James G Murphy (James M Murphy)

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 86

Top Venues

Cell death and differentiation

Nature communications

The EMBO journal

Cell death & disease

Walter and Eliza Hall Institute of Medical Research

Australian National University (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Walter and Eliza Hall Institute of Medical Research

Australia

Laboratory Head :: Cell Signalling & Cell Death Division

University of Melbourne

Australia

Honorary Fellow :: Department of Medical Biology

John Curtin School of Medical Research

Australia

Visiting Fellow

Walter and Eliza Hall Institute of Medical Research

Australia

Senior Research Officer :: Cell Signalling & Cell Death Division

Australian Research Council

Australia

Future Fellow

Walter and Eliza Hall Institute of Medical Research

Australia

Senior Research Officer :: Molecular Medicine Division

Walter and Eliza Hall Institute of Medical Research

Australia

CJ Martin Fellow :: Molecular Medicine Division

Lunenfeld-Tanenbaum Research Institute

Canada

CJ Martin Fellow :: Pawson Laboratory

Australian National University

Australia

Postdoctoral Research Assistant

Education History

Australian National University

Australia

PHD :: Biological Chemistry

Publications

Lung-Yu Liang, Niall D Geoghegan, Michael J Mlodzianoski, Andrew Leis, Lachlan W Whitehead, Minglyanna G Surudoi, Samuel N Young, Peter Janes, Doulin C Shepherd, Debnath Ghosal, Kelly L Rogers, James G Murphy, Isabelle S Lucet
Co-clustering of EphB6 and ephrinB1 in trans restrains cancer cell invasion. Communications biology 7 (1) (2024)
Sarah E Garnish, Christopher R Horne, Yanxiang Meng, Samuel N Young, Annette V Jacobsen, Joanne M Hildebrand, James G Murphy
Inhibitors identify an auxiliary role for mTOR signalling in necroptosis execution downstream of MLKL activation. The Biochemical journal 481 (17) (2024)
Shene Chiou, Aysha H Al-Ani, Yi Pan, Komal M Patel, Isabella Y Kong, Lachlan W Whitehead, Amanda Light, Samuel N Young, Marilou Barrios, Callum Sargeant, Pradeep Rajasekhar, Leah Zhu, Anne Hempel, Ann Lin, James A Rickard, Cathrine Hall, Pradnya Gangatirkar, Raymond K H Yip, Wayne Cawthorne, Annette V Jacobsen, Christopher R Horne, Katherine R Martin, Lisa J Ioannidis, Diana S Hansen, Jessica Day, Ian P Wicks, Charity Law, Matthew E Ritchie, Rory Bowden, Joanne M Hildebrand, Lorraine Ann O'Reilly, John Silke, Lisa Giulino-Roth, Ellen Tsui, Kelly L Rogers, Edwin D Hawkins, Britt Christensen, James G Murphy, André L Samson
An immunohistochemical atlas of necroptotic pathway expression. EMBO molecular medicine 16 (7) (2024)
Lung-Yu Liang, Niall D Geoghegan, Michael J Mlodzianoski, Andrew Leis, Lachlan W Whitehead, Minglyanna G Surudoi, Samuel N Young, Peter Janes, Doulin C Shepherd, Debnath Ghosal, Kelly L Rogers, James G Murphy, Isabelle S Lucet
Co-clustering of EphB6 and ephrinB1 in trans restrains cancer cell invasion. Communications biology 7 (1) (2024)
Shene Chiou, Aysha H Al-Ani, Yi Pan, Komal M Patel, Isabella Y Kong, Lachlan W Whitehead, Amanda Light, Samuel N Young, Marilou Barrios, Callum Sargeant, Pradeep Rajasekhar, Leah Zhu, Anne Hempel, Ann Lin, James A Rickard, Cathrine Hall, Pradnya Gangatirkar, Raymond K H Yip, Wayne Cawthorne, Annette V Jacobsen, Christopher R Horne, Katherine R Martin, Lisa J Ioannidis, Diana S Hansen, Jessica Day, Ian P Wicks, Charity Law, Matthew E Ritchie, Rory Bowden, Joanne M Hildebrand, Lorraine Ann O'Reilly, John Silke, Lisa Giulino-Roth, Ellen Tsui, Kelly L Rogers, Edwin D Hawkins, Britt Christensen, James G Murphy, André L Samson
An immunohistochemical atlas of necroptotic pathway expression. EMBO molecular medicine 16 (7) (2024)
Stefanie M Bader, James P Cooney, Reet Bhandari, Liana Mackiewicz, Merle Dayton, Dylan Sheerin, Smitha Rose Georgy, James G Murphy, Kathryn C Davidson, Cody C Allison, Marc Pellegrini, Marcel Doerflinger
Necroptosis does not drive disease pathogenesis in a mouse infective model of SARS-CoV-2 in vivo. Cell death & disease 15 (1) (2024)
André L Samson, James G Murphy
Mapping where and when necroptotic cell death occurs in disease. Cell death and differentiation (2024)
André L Samson, James G Murphy
Mapping where and when necroptotic cell death occurs in disease. Cell death and differentiation 31 (7) (2024)
