John Joseph Grubb Tesmer (John Jg Tesmer, John J G Tesmer)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 55

Top Venues

Nature structural & molecular biology

bioRxiv : the preprint server for biology

Molecular pharmacology

eLife

Purdue University

Purdue University (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Purdue University

United States

Walther Professor in Cancer Structural Biology :: Biological Sciences and Medicinal Chemistry and Molecular Pharmacology

Education History

Purdue University

United States

PHD :: Biological Sciences

Publications

Yu-Chen Yen, Yong Li, Chun-Liang Chen, Thomas Klose, Val J Watts, Carmen W Dessauer, John Joseph Grubb Tesmer
Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia. Nature structural & molecular biology (2024)
Sandeep K Ravala, John Joseph Grubb Tesmer
New Mechanisms Underlying Oncogenesis in Dbl Family Rho Guanine Nucleotide Exchange Factors. Molecular pharmacology 106 (3) (2024)
Yu-Chen Yen, Yong Li, Chun-Liang Chen, Thomas Klose, Val J Watts, Carmen W Dessauer, John Joseph Grubb Tesmer
Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia. Nature structural & molecular biology (2024)
Chun-Liang Chen, Ramizah Syahirah, Sandeep K Ravala, Yu-Chen Yen, Thomas Klose, Qing Deng, John Joseph Grubb Tesmer
Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ. Nature structural & molecular biology (2024)
Chun-Liang Chen, Ramizah Syahirah, Sandeep K Ravala, Yu-Chen Yen, Thomas Klose, Qing Deng, John Joseph Grubb Tesmer
Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ. Nature structural & molecular biology (2024)
Sandeep K Ravala, John Joseph Grubb Tesmer
New Mechanisms Underlying Oncogenesis in Dbl Family Rho Guanine Nucleotide Exchange Factors. Molecular pharmacology 106 (3) (2024)
Chun-Liang Chen, Ramizah Syahirah, Sandeep K Ravala, Yu-Chen Yen, Thomas Klose, Qing Deng, John Joseph Grubb Tesmer
Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ. Nature structural & molecular biology 31 (8) (2024)
Kelly A Manthei, Grace E Tremonti, Louise Chang, Akseli Niemelä, Laura Giorgi, Artturi Koivuniemi, John Joseph Grubb Tesmer
Rescue of Familial Lecithin:Cholesterol Acyltranferase Deficiency Mutations with an Allosteric Activator . Molecular pharmacology (2024)
Sandeep K Ravala, Sendi Rafael Adame-Garcia, Sheng Li, Chun-Liang Chen, Michael A Cianfrocco, J Silvio Gutkind, Jennifer N Cash, John Joseph Grubb Tesmer
Structural and dynamic changes in P-Rex1 upon activation by PIP 3 and inhibition by IP 4 . eLife 12 (2024)
Yu-Chen Yen, Yong Li, Chun-Liang Chen, Thomas Klose, Val J Watts, Carmen W Dessauer, John Joseph Grubb Tesmer
Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia. Nature structural & molecular biology (2024)
Sandeep K Ravala, Sendi Rafael Adame-Garcia, Sheng Li, Chun-Liang Chen, Michael A Cianfrocco, J Silvio Gutkind, Jennifer N Cash, John Joseph Grubb Tesmer
Structural and dynamic changes in P-Rex1 upon activation by PIP 3 and inhibition by IP 4 . eLife 12 (2024)
Sandeep K Ravala, John Joseph Grubb Tesmer
New Mechanisms Underlying Oncogenesis in Dbl Family Rho Guanine Nucleotide Exchange Factors. Molecular pharmacology 106 (3) (2024)
Yu-Chen Yen, Yong Li, Chun-Liang Chen, Thomas Klose, Val J Watts, Carmen W Dessauer, John Joseph Grubb Tesmer
Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia. Nature structural & molecular biology 31 (8) (2024)
