Wolfgang Sippl (W Sippl)

Scopus Author ID Loop profile ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 86

Top Venues

Journal of medicinal chemistry

Molecules (Basel, Switzerland)

International journal of molecular sciences

Pharmaceuticals (Basel, Switzerland)

Martin Luther Universität Halle-Wittenberg

Heinrich-Heine-Universitat Düsseldorf (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Martin Luther Universität Halle-Wittenberg Jul 01 2003

Germany

Professor :: Pharmacy

Education History

Heinrich-Heine-Universitat Düsseldorf Jan 02 1996 - Jul 01 2003

Germany

PHD :: Pharmaceutical Chemistry

Freie Universität Berlin Sep 01 1992 - Jan 31 1996

Germany

PHD :: Pharmacy

Publications

Martin Pannek, Zayan Alhalabi, Daniela Tomaselli, Martina Menna, Francesco Fiorentino, Dina Robaa, Michael Weyand, Maximilian Puhlmann, Stefano Tomassi, Federica Barreca, Marco Tafani, Elma Zaganjor, Marcia C Haigis, Wolfgang Sippl, Dante Rotili, Antonello Mai, Clemens Steegborn
Specific Inhibitors of Mitochondrial Deacylase Sirtuin 4 Endowed with Cellular Activity. Journal of medicinal chemistry 67 (3) (2024)
Fady Baselious, Sebastian Hilscher, Sven Hagemann, Sunita Tripathee, Dina Robaa, Cyril Barinka, Stefan Hüttelmaier, Mike Schutkowski, Wolfgang Sippl
Utilization of an optimized AlphaFold protein model for structure-based design of a selective HDAC11 inhibitor with anti-neuroblastoma activity. Archiv der Pharmazie (2024)
Anita G Kansy, Ramy Ashry, Al-Hassan M Mustafa, Abdallah M Alfayomy, Markus P Radsak, Yanira Zeyn, Matthias Bros, Wolfgang Sippl, Oliver Holger Krämer
Pharmacological degradation of ATR induces antiproliferative DNA replication stress in leukemic cells. Molecular oncology 18 (8) (2024)
Anita G Kansy, Ramy Ashry, Al-Hassan M Mustafa, Abdallah M Alfayomy, Markus P Radsak, Yanira Zeyn, Matthias Bros, Wolfgang Sippl, Oliver Holger Krämer
Pharmacological degradation of ATR induces antiproliferative DNA replication stress in leukemic cells. Molecular oncology 18 (8) (2024)
Aya Soudi, Onur Bender, İsmail Çelik, Amer Ali Abd El-Hafeez, Rumeysa Dogan, Arzu Atalay, Eslam B Elkaeed, Aisha A Alsfouk, El Shimaa M N Abdelhafez, Omar M Aly, Wolfgang Sippl, Taha Farouk Shehata Ali
Discovery and Anticancer Screening of Novel Oxindole-Based Derivative Bearing Pyridyl Group as Potent and Selective Dual FLT3/CDK2 Kinase Inhibitor. Pharmaceuticals (Basel, Switzerland) 17 (5) (2024)
Narges Cheshmazar, Maryam Hamzeh-Mivehroud, Salar Hemmati, Hoda Abolhasani, Fatemeh Heidari, Hojjatollah Nozad Charoudeh, Matthes Zessin, Mike Schutkowski, Wolfgang Sippl, Siavoush Dastmalchi
Key structural requirements of benzamide derivatives for histone deacetylase inhibition: design, synthesis and biological evaluation. Future medicinal chemistry 16 (9) (2024)
Arianna Colcerasa, Florian Friedrich, Jelena Melesina, Patrick Moser, Anja Vogelmann, Pavlos Tzortzoglou, Emilia Neuwirt, Manuela Sum, Dina Robaa, Lin Zhang, Elizabeth Ramos-Morales, Christophe Romier, Oliver Einsle, Eric Metzger, Roland Schüle, Olaf Groß, Wolfgang Sippl, Manfred Jung
Structure-Activity Studies of 1,2,4-Oxadiazoles for the Inhibition of the NAD + -Dependent Lysine Deacylase Sirtuin 2. Journal of medicinal chemistry 67 (12) (2024)
Christopher Vorreiter, Dina Robaa, Wolfgang Sippl
Exploring Aromatic Cage Flexibility Using Cosolvent Molecular Dynamics Simulations─An In-Silico Case Study of Tudor Domains. Journal of chemical information and modeling 64 (11) (2024)
Arianna Colcerasa, Florian Friedrich, Jelena Melesina, Patrick Moser, Anja Vogelmann, Pavlos Tzortzoglou, Emilia Neuwirt, Manuela Sum, Dina Robaa, Lin Zhang, Elizabeth Ramos-Morales, Christophe Romier, Oliver Einsle, Eric Metzger, Roland Schüle, Olaf Groß, Wolfgang Sippl, Manfred Jung
