Christopher D Scharer (Chris Scharer)

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 55

Top Venues

Journal of immunology (Baltimore, Md. : 1950)

Nature communications

Science signaling

ImmunoHorizons

Emory University

Emory University (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Emory University

United States

Assistant Professor :: Microbiology and Immunology

Education History

Emory University

United States

PHD

Publications

Daniel T McManus, Rajesh M Valanparambil, Christopher B Medina, Yinghong Hu, Christopher D Scharer, Ewelina Sobierajska, Daniel Y Chang, Andreas Wieland, Judong Lee, Tahseen H Nasti, Masao Hashimoto, James L Ross, Nataliya Prokhnevska, Maria Andrea Cardenas, Amanda L Gill, Elisa C Clark, Kathleen Abadie, Hao Yuan Kueh, Jonathan Kaye, Byron B Au-Yeung, Haydn T Kissick, Rajesh M Valanparambil
Early generation of a precursor CD8 T cell that can adapt to acute or chronic viral infection. Research square (2024)
Sarah A Weiss, Amy Y Huang, Megan E Fung, Daniela Martinez, Alex C Y Chen, Thomas J LaSalle, Brian C Miller, Christopher D Scharer, Mudra Hegde, Thao H Nguyen, Jared H Rowe, Jossef F Osborn, Dillon G Patterson, Natalia Sifnugel, C Mei-An Nolan, Richard A Davidson, Marc Andre Schwartz, Alexander P R Bally, Dennis K Neeld, Martin W LaFleur, Jeremy M Boss, John G Doench, W Nicholas Haining, Arlene H Sharpe, Debattama R Sen
Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control. Nature immunology (2024)
Weirong Chen, So-Hee Hong, Scott A Jenks, Fabliha A Anam, Christopher M Tipton, Matthew C Woodruff, Jennifer R Hom, Kevin S Cashman, Caterina Elisa Faliti, Xiaoqian Wang, Shuya Kyu, Chungwen Wei, Christopher D Scharer, Tian Mi, Sakeenah Hicks, Louise Hartson, Doan C Nguyen, Arezou Khosroshahi, Saeyun Lee, Youliang Wang, Regina Bugrovsky, Yusho Ishii, Frances Eun-Hyung Lee, Ignacio Sanz
Distinct transcriptomes and autocrine cytokines underpin maturation and survival of antibody-secreting cells in systemic lupus erythematosus. Nature communications 15 (1) (2024)
Weirong Chen, So-Hee Hong, Scott A Jenks, Fabliha A Anam, Christopher M Tipton, Matthew C Woodruff, Jennifer R Hom, Kevin S Cashman, Caterina Elisa Faliti, Xiaoqian Wang, Shuya Kyu, Chungwen Wei, Christopher D Scharer, Tian Mi, Sakeenah Hicks, Louise Hartson, Doan C Nguyen, Arezou Khosroshahi, Saeyun Lee, Youliang Wang, Regina Bugrovsky, Yusho Ishii, Frances Eun-Hyung Lee, Ignacio Sanz
Distinct transcriptomes and autocrine cytokines underpin maturation and survival of antibody-secreting cells in systemic lupus erythematosus. Nature communications 15 (1) (2024)
Joel Eggert, Wendy M Zinzow-Kramer, Yuesong Hu, Elizabeth Motunrayo Kolawole, Yuan-Li Tsai, Arthur Weiss, Brian D Evavold, Khalid Salaita, Christopher D Scharer, Byron B Au-Yeung
Cbl-b mitigates the responsiveness of naive CD8 + T cells that experience extensive tonic T cell receptor signaling. Science signaling 17 (822) (2024)
Joel Eggert, Wendy M Zinzow-Kramer, Yuesong Hu, Elizabeth Motunrayo Kolawole, Yuan-Li Tsai, Arthur Weiss, Brian D Evavold, Khalid Salaita, Christopher D Scharer, Byron B Au-Yeung
Cbl-b mitigates the responsiveness of naive CD8 + T cells that experience extensive tonic T cell receptor signaling. Science signaling 17 (822) (2024)
