Laura H Heitman

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 42

Top Topics

Structural Basis

Fluorescent Probe

Chemotherapy Induced

Top Venues

ACS chemical biology

International journal of molecular sciences

Journal of medicinal chemistry

Nature communications

This page only lists publications with an associated author ORCID identifier.

Publications

Leonard Mach, Anahid Omran, Jara Bouma, Silke Radetzki, David A Sykes, Wolfgang Guba, Xiaoting Li, Calvin Höffelmeyer, Axel Hentsch, Thais Gazzi, Yelena Mostinski, Malgorzata Wasinska-Kalwa, Fabio de Molnier, Cas van der Horst, Jens Peter von Kries, Marc Vendrell, Tian Hua, Dmitry B Veprintsev, Laura H Heitman, Uwe Grether, Marc Nazare
Highly Selective Drug-Derived Fluorescent Probes for the Cannabinoid Receptor Type 1 (CB 1 R). Journal of medicinal chemistry (2024)
Natalia V Ortiz Zacarías, Sascha Röth, Jeremy D Broekhuis, Laura H Heitman, Kevin Moreau, Laura H Heitman
Inducing Receptor Degradation as a Novel Approach to Target CC Chemokine Receptor 2 (CCR2). International journal of molecular sciences 25 (16) (2024)
Lisa S den Hollander, Adriaan P IJzerman, Laura H Heitman
Pharmacological characterization of allosteric modulators: A case for chemokine receptors. Medicinal research reviews 44 (5) (2024)
Bert L H Beerkens, Vasiliki Andrianopoulou, Xuesong Wang, Rongfang Liu, Gerard van Westen, Willem Jespers, Adriaan P IJzerman, Laura H Heitman, Laura H Heitman
N -Acyl- N -Alkyl Sulfonamide Probes for Ligand-Directed Covalent Labeling of GPCRs: The Adenosine A 2B Receptor as Case Study. ACS chemical biology 19 (7) (2024)
Bert L H Beerkens, Vasiliki Andrianopoulou, Xuesong Wang, Rongfang Liu, Gerard van Westen, Willem Jespers, Adriaan P IJzerman, Laura H Heitman, Laura H Heitman
N -Acyl- N -Alkyl Sulfonamide Probes for Ligand-Directed Covalent Labeling of GPCRs: The Adenosine A 2B Receptor as Case Study. ACS chemical biology (2024)
Bert L H Beerkens, Vasiliki Andrianopoulou, Xuesong Wang, Rongfang Liu, Gerard van Westen, Willem Jespers, Adriaan P IJzerman, Laura H Heitman, Laura H Heitman
N -Acyl- N -Alkyl Sulfonamide Probes for Ligand-Directed Covalent Labeling of GPCRs: The Adenosine A 2B Receptor as Case Study. ACS chemical biology 19 (7) (2024)
Leonard Mach, Anahid Omran, Jara Bouma, Silke Radetzki, David A Sykes, Wolfgang Guba, Xiaoting Li, Calvin Höffelmeyer, Axel Hentsch, Thais Gazzi, Yelena Mostinski, Malgorzata Wasinska-Kalwa, Fabio de Molnier, Cas van der Horst, Jens Peter von Kries, Marc Vendrell, Tian Hua, Dmitry B Veprintsev, Laura H Heitman, Uwe Grether, Marc Nazare
Highly Selective Drug-Derived Fluorescent Probes for the Cannabinoid Receptor Type 1 (CB 1 R). Journal of medicinal chemistry 67 (14) (2024)
Marina Gorostiola González, Pepijn R J Rakers, Willem Jespers, Adriaan P IJzerman, Laura H Heitman, Gerard van Westen
Computational Characterization of Membrane Proteins as Anticancer Targets: Current Challenges and Opportunities. International journal of molecular sciences 25 (7) (2024)
Lisa S den Hollander, Bert L H Beerkens, Sebastian Dekkers, Jacobus P D van Veldhoven, Natalia V Ortiz Zacarías, Cas van der Horst, Elisabeth G Sieders, Bert de Valk, Jianhui Wang, Adriaan P IJzerman, Laura H Heitman, Laura H Heitman
Labeling of CC Chemokine Receptor 2 with a Versatile Intracellular Allosteric Probe. ACS chemical biology (2024)
Marina Gorostiola González, Pepijn R J Rakers, Willem Jespers, Adriaan P IJzerman, Laura H Heitman, Gerard van Westen
Computational Characterization of Membrane Proteins as Anticancer Targets: Current Challenges and Opportunities. International journal of molecular sciences 25 (7) (2024)