Nathan Diplock, Maël Baudin, Xincheng Derek Xiang, Lung-Yu Liang, Weiwen Dai, James G Murphy, Isabelle S Lucet, Jana A Hassan, Jennifer D Lewis
Molecular dissection of the pseudokinase ZED1 expands effector recognition to the tomato immune receptor ZAR1. Plant physiology 196 (1) (2024)
Nathan Diplock, Maël Baudin, Xincheng Derek Xiang, Lung-Yu Liang, Weiwen Dai, James G Murphy, Isabelle S Lucet, Jana A Hassan, Jennifer D Lewis
Molecular dissection of the pseudokinase ZED1 expands effector recognition to the tomato immune receptor ZAR1. Plant physiology 196 (1) (2024)
Shene Chiou, Aysha H Al-Ani, Yi Pan, Komal M Patel, Isabella Y Kong, Lachlan W Whitehead, Amanda Light, Samuel N Young, Marilou Barrios, Callum Sargeant, Pradeep Rajasekhar, Leah Zhu, Anne Hempel, Ann Lin, James A Rickard, Cathrine Hall, Pradnya Gangatirkar, Raymond K H Yip, Wayne Cawthorne, Annette V Jacobsen, Christopher R Horne, Katherine R Martin, Lisa J Ioannidis, Diana S Hansen, Jessica Day, Ian P Wicks, Charity Law, Matthew E Ritchie, Rory Bowden, Joanne M Hildebrand, Lorraine Ann O'Reilly, John Silke, Lisa Giulino-Roth, Ellen Tsui, Kelly L Rogers, Edwin D Hawkins, Britt Christensen, James G Murphy, André L Samson
An immunohistochemical atlas of necroptotic pathway expression. EMBO molecular medicine 16 (7) (2024)
Stefanie M Bader, James P Cooney, Reet Bhandari, Liana Mackiewicz, Merle Dayton, Dylan Sheerin, Smitha Rose Georgy, James G Murphy, Kathryn C Davidson, Cody C Allison, Marc Pellegrini, Marcel Doerflinger
Necroptosis does not drive disease pathogenesis in a mouse infective model of SARS-CoV-2 in vivo. Cell death & disease 15 (1) (2024)
Lung-Yu Liang, Niall D Geoghegan, Michael J Mlodzianoski, Andrew Leis, Lachlan W Whitehead, Minglyanna G Surudoi, Samuel N Young, Peter Janes, Doulin C Shepherd, Debnath Ghosal, Kelly L Rogers, James G Murphy, Isabelle S Lucet
Co-clustering of EphB6 and ephrinB1 in trans restrains cancer cell invasion. Communications biology 7 (1) (2024)
Nathan Diplock, Maël Baudin, Xincheng Derek Xiang, Lung-Yu Liang, Weiwen Dai, James G Murphy, Isabelle S Lucet, Jana A Hassan, Jennifer D Lewis
Molecular dissection of the pseudokinase ZED1 expands effector recognition to the tomato immune receptor ZAR1. Plant physiology (2024)
Shene Chiou, Aysha H Al-Ani, Yi Pan, Komal M Patel, Isabella Y Kong, Lachlan W Whitehead, Amanda Light, Samuel N Young, Marilou Barrios, Callum Sargeant, Pradeep Rajasekhar, Leah Zhu, Anne Hempel, Ann Lin, James A Rickard, Cathrine Hall, Pradnya Gangatirkar, Raymond K H Yip, Wayne Cawthorne, Annette V Jacobsen, Christopher R Horne, Katherine R Martin, Lisa J Ioannidis, Diana S Hansen, Jessica Day, Ian P Wicks, Charity Law, Matthew E Ritchie, Rory Bowden, Joanne M Hildebrand, Lorraine Ann O'Reilly, John Silke, Lisa Giulino-Roth, Ellen Tsui, Kelly L Rogers, Edwin D Hawkins, Britt Christensen, James G Murphy, André L Samson
An immunohistochemical atlas of necroptotic pathway expression. EMBO molecular medicine (2024)
André L Samson, James G Murphy
Mapping where and when necroptotic cell death occurs in disease. Cell death and differentiation 31 (7) (2024)
Lung-Yu Liang, Niall D Geoghegan, Michael J Mlodzianoski, Andrew Leis, Lachlan W Whitehead, Minglyanna G Surudoi, Samuel N Young, Peter Janes, Doulin C Shepherd, Debnath Ghosal, Kelly L Rogers, James G Murphy, Isabelle S Lucet
Co-clustering of EphB6 and ephrinB1 in trans restrains cancer cell invasion. Communications biology 7 (1) (2024)
Stefanie M Bader, James P Cooney, Reet Bhandari, Liana Mackiewicz, Merle Dayton, Dylan Sheerin, Smitha Rose Georgy, James G Murphy, Kathryn C Davidson, Cody C Allison, Marc Pellegrini, Marcel Doerflinger
Necroptosis does not drive disease pathogenesis in a mouse infective model of SARS-CoV-2 in vivo. Cell death & disease 15 (1) (2024)
Lung-Yu Liang, Niall D Geoghegan, Michael J Mlodzianoski, Andrew Leis, Lachlan W Whitehead, Minglyanna G Surudoi, Samuel N Young, Peter Janes, Doulin C Shepherd, Debnath Ghosal, Kelly L Rogers, James G Murphy, Isabelle S Lucet
Co-clustering of EphB6 and ephrinB1 in trans restrains cancer cell invasion. Communications biology 7 (1) (2024)
Stefanie M Bader, James P Cooney, Reet Bhandari, Liana Mackiewicz, Merle Dayton, Dylan Sheerin, Smitha Rose Georgy, James G Murphy, Kathryn C Davidson, Cody C Allison, Marc Pellegrini, Marcel Doerflinger
