Clemens Steegborn

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 24

Top Topics

Structural Basis

Human Immunodeficiency Virus

Ischemia Reperfusion Injury

Top Venues

Journal of medicinal chemistry

Life (Basel, Switzerland)

Nature communications

Journal of chemical information and modeling

This page only lists publications with an associated author ORCID identifier.

Publications

Martin Pannek, Zayan Alhalabi, Daniela Tomaselli, Martina Menna, Francesco Fiorentino, Dina Robaa, Michael Weyand, Maximilian Puhlmann, Stefano Tomassi, Federica Barreca, Marco Tafani, Elma Zaganjor, Marcia C Haigis, Wolfgang Sippl, Dante Rotili, Antonello Mai, Clemens Steegborn
Specific Inhibitors of Mitochondrial Deacylase Sirtuin 4 Endowed with Cellular Activity. Journal of medicinal chemistry 67 (3) (2024)
Shan Sun, Makoto Fushimi, Thomas Rossetti, Navpreet Kaur, Jacob Ferreira, Michael Miller, Jonathan Quast, Joop van den Heuvel, Clemens Steegborn, Lonny R Levin, Jochen Buck, Robert W Myers, Stacia Kargman, Nigel Liverton, Peter T Meinke, David J Huggins
Addition to "Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation". Journal of chemical information and modeling 64 (3) (2024)
Weijie You, Alba L Montoya, Srikanta Dana, Raphael M Franzini, Clemens Steegborn
Elucidating the Unconventional Binding Mode of a DNA-Encoded Library Hit Provides a Blueprint for Sirtuin 6 Inhibitor Development. ChemMedChem (2024)
Weijie You, Alba L Montoya, Srikanta Dana, Raphael M Franzini, Clemens Steegborn
Elucidating the Unconventional Binding Mode of a DNA-Encoded Library Hit Provides a Blueprint for Sirtuin 6 Inhibitor Development. ChemMedChem (2024)
Martin Pannek, Zayan Alhalabi, Daniela Tomaselli, Martina Menna, Francesco Fiorentino, Dina Robaa, Michael Weyand, Maximilian Puhlmann, Stefano Tomassi, Federica Barreca, Marco Tafani, Elma Zaganjor, Marcia C Haigis, Wolfgang Sippl, Dante Rotili, Antonello Mai, Clemens Steegborn
Specific Inhibitors of Mitochondrial Deacylase Sirtuin 4 Endowed with Cellular Activity. Journal of medicinal chemistry (2024)
Martin Pannek, Zayan Alhalabi, Daniela Tomaselli, Martina Menna, Francesco Fiorentino, Dina Robaa, Michael Weyand, Maximilian Puhlmann, Stefano Tomassi, Federica Barreca, Marco Tafani, Elma Zaganjor, Marcia C Haigis, Wolfgang Sippl, Dante Rotili, Antonello Mai, Clemens Steegborn
Specific Inhibitors of Mitochondrial Deacylase Sirtuin 4 Endowed with Cellular Activity. Journal of medicinal chemistry 67 (3) (2024)
Shan Sun, Makoto Fushimi, Thomas Rossetti, Navpreet Kaur, Jacob Ferreira, Michael Miller, Jonathan Quast, Joop van den Heuvel, Clemens Steegborn, Lonny R Levin, Jochen Buck, Robert W Myers, Stacia Kargman, Nigel Liverton, Peter T Meinke, David J Huggins
Addition to "Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation". Journal of chemical information and modeling (2024)
Shan Sun, Makoto Fushimi, Thomas Rossetti, Navpreet Kaur, Jacob Ferreira, Michael Miller, Jonathan Quast, Joop van den Heuvel, Clemens Steegborn, Lonny R Levin, Jochen Buck, Robert W Myers, Stacia Kargman, Nigel Liverton, Peter T Meinke, David J Huggins
Addition to "Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation". Journal of chemical information and modeling 64 (3) (2024)
Melanie Balbach, Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Carla Ritagliati, Robert W Myers, David J Huggins, Clemens Steegborn, Ileana C Miranda, Peter T Meinke, Jochen Buck, Lonny R Levin
On-demand male contraception via acute inhibition of soluble adenylyl cyclase. Nature communications 14 (1) (2023)
Ramona S Adolph, Eileen Beck, Kristian Schweimer, Andrea Di Fonzo, Michael Weyand, Paul Rösch, Birgitta M Wöhrl, Clemens Steegborn
Molecular Mechanism of Sirtuin 1 Inhibition by Human Immunodeficiency Virus 1 Tat Protein. Life (Basel, Switzerland) 13 (4) (2023)
Ramona S Adolph, Eileen Beck, Kristian Schweimer, Andrea Di Fonzo, Michael Weyand, Paul Rösch, Birgitta M Wöhrl, Clemens Steegborn
Molecular Mechanism of Sirtuin 1 Inhibition by Human Immunodeficiency Virus 1 Tat Protein. Life (Basel, Switzerland) 13 (4) (2023)
