Warren J Leonard

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 37

Top Topics

Transcription Factor

Immune Response

Cell Proliferation

Top Venues

Nature communications

Proceedings of the National Academy of Sciences of the United States of America

This page only lists publications with an associated author ORCID identifier.

Publications

Jian-Xin Lin, Meili Ge, Cheng-Yu Liu, Ronald Holewinski, Thorkell Andresson, Zu-Xi Yu, Tesfay Gebregiorgis, Rosanne Spolski, Peng Li, Warren J Leonard
Tyrosine phosphorylation of both STAT5A and STAT5B is necessary for maximal IL-2 signaling and T cell proliferation. Nature communications 15 (1) (2024)
Warren J Leonard, Jian-Xin Lin
Publisher Correction: Strategies to therapeutically modulate cytokine action. Nature reviews. Drug discovery (2024)
Roland C Schelker, Jessica Fioravanti, Fabio Mastrogiovanni, Jeremy G Baldwin, Nisha Rana, Peng Li, Ping Chen, Timea Vadász, Rosanne Spolski, Christoph Heuser, Dragana Slavkovic-Lukic, Pedro Noronha, Giuseppe Damiano, Laura Raccosta, Daniela Maggioni, Sree Pullugula, Jian-Xin Lin, Jangsuk Oh, Patrick Grandinetti, Mario Lecce, Leo Hesse, Emilia Kocks, Azucena Martín-Santos, Claudia Gebhard, William G Telford, Yun Ji, Nicholas P Restifo, Vincenzo Russo, Michael Rehli, Wolfgang Herr, Warren J Leonard, Luca Gattinoni
LIM-domain-only 4 (LMO4) enhances CD8 + T-cell stemness and tumor rejection by boosting IL-21-STAT3 signaling. Signal transduction and targeted therapy 9 (1) (2024)
Roland C Schelker, Jessica Fioravanti, Fabio Mastrogiovanni, Jeremy G Baldwin, Nisha Rana, Peng Li, Ping Chen, Timea Vadász, Rosanne Spolski, Christoph Heuser, Dragana Slavkovic-Lukic, Pedro Noronha, Giuseppe Damiano, Laura Raccosta, Daniela Maggioni, Sree Pullugula, Jian-Xin Lin, Jangsuk Oh, Patrick Grandinetti, Mario Lecce, Leo Hesse, Emilia Kocks, Azucena Martín-Santos, Claudia Gebhard, William G Telford, Yun Ji, Nicholas P Restifo, Vincenzo Russo, Michael Rehli, Wolfgang Herr, Warren J Leonard, Luca Gattinoni
LIM-domain-only 4 (LMO4) enhances CD8 + T-cell stemness and tumor rejection by boosting IL-21-STAT3 signaling. Signal transduction and targeted therapy 9 (1) (2024)
Roland C Schelker, Jessica Fioravanti, Fabio Mastrogiovanni, Jeremy G Baldwin, Nisha Rana, Peng Li, Ping Chen, Timea Vadász, Rosanne Spolski, Christoph Heuser, Dragana Slavkovic-Lukic, Pedro Noronha, Giuseppe Damiano, Laura Raccosta, Daniela Maggioni, Sree Pullugula, Jian-Xin Lin, Jangsuk Oh, Patrick Grandinetti, Mario Lecce, Leo Hesse, Emilia Kocks, Azucena Martín-Santos, Claudia Gebhard, William G Telford, Yun Ji, Nicholas P Restifo, Vincenzo Russo, Michael Rehli, Wolfgang Herr, Warren J Leonard, Luca Gattinoni
LIM-domain-only 4 (LMO4) enhances CD8 + T-cell stemness and tumor rejection by boosting IL-21-STAT3 signaling. Signal transduction and targeted therapy 9 (1) (2024)
Jian-Xin Lin, Meili Ge, Cheng-Yu Liu, Ronald Holewinski, Thorkell Andresson, Zu-Xi Yu, Tesfay Gebregiorgis, Rosanne Spolski, Peng Li, Warren J Leonard
Tyrosine phosphorylation of both STAT5A and STAT5B is necessary for maximal IL-2 signaling and T cell proliferation. Nature communications 15 (1) (2024)
Jian-Xin Lin, Meili Ge, Cheng-Yu Liu, Ronald Holewinski, Thorkell Andresson, Zu-Xi Yu, Tesfay Gebregiorgis, Rosanne Spolski, Peng Li, Warren J Leonard
Tyrosine phosphorylation of both STAT5A and STAT5B is necessary for maximal IL-2 signaling and T cell proliferation. Nature communications 15 (1) (2024)