Structure-Activity Studies of 1,2,4-Oxadiazoles for the Inhibition of the NAD + -Dependent Lysine Deacylase Sirtuin 2. Journal of medicinal chemistry (2024)
Melisa Halilovic, Mohamed Abdelsalam, Joanna Zabkiewicz, Michelle Lazenby, Caroline L Alvares, Matthias Schmidt, Walburgis Brenner, Sara Najafi, Ina Oehme, Christoph Hieber, Yanira Zeyn, Matthias Bros, Wolfgang Sippl, Oliver Holger Krämer
Selective degradation of mutant FMS-like tyrosine kinase-3 requires BIM-dependent depletion of heat shock proteins. Leukemia (2024)
Narges Cheshmazar, Maryam Hamzeh-Mivehroud, Salar Hemmati, Hoda Abolhasani, Fatemeh Heidari, Hojjatollah Nozad Charoudeh, Matthes Zessin, Mike Schutkowski, Wolfgang Sippl, Siavoush Dastmalchi
Key structural requirements of benzamide derivatives for histone deacetylase inhibition: design, synthesis and biological evaluation. Future medicinal chemistry 16 (9) (2024)
Ayca Erdogan, Yagmur Ozhan, Hande Sipahi, Enise Ece Gurdal, Wolfgang Sippl, Meriç Köksal
iNOS/PGE 2 inhibitors as a novel template for analgesic/anti-inflammatory activity: Design, synthesis, in vitro biological activity and docking studies. Archiv der Pharmazie (2024)
Narges Cheshmazar, Maryam Hamzeh-Mivehroud, Salar Hemmati, Hoda Abolhasani, Fatemeh Heidari, Hojjatollah Nozad Charoudeh, Matthes Zessin, Mike Schutkowski, Wolfgang Sippl, Siavoush Dastmalchi
Key structural requirements of benzamide derivatives for histone deacetylase inhibition: design, synthesis and biological evaluation. Future medicinal chemistry (2024)
Narges Cheshmazar, Maryam Hamzeh-Mivehroud, Salar Hemmati, Hoda Abolhasani, Fatemeh Heidari, Hojjatollah Nozad Charoudeh, Matthes Zessin, Mike Schutkowski, Wolfgang Sippl, Siavoush Dastmalchi
Key structural requirements of benzamide derivatives for histone deacetylase inhibition: design, synthesis and biological evaluation. Future medicinal chemistry 16 (9) (2024)
Narges Cheshmazar, Maryam Hamzeh-Mivehroud, Salar Hemmati, Hoda Abolhasani, Fatemeh Heidari, Hojjatollah Nozad Charoudeh, Matthes Zessin, Mike Schutkowski, Wolfgang Sippl, Siavoush Dastmalchi
Key structural requirements of benzamide derivatives for histone deacetylase inhibition: design, synthesis and biological evaluation. Future medicinal chemistry 16 (9) (2024)
Anita G Kansy, Ramy Ashry, Al-Hassan M Mustafa, Abdallah M Alfayomy, Markus P Radsak, Yanira Zeyn, Matthias Bros, Wolfgang Sippl, Oliver Holger Krämer
Pharmacological degradation of ATR induces antiproliferative DNA replication stress in leukemic cells. Molecular oncology (2024)
Christopher Vorreiter, Dina Robaa, Wolfgang Sippl
Exploring Aromatic Cage Flexibility Using Cosolvent Molecular Dynamics Simulations─An In-Silico Case Study of Tudor Domains. Journal of chemical information and modeling 64 (11) (2024)
Christopher Vorreiter, Dina Robaa, Wolfgang Sippl
Exploring Aromatic Cage Flexibility Using Cosolvent Molecular Dynamics Simulations─An In-Silico Case Study of Tudor Domains. Journal of chemical information and modeling 64 (11) (2024)
Arianna Colcerasa, Florian Friedrich, Jelena Melesina, Patrick Moser, Anja Vogelmann, Pavlos Tzortzoglou, Emilia Neuwirt, Manuela Sum, Dina Robaa, Lin Zhang, Elizabeth Ramos-Morales, Christophe Romier, Oliver Einsle, Eric Metzger, Roland Schüle, Olaf Groß, Wolfgang Sippl, Manfred Jung
Structure-Activity Studies of 1,2,4-Oxadiazoles for the Inhibition of the NAD + -Dependent Lysine Deacylase Sirtuin 2. Journal of medicinal chemistry 67 (12) (2024)
Christopher Vorreiter, Dina Robaa, Wolfgang Sippl
Exploring Aromatic Cage Flexibility Using Cosolvent Molecular Dynamics Simulations─An In-Silico Case Study of Tudor Domains. Journal of chemical information and modeling (2024)
Aya Soudi, Onur Bender, İsmail Çelik, Amer Ali Abd El-Hafeez, Rumeysa Dogan, Arzu Atalay, Eslam B Elkaeed, Aisha A Alsfouk, El Shimaa M N Abdelhafez, Omar M Aly, Wolfgang Sippl, Taha Farouk Shehata Ali
