Christopher R Horne

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2019-2024
Publications (10 Years): 14

Top Venues

Nature communications

Cell death and differentiation

Proteins

Biochemical Society transactions

Walter and Eliza Hall Institute of Medical Research

University of Canterbury (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Walter and Eliza Hall Institute of Medical Research

Australia

Postdoctoral Research Fellow :: Inflammation Division

Education History

University of Canterbury

New Zealand

PHD :: Biological Sciences

Publications

Sarah E Garnish, Christopher R Horne, Yanxiang Meng, Samuel N Young, Annette V Jacobsen, Joanne M Hildebrand, James G Murphy
Inhibitors identify an auxiliary role for mTOR signalling in necroptosis execution downstream of MLKL activation. The Biochemical journal 481 (17) (2024)
Yanxiang Meng, Sarah E Garnish, Katherine A Davies, Katrina A Black, Andrew P Leis, Christopher R Horne, Joanne M Hildebrand, Hanadi Hoblos, Cheree Fitzgibbon, Samuel N Young, Toby Dite, Laura F Dagley, Aarya Venkat, Natarajan Kannan, Akiko Koide, Shohei Koide, Alisa Glukhova, Peter E Czabotar, James G Murphy
Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization. Nature communications 14 (1) (2023)
Sarah E Garnish, Katherine R Martin, Maria Kauppi, Victoria E Jackson, Rebecca Ambrose, Vik Ven Eng, Shene Chiou, Yanxiang Meng, Daniel Frank, Emma C Tovey Crutchfield, Komal M Patel, Annette V Jacobsen, Georgia K Atkin-Smith, Ladina Di Rago, Marcel Doerflinger, Christopher R Horne, Cathrine Hall, Samuel N Young, Matthew C Cook, Vicki Athanasopoulos, Carola G Vinuesa, Kate E Lawlor, Ian P Wicks, Gregor Ebert, Ashley P Ng, Charlotte A Slade, Jaclyn S Pearson, André L Samson, John Silke, James G Murphy, Joanne M Hildebrand
A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation. Nature communications 14 (1) (2023)
Yanxiang Meng, Christopher R Horne, André L Samson, Laura F Dagley, Samuel N Young, Jarrod John Sandow, Peter E Czabotar, James G Murphy
Human RIPK3 C-lobe phosphorylation is essential for necroptotic signaling. Cell death & disease 13 (6) (2022)
Ashish Sethi, Christopher R Horne, Cheree Fitzgibbon, Karyn L Wilde, Katherine A Davies, Sarah E Garnish, Annette V Jacobsen, André L Samson, Joanne M Hildebrand, Ahmad Z Wardak, Peter E Czabotar, Emma J Petrie, Paul R Gooley, James G Murphy
Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKL. Cell death and differentiation 29 (9) (2022)
David M Wood, Renwick C J Dobson, Christopher R Horne
Using cryo-EM to uncover mechanisms of bacterial transcriptional regulation. Biochemical Society transactions (2021)
Michael R Oliver, Christopher R Horne, Safal Shrestha, Jeremy Russell Keown, Lung-Yu Liang, Samuel N Young, Jarrod John Sandow, Andrew Ian Webb, David C Goldstone, Isabelle S Lucet, Natarajan Kannan, Peter Metcalf, James G Murphy
Granulovirus PK-1 kinase activity relies on a side-to-side dimerization mode centered on the regulatory αC helix. Nature communications 12 (1) (2021)
André L Samson, Cheree Fitzgibbon, Komal M Patel, Joanne M Hildebrand, Lachlan W Whitehead, Joel S Rimes, Annette V Jacobsen, Christopher R Horne, Xavier J Gavin, Samuel N Young, Kelly L Rogers, Edwin D Hawkins, James G Murphy
A toolbox for imaging RIPK1, RIPK3, and MLKL in mouse and human cells. Cell death and differentiation 28 (7) (2021)
Christopher R Horne, Hariprasad Venugopal, Santosh Panjikar, David M Wood, Amy Henrickson, Emre Brookes, Rachel A North, James G Murphy, Rosmarie Friemann, Michael D W Griffin, Georg Ramm, Borries Demeler, Renwick C J Dobson
Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism. Nature communications 12 (1) (2021)
Sarah E Garnish, Yanxiang Meng, Akiko Koide, Jarrod John Sandow, Eric Denbaum, Annette V Jacobsen, Wayland Yeung, André L Samson, Christopher R Horne, Cheree Fitzgibbon, Samuel N Young, Phoebe P C Smith, Andrew Ian Webb, Emma J Petrie, Joanne M Hildebrand, Natarajan Kannan, Peter E Czabotar, Shohei Koide, James G Murphy
Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis. Nature communications 12 (1) (2021)
Bernhard C Lechtenberg, Marina P Gehring, Taylor P Light, Christopher R Horne, Mike W Matsumoto, Kalina Hristova, Elena B Pasquale
Regulation of the EphA2 receptor intracellular region by phosphomimetic negative charges in the kinase-SAM linker. Nature communications 12 (1) (2021)
Yanxiang Meng, Katherine A Davies, Cheree Fitzgibbon, Samuel N Young, Sarah E Garnish, Christopher R Horne, Cindy Luo, Jean-Marc Garnier, Lung-Yu Liang, Angus D Cowan, André L Samson, Guillaume L Lessene, Jarrod John Sandow, Peter E Czabotar, James G Murphy
Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis. Nature communications 12 (1) (2021)
Christopher R Horne, Amy Henrickson, Borries Demeler, Renwick C J Dobson
Multi-wavelength analytical ultracentrifugation as a tool to characterise protein-DNA interactions in solution. European biophysics journal : EBJ 49 (8) (2020)
Christopher R Horne, Laura Kind, James S Davies, Renwick C J Dobson
On the structure and function of Escherichia coli YjhC: An oxidoreductase involved in bacterial sialic acid metabolism. Proteins 88 (5) (2019)

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Publication Activity (10 Years)

Top Topics

Top Venues

Christopher R Horne