Takaomi C Saido (Takaomi Saido)

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 50

Top Venues

Nature communications

bioRxiv : the preprint server for biology

Oxidative medicine and cellular longevity

eNeuro

RIKEN Center for Brain Science

This page only lists publications with an associated author ORCID identifier.

Affiliation History

RIKEN Center for Brain Science

Japan

Team Leader

Publications

Andrew Octavian Sasmita, Constanze Depp, Taisiia Nazarenko, Ting Sun, Sophie B Siems, Erinne Cherisse Ong, Yakum Bertrand Nkeh, Carolin Böhler, Xuan Yu, Bastian Bues, Lisa Evangelista, Shuying Mao, Barbara Morgado, Zoe Wu, Torben Ruhwedel, Swati Subramanian, Friederike Börensen, Katharina Overhoff, Lena Spieth, Stefan A Berghoff, Katherine Rose Sadleir, Robert Vassar, Simone Eggert, Sandra Goebbels, Takashi Saito, Takaomi C Saido, Gesine Saher, Wiebke Möbius, Gonçalo Castelo-Branco, Hans-Wolfgang Klafki, Oliver Wirths, Jens Wiltfang, Sarah Jäkel, Riqiang Yan, Klaus-Armin Nave
Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer's disease model mice. Nature neuroscience (2024)
Khairun Nisa Binti Hashim, Yukio Matsuba, Mika Takahashi, Naoko Kamano, Ikuo Tooyama, Takaomi C Saido, Shoko Hashimoto
Neuronal glutathione depletion elevates the Aβ42/Aβ40 ratio and tau aggregation in Alzheimer's disease mice. FEBS letters 598 (13) (2024)
Andrew Octavian Sasmita, Constanze Depp, Taisiia Nazarenko, Ting Sun, Sophie B Siems, Erinne Cherisse Ong, Yakum Bertrand Nkeh, Carolin Böhler, Xuan Yu, Bastian Bues, Lisa Evangelista, Shuying Mao, Barbara Morgado, Zoe Wu, Torben Ruhwedel, Swati Subramanian, Friederike Börensen, Katharina Overhoff, Lena Spieth, Stefan A Berghoff, Katherine Rose Sadleir, Robert Vassar, Simone Eggert, Sandra Goebbels, Takashi Saito, Takaomi C Saido, Gesine Saher, Wiebke Möbius, Gonçalo Castelo-Branco, Hans-Wolfgang Klafki, Oliver Wirths, Jens Wiltfang, Sarah Jäkel, Riqiang Yan, Klaus-Armin Nave
Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer's disease model mice. Nature neuroscience (2024)
Brent D Aulston, Kirstan Gimse, Hannah O Bazick, Eniko A Kramar, Donald P Pizzo, Leonardo A Parra, Jichao Sun, Kristen Branes-Guerrero, Nidhi Checka, Neda Bagheri, Nihal Satyadev, Jared Carlson-Stevermer, Takashi Saito, Takaomi C Saido, Anjon Audhya, Marcelo A Wood, Mark J Zylka, Krishanu Saha, Subhojit Roy
Long term rescue of Alzheimer's deficits in vivo by one-time gene-editing of App C-terminus. bioRxiv : the preprint server for biology (2024)
Kenya Sato, Hiroki Sasaguri, Wakako Kumita, Tetsushi Sakuma, Tomoe Morioka, Kenichi Nagata, Takashi Inoue, Yoko Kurotaki, Naomi Mihira, Michihira Tagami, Ri-Ichiroh Manabe, Kokoro Ozaki, Yasushi Okazaki, Takashi Yamamoto, Makoto Suematsu, Takaomi C Saido, Erika Sasaki
Production of a heterozygous exon skipping model of common marmosets using gene-editing technology. Lab animal 53 (9) (2024)
Naoto Watamura, Naomasa Kakiya, Ryo Fujioka, Naoko Kamano, Mika Takahashi, Per Nilsson, Takashi Saito, Nobuhisa Iwata, Shigeyoshi Fujisawa, Takaomi C Saido