Discovery and Anticancer Screening of Novel Oxindole-Based Derivative Bearing Pyridyl Group as Potent and Selective Dual FLT3/CDK2 Kinase Inhibitor. Pharmaceuticals (Basel, Switzerland) 17 (5) (2024)
Anita G Kansy, Ramy Ashry, Al-Hassan M Mustafa, Abdallah M Alfayomy, Markus P Radsak, Yanira Zeyn, Matthias Bros, Wolfgang Sippl, Oliver Holger Krämer
Pharmacological degradation of ATR induces antiproliferative DNA replication stress in leukemic cells. Molecular oncology 18 (8) (2024)
Martin Pannek, Zayan Alhalabi, Daniela Tomaselli, Martina Menna, Francesco Fiorentino, Dina Robaa, Michael Weyand, Maximilian Puhlmann, Stefano Tomassi, Federica Barreca, Marco Tafani, Elma Zaganjor, Marcia C Haigis, Wolfgang Sippl, Dante Rotili, Antonello Mai, Clemens Steegborn
Specific Inhibitors of Mitochondrial Deacylase Sirtuin 4 Endowed with Cellular Activity. Journal of medicinal chemistry (2024)
Martin Pannek, Zayan Alhalabi, Daniela Tomaselli, Martina Menna, Francesco Fiorentino, Dina Robaa, Michael Weyand, Maximilian Puhlmann, Stefano Tomassi, Federica Barreca, Marco Tafani, Elma Zaganjor, Marcia C Haigis, Wolfgang Sippl, Dante Rotili, Antonello Mai, Clemens Steegborn
Specific Inhibitors of Mitochondrial Deacylase Sirtuin 4 Endowed with Cellular Activity. Journal of medicinal chemistry 67 (3) (2024)
Fady Baselious, Sebastian Hilscher, Dina Robaa, Cyril Barinka, Mike Schutkowski, Wolfgang Sippl
Comparative Structure-Based Virtual Screening Utilizing Optimized AlphaFold Model Identifies Selective HDAC11 Inhibitor. International journal of molecular sciences 25 (2) (2024)
Sebastian Mielniczuk, Katharina Hoff, Fady Baselious, Yunqi Li, Jörg Haupenthal, Andreas M Kany, Maria Riedner, Holger Rohde, Katharina Rox, Anna Katharina Herta Hirsch, Isabelle Krimm, Wolfgang Sippl, Ralph Holl
Development of Fragment-Based Inhibitors of the Bacterial Deacetylase LpxC with Low Nanomolar Activity. Journal of medicinal chemistry (2024)
Fady Baselious, Sebastian Hilscher, Dina Robaa, Cyril Barinka, Mike Schutkowski, Wolfgang Sippl
Comparative Structure-Based Virtual Screening Utilizing Optimized AlphaFold Model Identifies Selective HDAC11 Inhibitor. International journal of molecular sciences 25 (2) (2024)
Francesco Berluti, Fady Baselious, Sven Hagemann, Sebastian Hilscher, Matthias Schmidt, Stefan Hüttelmaier, Mike Schutkowski, Wolfgang Sippl, Hany S Ibrahim
Development of new pyrazoles as class I HDAC inhibitors: Synthesis, molecular modeling, and biological characterization in leukemia cells. Archiv der Pharmazie (2024)
Ahmed Haider, Lu Wang, Luca C Gobbi, Yinlong Li, Ahmad Chaudhary, Xin Zhou, Jiahui Chen, Chunyu Zhao, Jian Rong, Zhiwei Xiao, Lu Hou, Nehal H Elghazawy, Wolfgang Sippl, April T Davenport, James B Daunais, Hazem Ahmed, Ron Crowe, Michael Honer, Axel Rominger, Uwe Grether, Steven H Liang, Simon M Ametamey
Evaluation of [ 18 F]RoSMA-18-d 6 as a CB2 PET Radioligand in Nonhuman Primates. ACS chemical neuroscience (2023)
Hany S Ibrahim, Wolfgang Sippl
Histone Acetyltransferase and Deacetylase Inhibitors-New Aspects and Developments. International journal of molecular sciences 24 (23) (2023)
Marvin Korff, Ahmad Chaudhary, Yinlong Li, Xin Zhou, Chunyu Zhao, Jian Rong, Jiahui Chen, Zhiwei Xiao, Nehal H Elghazawy, Wolfgang Sippl, April T Davenport, James B Daunais, Lu Wang, Carmen Abate, Hazem Ahmed, Ron Crowe, Thomas J Schmidt, Steven H Liang, Simon M Ametamey, Bernhard Wünsch, Ahmed Haider
Synthesis and Biological Evaluation of Enantiomerically Pure ( R ) - and ( S ) - [18F]OF-NB1 for Imaging the GluN2B Subunit-Containing NMDA Receptors. Journal of medicinal chemistry (2023)
Hazem Ahmed, Rahel Wallimann, Livio Gisler, Nehal H Elghazawy, Stefan Gruber, Claudia Keller, Steven H Liang, Wolfgang Sippl, Ahmed Haider, Simon M Ametamey