Joel Eggert, Wendy M Zinzow-Kramer, Yuesong Hu, Elizabeth Motunrayo Kolawole, Yuan-Li Tsai, Arthur Weiss, Brian D Evavold, Khalid Salaita, Christopher D Scharer, Byron B Au-Yeung
Cbl-b mitigates the responsiveness of naive CD8 + T cells that experience extensive tonic T cell receptor signaling. Science signaling 17 (822) (2024)
Rajesh M Valanparambil, Daniel McManus, Rajesh Valanparambil, Christopher Medina, Yinghong Hu, Christopher D Scharer, Ewelina Sobierajska, Daniel Y Chang, Andreas Wieland, Judong Lee, Tahseen Nasti, Masao Hashimoto, James Ross, Nataliya Prokhnevska, Maria Andrea Cardenas, Amanda L Gill, Elisa C Clark, Kathleen Abadie, Hao Yuan Kueh, Jonathan Kaye, Byron Au-Yeung, Haydn T Kissick
Early generation of a precursor CD8 T cell that can adapt to acute or chronic viral infection. Research square (2024)
Joel Eggert, Wendy M Zinzow-Kramer, Yuesong Hu, Elizabeth Motunrayo Kolawole, Yuan-Li Tsai, Arthur Weiss, Brian D Evavold, Khalid Salaita, Christopher D Scharer, Byron B Au-Yeung
Cbl-b mitigates the responsiveness of naive CD8 + T cells that experience extensive tonic T cell receptor signaling. Science signaling 17 (822) (2024)
Joel Eggert, Wendy M Zinzow-Kramer, Yuesong Hu, Elizabeth Motunrayo Kolawole, Yuan-Li Tsai, Arthur Weiss, Brian D Evavold, Khalid Salaita, Christopher D Scharer, Byron B Au-Yeung
Cbl-b mitigates the responsiveness of naive CD8 + T cells that experience extensive tonic T cell receptor signaling. Science signaling 17 (822) (2024)
Joel Eggert, Wendy M Zinzow-Kramer, Yuesong Hu, Elizabeth Motunrayo Kolawole, Yuan-Li Tsai, Arthur Weiss, Brian D Evavold, Khalid Salaita, Christopher D Scharer, Byron B Au-Yeung
Cbl-b mitigates the responsiveness of naive CD8 + T cells that experience extensive tonic T cell receptor signaling. Science signaling 17 (822) (2024)
Joel Eggert, Wendy M Zinzow-Kramer, Yuesong Hu, Elizabeth Motunrayo Kolawole, Yuan-Li Tsai, Arthur Weiss, Brian D Evavold, Khalid Salaita, Christopher D Scharer, Byron B Au-Yeung
Cbl-b mitigates the responsiveness of naive CD8 + T cells that experience extensive tonic T cell receptor signaling. Science signaling 17 (822) (2024)
Weirong Chen, So-Hee Hong, Scott A Jenks, Fabliha A Anam, Christopher M Tipton, Matthew C Woodruff, Jennifer R Hom, Kevin S Cashman, Caterina Elisa Faliti, Xiaoqian Wang, Shuya Kyu, Chungwen Wei, Christopher D Scharer, Tian Mi, Sakeenah Hicks, Louise Hartson, Doan C Nguyen, Arezou Khosroshahi, Saeyun Lee, Youliang Wang, Regina Bugrovsky, Yusho Ishii, Frances Eun-Hyung Lee, Ignacio Sanz
Distinct transcriptomes and autocrine cytokines underpin maturation and survival of antibody-secreting cells in systemic lupus erythematosus. Nature communications 15 (1) (2024)
Rajesh M Valanparambil, Daniel McManus, Rajesh Valanparambil, Christopher Medina, Yinghong Hu, Christopher D Scharer, Ewelina Sobierajska, Daniel Y Chang, Andreas Wieland, Judong Lee, Tahseen Nasti, Masao Hashimoto, James Ross, Nataliya Prokhnevska, Maria Andrea Cardenas, Amanda L Gill, Elisa C Clark, Kathleen Abadie, Hao Yuan Kueh, Jonathan Kaye, Byron Au-Yeung, Haydn T Kissick
Early generation of a precursor CD8 T cell that can adapt to acute or chronic viral infection. Research square (2024)
