Andrea Testa

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 21

Top Venues

Nature

ACS chemical biology

Journal of medicinal chemistry

Nature communications

Amphista Therapeutics

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Amphista Therapeutics Oct 01 2019

United Kingdom

Head of Chemistry

Publications

Oliver Hsia, Matthias Hinterndorfer, Angus D Cowan, Kentaro Iso, Tasuku Ishida, Ramasubramanian Sundaramoorthy, Mark A Nakasone, Hana Imrichova, Caroline Schätz, Andrea Rukavina, Koraljka Husnjak, Martin Wegner, Alejandro Correa-Sáez, Conner Craigon, Ryan Casement, Chiara Maniaci, Andrea Testa, Manuel Kaulich, Ivan Đikić, Georg E Winter, Alessio Ciulli
Targeted protein degradation via intramolecular bivalent glues. Nature 627 (8002) (2024)
Oliver Hsia, Matthias Hinterndorfer, Angus D Cowan, Kentaro Iso, Tasuku Ishida, Ramasubramanian Sundaramoorthy, Mark A Nakasone, Hana Imrichova, Caroline Schätz, Andrea Rukavina, Koraljka Husnjak, Martin Wegner, Alejandro Correa-Sáez, Conner Craigon, Ryan Casement, Chiara Maniaci, Andrea Testa, Manuel Kaulich, Ivan Đikić, Georg E Winter, Alessio Ciulli
Targeted protein degradation via intramolecular bivalent glues. Nature 627 (8002) (2024)
Oliver Hsia, Matthias Hinterndorfer, Angus D Cowan, Kentaro Iso, Tasuku Ishida, Ramasubramanian Sundaramoorthy, Mark A Nakasone, Hana Imrichova, Caroline Schätz, Andrea Rukavina, Koraljka Husnjak, Martin Wegner, Alejandro Correa-Sáez, Conner Craigon, Ryan Casement, Chiara Maniaci, Andrea Testa, Manuel Kaulich, Ivan Đikić, Georg E Winter, Alessio Ciulli
Targeted protein degradation via intramolecular bivalent glues. Nature 627 (8002) (2024)
Oliver Hsia, Matthias Hinterndorfer, Angus D Cowan, Kentaro Iso, Tasuku Ishida, Ramasubramanian Sundaramoorthy, Mark A Nakasone, Hana Imrichova, Caroline Schätz, Andrea Rukavina, Koraljka Husnjak, Martin Wegner, Alejandro Correa-Sáez, Conner Craigon, Ryan Casement, Chiara Maniaci, Andrea Testa, Manuel Kaulich, Ivan Đikić, Georg E Winter, Alessio Ciulli
Targeted protein degradation via intramolecular bivalent glues. Nature 627 (8002) (2024)
Oliver Hsia, Matthias Hinterndorfer, Angus D Cowan, Kentaro Iso, Tasuku Ishida, Ramasubramanian Sundaramoorthy, Mark A Nakasone, Hana Imrichova, Caroline Schätz, Andrea Rukavina, Koraljka Husnjak, Martin Wegner, Alejandro Correa-Sáez, Conner Craigon, Ryan Casement, Chiara Maniaci, Andrea Testa, Manuel Kaulich, Ivan Đikić, Georg E Winter, Alessio Ciulli
Targeted protein degradation via intramolecular bivalent glues. Nature 627 (8002) (2024)
Oliver Hsia, Matthias Hinterndorfer, Angus D Cowan, Kentaro Iso, Tasuku Ishida, Ramasubramanian Sundaramoorthy, Mark A Nakasone, Hana Imrichova, Caroline Schätz, Andrea Rukavina, Koraljka Husnjak, Martin Wegner, Alejandro Correa-Sáez, Conner Craigon, Ryan Casement, Chiara Maniaci, Andrea Testa, Manuel Kaulich, Ivan Đikić, Georg E Winter, Alessio Ciulli
Targeted protein degradation via intramolecular bivalent glues. Nature 627 (8002) (2024)
Oliver Hsia, Matthias Hinterndorfer, Angus D Cowan, Kentaro Iso, Tasuku Ishida, Ramasubramanian Sundaramoorthy, Mark A Nakasone, Hana Imrichova, Caroline Schätz, Andrea Rukavina, Koraljka Husnjak, Martin Wegner, Alejandro Correa-Sáez, Conner Craigon, Ryan Casement, Chiara Maniaci, Andrea Testa, Manuel Kaulich, Ivan Đikić, Georg E Winter, Alessio Ciulli
Targeted protein degradation via intramolecular bivalent glues. Nature 627 (8002) (2024)
Oliver Hsia, Matthias Hinterndorfer, Angus D Cowan, Kentaro Iso, Tasuku Ishida, Ramasubramanian Sundaramoorthy, Mark A Nakasone, Hana Imrichova, Caroline Schätz, Andrea Rukavina, Koraljka Husnjak, Martin Wegner, Alejandro Correa-Sáez, Conner Craigon, Ryan Casement, Chiara Maniaci, Andrea Testa, Manuel Kaulich, Ivan Đikić, Georg E Winter, Alessio Ciulli
Targeted protein degradation via intramolecular bivalent glues. Nature 627 (8002) (2024)