Characterization of ( R )- and ( S )-[ 18 F]OF-NB1 in Rodents as Positron Emission Tomography Probes for Imaging GluN2B Subunit-Containing N -Methyl-d-Aspartate Receptors. ACS chemical neuroscience (2023)
Wolfgang Sippl
Editorial for Special Issue-"Early-Stage Drug Discovery: Advances and Challenges". International journal of molecular sciences 24 (7) (2023)
Markus Schwark, José A Martínez Yerena, Kristin Röhrborn, Pavel Hrouzek, Petra Divoká, Lenka Štenclová, Kateřina Delawská, Heike Enke, Christopher Vorreiter, Faith Wiley, Wolfgang Sippl, Roman Sobotka, Subhasish Saha, Susan B Wilde, Jan Mareš, Timo Horst Johannes Niedermeyer
More than just an eagle killer: The freshwater cyanobacterium Aetokthonos hydrillicola produces highly toxic dolastatin derivatives. Proceedings of the National Academy of Sciences of the United States of America 120 (40) (2023)
Mohamed Abdelsalam, Mariia Zmyslia, Karin Schmidtkunz, Anita Vecchio, Sebastian Hilscher, Hany S Ibrahim, Mike Schutkowski, Manfred Jung, Claudia Jessen-Trefzer, Wolfgang Sippl
Design and synthesis of bioreductive prodrugs of class I histone deacetylase inhibitors and their biological evaluation in virally transfected acute myeloid leukemia cells. Archiv der Pharmazie (2023)
Conrad V Simoben, Smith B Babiaka, Aurélien F A Moumbock, Cyril T Namba-Nzanguim, Donatus Bekindaka Eni, José Luis Medina-Franco, Stefan Günther, Fidele Ntie-Kang, Wolfgang Sippl
Challenges in natural product-based drug discovery assisted with in silico -based methods. RSC advances 13 (45) (2023)
Husam Nassar, Wolfgang Sippl, Rana Abu Dahab, Mutasem Omar Taha
Molecular docking, molecular dynamics simulations and in vitro screening reveal cefixime and ceftriaxone as GSK3β covalent inhibitors. RSC advances 13 (17) (2023)
Bengisu Turgutalp, Prabesh Bhattarai, Tugba Ercetin, Chiara Luise, Rengin Reis, Enise Ece Gurdal, Andreas Isaak, Derya Biriken, Elisabeth Dinter, Hande Sipahi, Dirk Schepmann, Anna Junker, Bernhard Wünsch, Wolfgang Sippl, Hayrettin Ozan Gulcan, Caghan Kizil, Mine Yarim
Correction to "Discovery of Potent Cholinesterase Inhibition-Based Multi-Target-Directed Lead Compounds for Synaptoprotection in Alzheimer's Disease". Journal of medicinal chemistry (2023)
Laura Sinatra, Anja Vogelmann, Florian Friedrich, Margarita A Tararina, Emilia Neuwirt, Arianna Colcerasa, Philipp König, Lara Toy, Talha Z Yesiloglu, Sebastian Hilscher, Lena Gaitzsch, Niklas Papenkordt, Shiyang Zhai, Lin Zhang, Christophe Romier, Oliver Einsle, Wolfgang Sippl, Mike Schutkowski, Olaf Gross, Gerd Bendas, David W Christianson, Finn K Hansen, Manfred Jung, Matthias Schiedel
Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation. Journal of medicinal chemistry (2023)
Maurício Temotheo Tavares, Arne Krüger, Sun L Rei Yan, Karoline B Waitman, Vinicius de Morais Gomes, Daffiny Sumam de Oliveira, Franciarli Paz, Sebastian Hilscher, Mike Schutkowski, Wolfgang Sippl, Claudia Ruiz, Monica F Z J Toledo, Neuza Mariko Aymoto Hassimotto, João Agostinho Machado-Neto, Antti Poso, Michael D Cameron, Thomas D Bannister, Giuseppe Palmisano, Carsten Wrenger, Thales Kronenberger, Roberto Parise-Filho
1,3-Diphenylureido hydroxamate as a promising scaffold for generation of potent antimalarial histone deacetylase inhibitors. Scientific reports 13 (1) (2023)
Bengisu Turgutalp, Prabesh Bhattarai, Tugba Ercetin, Chiara Luise, Rengin Reis, Enise Ece Gurdal, Andreas Isaak, Derya Biriken, Elisabeth Dinter, Hande Sipahi, Dirk Schepmann, Anna Junker, Bernhard Wünsch, Wolfgang Sippl, Hayrettin Ozan Gulcan, Caghan Kizil, Mine Yarim
Correction to "Discovery of Potent Cholinesterase Inhibition-Based Multi-Target-Directed Lead Compounds for Synaptoprotection in Alzheimer's Disease". Journal of medicinal chemistry 66 (2) (2023)
