Neal X Rosen (Neal Rosen)

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 33

Top Topics

Insulin Resistance

Intellectual Disability

Metastatic Colorectal Cancer

Signaling Pathway

Top Venues

Clinical cancer research : an official journal of the American Association for Cancer Research

Nature communications

Cancer discovery

Research square

This page only lists publications with an associated author ORCID identifier.

Publications

Monica F Chen, Soo-Ryum Yang, Jessica J Tao, Antoine Desilets, Eli L Diamond, Clare J Wilhem, Ezra Y Rosen, Yixiao Gong, Kerry Mullaney, Jean Torrisi, Robert J Young, Romel Somwar, Helena Alexandra Yu, Mark G Kris, Gregory J Riely, Maria E Arcila, Marc Ladanyi, Mark T A Donoghue, Neal X Rosen, Rona Yaeger, Alexander E Drilon, Yonina R Murciano-Goroff, Michael D Offin
Tumor-agnostic genomic and clinical analysis of BRAF fusions identify actionable targets. Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Hidenori Kitai, Philip H Choi, Yu Chi Yang, Jacob A Boyer, Adele Whaley, Priya Pancholi, Claire Thant, Jason Reiter, Kevin Chen, Vladimir Markov, Hirokazu Taniguchi, Rui Yamaguchi, Hiromichi Ebi, James Evans, Jingjing Jiang, Bianca Lee, David Wildes, Elisa de Stanchina, Jacqueline A M Smith, Mallika Singh, Neal X Rosen
Combined inhibition of KRAS G12C and mTORC1 kinase is synergistic in non-small cell lung cancer. Nature communications 15 (1) (2024)
Sunyana Gadal, Jacob A Boyer, Simon F Roy, Noah A Outmezguine, Malvika Sharma, Hongyan Li, Ning Fan, Eric Chan, Yevgeniy Romin, Afsar Barlas, Qing Chang, Priya Pancholi, Neilawattie Merna Timaul, Michael Overholtzer, Rona Yaeger, Katia Manova-Todorova, Elisa de Stanchina, Marcus Bosenberg, Neal X Rosen
Tumorigenesis driven by the BRAF V600E oncoprotein requires secondary mutations that overcome its feedback inhibition of migration and invasion. bioRxiv : the preprint server for biology (2024)
Hidenori Kitai, Philip H Choi, Yu Chi Yang, Jacob A Boyer, Adele Whaley, Priya Pancholi, Claire Thant, Jason Reiter, Kevin Chen, Vladimir Markov, Hirokazu Taniguchi, Rui Yamaguchi, Hiromichi Ebi, James Evans, Jingjing Jiang, Bianca Lee, David Wildes, Elisa de Stanchina, Jacqueline A M Smith, Mallika Singh, Neal X Rosen
Combined inhibition of KRAS G12C and mTORC1 kinase is synergistic in non-small cell lung cancer. Nature communications 15 (1) (2024)
Monica F Chen, Soo-Ryum Yang, Jessica J Tao, Antoine Desilets, Eli L Diamond, Clare J Wilhem, Ezra Y Rosen, Yixiao Gong, Kerry Mullaney, Jean Torrisi, Robert J Young, Romel Somwar, Helena Alexandra Yu, Mark G Kris, Gregory J Riely, Maria E Arcila, Marc Ladanyi, Mark T A Donoghue, Neal X Rosen, Rona Yaeger, Alexander E Drilon, Yonina R Murciano-Goroff, Michael D Offin
Tumor-agnostic genomic and clinical analysis of BRAF fusions identify actionable targets. Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Rona Yaeger, Meredith A McKean, Rizwan Haq, J Thaddeus Beck, Matthew H Taylor, Jonathan Eliezer Cohen, Daniel W Bowles, Shirish M Gadgeel, Catalin Mihalcioiu, Kyriakos P Papadopoulos, Eli L Diamond, Keren B Sturtz, Gang Feng, Stefanie K Drescher, Micaela B Reddy, Bhaswati Sengupta, Arnab Kumar Maity, Suzy A Brown, Anurag Singh, Eric N Brown, Brian R Baer, Jim Wong, Tung-Chung Mou, Wen-I Wu, Dean R Kahn, Sunyana Gadal, Neal X Rosen, John J Gaudino, Patrice A Lee, Dylan P Hartley, S Michael Rothenberg