Lisa S den Hollander, Adriaan P IJzerman, Laura H Heitman
Pharmacological characterization of allosteric modulators: A case for chemokine receptors. Medicinal research reviews (2024)
Leonard Mach, Anahid Omran, Jara Bouma, Silke Radetzki, David A Sykes, Wolfgang Guba, Xiaoting Li, Calvin Höffelmeyer, Axel Hentsch, Thais Gazzi, Yelena Mostinski, Malgorzata Wasinska-Kalwa, Fabio de Molnier, Cas van der Horst, Jens Peter von Kries, Marc Vendrell, Tian Hua, Dmitry B Veprintsev, Laura H Heitman, Uwe Grether, Marc Nazare
Highly Selective Drug-Derived Fluorescent Probes for the Cannabinoid Receptor Type 1 (CB 1 R). Journal of medicinal chemistry 67 (14) (2024)
Lara Toy, Max E Huber, Minhee Lee, Ana Alonso Bartolomé, Natalia V Ortiz Zacarías, Sherif Nasser, Stephan Scholl, Darius P Zlotos, Yasmine M Mandour, Laura H Heitman, Martyna Szpakowska, Andy Chevigné, Matthias Schiedel
Fluorophore-Labeled Pyrrolones Targeting the Intracellular Allosteric Binding Site of the Chemokine Receptor CCR1. ACS pharmacology & translational science 7 (7) (2024)
Laura V De Paus, Yu An, Antonius P A Janssen, Richard J B H N van den Berg, Laura H Heitman, Mario van der Stelt
Discovery of a Photoaffinity Probe that Captures the Active Conformation of the Cannabinoid CB 2 Receptor. Chembiochem : a European journal of chemical biology 25 (7) (2024)
Majlen A Dilweg, Marina Gorostiola González, Martijn D de Ruiter, Nadine J Meijboom, Jacobus P D van Veldhoven, Rongfang Liu, Willem Jespers, Gerard van Westen, Laura H Heitman, Adriaan P IJzerman, Laura H Heitman
Exploring novel dilazep derivatives as hENT1 inhibitors and potentially covalent molecular tools. Purinergic signalling (2024)
Marina Gorostiola González, Pepijn R J Rakers, Willem Jespers, Adriaan P IJzerman, Laura H Heitman, Gerard van Westen
Computational Characterization of Membrane Proteins as Anticancer Targets: Current Challenges and Opportunities. International journal of molecular sciences 25 (7) (2024)
Leonard Mach, Anahid Omran, Jara Bouma, Silke Radetzki, David A Sykes, Wolfgang Guba, Xiaoting Li, Calvin Höffelmeyer, Axel Hentsch, Thais Gazzi, Yelena Mostinski, Malgorzata Wasinska-Kalwa, Fabio de Molnier, Cas van der Horst, Jens Peter von Kries, Marc Vendrell, Tian Hua, Dmitry B Veprintsev, Laura H Heitman, Uwe Grether, Marc Nazare
Highly Selective Drug-Derived Fluorescent Probes for the Cannabinoid Receptor Type 1 (CB 1 R). Journal of medicinal chemistry 67 (14) (2024)
Lara Toy, Max E Huber, Minhee Lee, Ana Alonso Bartolomé, Natalia V Ortiz Zacarías, Sherif Nasser, Stephan Scholl, Darius P Zlotos, Yasmine M Mandour, Laura H Heitman, Martyna Szpakowska, Andy Chevigné, Matthias Schiedel
Fluorophore-Labeled Pyrrolones Targeting the Intracellular Allosteric Binding Site of the Chemokine Receptor CCR1. ACS pharmacology & translational science 7 (7) (2024)
Leonard Mach, Anahid Omran, Jara Bouma, Silke Radetzki, David A Sykes, Wolfgang Guba, Xiaoting Li, Calvin Höffelmeyer, Axel Hentsch, Thais Gazzi, Yelena Mostinski, Malgorzata Wasinska-Kalwa, Fabio de Molnier, Cas van der Horst, Jens Peter von Kries, Marc Vendrell, Tian Hua, Dmitry B Veprintsev, Laura H Heitman, Uwe Grether, Marc Nazare
Highly Selective Drug-Derived Fluorescent Probes for the Cannabinoid Receptor Type 1 (CB 1 R). Journal of medicinal chemistry 67 (14) (2024)
Laura V De Paus, Yu An, Antonius P A Janssen, Richard J B H N van den Berg, Laura H Heitman, Mario van der Stelt
Discovery of a Photoaffinity Probe that Captures the Active Conformation of the Cannabinoid CB 2 Receptor. Chembiochem : a European journal of chemical biology 25 (7) (2024)