Ramy Ashry, Al-Hassan M Mustafa, Kristin Hausmann, Michael Linnebacher, Susanne Strand, Wolfgang Sippl, Matthias Wirth, Oliver Holger Krämer
NOXA Accentuates Apoptosis Induction by a Novel Histone Deacetylase Inhibitor. Cancers 15 (14) (2023)
Emre F Bülbül, Dina Robaa, Ping Sun, Fereshteh Mahmoudi, Jelena Melesina, Matthes Zessin, Mike Schutkowski, Wolfgang Sippl
Application of Ligand- and Structure-Based Prediction Models for the Design of Alkylhydrazide-Based HDAC3 Inhibitors as Novel Anti-Cancer Compounds. Pharmaceuticals (Basel, Switzerland) 16 (7) (2023)
Matthes Zessin, Marat Meleshin, Lucas Praetorius, Wolfgang Sippl, Cyril Barinka, Mike Schutkowski
Uncovering Robust Delactoylase and Depyruvoylase Activities of HDAC Isoforms. ACS chemical biology 17 (6) (2022)
Daniel Herp, Johannes Ridinger, Dina Robaa, Stephen A Shinsky, Karin Schmidtkunz, Talha Z Yesiloglu, Theresa Bayer, Raphael R Steimbach, Corey J Herbst-Gervasoni, Annika Merz, Christophe Romier, Peter Sehr, Nikolas Gunkel, Aubry K Miller, David W Christianson, Ina Oehme, Wolfgang Sippl, Manfred Jung
First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement. Chembiochem : a European journal of chemical biology 23 (14) (2022)
A Vogelmann, Matthias Schiedel, N Wössner, A Merz, D Herp, S Hammelmann, A Colcerasa, G Komaniecki, J Y Hong, M Sum, E Metzger, E Neuwirt, L Zhang, O Einsle, O Groß, R Schüle, Hening Lin, Wolfgang Sippl, Manfred Jung
Development of a NanoBRET assay to validate inhibitors of Sirt2-mediated lysine deacetylation and defatty-acylation that block prostate cancer cell migration. RSC chemical biology 3 (4) (2022)
Diana Kalbas, Marat Meleshin, Sandra Liebscher, Matthes Zessin, Jelena Melesina, Cordelia Schiene-Fischer, Emre Fatih Bülbül, Frank Bordusa, Wolfgang Sippl, Mike Schutkowski
Small Changes Make the Difference for SIRT2: Two Different Binding Modes for 3-Arylmercapto-Acylated Lysine Derivatives. Biochemistry 61 (17) (2022)
Salma Darwish, Ehab Ghazy, Tino Heimburg, Daniel Herp, Patrik Zeyen, Rabia Salem-Altintas, Johannes Ridinger, Dina Robaa, Karin Schmidtkunz, Frank Erdmann, Matthias Schmidt, Christophe Romier, Manfred Jung, Ina Oehme, Wolfgang Sippl
Design, Synthesis and Biological Characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with Anti-Neuroblastoma Activity. International journal of molecular sciences 23 (14) (2022)
Hazem Ahmed, Livio Gisler, Nehal H Elghazawy, Claudia Keller, Wolfgang Sippl, Steven H Liang, Ahmed Haider, Simon M Ametamey
Development and Validation of [ 3 H]OF-NB1 for Preclinical Assessment of GluN1/2B Candidate Drugs. Pharmaceuticals (Basel, Switzerland) 15 (8) (2022)
Ping Sun, Jing Wang, Khadija S Khan, Weiqin Yang, Billy Wai-Lung Ng, Nikita V Ilment, Matthes Zessin, Emre F Bülbül, Dina Robaa, Frank Erdmann, Matthias Schmidt, Christophe Romier, Mike Schutkowski, Alfred Sze-Lok Cheng, Wolfgang Sippl
Development of Alkylated Hydrazides as Highly Potent and Selective Class I Histone Deacetylase Inhibitors with T cell Modulatory Properties. Journal of medicinal chemistry (2022)
Emre F Bülbül, Jelena Melesina, Hany S Ibrahim, Mohamed Abdelsalam, Anita Vecchio, Dina Robaa, Matthes Zessin, Mike Schutkowski, Wolfgang Sippl
Docking, Binding Free Energy Calculations and In Vitro Characterization of Pyrazine Linked 2-Aminobenzamides as Novel Class I Histone Deacetylase (HDAC) Inhibitors. Molecules (Basel, Switzerland) 27 (8) (2022)
Ehab Ghazy, Mohamed Abdelsalam, Dina Robaa, Raymond J Pierce, Wolfgang Sippl
Histone Deacetylase (HDAC) Inhibitors for the Treatment of Schistosomiasis. Pharmaceuticals (Basel, Switzerland) 15 (1) (2022)
Matthes Zessin, Marat Meleshin, Wolfgang Sippl, Mike Schutkowski
Continuous Histone Deacylase Activity Assays. Methods in molecular biology (Clifton, N.J.) 2589 (2022)