A next-generation BRAF inhibitor overcomes resistance to BRAF inhibition in patients with BRAF-mutant cancers using pharmacokinetics-informed dose escalation. Cancer discovery (2024)
Monica F Chen, Soo-Ryum Yang, Jessica J Tao, Antoine Desilets, Eli L Diamond, Clare J Wilhem, Ezra Y Rosen, Yixiao Gong, Kerry Mullaney, Jean Torrisi, Robert J Young, Romel Somwar, Helena Alexandra Yu, Mark G Kris, Gregory J Riely, Maria E Arcila, Marc Ladanyi, Mark T A Donoghue, Neal X Rosen, Rona Yaeger, Alexander E Drilon, Yonina R Murciano-Goroff, Michael D Offin
Tumor-agnostic genomic and clinical analysis of BRAF fusions identify actionable targets. Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Monica F Chen, Soo-Ryum Yang, Jessica J Tao, Antoine Desilets, Eli L Diamond, Clare J Wilhem, Ezra Y Rosen, Yixiao Gong, Kerry Mullaney, Jean Torrisi, Robert J Young, Romel Somwar, Helena Alexandra Yu, Mark G Kris, Gregory J Riely, Maria E Arcila, Marc Ladanyi, Mark T A Donoghue, Neal X Rosen, Rona Yaeger, Alexander E Drilon, Yonina R Murciano-Goroff, Michael D Offin
Tumor-Agnostic Genomic and Clinical Analysis of BRAF Fusions Identifies Actionable Targets. Clinical cancer research : an official journal of the American Association for Cancer Research 30 (17) (2024)
Neal X Rosen, Radha Mukherjee, Priya Pancholi, Malvika Sharma, Hilla Solomon, Merna Timaul, Claire Thant, Rory McGriskin, Omar Hayatt, Vladimir Markov, John D'Allara, Simona Bekker, Jacqueline Candelier, Sebastian Carrasco, Elisa de Stanchina, Kiran Vanaja
Diet induced insulin resistance is due to induction of PTEN expression. Research square (2024)
Hidenori Kitai, Philip H Choi, Yu Chi Yang, Jacob A Boyer, Adele Whaley, Priya Pancholi, Claire Thant, Jason Reiter, Kevin Chen, Vladimir Markov, Hirokazu Taniguchi, Rui Yamaguchi, Hiromichi Ebi, James Evans, Jingjing Jiang, Bianca Lee, David Wildes, Elisa de Stanchina, Jacqueline A M Smith, Mallika Singh, Neal X Rosen
Combined inhibition of KRAS G12C and mTORC1 kinase is synergistic in non-small cell lung cancer. Nature communications 15 (1) (2024)
Monica F Chen, Soo-Ryum Yang, Jessica J Tao, Antoine Desilets, Eli L Diamond, Clare J Wilhem, Ezra Y Rosen, Yixiao Gong, Kerry Mullaney, Jean Torrisi, Robert J Young, Romel Somwar, Helena Alexandra Yu, Mark G Kris, Gregory J Riely, Maria E Arcila, Marc Ladanyi, Mark T A Donoghue, Neal X Rosen, Rona Yaeger, Alexander E Drilon, Yonina R Murciano-Goroff, Michael D Offin
Tumor-agnostic genomic and clinical analysis of BRAF fusions identify actionable targets. Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Neal X Rosen, Radha Mukherjee, Priya Pancholi, Malvika Sharma, Hilla Solomon, Merna Timaul, Claire Thant, Rory McGriskin, Omar Hayatt, Vladimir Markov, John D'Allara, Simona Bekker, Jacqueline Candelier, Sebastian Carrasco, Elisa de Stanchina, Kiran Vanaja
Diet induced insulin resistance is due to induction of PTEN expression. Research square (2024)
Lauren Dong, Hyejin Choi, Sadna Budhu, Isabell Schulze, Svena Verma, Levi Mark Mangarin, Valeria Estrada Navarro, Nezar Mehanna, Jonathan F Khan, Divya Venkatesh, Daniel Thach, Neal X Rosen, Jedd D Wolchok, Taha Merghoub
Intermittent MEK inhibition with GITR co-stimulation rescues T-cell function for increased efficacy with CTLA-4 blockade in solid tumor models. Cancer immunology research (2024)