Jian-Xin Lin, Meili Ge, Cheng-Yu Liu, Ronald Holewinski, Thorkell Andresson, Zu-Xi Yu, Tesfay Gebregiorgis, Rosanne Spolski, Peng Li, Warren J Leonard
Tyrosine phosphorylation of both STAT5A and STAT5B is necessary for maximal IL-2 signaling and T cell proliferation. Nature communications 15 (1) (2024)
Haoxi Chai, Harianto Tjong, Peng Li, Wei Liao, Ping Wang, Chee Hong Wong, Chew Yee Ngan, Warren J Leonard, Chia-Lin Wei, Yijun Ruan
ChIATAC is an efficient strategy for multi-omics mapping of 3D epigenomes from low-cell inputs. Nature communications 14 (1) (2023)
Haoxi Chai, Harianto Tjong, Peng Li, Wei Liao, Ping Wang, Chee Hong Wong, Chew Yee Ngan, Warren J Leonard, Chia-Lin Wei, Yijun Ruan
ChIATAC is an efficient strategy for multi-omics mapping of 3D epigenomes from low-cell inputs. Nature communications 14 (1) (2023)
Haoxi Chai, Harianto Tjong, Peng Li, Wei Liao, Ping Wang, Chee Hong Wong, Chew Yee Ngan, Warren J Leonard, Chia-Lin Wei, Yijun Ruan
ChIATAC is an efficient strategy for multi-omics mapping of 3D epigenomes from low-cell inputs. Nature communications 14 (1) (2023)
Haoxi Chai, Harianto Tjong, Peng Li, Wei Liao, Ping Wang, Chee Hong Wong, Chew Yee Ngan, Warren J Leonard, Chia-Lin Wei, Yijun Ruan
ChIATAC is an efficient strategy for multi-omics mapping of 3D epigenomes from low-cell inputs. Nature communications 14 (1) (2023)
Haoxi Chai, Harianto Tjong, Peng Li, Wei Liao, Ping Wang, Chee Hong Wong, Chew Yee Ngan, Warren J Leonard, Chia-Lin Wei, Yijun Ruan
ChIATAC is an efficient strategy for multi-omics mapping of 3D epigenomes from low-cell inputs. Nature communications 14 (1) (2023)
Yuanyuan Gao, Yan Wang, Daniel Chauss, Alejandro V Villarino, Verena M Link, Hiroyuki Nagashima, Camille A Spinner, Vishal N Koparde, Nicolas Bouladoux, Michael S Abers, Timothy J Break, Laura B Chopp, Jung-Hyun Park, Jinfang Zhu, David L Wiest, Warren J Leonard, Michail S Lionakis, John J O'Shea, Behdad Afzali, Yasmine Belkaid, Vanja Lazarevic
Transcription factor EGR2 controls homing and pathogenicity of T H 17 cells in the central nervous system. Nature immunology (2023)
Seth J Welsh, Benjamin G Barwick, Erin W Meermeier, Daniel L Riggs, Chang-Xin Shi, Yuan Xiao Zhu, Meaghen E Sharik, Megan T Du, Leslie D Abrego Rocha, Victoria M Garbitt, Caleb K Stein, Joachim L Petit, Nathalie Meurice, Yuliza Tafoya Alvarado, Rodrigo Fonseca, Kennedi T Todd, Sochilt Brown, Zachary J Hammond, Nicklus H Cuc, Courtney Wittenberg, Camille Herzog, Anna V Roschke, Yulia N Demchenko, Wei-Dong D Chen, Peng Li, Wei Liao, Warren J Leonard, Sagar Lonial, Nizar J Bahlis, Paola Neri, Lawrence H Boise, Marta Chesi, Peter Leif Bergsagel
Transcriptional heterogeneity overcomes super-enhancer disrupting drug combinations in multiple myeloma. Blood cancer discovery (2023)
Risa Ebina-Shibuya, Warren J Leonard
TSLP-targeting therapy: Beyond allergy? Clinical and translational medicine 13 (5) (2023)
Warren J Leonard, Jian-Xin Lin
Strategies to therapeutically modulate cytokine action. Nature reviews. Drug discovery (2023)
Haoxi Chai, Harianto Tjong, Peng Li, Wei Liao, Ping Wang, Chee Hong Wong, Chew Yee Ngan, Warren J Leonard, Chia-Lin Wei, Yijun Ruan
ChIATAC is an efficient strategy for multi-omics mapping of 3D epigenomes from low-cell inputs. Nature communications 14 (1) (2023)
Risa Ebina-Shibuya, Warren J Leonard
TSLP-targeting therapy: Beyond allergy? Clinical and translational medicine 13 (5) (2023)
Rosanne Spolski, Peng Li, Vivek Chandra, Boyoung Shin, Shubham Goel, Keiko Sakamoto, Chengyu Liu, Jangsuk Oh, Min Ren, Yutaka Enomoto, Erin E West, Stephen M Christensen, Edwin C K Wan, Meili Ge, Jian-Xin Lin, Bingyu Yan, Majid Kazemian, Zu-Xi Yu, Keisuke Nagao, Pandurangan Vijayanand, Ellen V Rothenberg, Warren J Leonard