Severin Lechner, Martin Ian P Malgapo, Christian Graetz, Raphael R Steimbach, Agnes Baron, Patrick Leopold Rüther, Simon Nadal, Carmen Stumpf, Christina Loos, Xin Ku, Polina Prokofeva, Ludwig Lautenbacher, Tino Heimburg, Vivian Würf, Chen Meng, Mathias Wilhelm, Wolfgang Sippl, Karin Kleigrewe, Josch K Pauling, Karl Kramer, Aubry K Miller, Michael W Pfaffl, Maurine E Linder, Bernhard Kuster, Guillaume Médard
Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target. Nature chemical biology 18 (8) (2022)
Bengisu Turgutalp, Prabesh Bhattarai, Tugba Ercetin, Chiara Luise, Rengin Reis, Enise Ece Gurdal, Andreas Isaak, Derya Biriken, Elisabeth Dinter, Hande Sipahi, Dirk Schepmann, Anna Junker, Bernhard Wünsch, Wolfgang Sippl, Hayrettin Ozan Gulcan, Caghan Kizil, Mine Yarim
Discovery of Potent Cholinesterase Inhibition-Based Multi-Target-Directed Lead Compounds for Synaptoprotection in Alzheimer's Disease. Journal of medicinal chemistry 65 (18) (2022)
Salma Darwish, Tino Heimburg, Johannes Ridinger, Daniel Herp, Matthias Schmidt, Christophe Romier, Manfred Jung, Ina Oehme, Wolfgang Sippl
Synthesis, Biochemical, and Cellular Evaluation of HDAC6 Targeting Proteolysis Targeting Chimeras. Methods in molecular biology (Clifton, N.J.) 2589 (2022)
Narges Cheshmazar, Salar Hemmati, Maryam Hamzeh-Mivehroud, Babak Sokouti, Matthes Zessin, Mike Schutkowski, Wolfgang Sippl, Hojjatollah Nozad Charoudeh, Siavoush Dastmalchi
Development of New Inhibitors of HDAC1-3 Enzymes Aided by In Silico Design Strategies. Journal of chemical information and modeling 62 (10) (2022)
Conrad V Simoben, Ehab Ghazy, Patrik Zeyen, Salma Darwish, Matthias Schmidt, Christophe Romier, Dina Robaa, Wolfgang Sippl
Binding Free Energy (BFE) Calculations and Quantitative Structure-Activity Relationship (QSAR) Analysis of Schistosoma mansoni Histone Deacetylase 8 (smHDAC8) Inhibitors. Molecules (Basel, Switzerland) 26 (9) (2021)
Lucile Pagliazzo, Stéphanie Caby, Julien Lancelot, Sophie Salome-Desnoulez, Jean Michel Saliou, Tino Heimburg, Thierry Chassat, Katia Cailliau, Wolfgang Sippl, Jérôme Vicogne, Raymond J Pierce
Histone deacetylase 8 interacts with the GTPase SmRho1 in Schistosoma mansoni. PLoS neglected tropical diseases 15 (11) (2021)
Hugo Rolando Vaca, Ana María Celentano, María Agustina Toscanini, Tino Heimburg, Ehab Ghazy, Patrik Zeyen, Alexander-Thomas Hauser, Guilherme Corrêa de Oliveira, María Celina Elissondo, Manfred Jung, Wolfgang Sippl, Federico Camicia, Mara Cecilia Rosenzvit
The potential for histone deacetylase (HDAC) inhibitors as cestocidal drugs. PLoS neglected tropical diseases 15 (3) (2021)
Bengisu Turgutalp, Merve Uslu, Sinem Helvacioglu, Mohammad Charehsaz, Enise Ece Gurdal, Wolfgang Sippl, Fatih KocabaŞ, Mine Yarim
Lead Optimization and Structure-Activity Relationship Studies on Myeloid Ecotropic Viral Integration Site 1 Inhibitor. Journal of medicinal chemistry 64 (19) (2021)
Chiara Luise, Dina Robaa, Wolfgang Sippl
Exploring aromatic cage flexibility of the histone methyllysine reader protein Spindlin1 and its impact on binding mode prediction: an in silico study. Journal of computer-aided molecular design 35 (6) (2021)
Hany S Ibrahim, Mohamed Abdelsalam, Yanira Zeyn, Matthes Zessin, Al-Hassan M Mustafa, Marten A Fischer, Patrik Zeyen, Ping Sun, Emre F Bülbül, Anita Vecchio, Frank Erdmann, Matthias Schmidt, Dina Robaa, Cyril Barinka, Christophe Romier, Mike Schutkowski, Oliver Holger Krämer, Wolfgang Sippl
Synthesis, Molecular Docking and Biological Characterization of Pyrazine Linked 2-Aminobenzamides as New Class I Selective Histone Deacetylase (HDAC) Inhibitors with Anti-Leukemic Activity. International journal of molecular sciences 23 (1) (2021)
Lars Fuhrmann, Saskia Lindner, Alexander-Thomas Hauser, Clemens Höse, Oliver Kretz, Clemens D Cohen, Maja T Lindenmeyer, Wolfgang Sippl, Manfred Jung, Tobias B Huber, Nicola Wanner