Sunyana Gadal, Jacob A Boyer, Simon F Roy, Noah A Outmezguine, Malvika Sharma, Hongyan Li, Ning Fan, Eric Chan, Yevgeniy Romin, Afsar Barlas, Qing Chang, Priya Pancholi, Neilawattie Merna Timaul, Michael Overholtzer, Rona Yaeger, Katia Manova-Todorova, Elisa de Stanchina, Marcus Bosenberg, Neal X Rosen
Tumorigenesis driven by the BRAF V600E oncoprotein requires secondary mutations that overcome its feedback inhibition of migration and invasion. bioRxiv : the preprint server for biology (2024)
Hidenori Kitai, Philip H Choi, Yu Chi Yang, Jacob A Boyer, Adele Whaley, Priya Pancholi, Claire Thant, Jason Reiter, Kevin Chen, Vladimir Markov, Hirokazu Taniguchi, Rui Yamaguchi, Hiromichi Ebi, James Evans, Jingjing Jiang, Bianca Lee, David Wildes, Elisa de Stanchina, Jacqueline A M Smith, Mallika Singh, Neal X Rosen
Combined inhibition of KRAS G12C and mTORC1 kinase is synergistic in non-small cell lung cancer. Nature communications 15 (1) (2024)
Rona Yaeger, Riccardo Mezzadra, Jenna Sinopoli, Yu Bian, Michelangelo Marasco, Esther Kaplun, Yijun Gao, HuiYong Zhao, Arnaud Da Cruz Paula, Yingjie Zhu, Almudena Chaves-Pérez, Kalyani Chadalavada, Edison Tse, Sudhir Chowdhry, Sydney Bowker, Qing Chang, Besnik Qeriqi, Jorge S Reis-Filho, Gouri J Nanjangud, Michael F Berger, Hirak Der-Torossian, Kenna Anderes, Nicholas D Socci, Jinru Shia, Gregory J Riely, Yonina R Murciano-Goroff, Bob T Li, James G Christensen, Jorge Sergio Reis-Filho, David B Solit, Elisa De Stanchina, Scott W Lowe, Neal X Rosen, Sandra Misale
Molecular characterization of acquired resistance to KRAS G12C-EGFR inhibition in colorectal cancer. Cancer discovery (2022)
Joshua M Weiss, Miranda V Hunter, Nelly M Cruz, Arianna Baggiolini, Mohita M Tagore, Yilun Ma, Sandra Misale, Michelangelo Marasco, Theresa Simon-Vermot, Nathaniel R Campbell, Felicity Newell, James S Wilmott, Peter A Johansson, John F Thompson, Georgina V Long, John V Pearson, Graham J Mann, Richard A Scolyer, Nicola Waddell, Emily D Montal, Ting-Hsiang Huang, Philip Jonsson, Mark T A Donoghue, Christopher C Harris, Barry S Taylor, Tianhao Xu, Ronan Chaligné, Pavel V Shliaha, Ronald Hendrickson, Achim A Jungbluth, Cecilia Lezcano, Richard P Koche, Lorenz Studer, Charlotte E Ariyan, David B Solit, Jedd D Wolchok, Taha Merghoub, Neal X Rosen, Nicholas K Hayward, Richard M White
Anatomic position determines oncogenic specificity in melanoma. Nature 604 (7905) (2022)
Sisi Chen, Rahul S Vedula, Antonio Cuevas-Navarro, Bin Lu, Simon J Hogg, Eric Wang, Salima Benbarche, Katherine Knorr, Won Jun Kim, Robert F Stanley, Hana Cho, Caroline Erickson, Michael Singer, Dan Cui, Steven Tittley, Benjamin H Durham, Tatiana S Pavletich, Elise Fiala, Michael F Walsh, Daichi Inoue, Sebastien Monette, Justin Taylor, Neal X Rosen, Frank McCormick, R Coleman Lindsley, Hatice Ulku Osmanbeyoglu, Omar Abdel-Wahab
Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation. Cancer discovery 12 (10) (2022)
Bianca J Lee, Jacob A Boyer, G Leslie Burnett, Arun P Thottumkara, Nidhi Tibrewal, Stacy L Wilson, Tientien Hsieh, Abby Marquez, Edward G Lorenzana, James W Evans, Laura Hulea, Gert Kiss, Hui Liu, Dong Lee, Ola Larsson, Shannon McLaughlan, Ivan Topisirovic, Zhengping Wang, Zhican Wang, Yongyuan Zhao, David Wildes, James B Aggen, Mallika Singh, Adrian L Gill, Jacqueline A M Smith, Neal X Rosen
Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth. Nature chemical biology 17 (10) (2021)