Yu-Chen Yen, Yong Li, Chun-Liang Chen, Thomas Klose, Val J Watts, Carmen W Dessauer, John Joseph Grubb Tesmer
Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia. Nature structural & molecular biology (2024)
Chun-Liang Chen, Ramizah Syahirah, Sandeep K Ravala, Yu-Chen Yen, Thomas Klose, Qing Deng, John Joseph Grubb Tesmer
Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ. Nature structural & molecular biology 31 (8) (2024)
Sandeep K Ravala, John Joseph Grubb Tesmer
New Mechanisms Underlying Oncogenesis in Dbl Family Rho Guanine Nucleotide Exchange Factors. Molecular pharmacology 106 (3) (2024)
Sandeep K Ravala, John Joseph Grubb Tesmer
New Mechanisms Underlying Oncogenesis in Dbl Family Rho Guanine Nucleotide Exchange Factors. Molecular pharmacology 106 (3) (2024)
Sandeep K Ravala, John Joseph Grubb Tesmer
New Mechanisms Underlying Oncogenesis in Dbl Family Rho Guanine Nucleotide Exchange Factors. Molecular pharmacology 106 (3) (2024)
Yu-Chen Yen, Yong Li, Chun-Liang Chen, Thomas Klose, Val J Watts, Carmen W Dessauer, John Joseph Grubb Tesmer
Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia. Nature structural & molecular biology (2024)
Sandeep K Ravala, Sendi Rafael Adame-Garcia, Sheng Li, Chun-Liang Chen, Michael A Cianfrocco, J Silvio Gutkind, Jennifer N Cash, John Joseph Grubb Tesmer
Structural and dynamic changes in P-Rex1 upon activation by PIP 3 and inhibition by IP 4 . eLife 12 (2024)
Sandeep K Ravala, Sendi Rafael Adame-Garcia, Sheng Li, Chun-Liang Chen, Michael A Cianfrocco, J Silvio Gutkind, Jennifer N Cash, John Joseph Grubb Tesmer
Structural and dynamic changes in P-Rex1 upon activation by PIP 3 and inhibition by IP 4 . eLife 12 (2024)
Chun-Liang Chen, Ramizah Syahirah, Sandeep K Ravala, Yu-Chen Yen, Thomas Klose, Qing Deng, John Joseph Grubb Tesmer
Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ. Nature structural & molecular biology (2024)
Yu-Chen Yen, Yong Li, Chun-Liang Chen, Thomas Klose, Val J Watts, Carmen W Dessauer, John Joseph Grubb Tesmer
Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia. Nature structural & molecular biology 31 (8) (2024)
Chun-Liang Chen, Ramizah Syahirah, Sandeep K Ravala, Yu-Chen Yen, Thomas Klose, Qing Deng, John Joseph Grubb Tesmer
Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ. Nature structural & molecular biology 31 (8) (2024)
Yu-Chen Yen, Yong Li, Chun-Liang Chen, Thomas Klose, Val J Watts, Carmen W Dessauer, John Joseph Grubb Tesmer
Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia. Nature structural & molecular biology 31 (8) (2024)
Yu-Chen Yen, Yong Li, Chun-Liang Chen, Thomas Klose, Val J Watts, Carmen W Dessauer, John Joseph Grubb Tesmer
Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia. Nature structural & molecular biology 31 (8) (2024)
Sandeep K Ravala, John Joseph Grubb Tesmer
New mechanisms underlying oncogenesis in Dbl family Rho guanine nucleotide exchange factors . Molecular pharmacology (2024)
Chun-Liang Chen, Ramizah Syahirah, Sandeep K Ravala, Yu-Chen Yen, Thomas Klose, Qing Deng, John Joseph Grubb Tesmer
Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ. Nature structural & molecular biology 31 (8) (2024)
Chun-Liang Chen, Ramizah Syahirah, Sandeep K Ravala, Yu-Chen Yen, Thomas Klose, Qing Deng, John Joseph Grubb Tesmer
Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ. bioRxiv : the preprint server for biology (2023)