Distinct use of super-enhancer elements controls cell type-specific CD25 transcription and function. Science immunology 8 (89) (2023)
Risa Ebina-Shibuya, Warren J Leonard
Role of thymic stromal lymphopoietin in allergy and beyond. Nature reviews. Immunology (2022)
Masao Hashimoto, Koichi Araki, Maria Andrea Cardenas, Peng Li, Rohit R Jadhav, Haydn T Kissick, William H Hudson, Donald J McGuire, Rebecca C Obeng, Andreas Wieland, Judong Lee, Daniel T McManus, James L Ross, Se Jin Im, Junghwa Lee, Jian-Xin Lin, Bin Hu, Erin E West, Christopher D Scharer, Gordon J Freeman, Arlene H Sharpe, Suresh R Ramalingam, Alex Pellerin, Volker Teichgräber, William J Greenleaf, Christiane Neumann, Jorg J Goronzy, Pablo Umaña, Warren J Leonard, Kendall A Smith, Rajesh M Valanparambil
PD-1 combination therapy with IL-2 modifies CD8 + T cell exhaustion program. Nature 610 (7930) (2022)
Kelly L Monaghan, Drake Aesoph, Amanda G Ammer, Wen Zheng, Shokofeh Rahimpour, Breanne Y Farris, Camille A Spinner, Peng Li, Jian-Xin Lin, Zu-Xi Yu, Vanja Lazarevic, Gangqing Hu, Warren J Leonard, Edwin C K Wan
Tetramerization of STAT5 promotes autoimmune-mediated neuroinflammation. Proceedings of the National Academy of Sciences of the United States of America 118 (52) (2022)
Anusha Kalbasi, Mikko Siurala, Leon L Su, Mito Tariveranmoshabad, Lora K Picton, Pranali Ravikumar, Peng Li, Jian-Xin Lin, Helena Escuin-Ordinas, Tong Da, Sarah V Kremer, Amy L Sun, María Sofía Castelli, Sangya Agarwal, John Scholler, Decheng Song, Philipp C Rommel, Enrico Radaelli, Regina M Young, Warren J Leonard, Antoni Ribas, Carl H June, K Christopher Garcia
Potentiating adoptive cell therapy using synthetic IL-9 receptors. Nature 607 (7918) (2022)
Katelyn J McCann, Stephen M Christensen, Devon H Colby, Peter J McGuire, Ian A Myles, Christa S Zerbe, Clifton L Dalgard, Gauthaman Sukumar, Warren J Leonard, Beth A McCormick, Steven M Holland
IFNγ regulates NAD+ metabolism to promote the respiratory burst in human monocytes. Blood advances 6 (12) (2022)
Yutaka Enomoto, Peng Li, Lisa M Jenkins, Dimitrios Anastasakis, Gaelyn C Lyons, Markus Hafner, Warren J Leonard
Cytokine-enhanced cytolytic activity of exosomes from NK Cells. Cancer gene therapy (2021)
Risa Ebina-Shibuya, Erin E West, Rosanne Spolski, Peng Li, Jangsuk Oh, Majid Kazemian, Daniel Gromer, Phillip Swanson, Ning Du, Dorian B McGavern, Warren J Leonard
Thymic stromal lymphopoietin limits primary and recall CD8+ T-cell anti-viral responses. eLife 10 (2021)
Caleb R Glassman, Leon L Su, Sonia S Majri-Morrison, Hauke Winkelmann, Fei Mo, Peng Li, Magdiel Pérez-Cruz, Peggy P Ho, Ievgen Koliesnik, Nadine Nagy, Tereza Hnizdilova, Lora K Picton, Marek Kovář, Paul L Bollyky, Lawrence Steinman, Everett Meyer, Jacob Piehler, Warren J Leonard, K Christopher Garcia
Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist. eLife 10 (2021)
Fei Mo, Zhiya Yu, Peng Li, Jangsuk Oh, Rosanne Spolski, Liang Zhao, Caleb R Glassman, Tori N Yamamoto, Yun Chen, Filip M Golebiowski, Dalton Hermans, Sonia Majri-Morrison, Lora K Picton, Wei Liao, Min Ren, Xiaoxuan Zhuang, Suman Mitra, Jian-Xin Lin, Luca Gattinoni, Jonathan D Powell, Nicholas P Restifo, K Christopher Garcia, Warren J Leonard
An engineered IL-2 partial agonist promotes CD8+ T cell stemness. Nature 597 (7877) (2021)