Alexander N Shoushtari, Walid K Chatila, Arshi Arora, Francisco Sanchez-Vega, Havish S Kantheti, Jorge A Rojas Zamalloa, Penina Krieger, Margaret K Callahan, Allison Betof Warner, Michael A Postow, Parisa Momtaz, Suresh Nair, Charlotte E Ariyan, Christopher A Barker, Mary Susan Brady, Daniel G Coit, Neal X Rosen, Paul B Chapman, Klaus J Busam, David B Solit, Katherine S Panageas, Jedd D Wolchok, Nikolaus Schultz
Therapeutic Implications of Detecting MAPK-Activating Alterations in Cutaneous and Unknown Primary Melanomas. Clinical cancer research : an official journal of the American Association for Cancer Research 27 (8) (2021)
Shanique Alabi, Saul Jaime-Figueroa, Zhan Yao, Yijun Gao, John Hines, Kusal T G Samarasinghe, Lea Vogt, Neal X Rosen, Craig M Crews
Mutant-selective degradation by BRAF-targeting PROTACs. Nature communications 12 (1) (2021)
Gregory D Jones, Raul Caso, Kay See Tan, Brooke Mastrogiacomo, Francisco Sanchez-Vega, Yuan Liu, James G Connolly, Yonina R Murciano-Goroff, Matthew J Bott, Prasad S Adusumilli, Daniela Molena, Gaetano Rocco, Valerie W Rusch, Smita Sihag, Sandra Misale, Rona Yaeger, Alexander E Drilon, Kathryn C Arbour, Gregory J Riely, Neal X Rosen, Piro Lito, Haiying Zhang, David C Lyden, Charles M Rudin, David R Jones, Bob T Li, James M Isbell
KRAS G12C Mutation Is Associated with Increased Risk of Recurrence in Surgically Resected Lung Adenocarcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research 27 (9) (2021)
Alison E Smith, Emanuela Ferraro, Anton Safonov, Cristina Bernado Morales, Enrique J Arenas Lahuerta, Qing Li, Amanda Kulick, Dara Ross, David B Solit, Elisa de Stanchina, Jorge Sergio Reis-Filho, Neal X Rosen, Joaquín Arribas, Pedram Razavi, Sarat Chandarlapaty
HER2 + breast cancers evade anti-HER2 therapy via a switch in driver pathway. Nature communications 12 (1) (2021)
Komal Jhaveri, Joshua Z Drago, Payal Deepak Shah, Rui Wang, Fresia Pareja, Fanni Ratzon, Alexia Iasonos, Sujata Patil, Neal X Rosen, Monica N Fornier, Nancy T Sklarin, Sarat Chandarlapaty, Shanu Modi
A Phase I Study of Alpelisib in Combination with Trastuzumab and LJM716 in Patients with PIK3CA-Mutated HER2-Positive Metastatic Breast Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 27 (14) (2021)
Ninghui Mao, Zeda Zhang, Young Sun Lee, Danielle Choi, Aura Agudelo Rivera, Dan Li, Cindy Lee, Samuel Haywood, Xiaoping Chen, Qing Chang, Guotai Xu, Hsuan-An Chen, Elisa de Stanchina, Charles L Sawyers, Neal X Rosen, Andrew C Hsieh, Juliet Chen, Brett S Carver
Defining the therapeutic selective dependencies for distinct subtypes of PI3K pathway-altered prostate cancers. Nature communications 12 (1) (2021)
Qing Li, Baishan Jiang, Jiaye Guo, Hong Shao, Isabella S Del Priore, Qing Chang, Rei Kudo, Zhiqiang Li, Pedram Razavi, Bo Liu, Andrew S Boghossian, Matthew G Rees, Melissa A Ronan, Jennifer A Roth, Katherine Aleisha Donovan, Marta Palafox, Jorge S Reis-Filho, Elisa de Stanchina, Eric S Fischer, Neal X Rosen, Violeta Serra, Andrew Koff, John D Chodera, Nathanael S Gray, Sarat Chandarlapaty
INK4 tumor suppressor proteins mediate resistance to CDK4/6 kinase inhibitors. Cancer discovery (2021)