Effects of Environmental Conditions on Nephron Number: Modeling Maternal Disease and Epigenetic Regulation in Renal Development. International journal of molecular sciences 22 (8) (2021)
Jelena Melesina, Conrad V Simoben, Lucas Praetorius, Emre F Bülbül, Dina Robaa, Wolfgang Sippl
Strategies To Design Selective Histone Deacetylase Inhibitors. ChemMedChem 16 (9) (2021)
Chiara Luise, Dina Robaa, Pierre Regenass, David Maurer, Dmytro Ostrovskyi, Ludwig Seifert, Johannes Bacher, Teresa Burgahn, Tobias Wagner, Johannes Seitz, Holger Greschik, Kwang-Su Park, Yan Xiong, Jian Jin, Roland Schüle, Bernhard Breit, Manfred Jung, Wolfgang Sippl
Structure-Based Design, Docking and Binding Free Energy Calculations of A366 Derivatives as Spindlin1 Inhibitors. International journal of molecular sciences 22 (11) (2021)
Wolfgang Sippl, Fidele Ntie-Kang
Editorial to Special Issue-"Structure-Activity Relationships (SAR) of Natural Products". Molecules (Basel, Switzerland) 26 (2) (2021)
Meriç Köksal, Ayca Dedeoglu-Erdogan, Marwa Bader, Enise Ece Gurdal, Wolfgang Sippl, Rengin Reis, Melda Ozgurbuz, Hande Sipahi, Turgay Celik
Design, synthesis, and molecular docking of novel 3,5-disubstituted-1,3,4-oxadiazole derivatives as iNOS inhibitors. Archiv der Pharmazie 354 (8) (2021)
Anne Wurzlbauer, Katharina Rüben, Ece Gürdal, Apirat Chaikuad, Stefan Knapp, Wolfgang Sippl, Walter Becker, Franz Bracher
How to Separate Kinase Inhibition from Undesired Monoamine Oxidase A Inhibition-The Development of the DYRK1A Inhibitor AnnH75 from the Alkaloid Harmine. Molecules (Basel, Switzerland) 25 (24) (2020)
Vitor Coutinho Carneiro, Isabel Caetano de Abreu da Silva, Murilo Sena Amaral, Adriana S A Pereira, Gilbert Oliveira Silveira, David da Silva Pires, Sergio Verjovski-Almeida, Frank J Dekker, Dante Rotili, Antonello Mai, Eduardo José Lopes-Torres, Dina Robaa, Wolfgang Sippl, Raymond J Pierce, María Teresa Borrello, Arasu Ganesan, Julien Lancelot, Silvana Carvalho Thiengo, Monica Ammon Fernandez, Amanda Roberta Revoredo Vicentino, Marina Moraes Mourão, Fernanda Sales Coelho, Marcelo Rosado Fantappié
Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma mansoni. PLoS neglected tropical diseases 14 (7) (2020)
Berin Karaman Mayack, Wolfgang Sippl, Fidele Ntie-Kang
Natural Products as Modulators of Sirtuins. Molecules (Basel, Switzerland) 25 (14) (2020)
Boris D Bekono, Fidele Ntie-Kang, Pascal Amoa Onguéné, Lydia L Lifongo, Wolfgang Sippl, Karin Fester, Luc C O Owono
The potential of anti-malarial compounds derived from African medicinal plants: a review of pharmacological evaluations from 2013 to 2019. Malaria journal 19 (1) (2020)
Smith B Babiaka, Conrad V Simoben, Kennedy O Abuga, James A Mbah, Rajshekhar Karpoormath, Dennis Ongarora, Hannington Mugo, Elvis Monya, Fidelis Cho-Ngwa, Wolfgang Sippl, E Joel Loveridge, Fidele Ntie-Kang
Alkaloids with Anti-Onchocercal Activity from Voacanga africana Stapf (Apocynaceae): Identification and Molecular Modeling. Molecules (Basel, Switzerland) 26 (1) (2020)
Martin Roatsch, Inga Hoffmann, Martine I Abboud, Rebecca L Hancock, Hanna Tarhonskaya, Kuo-Feng Hsu, Sarah E Wilkins, Tzu-Lan Yeh, Kerstin Lippl, Kerstin Serrer, Isabelle Moneke, Theresa D Ahrens, Dina Robaa, Sandra Wenzler, Nicolas P F Barthes, Henriette Franz, Wolfgang Sippl, Silke Lassmann, Sven Diederichs, Erik Schleicher, Christopher J Schofield, Akane Kawamura, Roland Schüle, Manfred Jung
The Clinically Used Iron Chelator Deferasirox Is an Inhibitor of Epigenetic JumonjiC Domain-Containing Histone Demethylases. ACS chemical biology 14 (8) (2019)
Matthes Zessin, Zsófia Kutil, Marat Meleshin, Zora Novakova, Ehab Ghazy, Diana Kalbas, Martin Marek, Christophe Romier, Wolfgang Sippl, Cyril Barinka, Mike Schutkowski
One-Atom Substitution Enables Direct and Continuous Monitoring of Histone Deacylase Activity. Biochemistry 58 (48) (2019)