Joel Eggert, Wendy M Zinzow-Kramer, Yuesong Hu, Elizabeth Motunrayo Kolawole, Yuan-Li Tsai, Arthur Weiss, Brian D Evavold, Khalid Salaita, Christopher D Scharer, Byron B Au-Yeung
Cbl-b mitigates the responsiveness of naive CD8 + T cells that experience extensive tonic T cell receptor signaling. Science signaling 17 (822) (2024)
Weirong Chen, So-Hee Hong, Scott A Jenks, Fabliha A Anam, Christopher M Tipton, Matthew C Woodruff, Jennifer R Hom, Kevin S Cashman, Caterina Elisa Faliti, Xiaoqian Wang, Shuya Kyu, Chungwen Wei, Christopher D Scharer, Tian Mi, Sakeenah Hicks, Louise Hartson, Doan C Nguyen, Arezou Khosroshahi, Saeyun Lee, Youliang Wang, Regina Bugrovsky, Yusho Ishii, Frances Eun-Hyung Lee, Ignacio Sanz
Distinct transcriptomes and autocrine cytokines underpin maturation and survival of antibody-secreting cells in systemic lupus erythematosus. Nature communications 15 (1) (2024)
Ignacio Sanz, Weirong Chen, So-Hee Hong, Scott Jenks, Fabliha Anam, Christopher Tipton, Matthew Woodruff, Jennifer Hom, Kevin Cashman, Caterina Faliti, Xiaoqian Wang, Shuya Kyu, Chungwen Wei, Christopher D Scharer, Tian Mi, Sakeenah Hicks, Louise Hartson, Doan C Nguyen, Arezou Khosroshahi, Saeyun Lee, Youliang Wang, Regina Bugrovsky, Yusho Ishii, Frances Eun-Hyung Lee
SLE Antibody-Secreting Cells Are Characterized by Enhanced Peripheral Maturation and Survival Programs. Research square (2023)
Joel Eggert, Wendy M Zinzow-Kramer, Yuesong Hu, Yuan-Li Tsai, Arthur Weiss, Khalid Salaita, Christopher D Scharer, Byron B Au-Yeung
Accumulation of TCR signaling from self-antigens in naive CD8 T cells mitigates early responsiveness. bioRxiv : the preprint server for biology (2023)
Ida E M Uddbäck, Sarah E Michalets, Ananya Saha, Cameron Mattingly, Kirsten N Kost, M Elliott Williams, Laurel A Lawrence, Sakeenah L Hicks, Anice C Lowen, Hasan Ahmed, Allan Randrup Thomsen, Charles J Russell, Christopher D Scharer, Jeremy M Boss, Katia Koelle, Morie A Gertz, Jan Pravsgaard Christensen, Jacob E Kohlmeier
Prevention of respiratory virus transmission by resident memory CD8 + T cells. Nature (2023)
Michael D Powell, Peiyuan Lu, Dennis K Neeld, Anna K Kania, Lou-Ella M M George-Alexander, Alexander P R Bally, Christopher D Scharer, Jeremy M Boss
IL-6/STAT3 Signaling Axis Enhances and Prolongs Pdcd1 Expression in Murine CD8 T Cells. ImmunoHorizons 6 (12) (2023)
Joel Eggert, Wendy M Zinzow-Kramer, Yuesong Hu, Yuan-Li Tsai, Arthur Weiss, Khalid Salaita, Christopher D Scharer, Byron B Au-Yeung
Accumulation of TCR signaling from self-antigens in naive CD8 T cells mitigates early responsiveness. bioRxiv : the preprint server for biology (2023)
James R Rose, Bagdeser Akdogan-Ozdilek, Andrew R Rahmberg, Michael D Powell, Sakeenah L Hicks, Christopher D Scharer, Jeremy M Boss
Distinct transcriptomic and epigenomic modalities underpin human memory T cell subsets and their activation potential. Communications biology 6 (1) (2023)
Michael D Powell, Peiyuan Lu, Dennis K Neeld, Anna K Kania, Lou-Ella M M George-Alexander, Alexander P R Bally, Christopher D Scharer, Jeremy M Boss
IL-6/STAT3 Signaling Axis Enhances and Prolongs Pdcd1 Expression in Murine CD8 T Cells. ImmunoHorizons 6 (12) (2023)