Oliver Hsia, Matthias Hinterndorfer, Angus D Cowan, Kentaro Iso, Tasuku Ishida, Ramasubramanian Sundaramoorthy, Mark A Nakasone, Hana Imrichova, Caroline Schätz, Andrea Rukavina, Koraljka Husnjak, Martin Wegner, Alejandro Correa-Sáez, Conner Craigon, Ryan Casement, Chiara Maniaci, Andrea Testa, Manuel Kaulich, Ivan Đikić, Georg E Winter, Alessio Ciulli
Targeted protein degradation via intramolecular bivalent glues. Nature (2024)
Alessio Ciulli, Suzanne O'Connor, Chun-Wa Chung, Ingo V Hartung, Andrea Testa, Danette L Daniels, Laura H Heitman
The 17 th EFMC Short Course on Medicinal Chemistry on Small Molecule Protein Degraders. ChemMedChem (2023)
Christoph Grohmann, Charlene M Magtoto, Joel R Walker, Ngee Kiat Chua, Anna Gabrielyan, Mary Hall, Simon A Cobbold, Stephen Mieruszynski, Martin Brzozowski, Daniel S Simpson, Hao Dong, Bridget Dorizzi, Annette V Jacobsen, Emma Morrish, Natasha Silke, James G Murphy, Joan Kathleen Heath, Andrea Testa, Chiara Maniaci, Alessio Ciulli, Guillaume L Lessene, John Silke, Rebecca Feltham
Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms. Nature communications 13 (1) (2022)
Chiara Tarantelli, Eleonora Cannas, Hillarie Ekeh, Carmelo Moscatello, Eugenio Gaudio, Luciano Cascione, Sara Napoli, Cesare Rech, Andrea Testa, Chiara Maniaci, Andrea Rinaldi, Emanuele Zucca, Anastasios Stathis, Alessio Ciulli, Francesco Bertoni
The bromodomain and extra-terminal domain degrader MZ1 exhibits preclinical anti-tumoral activity in diffuse large B-cell lymphoma of the activated B cell-like type. Exploration of targeted anti-tumor therapy 2 (6) (2021)
Hannah Tovell, Andrea Testa, Chiara Maniaci, Houjiang Zhou, Alan R Prescott, Thomas Macartney, Alessio Ciulli, Dario R Alessi
Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader. ACS chemical biology 14 (5) (2019)
Hannah Tovell, Andrea Testa, Houjiang Zhou, Natalia Shpiro, Claire Crafter, Alessio Ciulli, Dario R Alessi
Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader. ACS chemical biology 14 (9) (2019)
Andrea Testa, Xavier Lucas, Guilherme V Castro, Kwok-Ho Chan, Jane E Wright, Andrew C Runcie, Morgan S Gadd, William T A Harrison, Eun-Jung Ko, Daniel Fletcher, Alessio Ciulli
Correction to "3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation". Journal of the American Chemical Society 141 (18) (2019)
Andrea Testa, Scott J Hughes, Xavier Lucas, Jane E Wright, Alessio Ciulli
Structure-Based Design of a Macrocyclic PROTAC. Angewandte Chemie (International ed. in English) 59 (4) (2019)
Andrea Testa, Sergio Dall'Angelo, Marco Mingarelli, Andrea Augello, Lutz Schweiger, Andrew Welch, Charles S Elmore, Dana Dawson, Pradeep Sharma, Matteo Zanda
Preclinical Evaluation of [18F]LCATD as a PET Tracer to Study Drug-Drug Interactions Caused by Inhibition of Hepatic Transporters. Contrast media & molecular imaging 2018 (2018)
Vittoria Zoppi, Scott J Hughes, Chiara Maniaci, Andrea Testa, Teresa Gmaschitz, Corinna Wieshofer, Manfred Koegl, Kristin M Riching, Danette L Daniels, Andrea Spallarossa, Alessio Ciulli
Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel-Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7. Journal of medicinal chemistry 62 (2) (2018)
Andrea Testa, Xavier Lucas, Guilherme V Castro, Kwok-Ho Chan, Jane E Wright, Andrew C Runcie, Morgan S Gadd, William T A Harrison, Eun-Jung Ko, Daniel Fletcher, Alessio Ciulli
3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation. Journal of the American Chemical Society 140 (29) (2018)
Chiara Maniaci, Scott J Hughes, Andrea Testa, Wenzhang Chen, Douglas J Lamont, Sonia Rocha, Dario R Alessi, Roberto Romeo, Alessio Ciulli
Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nature communications 8 (1) (2017)
Francesca Ester Morreale, Andrea Testa, Viduth K Chaugule, Alessio Bortoluzzi, Alessio Ciulli, Helen Walden
Mind the Metal: A Fragment Library-Derived Zinc Impurity Binds the E2 Ubiquitin-Conjugating Enzyme Ube2T and Induces Structural Rearrangements. Journal of medicinal chemistry 60 (19) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Andrea Testa