Lisa S den Hollander, Bert L H Beerkens, Sebastian Dekkers, Jacobus P D van Veldhoven, Natalia V Ortiz Zacarías, Cas van der Horst, Elisabeth G Sieders, Bert de Valk, Jianhui Wang, Adriaan P IJzerman, Laura H Heitman, Laura H Heitman
Labeling of CC Chemokine Receptor 2 with a Versatile Intracellular Allosteric Probe. ACS chemical biology (2024)
Natalia V Ortiz Zacarías, Sascha Röth, Jeremy D Broekhuis, Laura H Heitman, Kevin Moreau, Laura H Heitman
Inducing Receptor Degradation as a Novel Approach to Target CC Chemokine Receptor 2 (CCR2). International journal of molecular sciences 25 (16) (2024)
Bert L H Beerkens, Vasiliki Andrianopoulou, Xuesong Wang, Rongfang Liu, Gerard van Westen, Willem Jespers, Adriaan P IJzerman, Laura H Heitman, Laura H Heitman
N -Acyl- N -Alkyl Sulfonamide Probes for Ligand-Directed Covalent Labeling of GPCRs: The Adenosine A 2B Receptor as Case Study. ACS chemical biology 19 (7) (2024)
Lisa S den Hollander, Adriaan P IJzerman, Laura H Heitman
Pharmacological characterization of allosteric modulators: A case for chemokine receptors. Medicinal research reviews 44 (5) (2024)
Laura V De Paus, Yu An, Antonius P A Janssen, Richard J B H N van den Berg, Laura H Heitman, Mario van der Stelt
Discovery of a Photoaffinity Probe that Captures the Active Conformation of the Cannabinoid CB 2 Receptor. Chembiochem : a European journal of chemical biology (2024)
Alessio Ciulli, Suzanne O'Connor, Chun-Wa Chung, Ingo V Hartung, Andrea Testa, Danette L Daniels, Laura H Heitman
The 17 th EFMC Short Course on Medicinal Chemistry on Small Molecule Protein Degraders. ChemMedChem (2023)
Xiaoting Li, Hao Chang, Jara Bouma, Laura V De Paus, Partha Mukhopadhyay, Janos Paloczi, Mohammed Mustafa, Cas van der Horst, Sanjay Sunil Kumar, Lijie Wu, Yanan Yu, Richard J B H N van den Berg, Antonius P A Janssen, Aron Lichtman, Zhi-Jie Liu, Pal Pacher, Mario van der Stelt, Laura H Heitman, Tian Hua
Structural basis of selective cannabinoid CB 2 receptor activation. Nature communications 14 (1) (2023)
Anna Vlachodimou, Jara Bouma, Michel De Cleyn, Didier Berthelot, Stefan Pype, Jean-Paul Bosmans, Herman W T van Vlijmen, Berthold Wroblowski, Laura H Heitman, Adriaan P IJzerman
Kinetic profiling of novel spirobenzo-oxazinepiperidinone derivatives as equilibrative nucleoside transporter 1 inhibitors. Purinergic signalling (2023)
Vi Pham, Maria Clazina Cornelia Habben Jansen, Geoff Thompson, Laura H Heitman, Arthur Christopoulos, David M Thal, Celine Valant
Role of conserved tyrosine lid residues in the activation of the M 2 muscarinic acetylcholine receptor. Molecular pharmacology (2023)
Xiaoting Li, Hao Chang, Jara Bouma, Laura V De Paus, Partha Mukhopadhyay, Janos Paloczi, Mohammed Mustafa, Cas van der Horst, Sanjay Sunil Kumar, Lijie Wu, Yanan Yu, Richard J B H N van den Berg, Antonius P A Janssen, Aron Lichtman, Zhi-Jie Liu, Pal Pacher, Mario van der Stelt, Laura H Heitman, Tian Hua
Structural basis of selective cannabinoid CB 2 receptor activation. Nature communications 14 (1) (2023)
Xiaoting Li, Hao Chang, Jara Bouma, Laura V De Paus, Partha Mukhopadhyay, Janos Paloczi, Mohammed Mustafa, Cas van der Horst, Sanjay Sunil Kumar, Lijie Wu, Yanan Yu, Richard J B H N van den Berg, Antonius P A Janssen, Aron Lichtman, Zhi-Jie Liu, Pal Pacher, Mario van der Stelt, Laura H Heitman, Tian Hua
Structural basis of selective cannabinoid CB 2 receptor activation. Nature communications 14 (1) (2023)