Necroptosis does not drive disease pathogenesis in a mouse infective model of SARS-CoV-2 in vivo. Cell death & disease 15 (1) (2024)
Shene Chiou, Aysha H Al-Ani, Yi Pan, Komal M Patel, Isabella Y Kong, Lachlan W Whitehead, Amanda Light, Samuel N Young, Marilou Barrios, Callum Sargeant, Pradeep Rajasekhar, Leah Zhu, Anne Hempel, Ann Lin, James A Rickard, Cathrine Hall, Pradnya Gangatirkar, Raymond K H Yip, Wayne Cawthorne, Annette V Jacobsen, Christopher R Horne, Katherine R Martin, Lisa J Ioannidis, Diana S Hansen, Jessica Day, Ian P Wicks, Charity Law, Matthew E Ritchie, Rory Bowden, Joanne M Hildebrand, Lorraine Ann O'Reilly, John Silke, Lisa Giulino-Roth, Ellen Tsui, Kelly L Rogers, Edwin D Hawkins, Britt Christensen, James G Murphy, André L Samson
An immunohistochemical atlas of necroptotic pathway expression. EMBO molecular medicine (2024)
Christopher R Gardner, Katherine A Davies, Ying Zhang, Martin Brzozowski, Peter E Czabotar, James G Murphy, Guillaume L Lessene
From (Tool)Bench to Bedside: The Potential of Necroptosis Inhibitors. Journal of medicinal chemistry 66 (4) (2023)
Sebastian A Hughes, Meng Lin, Ashley Weir, Bing Huang, Liya Xiong, Ngee Kiat Chua, Jiyi Pang, Jascinta P Santavanond, Rochelle Tixeira, Marcel Doerflinger, Yexuan Deng, Chien-Hsiung Yu, Natasha Silke, Stephanie A Conos, Daniel Frank, Daniel S Simpson, James G Murphy, Kate E Lawlor, Jaclyn S Pearson, John Silke, Marc Pellegrini, Marco J Herold, Ivan K H Poon, Seth L Masters, Mingsong Li, Qin Tang, Yuxia Zhang, Maryam Rashidi, Lan-Lan Geng, James E Vince
Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1β release in X-linked inhibitor of apoptosis (XIAP) deficiency. The EMBO journal 42 (5) (2023)
Yanxiang Meng, Sarah E Garnish, Katherine A Davies, Katrina A Black, Andrew P Leis, Christopher R Horne, Joanne M Hildebrand, Hanadi Hoblos, Cheree Fitzgibbon, Samuel N Young, Toby Dite, Laura F Dagley, Aarya Venkat, Natarajan Kannan, Akiko Koide, Shohei Koide, Alisa Glukhova, Peter E Czabotar, James G Murphy
Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization. Nature communications 14 (1) (2023)
Benedikt Kolbrink, Friedrich A von Samson-Himmelstjerna, James G Murphy, Stefan Krautwald
Role of necroptosis in kidney health and disease. Nature reviews. Nephrology (2023)
Sebastian A Hughes, Meng Lin, Ashley Weir, Bing Huang, Liya Xiong, Ngee Kiat Chua, Jiyi Pang, Jascinta P Santavanond, Rochelle Tixeira, Marcel Doerflinger, Yexuan Deng, Chien-Hsiung Yu, Natasha Silke, Stephanie A Conos, Daniel Frank, Daniel S Simpson, James G Murphy, Kate E Lawlor, Jaclyn S Pearson, John Silke, Marc Pellegrini, Marco J Herold, Ivan K H Poon, Seth L Masters, Mingsong Li, Qin Tang, Yuxia Zhang, Maryam Rashidi, Lan-Lan Geng, James E Vince
Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1β release in X-linked inhibitor of apoptosis (XIAP) deficiency. The EMBO journal (2023)
Catia L Pierotti, Annette V Jacobsen, Christoph Grohmann, Ruby K Dempsey, Nima Etemadi, Joanne M Hildebrand, Cheree Fitzgibbon, Samuel N Young, Katherine A Davies, Wilhelmus J A Kersten, John Silke, Kym N Lowes, Hélène Jousset Sabroux, David C S Huang, Mark F van Delft, James G Murphy, Guillaume Lessene
The VEGFR/PDGFR tyrosine kinase inhibitor, ABT-869, blocks necroptosis by targeting RIPK1 kinase. The Biochemical journal 480 (9) (2023)
Christopher R Gardner, Katherine A Davies, Ying Zhang, Martin Brzozowski, Peter E Czabotar, James G Murphy, Guillaume L Lessene
From (Tool)Bench to Bedside: The Potential of Necroptosis Inhibitors. Journal of medicinal chemistry 66 (4) (2023)
James G Murphy
Biochemical Society Transactions: celebrating 50 years. Biochemical Society transactions (2023)
Sebastian A Hughes, Meng Lin, Ashley Weir, Bing Huang, Liya Xiong, Ngee Kiat Chua, Jiyi Pang, Jascinta P Santavanond, Rochelle Tixeira, Marcel Doerflinger, Yexuan Deng, Chien-Hsiung Yu, Natasha Silke, Stephanie A Conos, Daniel Frank, Daniel S Simpson, James G Murphy, Kate E Lawlor, Jaclyn S Pearson, John Silke, Marc Pellegrini, Marco J Herold, Ivan K H Poon, Seth L Masters, Mingsong Li, Qin Tang, Yuxia Zhang, Maryam Rashidi, Lan-Lan Geng, James E Vince
Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1β release in X-linked inhibitor of apoptosis (XIAP) deficiency. The EMBO journal 42 (5) (2023)
