Guillaume L Lessene (Guillaume Lessene)

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 39

Top Topics

Chronic Lymphocytic Leukemia

Lipopolysaccharide Induced

Endoplasmic Reticulum Stress

Top Venues

Nature communications

Cell death and differentiation

Journal of medicinal chemistry

Cell death & disease

This page only lists publications with an associated author ORCID identifier.

Publications

Xinyu Wu, Margareta Go, Julie V Nguyen, Nathan W Kuchel, Bernadine G C Lu, Kathleen Zeglinski, Kym N Lowes, Dale J Calleja, Jeffrey P Mitchell, Guillaume L Lessene, David Komander, Matthew E Call, Melissa J Call
Mutational profiling of SARS-CoV-2 papain-like protease reveals requirements for function, structure, and drug escape. Nature communications 15 (1) (2024)
Xinyu Wu, Margareta Go, Julie V Nguyen, Nathan W Kuchel, Bernadine G C Lu, Kathleen Zeglinski, Kym N Lowes, Dale J Calleja, Jeffrey P Mitchell, Guillaume L Lessene, David Komander, Matthew E Call, Melissa J Call
Mutational profiling of SARS-CoV-2 papain-like protease reveals requirements for function, structure, and drug escape. Nature communications 15 (1) (2024)
Xinyu Wu, Margareta Go, Julie V Nguyen, Nathan W Kuchel, Bernadine G C Lu, Kathleen Zeglinski, Kym N Lowes, Dale J Calleja, Jeffrey P Mitchell, Guillaume L Lessene, David Komander, Matthew E Call, Melissa J Call
Mutational profiling of SARS-CoV-2 papain-like protease reveals requirements for function, structure, and drug escape. Nature communications 15 (1) (2024)
Xinyu Wu, Margareta Go, Julie V Nguyen, Nathan W Kuchel, Bernadine G C Lu, Kathleen Zeglinski, Kym N Lowes, Dale J Calleja, Jeffrey P Mitchell, Guillaume L Lessene, David Komander, Matthew E Call, Melissa J Call
Mutational profiling of SARS-CoV-2 papain-like protease reveals requirements for function, structure, and drug escape. Nature communications 15 (1) (2024)
Christopher R Gardner, Katherine A Davies, Ying Zhang, Martin Brzozowski, Peter E Czabotar, James G Murphy, Guillaume L Lessene
From (Tool)Bench to Bedside: The Potential of Necroptosis Inhibitors. Journal of medicinal chemistry 66 (4) (2023)
Zilu Wang, Huimin Hu, Luuk Heitink, Kelly L Rogers, Yue You, Tao Tan, Connie Li Wai Suen, Alex Garnham, Hao Chen, Elizabeth Lieschke, Sarah T Diepstraten, Catherine Chang, Tianwei Chen, Diane Moujalled, Kate D Sutherland, Guillaume L Lessene, Oliver M Sieber, Jane Visvader, Gemma L Kelly, Andreas Strasser
The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells. Cell death and differentiation (2023)
Zilu Wang, Huimin Hu, Luuk Heitink, Kelly L Rogers, Yue You, Tao Tan, Connie Li Wai Suen, Alex Garnham, Hao Chen, Elizabeth Lieschke, Sarah T Diepstraten, Catherine Chang, Tianwei Chen, Diane Moujalled, Kate D Sutherland, Guillaume L Lessene, Oliver M Sieber, Jane Visvader, Gemma L Kelly, Andreas Strasser
Correction to: The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells. Cell death and differentiation (2023)
Zilu Wang, Huimin Hu, Luuk Heitink, Kelly L Rogers, Yue You, Tao Tan, Connie Li Wai Suen, Alex Garnham, Hao Chen, Elizabeth Lieschke, Sarah T Diepstraten, Catherine Chang, Tianwei Chen, Diane Moujalled, Kate D Sutherland, Guillaume L Lessene, Oliver M Sieber, Jane Visvader, Gemma L Kelly, Andreas Strasser