Joel Eggert, Wendy M Zinzow-Kramer, Yuesong Hu, Yuan-Li Tsai, Arthur Weiss, Khalid Salaita, Christopher D Scharer, Byron B Au-Yeung
Accumulation of TCR signaling from self-antigens in naive CD8 T cells mitigates early responsiveness. bioRxiv : the preprint server for biology (2023)
Miyoung Lee, Jamie A G Hamilton, Ganesh R Talekar, Anthony J Ross, Langston Michael, Manali Rupji, Bhakti Dwivedi, Sunil S Raikar, Jeremy M Boss, Christopher D Scharer, Douglas K Graham, Deborah DeRyckere, Christopher C Porter, Curtis J Henry
Obesity-induced galectin-9 is a therapeutic target in B-cell acute lymphoblastic leukemia. Nature communications 13 (1) (2022)
Anna K Kania, Madeline J Price, Lou-Ella George-Alexander, Dillon G Patterson, Sakeenah L Hicks, Christopher D Scharer, Jeremy M Boss
H3K27me3 Demethylase UTX Restrains Plasma Cell Formation. Journal of immunology (Baltimore, Md. : 1950) 208 (8) (2022)
Masao Hashimoto, Koichi Araki, Maria Andrea Cardenas, Peng Li, Rohit R Jadhav, Haydn T Kissick, William H Hudson, Donald J McGuire, Rebecca C Obeng, Andreas Wieland, Judong Lee, Daniel T McManus, James L Ross, Se Jin Im, Junghwa Lee, Jian-Xin Lin, Bin Hu, Erin E West, Christopher D Scharer, Gordon J Freeman, Arlene H Sharpe, Suresh R Ramalingam, Alex Pellerin, Volker Teichgräber, William J Greenleaf, Christiane Neumann, Jorg J Goronzy, Pablo Umaña, Warren J Leonard, Kendall A Smith, Rajesh M Valanparambil
PD-1 combination therapy with IL-2 modifies CD8 + T cell exhaustion program. Nature 610 (7930) (2022)
Michael D Powell, Peiyuan Lu, Dennis K Neeld, Anna K Kania, Lou-Ella M M George-Alexander, Alexander P R Bally, Christopher D Scharer, Jeremy M Boss
IL-6/STAT3 Signaling Axis Enhances and Prolongs Pdcd1 Expression in Murine CD8 T Cells. ImmunoHorizons 6 (12) (2022)
Michael D Powell, Peiyuan Lu, Dennis K Neeld, Anna K Kania, Lou-Ella M M George-Alexander, Alexander P R Bally, Christopher D Scharer, Jeremy M Boss
IL-6/STAT3 Signaling Axis Enhances and Prolongs Pdcd1 Expression in Murine CD8 T Cells. ImmunoHorizons 6 (12) (2022)
Wendy M Zinzow-Kramer, Elizabeth Motunrayo Kolawole, Joel Eggert, Brian D Evavold, Christopher D Scharer, Byron B Au-Yeung
Strong Basal/Tonic TCR Signals Are Associated with Negative Regulation of Naive CD4<sup>+</sup> T Cells. ImmunoHorizons 6 (9) (2022)
Mingyong Liu, Dmytro Starenki, Christopher D Scharer, Aaron Silva-Sanchez, Patrick A Molina, Jennifer S Pollock, Sara J Cooper, Rebecca C Arend, Alexander F Rosenberg, Troy D Randall, Selene Meza-Perez
Circulating Tregs Accumulate in Omental Tumors and Acquire Adipose-Resident Features. Cancer immunology research 10 (5) (2022)
Gordon A Dale, Daniel J Wilkins, M Jordan Rowley, Christopher D Scharer, Christopher M Tipton, Jennifer Hom, Jeremy M Boss, Victor G Corces, Ignacio Sanz, Joshy Jacob
Somatic Diversification of Rearranged Antibody Gene Segments by Intra- and Interchromosomal Templated Mutagenesis. Journal of immunology (Baltimore, Md. : 1950) 208 (9) (2022)
Jenna L Lobby, Ida E M Uddbäck, Christopher D Scharer, Tian Mi, Jeremy M Boss, Allan Randrup Thomsen, Jan Pravsgaard Christensen, Jacob E Kohlmeier
Persistent Antigen Harbored by Alveolar Macrophages Enhances the Maintenance of Lung-Resident Memory CD8 + T Cells. Journal of immunology (Baltimore, Md. : 1950) 209 (9) (2022)