Christopher R Gardner, Katherine A Davies, Ying Zhang, Martin Brzozowski, Peter E Czabotar, James G Murphy, Guillaume L Lessene
From (Tool)Bench to Bedside: The Potential of Necroptosis Inhibitors. Journal of medicinal chemistry 66 (4) (2023)
Sebastian A Hughes, Meng Lin, Ashley Weir, Bing Huang, Liya Xiong, Ngee Kiat Chua, Jiyi Pang, Jascinta P Santavanond, Rochelle Tixeira, Marcel Doerflinger, Yexuan Deng, Chien-Hsiung Yu, Natasha Silke, Stephanie A Conos, Daniel Frank, Daniel S Simpson, James G Murphy, Kate E Lawlor, Jaclyn S Pearson, John Silke, Marc Pellegrini, Marco J Herold, Ivan K H Poon, Seth L Masters, Mingsong Li, Qin Tang, Yuxia Zhang, Maryam Rashidi, Lan-Lan Geng, James E Vince
Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1β release in X-linked inhibitor of apoptosis (XIAP) deficiency. The EMBO journal (2023)
Sarah E Garnish, Katherine R Martin, Maria Kauppi, Victoria E Jackson, Rebecca Ambrose, Vik Ven Eng, Shene Chiou, Yanxiang Meng, Daniel Frank, Emma C Tovey Crutchfield, Komal M Patel, Annette V Jacobsen, Georgia K Atkin-Smith, Ladina Di Rago, Marcel Doerflinger, Christopher R Horne, Cathrine Hall, Samuel N Young, Matthew C Cook, Vicki Athanasopoulos, Carola G Vinuesa, Kate E Lawlor, Ian P Wicks, Gregor Ebert, Ashley P Ng, Charlotte A Slade, Jaclyn S Pearson, André L Samson, John Silke, James G Murphy, Joanne M Hildebrand
A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation. Nature communications 14 (1) (2023)
Sebastian A Hughes, Meng Lin, Ashley Weir, Bing Huang, Liya Xiong, Ngee Kiat Chua, Jiyi Pang, Jascinta P Santavanond, Rochelle Tixeira, Marcel Doerflinger, Yexuan Deng, Chien-Hsiung Yu, Natasha Silke, Stephanie A Conos, Daniel Frank, Daniel S Simpson, James G Murphy, Kate E Lawlor, Jaclyn S Pearson, John Silke, Marc Pellegrini, Marco J Herold, Ivan K H Poon, Seth L Masters, Mingsong Li, Qin Tang, Yuxia Zhang, Maryam Rashidi, Lan-Lan Geng, James E Vince
Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1β release in X-linked inhibitor of apoptosis (XIAP) deficiency. The EMBO journal 42 (5) (2023)
Christopher R Gardner, Katherine A Davies, Ying Zhang, Martin Brzozowski, Peter E Czabotar, James G Murphy, Guillaume L Lessene
From (Tool)Bench to Bedside: The Potential of Necroptosis Inhibitors. Journal of medicinal chemistry 66 (4) (2023)
Sebastian A Hughes, Meng Lin, Ashley Weir, Bing Huang, Liya Xiong, Ngee Kiat Chua, Jiyi Pang, Jascinta P Santavanond, Rochelle Tixeira, Marcel Doerflinger, Yexuan Deng, Chien-Hsiung Yu, Natasha Silke, Stephanie A Conos, Daniel Frank, Daniel S Simpson, James G Murphy, Kate E Lawlor, Jaclyn S Pearson, John Silke, Marc Pellegrini, Marco J Herold, Ivan K H Poon, Seth L Masters, Mingsong Li, Qin Tang, Yuxia Zhang, Maryam Rashidi, Lan-Lan Geng, James E Vince
Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1β release in X-linked inhibitor of apoptosis (XIAP) deficiency. The EMBO journal 42 (5) (2023)
Christopher R Gardner, Katherine A Davies, Ying Zhang, Martin Brzozowski, Peter E Czabotar, James G Murphy, Guillaume L Lessene
From (Tool)Bench to Bedside: The Potential of Necroptosis Inhibitors. Journal of medicinal chemistry (2023)
Emma C Tovey Crutchfield, Sarah E Garnish, Jessica Day, Holly Anderton, Shene Chiou, Anne Hempel, Cathrine Hall, Komal M Patel, Pradnya Gangatirkar, Katherine R Martin, Connie Li Wai Suen, Alexandra L Garnham, Andrew J Kueh, Ian P Wicks, John Silke, Ueli Nachbur, André L Samson, James G Murphy, Joanne M Hildebrand
MLKL deficiency protects against low-grade, sterile inflammation in aged mice. Cell death and differentiation (2023)
Teresa Sadras, Fatimah B Jalud, Hansen J Kosasih, Christopher R Horne, Lauren M Brown, Sam El-Kamand, Charles E de Bock, Lachlan McAloney, Ashley P Ng, Nadia M Davidson, Louise E A Ludlow, Alicia Oshlack, Mark J Cowley, Seong L Khaw, James G Murphy, Paul G Ekert
Unusual PDGFRB fusion reveals novel mechanism of kinase activation in Ph-like B-ALL. Leukemia (2023)
Andres Tapia Del Fierro, Bianca den Hamer, Natalia Benetti, Natasha Jansz, Kelan Chen, Tamara Beck, Hannah Vanyai, Alexandra D Gurzau, Lucia Daxinger, Shifeng Xue, Thanh Thao Nguyen Ly, Iromi Wanigasuriya, Megan Iminitoff, Kelsey A Breslin, Harald Oey, Yvonne D Krom, Dinja van der Hoorn, Linde F Bouwman, Timothy M Johanson, Matthew E Ritchie, Quentin A Gouil, Bruno Reversade, Fabrice Prin, Timothy Mohun, Silvère M van der Maarel, Edwina McGlinn, James G Murphy, Andrew Keniry, Jessica C de Greef, Marnie E Blewitt