Correction to: The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells. Cell death and differentiation (2023)
Christopher R Gardner, Katherine A Davies, Ying Zhang, Martin Brzozowski, Peter E Czabotar, James G Murphy, Guillaume L Lessene
From (Tool)Bench to Bedside: The Potential of Necroptosis Inhibitors. Journal of medicinal chemistry 66 (4) (2023)
Christopher R Gardner, Katherine A Davies, Ying Zhang, Martin Brzozowski, Peter E Czabotar, James G Murphy, Guillaume L Lessene
From (Tool)Bench to Bedside: The Potential of Necroptosis Inhibitors. Journal of medicinal chemistry 66 (4) (2023)
Christopher R Gardner, Katherine A Davies, Ying Zhang, Martin Brzozowski, Peter E Czabotar, James G Murphy, Guillaume L Lessene
From (Tool)Bench to Bedside: The Potential of Necroptosis Inhibitors. Journal of medicinal chemistry 66 (4) (2023)
Christopher R Gardner, Katherine A Davies, Ying Zhang, Martin Brzozowski, Peter E Czabotar, James G Murphy, Guillaume L Lessene
From (Tool)Bench to Bedside: The Potential of Necroptosis Inhibitors. Journal of medicinal chemistry (2023)
Zilu Wang, Huimin Hu, Luuk Heitink, Kelly L Rogers, Yue You, Tao Tan, Connie Li Wai Suen, Alex Garnham, Hao Chen, Elizabeth Lieschke, Sarah T Diepstraten, Catherine Chang, Diane Moujalled, Kate D Sutherland, Guillaume L Lessene, Oliver M Sieber, Jane Visvader, Gemma L Kelly, Andreas Strasser
The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells. Cell death and differentiation (2023)
Zilu Wang, Huimin Hu, Luuk Heitink, Kelly L Rogers, Yue You, Tao Tan, Connie Li Wai Suen, Alex Garnham, Hao Chen, Elizabeth Lieschke, Sarah T Diepstraten, Catherine Chang, Diane Moujalled, Kate D Sutherland, Guillaume L Lessene, Oliver M Sieber, Jane Visvader, Gemma L Kelly, Andreas Strasser
The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells. Cell death and differentiation (2023)
Zilu Wang, Huimin Hu, Luuk Heitink, Kelly L Rogers, Yue You, Tao Tan, Connie Li Wai Suen, Alex Garnham, Hao Chen, Elizabeth Lieschke, Sarah T Diepstraten, Catherine Chang, Tianwei Chen, Diane Moujalled, Kate D Sutherland, Guillaume L Lessene, Oliver M Sieber, Jane Visvader, Gemma L Kelly, Andreas Strasser
The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells. Cell death and differentiation (2023)
Diane Moujalled, Adam G Southon, Eiman Saleh, Kerstin Brinkmann, Francine F S Ke, Melinda Iliopoulos, Ryan S Cross, Misty R Jenkins, Duong Nhu, Zilu Wang, Melissa X Shi, Ruth M Kluck, Guillaume L Lessene, Stephanie Grabow, Ashley I Bush, Andreas Strasser
BH3 mimetic drugs cooperate with Temozolomide, JQ1 and inducers of ferroptosis in killing glioblastoma multiforme cells. Cell death and differentiation 29 (7) (2022)
Lahiru Gangoda, Robyn L Schenk, Lin Tai, Pacman Szeto, Jen G Cheung, Andreas Strasser, Guillaume L Lessene, Mark Shackleton, Marco J Herold
Removal of BFL-1 sensitises some melanoma cells to killing by BH3 mimetic drugs. Cell death & disease 13 (4) (2022)
