pietro Sormanni, Prajwal Ciryam, Christopher M Dobson, Christopher M Dobson, Edward P O'Brien
Identifying A- and P-site locations on ribosome-protected mRNA fragments using Integer Programming. Scientific reports 9 (1) (2019)
Hongze Gang, Céline Galvagnion, Georg Meisl, Thomas Müller, Manuela Pfammatter, Alexander K Buell, Aviad Levin, Christopher M Dobson, Bozhong Mu, Tuomas P J Knowles
Microfluidic Diffusion Platform for Characterizing the Sizes of Lipid Vesicles and the Thermodynamics of Protein-Lipid Interactions. Analytical chemistry 90 (5) (2018)
Dezerae Cox, Daniel R Whiten, James W P Brown, Mathew H Horrocks, Rebecca San Gil, Christopher M Dobson, David Klenerman, Antoine M van Oijen, Heath Ecroyd
The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity. The Journal of biological chemistry 293 (12) (2018)
Michele Perni, Patrick Flagmeier, Ryan Limbocker, Roberta Cascella, Francesco Antonio Aprile, Céline Galvagnion, Gabriella T Heller, Georg Meisl, Serene W Chen, Janet R Kumita, Pavan Kumar Challa, Julius B Kirkegaard, Samuel I A Cohen, Benedetta Mannini, Denise Barbut, Ellen A A Nollen, Cristina Cecchi, Nunilo Cremades, Tuomas P J Knowles, Fabrizio Chiti, Michael Zasloff, Christopher M Dobson, Christopher M Dobson
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine. ACS chemical biology 13 (8) (2018)
Giuliana Fusco, Serene W Chen, Philip T F Williamson, Roberta Cascella, Michele Perni, James A Jarvis, Cristina Cecchi, Michele Vendruscolo, Fabrizio Chiti, Nunilo Cremades, Liming Ying, Christopher M Dobson, Alfonso De Simone
Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers. Science (New York, N.Y.) 358 (6369) (2018)
Ingrid M van der Wateren, Tuomas P J Knowles, Alexander K Buell, Christopher M Dobson, Céline Galvagnion
C-terminal truncation of α-synuclein promotes amyloid fibril amplification at physiological pH. Chemical science 9 (25) (2018)
Juan A Varela, Margarida Rodrigues, Suman De, Patrick Flagmeier, Sonia Gandhi, Christopher M Dobson, David Klenerman, Steven F Lee
Optical Structural Analysis of Individual α-Synuclein Oligomers. Angewandte Chemie (International ed. in English) 57 (18) (2018)
Giuliana Fusco, Maximo Sanz-Hernandez, Francesco Simone Ruggeri, Christopher M Dobson, Christopher M Dobson, Alfonso De Simone
Molecular determinants of the interaction of EGCG with ordered and disordered proteins. Biopolymers 109 (10) (2018)
James W P Brown, Georg Meisl, Tuomas P J Knowles, Alexander K Buell, Christopher M Dobson, Céline Galvagnion
Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrils. Chemical communications (Cambridge, England) 54 (56) (2018)
Georg Meisl, Luke Rajah, Samuel A I Cohen, Manuela Pfammatter, And Ela Šarić, Erik Hellstrand, Alexander K Buell, Adriano Aguzzi, Sara Linse, Michele Vendruscolo, Christopher M Dobson, Tuomas P J Knowles
Scaling behaviour and rate-determining steps in filamentous self-assembly. Chemical science 8 (10) (2017)
Patrick Flagmeier, Suman De, David C Wirthensohn, Steven F Lee, Cécile Vincke, Serge Muyldermans, Tuomas P J Knowles, Sonia Gandhi, Christopher M Dobson, David Klenerman
Ultrasensitive Measurement of Ca2+ Influx into Lipid Vesicles Induced by Protein Aggregates. Angewandte Chemie (International ed. in English) 56 (27) (2017)