SMCHD1 has separable roles in chromatin architecture and gene silencing that could be targeted in disease. Nature communications 14 (1) (2023)
Benedikt Kolbrink, Friedrich A von Samson-Himmelstjerna, James G Murphy, Stefan Krautwald
Role of necroptosis in kidney health and disease. Nature reviews. Nephrology (2023)
Emma C Tovey Crutchfield, Sarah E Garnish, Jessica Day, Holly Anderton, Shene Chiou, Anne Hempel, Cathrine Hall, Komal M Patel, Pradnya Gangatirkar, Katherine R Martin, Connie Li Wai Suen, Alexandra L Garnham, Andrew J Kueh, Ian P Wicks, John Silke, Ueli Nachbur, André L Samson, James G Murphy, Joanne M Hildebrand
MLKL deficiency protects against low-grade, sterile inflammation in aged mice. Cell death and differentiation (2023)
Sebastian A Hughes, Meng Lin, Ashley Weir, Bing Huang, Liya Xiong, Ngee Kiat Chua, Jiyi Pang, Jascinta P Santavanond, Rochelle Tixeira, Marcel Doerflinger, Yexuan Deng, Chien-Hsiung Yu, Natasha Silke, Stephanie A Conos, Daniel Frank, Daniel S Simpson, James G Murphy, Kate E Lawlor, Jaclyn S Pearson, John Silke, Marc Pellegrini, Marco J Herold, Ivan K H Poon, Seth L Masters, Mingsong Li, Qin Tang, Yuxia Zhang, Maryam Rashidi, Lan-Lan Geng, James E Vince
Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1β release in X-linked inhibitor of apoptosis (XIAP) deficiency. The EMBO journal 42 (5) (2023)
Jacqueline Kaiser, Kevin Nay, Christopher R Horne, Luke M McAloon, Oliver K Fuller, Abbey G Muller, Douglas G Whyte, Anthony R Means, Ken Walder, Michael Berk, Anthony J Hannan, James G Murphy, Mark A Febbraio, Andrew L Gundlach, John W Scott
CaMKK2 as an emerging treatment target for bipolar disorder. Molecular psychiatry (2023)
Emma C Tovey Crutchfield, Sarah E Garnish, Jessica Day, Holly Anderton, Shene Chiou, Anne Hempel, Cathrine Hall, Komal M Patel, Pradnya Gangatirkar, Katherine R Martin, Connie Li Wai Suen, Alexandra L Garnham, Andrew J Kueh, Ian P Wicks, John Silke, Ueli Nachbur, André L Samson, James G Murphy, Joanne M Hildebrand
MLKL deficiency protects against low-grade, sterile inflammation in aged mice. Cell death and differentiation (2023)
Yanxiang Meng, Christopher R Horne, André L Samson, Laura F Dagley, Samuel N Young, Jarrod John Sandow, Peter E Czabotar, James G Murphy
Human RIPK3 C-lobe phosphorylation is essential for necroptotic signaling. Cell death & disease 13 (6) (2022)
Víctor Martínez-Loredo, Alba González-Roz, Lynne Dawkins, Desmond Singh, James G Murphy, James M MacKillop
Is E-cigarette Use Associated With Persistence or Discontinuation of Combustible Cigarettes? A 24-Month Longitudinal Investigation in Young Adult Binge Drinkers. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 24 (7) (2022)
Annette V Jacobsen, Catia L Pierotti, Kym N Lowes, Amanda E Au, Ying Zhang, Nima Etemadi, Cheree Fitzgibbon, Wilhelmus J A Kersten, André L Samson, Mark F van Delft, David Ching Siang Huang, Hélène Jousset Sabroux, Guillaume L Lessene, John Silke, James G Murphy
The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL. Cell death & disease 13 (4) (2022)
Ashish Sethi, Christopher R Horne, Cheree Fitzgibbon, Karyn L Wilde, Katherine A Davies, Sarah E Garnish, Annette V Jacobsen, André L Samson, Joanne M Hildebrand, Ahmad Z Wardak, Peter E Czabotar, Emma J Petrie, Paul R Gooley, James G Murphy
Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKL. Cell death and differentiation 29 (9) (2022)
Stefanie M Bader, Simon P Preston, Katie Saliba, Adam Lipszyc, Zoe L Grant, Liana Mackiewicz, Andrew Baldi, Anne Hempel, Michelle P Clark, Thanushi Peiris, William Clow, Jan Bjelic, Michael D Stutz, Philip Arandjelovic, Jack Teale, Fashuo Du, Leigh Coultas, James G Murphy, Cody C Allison, Marc Pellegrini, André L Samson
Endothelial Caspase-8 prevents fatal necroptotic hemorrhage caused by commensal bacteria. Cell death and differentiation (2022)
Christoph Grohmann, Charlene M Magtoto, Joel R Walker, Ngee Kiat Chua, Anna Gabrielyan, Mary Hall, Simon A Cobbold, Stephen Mieruszynski, Martin Brzozowski, Daniel S Simpson, Hao Dong, Bridget Dorizzi, Annette V Jacobsen, Emma Morrish, Natasha Silke, James G Murphy, Joan Kathleen Heath, Andrea Testa, Chiara Maniaci, Alessio Ciulli, Guillaume L Lessene, John Silke, Rebecca Feltham
Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms. Nature communications 13 (1) (2022)
Diane Moujalled, Pradnya Gangatirkar, Maria Kauppi, Jason Corbin, Marion Lebois, James G Murphy, Najoua Lalaoui, Joanne M Hildebrand, John Silke, Warren S Alexander, Emma C Josefsson
The necroptotic cell death pathway operates in megakaryocytes, but not in platelet synthesis. Cell death & disease 12 (1) (2021)
Taide Wang, Doris Tomas, Nirma D Perera, Brittany Cuic, Sophia Luikinga, Aida Viden, Samantha K Barton, Catriona A McLean, André L Samson, Adam Southon, Ashley I Bush, James G Murphy, Bradley J Turner
Ferroptosis mediates selective motor neuron death in amyotrophic lateral sclerosis. Cell death and differentiation (2021)
Joanne M Hildebrand, Bernice Lo, Sara Tomei, Valentina Mattei, Samuel N Young, Cheree Fitzgibbon, James G Murphy, Abeer Fadda
A family harboring an MLKL loss of function variant implicates impaired necroptosis in diabetes. Cell death & disease 12 (4) (2021)
Lung-Yu Liang, Michael Roy, Christopher R Horne, Jarrod John Sandow, Minglyanna Surudoi, Laura F Dagley, Samuel N Young, Toby Dite, Jeffrey J Babon, Peter W Janes, Onisha Patel, James G Murphy, Isabelle S Lucet
The intracellular domains of the EphB6 and EphA10 receptor tyrosine pseudokinases function as dynamic signalling hubs. The Biochemical journal 478 (17) (2021)
André L Samson, Sarah E Garnish, Joanne M Hildebrand, James G Murphy
Location, location, location: A compartmentalized view of TNF-induced necroptotic signaling. Science signaling 14 (668) (2021)
Swarna L Vijayaraj, Rebecca Feltham, Maryam Rashidi, Daniel Frank, Zhengyang Liu, Daniel S Simpson, Gregor Ebert, Angelina Vince, Marco J Herold, Andrew Kueh, Jaclyn S Pearson, Laura F Dagley, James G Murphy, Andrew Ian Webb, Kate E Lawlor, James E Vince
The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation. Nature communications 12 (1) (2021)
Zikou Liu, Laura F Dagley, Kristy Shield-Artin, Samuel N Young, Aleksandra Bankovacki, Xiangyi Wang, Michelle Tang, Jason Howitt, Che A Stafford, Ueli Nachbur, Cheree Fitzgibbon, Sarah E Garnish, Andrew Ian Webb, David Komander, James G Murphy, Joanne M Hildebrand, John Silke
Oligomerization-driven MLKL ubiquitylation antagonizes necroptosis. The EMBO journal 40 (23) (2021)
Rhiannon Morris, Yaoyuan Zhang, Julia I Ellyard, Carola G Vinuesa, James G Murphy, Artem Laktyushin, Nadia J Kershaw, Jeffrey J Babon
Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK. Nature communications 12 (1) (2021)
Alexandra D Gurzau, Christopher R Horne, Yee-Foong Mok, Megan Iminitoff, Tracy A Willson, Samuel N Young, Marnie E Blewitt, James G Murphy
SMCHD1's ubiquitin-like domain is required for N-terminal dimerization and chromatin localization. The Biochemical journal 478 (13) (2021)
Michael R Oliver, Christopher R Horne, Safal Shrestha, Jeremy Russell Keown, Lung-Yu Liang, Samuel N Young, Jarrod John Sandow, Andrew Ian Webb, David C Goldstone, Isabelle S Lucet, Natarajan Kannan, Peter Metcalf, James G Murphy
Granulovirus PK-1 kinase activity relies on a side-to-side dimerization mode centered on the regulatory αC helix. Nature communications 12 (1) (2021)
André L Samson, Cheree Fitzgibbon, Komal M Patel, Joanne M Hildebrand, Lachlan W Whitehead, Joel S Rimes, Annette V Jacobsen, Christopher R Horne, Xavier J Gavin, Samuel N Young, Kelly L Rogers, Edwin D Hawkins, James G Murphy
A toolbox for imaging RIPK1, RIPK3, and MLKL in mouse and human cells. Cell death and differentiation 28 (7) (2021)
Christopher R Horne, Hariprasad Venugopal, Santosh Panjikar, David M Wood, Amy Henrickson, Emre Brookes, Rachel A North, James G Murphy, Rosmarie Friemann, Michael D W Griffin, Georg Ramm, Borries Demeler, Renwick C J Dobson
Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism. Nature communications 12 (1) (2021)
Sarah E Garnish, Yanxiang Meng, Akiko Koide, Jarrod John Sandow, Eric Denbaum, Annette V Jacobsen, Wayland Yeung, André L Samson, Christopher R Horne, Cheree Fitzgibbon, Samuel N Young, Phoebe P C Smith, Andrew Ian Webb, Emma J Petrie, Joanne M Hildebrand, Natarajan Kannan, Peter E Czabotar, Shohei Koide, James G Murphy
Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis. Nature communications 12 (1) (2021)