Dalton Hermans, Sanjivan Gautam, Juan Carlos García-Cañaveras, Daniel Gromer, Suman Mitra, Rosanne Spolski, Peng Li, Stephen Christensen, Rosa Nguyen, Jian-Xin Lin, Jangsuk Oh, Ning Du, Sharon Veenbergen, Jessica Fioravanti, Risa Ebina-Shibuya, Christopher K E Bleck, Leonard M Neckers, Joshua D Rabinowitz, Luca Gattinoni, Warren J Leonard
Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8+ T cell stemness and antitumor immunity. Proceedings of the National Academy of Sciences of the United States of America 117 (11) (2020)
Vivien Béziat, Juan Li, Jian-Xin Lin, Cindy S Ma, Peng Li, Aziz Bousfiha, Isabelle Pellier, Samaneh Zoghi, Safa Baris, Sevgi Keles, Paul Gray, Ning Du, Yi Wang, Yoann Zerbib, Romain Levy, Thibaut Leclercq, Frédégonde About, Ai Ing Lim, Geetha Rao, Kathryn J Payne, Simon J Pelham, Danielle T Avery, Elissa K Deenick, Bethany Pillay, Janet Chou, Romain Guery, Aziz Belkadi, Antoine Guérin, Mélanie Migaud, Vimel Rattina, Fatima Ailal, Ibtihal Benhsaien, Matthieu Bouaziz, Tanwir Habib, Damien Chaussabel, Nico Marr, Jamel El-Benna, Bodo Grimbacher, Orli Wargon, Jacinta Bustamante, Bertrand Boisson, Ingrid Müller-Fleckenstein, Bernhard Fleckenstein, Marie-Olivia Chandesris, Matthias Titeux, Sylvie Fraitag, Marie-Alexandra Alyanakian, Marianne Leruez-Ville, Capucine Picard, Isabelle Meyts, James P Di Santo, Alain Hovnanian, Ayper Somer, Ahmet Ozen, Nima Rezaei, Talal A Chatila, Laurent Abel, Warren J Leonard, Stuart G Tangye, Anne Puel, Jean Laurent Casanova
A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity. Science immunology 3 (24) (2019)
Rosanne Spolski, Erin E West, Peng Li, Sharon Veenbergen, Sunny Yung, Majid Kazemian, Jangsuk Oh, Zu-Xi Yu, Alexandra F Freeman, Stephen M Holland, Philip M Murphy, Warren J Leonard
IL-21/type I interferon interplay regulates neutrophil-dependent innate immune responses to Staphylococcus aureus. eLife 8 (2019)
Hongsheng Wang, Shweta Jain, Peng Li, Jian-Xin Lin, Jangsuk Oh, Chenfeng Qi, Yuanyuan Gao, Jiafang Sun, Tomomi Sakai, Zohreh Naghashfar, Sadia Abbasi, Alexander L Kovalchuk, Silvia Bolland, Stephen L Nutt, Warren J Leonard, Herbert C Morse
Transcription factors IRF8 and PU.1 are required for follicular B cell development and BCL6-driven germinal center responses. Proceedings of the National Academy of Sciences of the United States of America 116 (19) (2019)
Takahiro Hatayama, Ryosuke Segawa, Natsumi Mizuno, Sumiko Eguchi, Hiroshi Akamatsu, Misaki Fukuda, Fumihisa Nakata, Warren J Leonard, Masahiro Hiratsuka, Noriyasu Hirasawa
All-Trans Retinoic Acid Enhances Antibody Production by Inducing the Expression of Thymic Stromal Lymphopoietin Protein. Journal of immunology (Baltimore, Md. : 1950) 200 (8) (2018)
Yrina Rochman, Krista Dienger-Stambaugh, Phoebe K Richgels, Ian P Lewkowich, Andrey V Kartashov, Artem Barski, Gurjit K Khurana Hershey, Warren J Leonard, Harinder Singh
TSLP signaling in CD4+ T cells programs a pathogenic T helper 2 cell state. Science signaling 11 (521) (2018)
Rosanne Spolski, Daniel Gromer, Warren J Leonard
The γ c family of cytokines: fine-tuning signals from IL-2 and IL-21 in the regulation of the immune response. F1000Research 6 (2017)
Peng Li, Suman Mitra, Rosanne Spolski, Jangsuk Oh, Wei Liao, Zhonghui Tang, Fei Mo, Xingwang Li, Erin E West, Daniel Gromer, Jian-Xin Lin, Chengyu Liu, Yijun Ruan, Warren J Leonard
STAT5-mediated chromatin interactions in superenhancers activate IL-2 highly inducible genes: Functional dissection of the Il2ra gene locus. Proceedings of the National Academy of Sciences of the United States of America 114 (46) (2017)