Annette V Jacobsen, Catia L Pierotti, Kym N Lowes, Amanda E Au, Ying Zhang, Nima Etemadi, Cheree Fitzgibbon, Wilhelmus J A Kersten, André L Samson, Mark F van Delft, David Ching Siang Huang, Hélène Jousset Sabroux, Guillaume L Lessene, John Silke, James G Murphy
The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL. Cell death & disease 13 (4) (2022)
Donia M Moujalled, Fiona C Brown, Chong Chyn Chua, Michael A Dengler, Giovanna Pomilio, Natasha S Anstee, Veronique Litalien, Ella R Thompson, Thomas David Morley, Sarah MacRaild, Ing Soo Tiong, Rhiannon Morris, Karen Dun, Adrian Carl Zordan, Jaynish S Shah, Sébastien Banquet, Ensar Halilovic, Erick J Morris, Marco J Herold, Guillaume L Lessene, Jerry M Adams, David Ching Siang Huang, Andrew W Roberts, Piers Blombery, Andrew H Wei
Acquired mutations in BAX confer resistance to BH3-mimetic therapy in Acute Myeloid Leukemia. Blood (2022)
Christoph Grohmann, Charlene M Magtoto, Joel R Walker, Ngee Kiat Chua, Anna Gabrielyan, Mary Hall, Simon A Cobbold, Stephen Mieruszynski, Martin Brzozowski, Daniel S Simpson, Hao Dong, Bridget Dorizzi, Annette V Jacobsen, Emma Morrish, Natasha Silke, James G Murphy, Joan Kathleen Heath, Andrea Testa, Chiara Maniaci, Alessio Ciulli, Guillaume L Lessene, John Silke, Rebecca Feltham
Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms. Nature communications 13 (1) (2022)
Michael J Roy, Amelia Vom, Toru Okamoto, Brian J Smith, Richard W Birkinshaw, Hong Yang, Houda Abdo, Christine A White, David Segal, David C S Huang, Jonathan B Baell, Peter M Colman, Peter E Czabotar, Guillaume L Lessene
Structure-Guided Development of Potent Benzoylurea Inhibitors of BCL-XL and BCL-2. Journal of medicinal chemistry 64 (9) (2021)
Emma M Carrington, Cynthia Louis, Tobias Kratina, Manuela Hancock, Christine R Keenan, Nadia Iannarella, Rhys S Allan, Ahmad Z Wardak, Peter E Czabotar, Marco J Herold, Robyn L Schenk, Christine A White, Damian D'Silva, Yuyan Yang, Wesley Wong, Huon Wong, Vanessa L Bryant, Nicholas D Huntington, Jai Rautela, Robyn M Sutherland, Yifan Zhan, Jacinta A Hansen, Duong Nhu, Guillaume L Lessene, Ian P Wicks, Andrew M Lew
BCL-XL antagonism selectively reduces neutrophil life span within inflamed tissues without causing neutropenia. Blood advances 5 (11) (2021)
Christoph Grohmann, Francesca Walker, Mark Devlin, Meng-Xiao Luo, Anderly C Chüeh, Judy Doherty, François Vaillant, Gwo-Yaw Ho, Matthew J Wakefield, Clare E Weeden, Alvin Kamili, Jayne Murray, Sela T Po'uha, Janet Weinstock, Serena R Kane, Maree C Faux, Esmee Broekhuizen, Ye Zheng, Kristy Shield-Artin, Nadia J Kershaw, Chin Wee Tan, Helen M Witchard, Gregor Ebert, Susan A Charman, Ian Street, Maria Kavallaris, Michelle Haber, Jamie I Fletcher, Marie-Liesse Asselin-Labat, Clare L Scott, Jane E Visvader, Geoffrey J Lindeman, Keith G Watson, Antony W Burgess, Guillaume L Lessene
Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors. Cell death & disease 12 (3) (2021)
Yanxiang Meng, Katherine A Davies, Cheree Fitzgibbon, Samuel N Young, Sarah E Garnish, Christopher R Horne, Cindy Luo, Jean-Marc Garnier, Lung-Yu Liang, Angus D Cowan, André L Samson, Guillaume L Lessene, Jarrod John Sandow, Peter E Czabotar, James G Murphy
Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis. Nature communications 12 (1) (2021)
Sarah T Diepstraten, Mary Ann Anderson, Peter E Czabotar, Guillaume L Lessene, Andreas Strasser, Gemma L Kelly
The manipulation of apoptosis for cancer therapy using BH3-mimetic drugs. Nature reviews. Cancer (2021)
Catia L Pierotti, Maria C Tanzer, Annette V Jacobsen, Joanne M Hildebrand, Jean-Marc Garnier, Pooja Sharma, Isabelle S Lucet, Angus D Cowan, Wilhelmus J A Kersten, Meng-Xiao Luo, Lung-Yu Liang, Cheree Fitzgibbon, Sarah E Garnish, Anne Hempel, Ueli Nachbur, David C S Huang, Peter E Czabotar, John Silke, Mark F van Delft, James G Murphy, Guillaume L Lessene
Potent Inhibition of Necroptosis by Simultaneously Targeting Multiple Effectors of the Pathway. ACS chemical biology 15 (10) (2020)
Kerstin Brinkmann, Paul Waring, Stefan P Glaser, Verena Wimmer, Denny L Cottle, Ming Shen Tham, Duong Nhu, Lachlan Whitehead, Alex Rd Delbridge, Guillaume L Lessene, Ian M Smyth, Marco J Herold, Gemma L Kelly, Stephanie Grabow, Andreas Strasser
BCL-XL exerts a protective role against anemia caused by radiation-induced kidney damage. The EMBO journal 39 (24) (2020)
Theresa Klemm, Gregor Ebert, Dale J Calleja, Cody C Allison, Lachlan W Richardson, Jonathan P Bernardini, Bernadine G C Lu, Nathan W Kuchel, Christoph Grohmann, Yuri Shibata, Zhong Yan Gan, James P Cooney, Marcel Doerflinger, Amanda E Au, Timothy R Blackmore, Gerbrand J van der Heden van Noort, Paul P Geurink, Huib Ovaa, Janet Newman, Alan Riboldi-Tunnicliffe, Peter E Czabotar, Jeffrey P Mitchell, Rebecca Feltham, Bernhard C Lechtenberg, Kym N Lowes, Grant Dewson, Marc Pellegrini, Guillaume L Lessene, David Komander
Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2. The EMBO journal 39 (18) (2020)
André L Samson, Ying Zhang, Niall D Geoghegan, Xavier J Gavin, Katherine A Davies, Michael J Mlodzianoski, Lachlan W Whitehead, Daniel Frank, Sarah E Garnish, Cheree Fitzgibbon, Anne Hempel, Samuel N Young, Annette V Jacobsen, Wayne Cawthorne, Emma J Petrie, Maree C Faux, Kristy Shield-Artin, Najoua Lalaoui, Joanne M Hildebrand, John Silke, Kelly L Rogers, Guillaume L Lessene, Edwin D Hawkins, James G Murphy
MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis. Nature communications 11 (1) (2020)
Richard W Birkinshaw, Jia-Nan Gong, Cindy S Luo, Daisy Lio, Christine A White, Mary Ann Anderson, Piers Blombery, Guillaume L Lessene, Ian J Majewski, Rachel Thijssen, Andrew W Roberts, David C S Huang, Peter M Colman, Peter E Czabotar
Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations. Nature communications 10 (1) (2019)
Mark F van Delft, Stephane Chappaz, Yelena Khakham, Chinh T Bui, Marlyse A Debrincat, Kym N Lowes, Jason M Brouwer, Christoph Grohmann, Phillip P Sharp, Laura F Dagley, Lucy Li, Kate McArthur, Meng-Xiao Luo, Hui San Chin, W Douglas Fairlie, Erinna F Lee, David Segal, Stéphane Duflocq, Romina Lessene, Sabrina Bernard, Laure Peilleron, Thao Nguyen, Caroline Miles, Soo San Wan, Rachael M Lane, Ahmad Wardak, Kurt Lackovic, Peter M Colman, Jarrod J Sandow, Andrew I Webb, Peter E Czabotar, Grant Dewson, Keith G Watson, David C S Huang, Guillaume L Lessene, Benjamin T Kile