Laura Ramos Garcia, Tencho Tenev, Richard Newman, Rachel O Haich, Gianmaria Liccardi, Sidonie Wicky John, Alessandro Annibaldi, Lu Yu, Mercedes Calvo Pardo, Samuel N Young, Cheree Fitzgibbon, Winnie Fernando, Naomi Guppy, Hyojin Kim, Lung-Yu Liang, Isabelle S Lucet, Andrew Kueh, Ioannis Roxanis, Patrycja Gazinska, Martin Sims, Tomoko Smyth, George Ward, John Bertin, Allison M Beal, Brad Geddes, Jyoti Sharma Choudhary, James G Murphy, K Aurelia Ball, Jason W Upton, Pascal Meier
Ubiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance. Nature communications 12 (1) (2021)
Yanxiang Meng, Katherine A Davies, Cheree Fitzgibbon, Samuel N Young, Sarah E Garnish, Christopher R Horne, Cindy Luo, Jean-Marc Garnier, Lung-Yu Liang, Angus D Cowan, André L Samson, Guillaume L Lessene, Jarrod John Sandow, Peter E Czabotar, James G Murphy
Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis. Nature communications 12 (1) (2021)
Yanxiang Meng, Jarrod John Sandow, Peter E Czabotar, James G Murphy
The regulation of necroptosis by post-translational modifications. Cell death and differentiation 28 (3) (2021)
Sarah J Trevelyan, Jodi L Brewster, Abigail E Burgess, Jennifer M Crowther, Antonia L Cadell, Benjamin L Parker, David R Croucher, Renwick C J Dobson, James G Murphy, Peter D Mace
Structure-based mechanism of preferential complex formation by apoptosis signal-regulating kinases. Science signaling 13 (622) (2020)
Joanne M Hildebrand, Maria Kauppi, Ian J Majewski, Zikou Liu, Allison J Cox, Sanae Miyake, Emma J Petrie, Michael A Silk, Zhixiu Li, Maria C Tanzer, Gabriela Brumatti, Samuel N Young, Cathrine Hall, Sarah E Garnish, Jason Corbin, Michael D Stutz, Ladina Di Rago, Pradnya Gangatirkar, Emma C Josefsson, Kristin Rigbye, Holly Anderton, James A Rickard, Anne Tripaydonis, Julie M Sheridan, Thomas S Scerri, Victoria E Jackson, Peter E Czabotar, Jian-Guo Zhang, Leila Varghese, Cody C Allison, Marc Pellegrini, Gillian M Tannahill, Esme C Hatchell, Tracy A Willson, Dina Stockwell, Carolyn A de Graaf, Janelle Collinge, Adrienne Hilton, Natasha Silke, Sukhdeep K Spall, Diep Chau, Vicki Athanasopoulos, Donald Metcalf, Ronald M Laxer, Alexander G Bassuk, Benjamin W Darbro, Maria A Fiatarone Singh, Nicole Vlahovich, David Hughes, Maria Kozlovskaia, David Benjamin Ascher, Klaus Warnatz, Nils Venhoff, Jens Thiel, Christine Biben, Stefan Blum, John Reveille, Michael S Hildebrand, Carola G Vinuesa, Pamela A McCombe, Matthew A Brown, Benjamin T Kile, Catriona A Mclean, Melanie Bahlo, Seth L Masters, Hiroyasu Nakano, Polly J Ferguson, James G Murphy, Warren S Alexander, John Silke
A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction. Nature communications 11 (1) (2020)
Kelan Chen, Richard W Birkinshaw, Alexandra D Gurzau, Iromi Wanigasuriya, Ruoyun Wang, Megan Iminitoff, Jarrod J Sandow, Samuel N Young, Patrick J Hennessy, Tracy A Willson, Denise A Heckmann, Andrew Ian Webb, Marnie E Blewitt, Peter E Czabotar, James G Murphy
Crystal structure of the hinge domain of Smchd1 reveals its dimerization mode and nucleic acid-binding residues. Science signaling 13 (636) (2020)
Catia L Pierotti, Maria C Tanzer, Annette V Jacobsen, Joanne M Hildebrand, Jean-Marc Garnier, Pooja Sharma, Isabelle S Lucet, Angus D Cowan, Wilhelmus J A Kersten, Meng-Xiao Luo, Lung-Yu Liang, Cheree Fitzgibbon, Sarah E Garnish, Anne Hempel, Ueli Nachbur, David C S Huang, Peter E Czabotar, John Silke, Mark F van Delft, James G Murphy, Guillaume L Lessene
Potent Inhibition of Necroptosis by Simultaneously Targeting Multiple Effectors of the Pathway. ACS chemical biology 15 (10) (2020)
Yoon Lim, Dylan De Bellis, Jarrod John Sandow, Luisa Capalbo, Pier Paolo D'Avino, James G Murphy, Andrew Ian Webb, Loretta Dorstyn, Sharad Kumar
Phosphorylation by Aurora B kinase regulates caspase-2 activity and function. Cell death and differentiation 28 (1) (2020)
James G Murphy
The long-awaited structure of HIPK2. The Journal of biological chemistry 294 (37) (2020)
Silvia Alvarez-Diaz, Adele Preaudet, André L Samson, Paul M Nguyen, Ka Yee Fung, Alexandra L Garnham, Warren S Alexander, Andreas Strasser, Matthias Ernst, Tracy L Putoczki, James G Murphy
Necroptosis is dispensable for the development of inflammation-associated or sporadic colon cancer in mice. Cell death and differentiation 28 (5) (2020)