The dopaminergic system promotes neprilysin-mediated degradation of amyloid-β in the brain. Science signaling 17 (848) (2024)
Khairun Nisa Binti Hashim, Yukio Matsuba, Mika Takahashi, Naoko Kamano, Ikuo Tooyama, Takaomi C Saido, Shoko Hashimoto
Neuronal glutathione depletion elevates the Aβ42/Aβ40 ratio and tau aggregation in Alzheimer's disease mice. FEBS letters 598 (13) (2024)
Brent D Aulston, Kirstan Gimse, Hannah O Bazick, Eniko A Kramar, Donald P Pizzo, Leonardo A Parra, Jichao Sun, Kristen Branes-Guerrero, Nidhi Checka, Neda Bagheri, Nihal Satyadev, Jared Carlson-Stevermer, Takashi Saito, Takaomi C Saido, Anjon Audhya, Marcelo A Wood, Mark J Zylka, Krishanu Saha, Subhojit Roy
Long term rescue of Alzheimer's deficits in vivo by one-time gene-editing of App C-terminus. bioRxiv : the preprint server for biology (2024)
Brent D Aulston, Kirstan Gimse, Hannah O Bazick, Eniko A Kramar, Donald P Pizzo, Leonardo A Parra, Jichao Sun, Kristen Branes-Guerrero, Nidhi Checka, Neda Bagheri, Nihal Satyadev, Jared Carlson-Stevermer, Takashi Saito, Takaomi C Saido, Anjon Audhya, Marcelo A Wood, Mark J Zylka, Krishanu Saha, Subhojit Roy
Long term rescue of Alzheimer's deficits in vivo by one-time gene-editing of App C-terminus. bioRxiv : the preprint server for biology (2024)
Khairun Nisa Binti Hashim, Yukio Matsuba, Mika Takahashi, Naoko Kamano, Ikuo Tooyama, Takaomi C Saido, Shoko Hashimoto
Neuronal glutathione depletion elevates the Aβ42/Aβ40 ratio and tau aggregation in Alzheimer's disease mice. FEBS letters (2024)
Cinzia Vicidomini, Travis D Goode, Kathleen M McAvoy, Ruilin Yu, Conor H Beveridge, Sanjay N Iyer, Matheus B Victor, Noelle Leary, Liam Evans, Michael J Steinbaugh, Zon Weng Lai, Marina C Lyon, Manuel Rico F S Silvestre, Gracia Bonilla, Ruslan I Sadreyev, Tobias C Walther, Shannan Ho Sui, Takaomi C Saido, Kei Yamamoto, Makoto Murakami, Li-Huei Tsai, Gaurav Chopra, Amar Sahay
An aging-sensitive compensatory secretory phospholipase that confers neuroprotection and cognitive resilience. bioRxiv : the preprint server for biology (2024)
Kenya Sato, Hiroki Sasaguri, Wakako Kumita, Tetsushi Sakuma, Tomoe Morioka, Kenichi Nagata, Takashi Inoue, Yoko Kurotaki, Naomi Mihira, Michihira Tagami, Ri-Ichiroh Manabe, Kokoro Ozaki, Yasushi Okazaki, Takashi Yamamoto, Makoto Suematsu, Takaomi C Saido, Erika Sasaki
Production of a heterozygous exon skipping model of common marmosets using gene-editing technology. Lab animal (2024)
Lulu Jiang, Rebecca Roberts, Melissa Wong, Lushuang Zhang, Chelsea Joy Webber, Alper Kilci, Matthew Jenkins, Guangxin Sun, Sherif Rashad, Jingjing Sun, Peter C Dedon, Sarah Anne Daley, Weiming Xia, Alejandro Rondón Ortiz, Luke Dorrian, Takashi Saito, Takaomi C Saido, Benjamin Wolozin
Accumulation of m 6 A exhibits stronger correlation with MAPT than β-amyloid pathology in an APP NL-G-F /MAPT P301S mouse model of Alzheimer's disease. bioRxiv : the preprint server for biology (2023)
Hanseul Park, Byounggook Cho, Hongwon Kim, Takashi Saito, Takaomi C Saido, Kyoung Jae Won, Jongpil Kim