Melanie Balbach, Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Carla Ritagliati, Robert W Myers, David J Huggins, Clemens Steegborn, Ileana C Miranda, Peter T Meinke, Jochen Buck, Lonny R Levin
On-demand male contraception via acute inhibition of soluble adenylyl cyclase. Nature communications 14 (1) (2023)
Ramona S Adolph, Eileen Beck, Kristian Schweimer, Andrea Di Fonzo, Michael Weyand, Paul Rösch, Birgitta M Wöhrl, Clemens Steegborn
Molecular Mechanism of Sirtuin 1 Inhibition by Human Immunodeficiency Virus 1 Tat Protein. Life (Basel, Switzerland) 13 (4) (2023)
Shan Sun, Makoto Fushimi, Thomas Rossetti, Navpreet Kaur, Jacob Ferreira, Michael Miller, Jonathan Quast, Joop van den Heuvel, Clemens Steegborn, Lonny R Levin, Jochen Buck, Robert W Myers, Stacia Kargman, Nigel Liverton, Peter T Meinke, David J Huggins
Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation. Journal of chemical information and modeling (2023)
Ramona S Adolph, Eileen Beck, Kristian Schweimer, Andrea Di Fonzo, Michael Weyand, Paul Rösch, Birgitta M Wöhrl, Clemens Steegborn
Molecular Mechanism of Sirtuin 1 Inhibition by Human Immunodeficiency Virus 1 Tat Protein. Life (Basel, Switzerland) 13 (4) (2023)
Melanie Balbach, Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Carla Ritagliati, Robert W Myers, David J Huggins, Clemens Steegborn, Ileana C Miranda, Peter T Meinke, Jochen Buck, Lonny R Levin
On-demand male contraception via acute inhibition of soluble adenylyl cyclase. Nature communications 14 (1) (2023)
Clemens Zwergel, Michele Aventaggiato, Sabrina Garbo, Elisabetta Di Bello, Bruno Fassari, Beatrice Noce, Carola Castiello, Chiara Lambona, Federica Barreca, Dante Rotili, Rossella Fioravanti, Thomas Schmalz, Michael Weyand, Amelie Niedermeier, Marco Tripodi, Gianni Colotti, Clemens Steegborn, Cecilia Battistelli, Marco Tafani, Sergio Valente, Antonello Mai
Novel 1,4-Dihydropyridines as Specific Binders and Activators of SIRT3 Impair Cell Viability and Clonogenicity and Downregulate Hypoxia-Induced Targets in Cancer Cells. Journal of medicinal chemistry (2023)
Melanie Balbach, Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Carla Ritagliati, Robert W Myers, David J Huggins, Clemens Steegborn, Ileana C Miranda, Peter T Meinke, Jochen Buck, Lonny R Levin
On-demand male contraception via acute inhibition of soluble adenylyl cyclase. Nature communications 14 (1) (2023)
Sandra Weiss, Ramona S Adolph, Kristian Schweimer, Andrea DiFonzo, Marat Meleshin, Mike Schutkowski, Clemens Steegborn
Molecular Mechanism of Sirtuin 1 Modulation by the AROS Protein. International journal of molecular sciences 23 (21) (2022)
Benjamin Suenkel, Sergio Valente, Clemens Zwergel, Sandra Weiss, Elisabetta Di Bello, Rossella Fioravanti, Michele Aventaggiato, João A Amorim, Neha Garg, Surinder Kumar, David B Lombard, Tuo Hu, Pankaj K Singh, Marco Tafani, Carlos M Palmeira, David Sinclair, Antonello Mai, Clemens Steegborn
Potent and Specific Activators for Mitochondrial Sirtuins Sirt3 and Sirt5. Journal of medicinal chemistry 65 (20) (2022)
Michael Miller, Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Melanie Balbach, Navpreet Kaur, Lonny R Levin, Jochen Buck, Maria Kehr, Sandrine Coquille, Joop van den Heuvel, Clemens Steegborn, Makoto Fushimi, Efrat Finkin-Groner, Robert W Myers, Stacia Kargman, Nigel J Liverton, David J Huggins, Peter T Meinke
Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates. Journal of medicinal chemistry 65 (22) (2022)
Makoto Fushimi, Hannes Buck, Melanie Balbach, Anna Gorovyy, Jacob Ferreira, Thomas Rossetti, Navpreet Kaur, Lonny R Levin, Jochen Buck, Jonathan Quast, Joop van den Heuvel, Clemens Steegborn, Efrat Finkin-Groner, Stacia Kargman, Mayako Michino, Michael A Foley, Michael Miller, Nigel J Liverton, David J Huggins, Peter T Meinke
Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10). ACS medicinal chemistry letters 12 (8) (2021)
Weijie You, Clemens Steegborn
Binding site for activator MDL-801 on SIRT6. Nature chemical biology 17 (5) (2021)
Weijie You, Clemens Steegborn
Structural Basis of Sirtuin 6 Inhibition by the Hydroxamate Trichostatin A: Implications for Protein Deacylase Drug Development. Journal of medicinal chemistry 61 (23) (2018)