Parimal Majumder, Joshua T Lee, Benjamin G Barwick, Dillon G Patterson, Alexander P R Bally, Christopher D Scharer, Jeremy M Boss
The Murine MHC Class II Super Enhancer IA/IE-SE Contains a Functionally Redundant CTCF-Binding Component and a Novel Element Critical for Maximal Expression. Journal of immunology (Baltimore, Md. : 1950) 206 (9) (2021)
Anna K Kania, Muyao Guo, Christopher D Scharer, Jeremy M Boss
Inhibition of H3K27me3 Demethylases Promotes Plasmablast Formation. ImmunoHorizons 5 (12) (2021)
Dillon G Patterson, Anna K Kania, Madeline J Price, James R Rose, Christopher D Scharer, Jeremy M Boss
An IRF4-MYC-mTORC1 Integrated Pathway Controls Cell Growth and the Proliferative Capacity of Activated B Cells during B Cell Differentiation In Vivo. Journal of immunology (Baltimore, Md. : 1950) 207 (7) (2021)
Dillon G Patterson, Anna K Kania, Zhihong Zuo, Christopher D Scharer, Jeremy M Boss
Epigenetic gene regulation in plasma cells. Immunological reviews 303 (1) (2021)
Andrea Di Pietro, Jack Polmear, Lucy Cooper, Timon Damelang, Tabinda Hussain, Lauren Hailes, Kristy O'Donnell, Vibha Udupa, Tian Mi, Simon P Preston, Areen Shtewe, Uri Hershberg, Stephen J Turner, Nicole L La Gruta, Amy W Chung, David Mathew Tarlinton, Christopher D Scharer, Kim L Good-Jacobson
Targeting BMI-1 in B cells restores effective humoral immune responses and controls chronic viral infection. Nature immunology (2021)
Madeline J Price, Christopher D Scharer, Anna K Kania, Troy D Randall, Jeremy M Boss
Conserved Epigenetic Programming and Enhanced Heme Metabolism Drive Memory B Cell Reactivation. Journal of immunology (Baltimore, Md. : 1950) 206 (7) (2021)
Chester J Joyner, Ariel M Ley, Doan C Nguyen, Mohammad Ali, Alessia Corrado, Christopher Tipton, Christopher D Scharer, Tian Mi, Matthew C Woodruff, Jennifer Hom, Jeremy M Boss, Meixue Duan, Greg Gibson, Danielle Roberts, Joel Andrews, Sagar Lonial, Inaki Sanz, Frances Eun-Hyung Lee
Generation of human long-lived plasma cells by developmentally regulated epigenetic imprinting. Life science alliance 5 (3) (2021)
Christopher D Scharer, Dillon G Patterson, Tian Mi, Madeline J Price, Sakeenah L Hicks, Jeremy M Boss
Antibody-secreting cell destiny emerges during the initial stages of B-cell activation. Nature communications 11 (1) (2020)
Sarah L Hayward, Christopher D Scharer, Emily K Cartwright, Shiki Takamura, Zheng-Rong Tiger Li, Jeremy M Boss, Jacob E Kohlmeier
Environmental cues regulate epigenetic reprogramming of airway-resident memory CD8+ T cells. Nature immunology 21 (3) (2020)
Keenan J Wiggins, Christopher D Scharer
Roadmap to a plasma cell: Epigenetic and transcriptional cues that guide B cell differentiation. Immunological reviews 300 (1) (2020)
Christopher M Collins, Christopher D Scharer, Thomas J Murphy, Jeremy M Boss, Samuel H Speck
Murine gammaherpesvirus infection is skewed toward Igλ+ B cells expressing a specific heavy chain V-segment. PLoS pathogens 16 (4) (2020)
Christopher D Scharer, Karen A Fortner, Julie A Dragon, Scott Tighe, Jeremy M Boss, Ralph C Budd
Selective DNA Demethylation Accompanies T Cell Homeostatic Proliferation and Gene Regulation in Lupus-Prone lpr Mice. ImmunoHorizons 4 (10) (2020)