Single-cell RNA-sequencing identifies disease-associated oligodendrocytes in male APP NL-G-F and 5XFAD mice. Nature communications 14 (1) (2023)
Hanseul Park, Byounggook Cho, Hongwon Kim, Takashi Saito, Takaomi C Saido, Kyoung Jae Won, Jongpil Kim
Single-cell RNA-sequencing identifies disease-associated oligodendrocytes in male APP NL-G-F and 5XFAD mice. Nature communications 14 (1) (2023)
Hanseul Park, Byounggook Cho, Hongwon Kim, Takashi Saito, Takaomi C Saido, Kyoung Jae Won, Jongpil Kim
Single-cell RNA-sequencing identifies disease-associated oligodendrocytes in male APP NL-G-F and 5XFAD mice. Nature communications 14 (1) (2023)
Hanseul Park, Byounggook Cho, Hongwon Kim, Takashi Saito, Takaomi C Saido, Kyoung Jae Won, Jongpil Kim
Single-cell RNA-sequencing identifies disease-associated oligodendrocytes in male APP NL-G-F and 5XFAD mice. Nature communications 14 (1) (2023)
Yuri Mizuno, Nona Abolhassani, Guianfranco Mazzei, Kunihiko Sakumi, Takashi Saito, Takaomi C Saido, Toshiharu Ninomiya, Toru Iwaki, Ryo Yamasaki, Jun-Ichi Kira, Yusaku Nakabeppu
Corrigendum to "MUTYH Actively Contributes to Microglial Activation and Impaired Neurogenesis in the Pathogenesis of Alzheimer's Disease". Oxidative medicine and cellular longevity 2023 (2023)
Yuri Mizuno, Nona Abolhassani, Guianfranco Mazzei, Kunihiko Sakumi, Takashi Saito, Takaomi C Saido, Toshiharu Ninomiya, Toru Iwaki, Ryo Yamasaki, Jun-Ichi Kira, Yusaku Nakabeppu
Corrigendum to "MUTYH Actively Contributes to Microglial Activation and Impaired Neurogenesis in the Pathogenesis of Alzheimer's Disease". Oxidative medicine and cellular longevity 2023 (2023)
Saori Hata, Haruka Saito, Takeharu Kakiuchi, Dai Fukumoto, Shigeyuki Yamamoto, Kensaku Kasuga, Ayano Kimura, Koichi Moteki, Ruriko Abe, Shungo Adachi, Shoich Kinoshita, Kumiko Yoshizawa-Kumagaye, Hideki Nishio, Takashi Saito, Takaomi C Saido, Tohru Yamamoto, Masaki Nishimura, Hidenori Taru, Yuriko Sobu, Hiroyuki Ohba, Shingo Nishiyama, Norihiro Harada, Takeshi Ikeuchi, Hideo Tsukada, Yasuomi Ouchi, Toshiharu Suzuki
Brain p3-Alcβ peptide restores neuronal viability impaired by Alzheimer's amyloid β-peptide. EMBO molecular medicine (2023)
Hanseul Park, Byounggook Cho, Hongwon Kim, Takashi Saito, Takaomi C Saido, Kyoung Jae Won, Jongpil Kim
Single-cell RNA-sequencing identifies disease-associated oligodendrocytes in male APP NL-G-F and 5XFAD mice. Nature communications 14 (1) (2023)
Waka Sato, Miho Watanabe-Takahashi, Takuya Murata, Naoko Utsunomiya-Tate, Jun Motoyama, Masataka Anzai, Seiko Ishihara, Nanako Nishioka, Hina Uchiyama, Juri Togashi, Saeka Nishihara, Kiyoshi Kawasaki, Takashi Saito, Takaomi C Saido, Satoru Funamoto, Kiyotaka Nishikawa
A tailored tetravalent peptide displays dual functions to inhibit amyloid β production and aggregation. Communications biology 6 (1) (2023)
Xinyi Zhao, Wen Zeng, Hong Xu, Zihan Sun, Yingxin Hu, Beibei Peng, Jennifer D McBride, Jiangtao Duan, Juan Deng, Bin Zhang, Soo-Jung Kim, Bryan Zoll, Takashi Saito, Hiroki Sasaguri, Takaomi C Saido, Carlo Ballatore, Haishan Yao, Zhaoyin Wang, John Q Trojanowski, Kurt R Brunden, Virginia M Y Lee, Zhuohao He