Bob T Li, Flavia Michelini, Sandra Misale, Emiliano Cocco, Laura Baldino, Yanyan Cai, Sophie Shifman, Hai-Yan Tu, Mackenzie L Myers, Chong-Rui Xu, Marissa Mattar, Inna Khodos, Megan Little, Besnik Qeriqi, Gregory Weitsman, Clare J Wilhem, Alshad S Lalani, Irmina Diala, Rachel A Freedman, Nancy U Lin, David B Solit, Michael F Berger, Paul R Barber, Tony Ng, Michael D Offin, James M Isbell, David R Jones, Helena A Yu, Sheeno Thyparambil, Wei-Li Liao, Anuja Bhalkikar, Fabiola Cecchi, David M Hyman, Jason S Lewis, Darren J Buonocore, Alan L Ho, Vicky Makker, Jorge S Reis-Filho, Pedram Razavi, Maria E Arcila, Mark G Kris, John T Poirier, Ronglai Shen, Junji Tsurutani, Gary A Ulaner, Elisa de Stanchina, Neal X Rosen, Charles M Rudin, Maurizio Scaltriti
HER2-Mediated Internalization of Cytotoxic Agents in ERBB2 Amplified or Mutant Lung Cancers. Cancer discovery 10 (5) (2020)
Hiroki Sato, Adam J Schoenfeld, Evan Siau, Yue Christine Lu, Huichun Tai, Ken Suzawa, Daisuke Kubota, Allan J W Lui, Besnik Qeriqi, Marissa Mattar, Michael D Offin, Masakiyo Sakaguchi, Shinichi Toyooka, Alexander E Drilon, Neal X Rosen, Mark G Kris, David Solit, Elisa De Stanchina, Monika A Davare, Gregory J Riely, Marc Ladanyi, Romel Somwar
MAPK Pathway Alterations Correlate with Poor Survival and Drive Resistance to Therapy in Patients with Lung Cancers Driven by ROS1 Fusions. Clinical cancer research : an official journal of the American Association for Cancer Research 26 (12) (2020)
Ninghui Mao, Dong Gao, Wenhuo Hu, Sunyana Gadal, Haley Hieronymus, Shangqian Wang, Young Sun Lee, Patrick Sullivan, Zeda Zhang, Danielle Choi, Neal X Rosen, Charles L Sawyers, Anuradha Gopalan, Yu Chen, Brett S Carver
Oncogenic ERG Represses PI3K Signaling through Downregulation of IRS2. Cancer research 80 (7) (2020)
Aphrothiti J Hanrahan, Brooke E Sylvester, Matthew T Chang, Arijh Elzein, Jianjiong Gao, Weiwei Han, Ye Liu, Dong Xu, Sizhi P Gao, Alexander N Gorelick, Alexis M Jones, Amber J Kiliti, Moriah H Nissan, Clare A Nimura, Abigail N Poteshman, Zhan Yao, Yijun Gao, Wenhuo Hu, Hannah C Johnsen, Elena I Gavrila, Shakuntala Tiwari, Agnes Viale, Omar Abdel-Wahab, Taha Merghoub, Michael F Berger, Neal X Rosen, Barry S Taylor, David B Solit
Leveraging Systematic Functional Analysis to Benchmark an In Silico Framework Distinguishes Driver from Passenger MEK Mutants in Cancer. Cancer research 80 (19) (2020)
Rona Yaeger, Daisuke Kotani, Sebastián Mondaca, Aparna R Parikh, Hideaki Bando, Emily E Van Seventer, Hiroya Taniguchi, HuiYong Zhao, Claire N Thant, Elisa de Stanchina, Neal X Rosen, Ryan B Corcoran, Takayuki Yoshino, Zhan Yao, Hiromichi Ebi
Response to Anti-EGFR Therapy in Patients with BRAF non-V600-Mutant Metastatic Colorectal Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 25 (23) (2019)
Yijun Gao, Ann Maria, Na Na, Arnaud da Cruz Paula, Alexander N Gorelick, Jaclyn F Hechtman, Julianne Carson, Robert A Lefkowitz, Britta Weigelt, Barry S Taylor, HuiYong Zhao, Jorge S Reis-Filho, Elisa de Stanchina, Neal X Rosen, Zhan Yao, Rona Yaeger
V211D Mutation in MEK1 Causes Resistance to MEK Inhibitors in Colon Cancer. Cancer discovery 9 (9) (2019)
Zhan Yao, Yijun Gao, Wenjing Su, Rona Yaeger, Jessica Tao, Na Na, Ying Zhang, Chao Zhang, Andrey Rymar, Anthony Tao, Neilawattie M Timaul, Rory Mcgriskin, Nathaniel A Outmezguine, HuiYong Zhao, Qing Chang, Besnik Qeriqi, Mariano Barbacid, Elisa de Stanchina, David M Hyman, Gideon Bollag, Neal X Rosen
RAF inhibitor PLX8394 selectively disrupts BRAF dimers and RAS-independent BRAF-mutant-driven signaling. Nature medicine 25 (2) (2018)