Katharina Vögerl, Nghia Ong, Johanna Senger, Daniel Herp, Karin Schmidtkunz, Martin Marek, Martin Müller, Karin Bartel, Tajith Baba Shaik, Nicholas J Porter, Dina Robaa, David W Christianson, Christophe Romier, Wolfgang Sippl, Manfred Jung, Franz Bracher
Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors. Journal of medicinal chemistry 62 (3) (2019)
Theresa Bayer, Alokta Chakrabarti, Julien Lancelot, Tajith B Shaik, Kristin Hausmann, Jelena Melesina, Karin Schmidtkunz, Martin Marek, Frank Erdmann, Matthias Schmidt, Dina Robaa, Christophe Romier, Raymond J Pierce, Manfred Jung, Wolfgang Sippl
Synthesis, Crystallization Studies, and in vitro Characterization of Cinnamic Acid Derivatives as SmHDAC8 Inhibitors for the Treatment of Schistosomiasis. ChemMedChem 13 (15) (2018)
Diana Kalbas, Sandra Liebscher, Theresa Nowak, Marat Meleshin, Martin Pannek, Corinna Popp, Zayan Alhalabi, Frank Bordusa, Wolfgang Sippl, Clemens Steegborn, Mike Schutkowski
Potent and Selective Inhibitors of Human Sirtuin 5. Journal of medicinal chemistry 61 (6) (2018)
Martin Marek, Tajith B Shaik, Tino Heimburg, Alokta Chakrabarti, Julien Lancelot, Elizabeth Ramos-Morales, Cyrielle Da Veiga, Dmitrii Kalinin, Jelena Melesina, Dina Robaa, Karin Schmidtkunz, Takayoshi Suzuki, Ralph Holl, Eric Ennifar, Raymond J Pierce, Manfred Jung, Wolfgang Sippl, Christophe Romier
Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants. Journal of medicinal chemistry 61 (22) (2018)
Kristina King, Alexander-Thomas Hauser, Jelena Melesina, Wolfgang Sippl, Manfred Jung
Carbamates as Potential Prodrugs and a New Warhead for HDAC Inhibition. Molecules (Basel, Switzerland) 23 (2) (2018)
Max Holzer, Nico Schade, Ansgar Opitz, Isabel Hilbrich, Jens Stieler, Tim Vogel, Valentina Neukel, Moritz Oberstadt, Frank Totzke, Christoph Schächtele, Wolfgang Sippl, Andreas Hilgeroth
Novel Protein Kinase Inhibitors Related to Tau Pathology Modulate Tau Protein-Self Interaction Using a Luciferase Complementation Assay. Molecules (Basel, Switzerland) 23 (9) (2018)
Conrad V Simoben, Dina Robaa, Alokta Chakrabarti, Karin Schmidtkunz, Martin Marek, Julien Lancelot, Srinivasaraghavan Kannan, Jelena Melesina, Tajith Baba Shaik, Raymond J Pierce, Christophe Romier, Manfred Jung, Wolfgang Sippl
A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing. Molecules (Basel, Switzerland) 23 (3) (2018)
Conrad V Simoben, Fidele Ntie-Kang, Sergi H Akone, Wolfgang Sippl
Compounds from African Medicinal Plants with Activities Against Selected Parasitic Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis. Natural products and bioprospecting 8 (3) (2018)
Berin Karaman, Zayan Alhalabi, Sören Swyter, Shetonde O Mihigo, Kerstin Andrae-Marobela, Manfred Jung, Wolfgang Sippl, Fidele Ntie-Kang
Identification of Bichalcones as Sirtuin Inhibitors by Virtual Screening and In Vitro Testing. Molecules (Basel, Switzerland) 23 (2) (2018)
Matthias Wünsch, Johanna Senger, Philipp Schultheisz, Sabrina Schwarzbich, Karin Schmidtkunz, Carmela Michalek, Michaela Klaß, Stefanie Goskowitz, Philipp Borchert, Lucas Praetorius, Wolfgang Sippl, Manfred Jung, Norbert Sewald
Structure-Activity Relationship of Propargylamine-Based HDAC Inhibitors. ChemMedChem 12 (24) (2017)
Tino Heimburg, Fiona R Kolbinger, Patrik Zeyen, Ehab Ghazy, Daniel Herp, Karin Schmidtkunz, Jelena Melesina, Tajith Baba Shaik, Frank Erdmann, Matthias Schmidt, Christophe Romier, Dina Robaa, Olaf Witt, Ina Oehme, Manfred Jung, Wolfgang Sippl
Structure-Based Design and Biological Characterization of Selective Histone Deacetylase 8 (HDAC8) Inhibitors with Anti-Neuroblastoma Activity. Journal of medicinal chemistry 60 (24) (2017)

Wolfgang Sippl.css-eqlu8i{font-size:small;padding-left:4px;} (W Sippl)

Publication Activity (10 Years)

Top Topics

Top Venues

Wolfgang Sippl (W Sippl)