A microtubule stabilizer ameliorates protein pathogenesis and neurodegeneration in mouse models of repetitive traumatic brain injury. Science translational medicine 15 (713) (2023)
Constanze Depp, Ting Sun, Andrew Octavian Sasmita, Lena Spieth, Stefan A Berghoff, Taisiia Nazarenko, Katharina Overhoff, Agnes A Steixner-Kumar, Swati Subramanian, Sahab Arinrad, Torben Ruhwedel, Wiebke Möbius, Sandra Göbbels, Gesine Saher, Hauke B Werner, Alkmini Damkou, Silvia Zampar, Oliver Wirths, Maik Thalmann, Mikael Simons, Takashi Saito, Takaomi C Saido, Dilja Krueger-Burg, Riki Kawaguchi, Michael Willem, Christian Haass, Daniel H Geschwind, Hannelore Ehrenreich, Ruth Stassart, Klaus-Armin Nave
Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease. Nature (2023)
Ernest Palomer, Núria Martín-Flores, Sarah Jolly, Patricia Pascual-Vargas, Stefano Benvegnù, Marina Podpolny, Samuel Teo, Kadi Vaher, Takashi Saito, Takaomi C Saido, Paul Whiting, Patricia C Salinas
Epigenetic repression of Wnt receptors in AD: a role for Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7 promoters. Molecular psychiatry 27 (7) (2022)
Paige S Mumford, Justin Tosh, Silvia Anderle, Eleni Gkanatsiou Wikberg, Gloria Lau, Sue Noy, Karen Cleverley, Takashi Saito, Takaomi C Saido, Eugene Yu, Gunnar Brinkmalm, Erik Portelius, Kaj Blennow, Henrik Zetterberg, Victor L J Tybulewicz, Elizabeth M C Fisher, Frances K Wiseman
Genetic Mapping of APP and Amyloid-β Biology Modulation by Trisomy 21. The Journal of neuroscience : the official journal of the Society for Neuroscience 42 (33) (2022)
Naoto Watamura, Kaori Sato, Gen Shiihashi, Ayami Iwasaki, Naoko Kamano, Mika Takahashi, Misaki Sekiguchi, Naomi Mihira, Ryo Fujioka, Kenichi Nagata, Shoko Hashimoto, Takashi Saito, Toshio Ohshima, Takaomi C Saido, Hiroki Sasaguri
An isogenic panel of App knock-in mouse models: Profiling β-secretase inhibition and endosomal abnormalities. Science advances 8 (23) (2022)
Yuri Mizuno, Nona Abolhassani, Guianfranco Mazzei, Kunihiko Sakumi, Takashi Saito, Takaomi C Saido, Toshiharu Ninomiya, Toru Iwaki, Ryo Yamasaki, Jun-Ichi Kira, Yusaku Nakabeppu
MUTYH Actively Contributes to Microglial Activation and Impaired Neurogenesis in the Pathogenesis of Alzheimer's Disease. Oxidative medicine and cellular longevity 2021 (2021)
Fang Zhang, Mary Gannon, Yunjia Chen, Shun Yan, Sixue Zhang, Wendy Feng, Jiahui Tao, Bingdong Sha, Zhenghui Liu, Takashi Saito, Takaomi C Saido, C Dirk Keene, Kai Jiao, Erik D Roberson, Huaxi Xu, Qin Wang
β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade. Science translational medicine 12 (526) (2021)
Barbara Bettegazzi, Laura Sebastian Monasor, Serena Bellani, Franca Codazzi, Lisa Michelle Restelli, Alessio Vittorio Colombo, Nikolaus Deigendesch, Savas Deniz Soysal, Takashi Saito, Takaomi C Saido, Sven Lammich, Sabina Tahirovic, Fabio Grohovaz, Daniele Zacchetti