Angus D Cowan, Nicholas A Smith, Jarrod John Sandow, Eugene A Kapp, Yepy Hardi Rustam, James G Murphy, Jason M Brouwer, Jonathan P Bernardini, Michael J Roy, Ahmad Z Wardak, Iris K Tan, Andrew Ian Webb, Jacqueline M Gulbis, Brian J Smith, Gavin E Reid, Grant Dewson, Peter M Colman, Peter E Czabotar
BAK core dimers bind lipids and can be bridged by them. Nature structural & molecular biology 27 (11) (2020)
Katherine A Davies, Cheree Fitzgibbon, Samuel N Young, Sarah E Garnish, Wayland Yeung, Diane Coursier, Richard W Birkinshaw, Jarrod John Sandow, Wil I L Lehmann, Lung-Yu Liang, Isabelle S Lucet, James D Chalmers, Wayne M Patrick, Natarajan Kannan, Emma J Petrie, Peter E Czabotar, James G Murphy
Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues. Nature communications 11 (1) (2020)
Emma J Petrie, Richard W Birkinshaw, Akiko Koide, Eric Denbaum, Joanne M Hildebrand, Sarah E Garnish, Katherine A Davies, Jarrod J Sandow, Andre L Samson, Xavier Gavin, Cheree Fitzgibbon, Samuel N Young, Patrick J Hennessy, Phoebe P C Smith, Andrew Ian Webb, Peter E Czabotar, Shohei Koide, James G Murphy
Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies. Proceedings of the National Academy of Sciences of the United States of America 117 (15) (2020)
André L Samson, Ying Zhang, Niall D Geoghegan, Xavier J Gavin, Katherine A Davies, Michael J Mlodzianoski, Lachlan W Whitehead, Daniel Frank, Sarah E Garnish, Cheree Fitzgibbon, Anne Hempel, Samuel N Young, Annette V Jacobsen, Wayne Cawthorne, Emma J Petrie, Maree C Faux, Kristy Shield-Artin, Najoua Lalaoui, Joanne M Hildebrand, John Silke, Kelly L Rogers, Guillaume L Lessene, Edwin D Hawkins, James G Murphy
MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis. Nature communications 11 (1) (2020)
Antonio J M Ribeiro, Sayoni Das, Natalie Dawson, Rossana Zaru, Sandra E Orchard, Janet M Thornton, Christine Orengo, Elton Zeqiraj, James G Murphy, Patrick A Eyers
Emerging concepts in pseudoenzyme classification, evolution, and signaling. Science signaling 12 (594) (2019)
Lung-Yu Liang, Onisha Patel, Peter W Janes, James G Murphy, Isabelle S Lucet
Eph receptor signalling: from catalytic to non-catalytic functions. Oncogene 38 (39) (2019)
Taide Wang, Nirma D Perera, Mathew D F Chiam, Brittany Cuic, Nayomi Wanniarachchillage, Doris Tomas, André L Samson, Wayne Cawthorne, Eric N Valor, James G Murphy, Bradley J Turner
Necroptosis is dispensable for motor neuron degeneration in a mouse model of ALS. Cell death and differentiation 27 (5) (2019)
Maryam Rashidi, Daniel S Simpson, Anne Hempel, Daniel Frank, Emma Petrie, Angelina Vince, Rebecca Feltham, Jane Murphy, Simon M Chatfield, Guy S Salvesen, James G Murphy, Ian P Wicks, James E Vince
The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid Crystals but Is Dispensable for Cell Death and IL-1β Release. Journal of immunology (Baltimore, Md. : 1950) 203 (3) (2019)
Natasha Jansz, Andrew Keniry, Marie Trussart, Heidi Bildsoe, Tamara Beck, Ian D Tonks, Arne W Mould, Peter F Hickey, Kelsey Breslin, Megan Iminitoff, Matthew E Ritchie, Edwina McGlinn, Graham F Kay, James G Murphy, Marnie E Blewitt
Smchd1 regulates long-range chromatin interactions on the inactive X chromosome and at Hox clusters. Nature structural & molecular biology 25 (9) (2018)
Martina Foglizzo, Adam J Middleton, Abigail E Burgess, Jennifer M Crowther, Renwick C J Dobson, James G Murphy, Catherine L Day, Peter D Mace
A bidentate Polycomb Repressive-Deubiquitinase complex is required for efficient activity on nucleosomes. Nature communications 9 (1) (2018)
Caroline Moerke, Isabel Jaco, Christin Dewitz, Tammo Müller, Annette V Jacobsen, Jérémie Gautheron, Jürgen Fritsch, Jessica Schmitz, Jan Hinrich Bräsen, Claudia Günther, James G Murphy, Ulrich Kunzendorf, Pascal Meier, Stefan Krautwald
The anticonvulsive Phenhydan® suppresses extrinsic cell death. Cell death and differentiation 26 (9) (2018)
Alexandra D Gurzau, Kelan Chen, Shifeng Xue, Weiwen Dai, Isabelle S Lucet, Thanh Thao Nguyen Ly, Bruno Reversade, Marnie E Blewitt, James G Murphy
FSHD2- and BAMS-associated mutations confer opposing effects on SMCHD1 function. The Journal of biological chemistry 293 (25) (2018)

James G Murphy.css-eqlu8i{font-size:small;padding-left:4px;} (James M Murphy)

Publication Activity (10 Years)

Top Topics

Top Venues

James G Murphy (James M Murphy)