A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis. Nature chemical biology 15 (11) (2019)
Emma J Petrie, Jarrod J Sandow, Annette V Jacobsen, Brian J Smith, Michael D W Griffin, Isabelle S Lucet, Weiwen Dai, Samuel N Young, Maria C Tanzer, Ahmad Wardak, Lung-Yu Liang, Angus D Cowan, Joanne M Hildebrand, Wilhelmus J A Kersten, Guillaume L Lessene, John Silke, Peter E Czabotar, Andrew I Webb, James M Murphy
Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis. Nature communications 9 (1) (2018)
Margs S Brennan, Catherine Chang, Lin Tai, Guillaume L Lessene, Andreas Strasser, Grant Dewson, Gemma L Kelly, Marco J Herold
Humanized Mcl-1 mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use. Blood 132 (15) (2018)
Kate McArthur, Lachlan W Whitehead, John M Heddleston, Lucy Li, Benjamin Scott Padman, Viola Oorschot, Niall D Geoghegan, Stephane Chappaz, Sophia Davidson, Hui San Chin, Rachael M Lane, Marija Dramicanin, Tahnee L Saunders, Canny Sugiana, Romina Lessene, Laura D Osellame, Teng-Leong Chew, Grant Dewson, Michael Lazarou, Georg Ramm, Guillaume L Lessene, Michael T Ryan, Kelly L Rogers, Mark F van Delft, Benjamin T Kile
BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis. Science (New York, N.Y.) 359 (6378) (2018)
Richard A Lamb, Nigel T Lucas, Guillaume L Lessene, Bill C Hawkins
Strategies, Setbacks, and Successes in the Synthesis of (-)-Spiroleucettadine. The Journal of organic chemistry 83 (17) (2018)
Delphine Merino, James R Whittle, François Vaillant, Antonin Serrano, Goknur Giner, Ana Leticia Maragno, Maïa Chanrion, Emilie Schneider, Bhupinder Pal, Xiang Li, Grant Dewson, Julius Gräsel, Kevin Liu, Najoua Lalaoui, David Segal, Marco J Herold, David Ching Siang Huang, Aaron T L Lun, Olivier Geneste, Guillaume L Lessene, Jane E Visvader, Geoffrey J Lindeman
Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer. Science translational medicine 9 (401) (2018)
Alex Rd Delbridge, Brandon J Aubrey, Craig Hyland, Jonathan P Bernardini, Ladina Di Rago, Jean-Marc Garnier, Guillaume L Lessene, Andreas Strasser, Warren S Alexander, Stephanie Grabow
The BH3-only proteins BIM and PUMA are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL. Cell death & disease 8 (7) (2017)
Antonin Serrano, Tiffany Khong, David Segal, Yuan Yao, Chris D Riffkin, Jean-Marc Garnier, Seong Lin Khaw, Guillaume L Lessene, Andrew Spencer, Marco J Herold, Andrew W Roberts, David Ching Siang Huang
Hierarchy for targeting prosurvival BCL2 family proteins in multiple myeloma: pivotal role of MCL1. Blood 128 (14) (2016)
Stephanie Berger, Erik Procko, Daciana Margineantu, Erinna F Lee, Betty W Shen, Alex Zelter, Daniel-Adriano Silva, Kusum Chawla, Marco J Herold, Jean-Marc Garnier, Richard Johnson, Michael J MacCoss, Guillaume L Lessene, Trisha N Davis, Patrick S Stayton, Barry L Stoddard, W Douglas Fairlie, David M Hockenbery, Julien S Baker
Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer. eLife 5 (2016)