Casein Kinase 2 dependent phosphorylation of eIF4B regulates BACE1 expression in Alzheimer's disease. Cell death & disease 12 (8) (2021)
Hikari Tanaka, Kanoh Kondo, Kyota Fujita, Hidenori Homma, Kazuhiko Tagawa, Xiaocen Jin, Meihua Jin, Yuki Yoshioka, Sumire Takayama, Hitomi Masuda, Rie Tokuyama, Yukoh Nakazaki, Takashi Saito, Takaomi C Saido, Shigeo Murayama, Teikichi Ikura, Nobutoshi Ito, Yu Yamamori, Kentaro Tomii, Marco Emilio Bianchi, Hitoshi Okazawa
HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer's disease pathology. Communications biology 4 (1) (2021)
Naoto Watamura, Naomasa Kakiya, Per Nilsson, Satoshi Tsubuki, Naoko Kamano, Mika Takahashi, Shoko Hashimoto, Hiroki Sasaguri, Takashi Saito, Takaomi C Saido
Somatostatin-evoked Aβ catabolism in the brain: Mechanistic involvement of α-endosulfine-KATP channel pathway. Molecular psychiatry (2021)
Sakura Eri B Maezono, Mika Kanuka, Chika Tatsuzawa, Miho Morita, Taizo Kawano, Mitsuaki Kashiwagi, Pimpimon Nondhalee, Masanori Sakaguchi, Takashi Saito, Takaomi C Saido, Yu Hayashi
Progressive Changes in Sleep and Its Relations to Amyloid-β Distribution and Learning in Single App Knock-In Mice. eNeuro 7 (2) (2020)
Shoko Hashimoto, Takaomi C Saido
Critical review: involvement of endoplasmic reticulum stress in the aetiology of Alzheimer's disease. Open biology 8 (4) (2019)
Yasufumi Sakakibara, Michiko Sekiya, Takashi Saito, Takaomi C Saido, Koichi M Iijima
Amyloid-β plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer's disease. BMC neuroscience 20 (1) (2019)
Ross Nortley, Nils Korte, Pablo Izquierdo, Chanawee Hirunpattarasilp, Anusha Mishra, Zane T Jaunmuktane, Vasiliki Kyrargyri, Thomas Pfeiffer, Lila Khennouf, Christian Madry, Hui Gong, Angela Richard-Loendt, Wenhui Huang, Takashi Saito, Takaomi C Saido, Sebastian Brandner, Huma Sethi, David Attwell
Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes. Science (New York, N.Y.) 365 (6450) (2019)
Shoko Hashimoto, Yukio Matsuba, Naoko Kamano, Naomi Mihira, Naruhiko Sahara, Jiro Takano, Shin-Ichi Muramatsu, Takaomi C Saido, Takashi Saito
Tau binding protein CAPON induces tau aggregation and neurodegeneration. Nature communications 10 (1) (2019)
Yong U Liu, Aiwu Cheng, Yu-Jiao Li, Ying Yang, Yuki Kishimoto, Shi Zhang, Yue Wang, Ruiqian Wan, Sophia M Raefsky, Daoyuan Lu, Takashi Saito, Takaomi C Saido, Jian Zhu, Long Jun Wu, Mark P Mattson
SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice. Nature communications 10 (1) (2019)
Shoko Hashimoto, Yukio Matsuba, Naoko Kamano, Naomi Mihira, Naruhiko Sahara, Jiro Takano, Shin-Ichi Muramatsu, Takaomi C Saido, Takashi Saito
Author Correction: Tau binding protein CAPON induces tau aggregation and neurodegeneration. Nature communications 10 (1) (2019)
Kiwami Kidana, Takuya Tatebe, Kaori Ito, Norikazu Hara, Akiyoshi Kakita, Takashi Saito, Sho Takatori, Yasuyoshi Ouchi, Takeshi Ikeuchi, Mitsuhiro Makino, Takaomi C Saido, Masahiro Akishita, Takeshi Iwatsubo, Yukiko Hori, Taisuke Tomita
Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice. EMBO molecular medicine 10 (3) (2019)
Kenichi Nagata, Mika Takahashi, Yukio Matsuba, Fumi Okuyama-Uchimura, Kaori Sato, Shoko Hashimoto, Takashi Saito, Takaomi C Saido
Generation of App knock-in mice reveals deletion mutations protective against Alzheimer's disease-like pathology. Nature communications 9 (1) (2018)
Shoko Hashimoto, Ayano Ishii, Naoko Kamano, Naoto Watamura, Takashi Saito, Toshio Ohshima, Makoto Yokosuka, Takaomi C Saido
Endoplasmic reticulum stress responses in mouse models of Alzheimer's disease: Overexpression paradigm versus knockin paradigm. The Journal of biological chemistry 293 (9) (2018)
Takashi Saito, Takaomi C Saido
Neuroinflammation in mouse models of Alzheimer's disease. Clinical & experimental neuroimmunology 9 (4) (2018)
Lingxuan Chen, Takashi Saito, Takaomi C Saido, Istvan Mody
Novel Quantitative Analyses of Spontaneous Synaptic Events in Cortical Pyramidal Cells Reveal Subtle Parvalbumin-Expressing Interneuron Dysfunction in a Knock-In Mouse Model of Alzheimer's Disease. eNeuro 5 (4) (2018)
Hiroki Sasaguri, Kenichi Nagata, Misaki Sekiguchi, Ryo Fujioka, Yukio Matsuba, Shoko Hashimoto, Kaori Sato, Deepika Kurup, Takanori Yokota, Takaomi C Saido
Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID. Nature communications 9 (1) (2018)
Hikari Tanaka, Kanoh Kondo, Xigui Chen, Hidenori Homma, Kazuhiko Tagawa, Aurelien Kerever, Shigeki Aoki, Takashi Saito, Takaomi C Saido, Shin-Ichi Muramatsu, Kyota Fujita, Hitoshi Okazawa
The intellectual disability gene PQBP1 rescues Alzheimer's disease pathology. Molecular psychiatry 23 (10) (2018)
Disha Shah, Amira Latif-Hernandez, Bart De Strooper, Takashi Saito, Takaomi C Saido, Marleen Verhoye, Rudi D'Hooge, Annemie Van der Linden
Spatial reversal learning defect coincides with hypersynchronous telencephalic BOLD functional connectivity in APPNL-F/NL-F knock-in mice. Scientific reports 8 (1) (2018)
Rosalind Brown, Alice D Lam, Alfredo Gonzalez-Sulser, Andrew Ying, Mary Jones, Robert Chang-Chih Chou, Makis Tzioras, Crispin Y Jordan, Izabela Jedrasiak-Cape, Anne-Laure Hemonnot-Girard, Maurice Abou Jaoude, Andrew J Cole, Syndey S Cash, Takashi Saito, Takaomi C Saido, Richard R Ribchester, Kevan Hashemi, Iris Oren
Circadian and Brain State Modulation of Network Hyperexcitability in Alzheimer's Disease. eNeuro 5 (2) (2018)
Takashi Saito, Yukio Matsuba, Naomi Yamazaki, Shoko Hashimoto, Takaomi C Saido
Calpain Activation in Alzheimer's Model Mice Is an Artifact of APP and Presenilin Overexpression. The Journal of neuroscience : the official journal of the Society for Neuroscience 36 (38) (2017)
Hiroki Sasaguri, Per Nilsson, Shoko Hashimoto, Kenichi Nagata, Takashi Saito, Bart De Strooper, John A Hardy, Robert Vassar, Bengt Winblad, Takaomi C Saido
APP mouse models for Alzheimer's disease preclinical studies. The EMBO journal 36 (17) (2017)

Takaomi C Saido.css-eqlu8i{font-size:small;padding-left:4px;} (Takaomi Saido)

Publication Activity (10 Years)

Top Topics

Top Venues

Takaomi C Saido (Takaomi Saido)