Ming Jiang, Mirjam C W Huizenga, Jonah L Wirt, Janos Paloczi, Avand Amedi, Richard J B H N van den Berg, Joerg Benz, Ludovic Collin, Hui Deng, Xinyu Di, Wouter F Driever, Bogdan I Florea, Uwe Grether, Antonius P A Janssen, Thomas Hankemeier, Laura H Heitman, Tsang-Wai Lam, Florian Mohr, Anto Pavlovic, Iris Ruf, Helma van den Hurk, Anna F Stevens, Daan van der Vliet, Tom van der Wel, Matthias B Wittwer, Constant A A van Boeckel, Pal Pacher, Andrea G Hohmann, Mario van der Stelt
A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence. Nature communications 14 (1) (2023)
Theresa Kissel, Changrong Ge, Lise Hafkenscheid, Joanneke C Kwekkeboom, Linda M Slot, Marco Cavallari, Yibo He, Karin Anna van Schie, Rochelle D Vergroesen, Arieke Suzanna Berendina Kampstra, Sanne Reijm, Gerrie Stoeken-Rijsbergen, Carolien A M Koeleman, Lennard M Voortman, Laura H Heitman, Bingze Xu, Ger J M Pruijn, Dana L E Vergoossen, Theo Rispens, Thomas Wj Huizinga, Hans Ulrich Scherer, Michael Reth, Rickard Holmdahl, René E M Toes
Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation. Science advances 8 (6) (2022)
Xuesong Wang, Willem Jespers, Just J de Waal, Kim A N Wolff, Liedeke van Uden, Adriaan P IJzerman, Gerard J P van Westen, Laura H Heitman
Cancer-related somatic mutations alter adenosine A 1 receptor pharmacology-A focus on mutations in the loops and C-terminus. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 36 (6) (2022)
Xuesong Wang, Willem Jespers, Kim A N Wolff, Jill Buytelaar, Adriaan P IJzerman, Gerard van Westen, Laura H Heitman
Cancer-Related Somatic Mutations in Transmembrane Helices Alter Adenosine A1 Receptor Pharmacology. Molecules (Basel, Switzerland) 27 (12) (2022)
Tamara A M Mocking, Hubert J Sijben, Yimé W Vermeulen, Adriaan P IJzerman, Laura H Heitman
MPP + -Induced Changes in Cellular Impedance as a Measure for Organic Cation Transporter (SLC22A1-3) Activity and Inhibition. International journal of molecular sciences 23 (3) (2022)
Chenlin Feng, Xuesong Wang, Willem Jespers, Rongfang Liu, Sofía Denise Zamarbide Losada, Marina Gorostiola González, Gerard van Westen, Erik H J Danen, Laura H Heitman
Cancer-Associated Mutations of the Adenosine A 2A Receptor Have Diverse Influences on Ligand Binding and Receptor Functions. Molecules (Basel, Switzerland) 27 (15) (2022)
Jan Phillip Lemmerhirt, Andreas Isaak, Rongfang Liu, Max Kock, Constantin Gabriel Daniliuc, Kenneth A Jacobson, Laura H Heitman, Anna Junker
Development of Bicyclo[3.1.0]hexane-Based A 3 Receptor Ligands: Closing the Gaps in the Structure-Affinity Relationships. Molecules (Basel, Switzerland) 27 (7) (2022)
Willem Jespers, Laura H Heitman, Adriaan P IJzerman, Eddy Sotelo, Gerard J P van Westen, Johan Åqvist, Hugo Gutiérrez-de-Terán
Deciphering conformational selectivity in the A2A adenosine G protein-coupled receptor by free energy simulations. PLoS computational biology 17 (11) (2021)
Anna Vlachodimou, Adriaan P IJzerman, Laura H Heitman
Label-free detection of transporter activity via GPCR signalling in living cells: A case for SLC29A1, the equilibrative nucleoside transporter 1. Scientific reports 9 (1) (2019)
Dominik Heimann, Corinna Lueg, Henk de Vries, Bastian Frehland, Dirk Schepmann, Laura H Heitman, Bernhard Wünsch
Bioisosteric replacement of central 1,2,4-oxadiazole ring of high affinity CB2 ligands by regioisomeric 1,3,4-oxadiazole ring. MedChemComm 8 (8) (2017)
Indira Nederpelt, Maria Kuzikov, Wilbert E A de Witte, Patrick Schnider, Bruno Tuijt, Sheraz Gul, Adriaan P IJzerman, Elizabeth C M de Lange, Laura H Heitman
From receptor binding kinetics to signal transduction; a missing link in predicting in vivo drug-action. Scientific reports 7 (1) (2017)