Katherine E Squires, Kyle J Gerber, Matthew C Tillman, Daniel J Lustberg, Carolina Montañez-Miranda, Meilan Zhao, Suneela Ramineni, Christopher D Scharer, Ramendra N Saha, Feng-Jue Shu, Jason P Schroeder, Eric A Ortlund, David Weinshenker, Serena M Dudek, John R Hepler
Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons. The Journal of biological chemistry (2020)
Esther Zumaquero, Sara Lynn Stone, Christopher D Scharer, Scott A Jenks, Anoma Nellore, Betty Mousseau, Antonio Rosal-Vela, Davide Botta, John E Bradley, Wojciech Wojciechowski, Travis Ptacek, Maria I Danila, Jeffrey C Edberg, S Louis Bridges, Robert P Kimberly, W Winn Chatham, Trenton R Schoeb, Alexander F Rosenberg, Jeremy M Boss, Ignacio Sanz, Frances E Lund
IFNγ induces epigenetic programming of human T-bethi B cells and promotes TLR7/8 and IL-21 induced differentiation. eLife 8 (2019)
Robert R Haines, Christopher D Scharer, Jenna L Lobby, Jeremy M Boss
LSD1 Cooperates with Noncanonical NF-κB Signaling to Regulate Marginal Zone B Cell Development. Journal of immunology (Baltimore, Md. : 1950) 203 (7) (2019)
Madeline J Price, Sakeenah L Hicks, John E Bradley, Troy D Randall, Jeremy M Boss, Christopher D Scharer
IgM, IgG, and IgA Influenza-Specific Plasma Cells Express Divergent Transcriptomes. Journal of immunology (Baltimore, Md. : 1950) 203 (8) (2019)
Christopher D Scharer, Emily L Blalock, Tian Mi, Benjamin G Barwick, Scott A Jenks, Tsuneo Deguchi, Kevin S Cashman, Bridget E Neary, Dillon G Patterson, Sakeenah L Hicks, Arezou Khosroshahi, F Eun-Hyung Lee, Chungwen Wei, Iñaki Sanz, Jeremy M Boss
Epigenetic programming underpins B cell dysfunction in human SLE. Nature immunology 20 (8) (2019)
Christopher D Scharer, Benjamin G Barwick, Muyao Guo, Alexander P R Bally, Jeremy M Boss
Plasma cell differentiation is controlled by multiple cell division-coupled epigenetic programs. Nature communications 9 (1) (2018)
Robert R Haines, Benjamin G Barwick, Christopher D Scharer, Parimal Majumder, Troy D Randall, Jeremy M Boss
The Histone Demethylase LSD1 Regulates B Cell Proliferation and Plasmablast Differentiation. Journal of immunology (Baltimore, Md. : 1950) 201 (9) (2018)
Benjamin G Barwick, Christopher D Scharer, Ryan J Martinez, Madeline J Price, Alexander N Wein, Robert R Haines, Alexander P R Bally, Jacob E Kohlmeier, Jeremy M Boss
B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation. Nature communications 9 (1) (2018)
Christopher D Scharer, Alexander P R Bally, Bhanu Gandham, Jeremy M Boss
Cutting Edge: Chromatin Accessibility Programs CD8 T Cell Memory. Journal of immunology (Baltimore, Md. : 1950) 198 (6) (2017)
Muyao Guo, Madeline J Price, Dillon G Patterson, Benjamin G Barwick, Robert R Haines, Anna K Kania, John E Bradley, Troy D Randall, Jeremy M Boss, Christopher D Scharer
EZH2 Represses the B Cell Transcriptional Program and Regulates Antibody-Secreting Cell Metabolism and Antibody Production. Journal of immunology (Baltimore, Md. : 1950) 200 (3) (2017)

Christopher D Scharer.css-eqlu8i{font-size:small;padding-left:4px;} (Chris Scharer)

Publication Activity (10 Years)

Top Topics

Top Venues

Christopher D Scharer (Chris Scharer)