Yu-Chen Yen, Yong Li, Chun-Liang Chen, Thomas Klose, Val J Watts, Carmen W Dessauer, John Joseph Grubb Tesmer
Isoform Specific Regulation of Adenylyl Cyclase 5 by Gβγ. bioRxiv : the preprint server for biology (2023)
Yu-Chen Yen, Yong Li, Chun-Liang Chen, Thomas Klose, Val J Watts, Carmen W Dessauer, John Joseph Grubb Tesmer
Isoform Specific Regulation of Adenylyl Cyclase 5 by Gβγ. bioRxiv : the preprint server for biology (2023)
Sandeep K Ravala, Sendi Rafael Adame-Garcia, Sheng Li, Chun-Liang Chen, Michael A Cianfrocco, J Silvio Gutkind, Jennifer N Cash, John Joseph Grubb Tesmer
Structural and dynamic changes in P-Rex1 upon activation by PIP 3 and inhibition by IP 4 . bioRxiv : the preprint server for biology (2023)
Qiuyan Chen, Christopher T Schafer, Somnath Mukherjee, Martin Gustavsson, Parth Agrawal, Xin-Qiu Yao, Anthony A Kossiakoff, Tracy M Handel, John Joseph Grubb Tesmer
ACKR3-arrestin2/3 complexes reveal molecular consequences of GRK-dependent barcoding. bioRxiv : the preprint server for biology (2023)
Christopher T Schafer, Qiuyan Chen, John Joseph Grubb Tesmer, Tracy M Handel
Atypical Chemokine Receptor 3 'Senses' CXC Chemokine Receptor 4 Activation Through GPCR Kinase Phosphorylation. bioRxiv : the preprint server for biology (2023)
Christopher T Schafer, Qiuyan Chen, John Joseph Grubb Tesmer, Tracy M Handel
Atypical Chemokine Receptor 3 'Senses' CXC Chemokine Receptor 4 Activation Through GPCR Kinase Phosphorylation. bioRxiv : the preprint server for biology (2023)
Christopher T Schafer, Qiuyan Chen, John Joseph Grubb Tesmer, Tracy M Handel
Atypical Chemokine Receptor 3 'Senses' CXC Chemokine Receptor 4 Activation Through GPCR Kinase Phosphorylation. bioRxiv : the preprint server for biology (2023)
Christopher T Schafer, Qiuyan Chen, John Joseph Grubb Tesmer, Tracy M Handel
Atypical Chemokine Receptor 3 'Senses' CXC Chemokine Receptor 4 Activation Through GPCR Kinase Phosphorylation. bioRxiv : the preprint server for biology (2023)
Chun-Liang Chen, Ramizah Syahirah, Sandeep K Ravala, Yu-Chen Yen, Thomas Klose, Qing Deng, John Joseph Grubb Tesmer
Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ. bioRxiv : the preprint server for biology (2023)
Christopher T Schafer, Qiuyan Chen, John Joseph Grubb Tesmer, Tracy M Handel
Atypical Chemokine Receptor 3 'Senses' CXC Chemokine Receptor 4 Activation Through GPCR Kinase Phosphorylation. bioRxiv : the preprint server for biology (2023)
Yu-Chen Yen, Christopher T Schafer, Martin Gustavsson, Stefanie Alexandra Eberle, Pawel K Dominik, Dawid Deneka, Penglie Zhang, Thomas J Schall, Anthony A Kossiakoff, John Joseph Grubb Tesmer, Tracy M Handel
Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias. Science advances 8 (28) (2022)
Ronald F Siebenaler, Seema Chugh, Jessica J Waninger, Vijaya L Dommeti, Carson Kenum, Malay Mody, Anudeeta Gautam, Nidhi Patel, Alec Chu, Pushpinder Bawa, Jennifer Hon, Richard D Smith, Heather Carlson, Xuhong Cao, John Joseph Grubb Tesmer, Sunita Shankar, Arul M Chinnaiyan
Argonaute 2 modulates EGFR-RAS signaling to promote mutant HRAS and NRAS- driven malignancies. PNAS nexus 1 (3) (2022)
M Claire Cato, Yu-Chen Yen, Charnelle J Francis, Kaely E Elkins, Afzaal M Shareef, Rachel Sterne-Marr, John Joseph Grubb Tesmer
The Open Question of How GPCRs Interact with GPCR Kinases (GRKs). Biomolecules 11 (3) (2021)
Qiuyan Chen, Manolo Plasencia, Zhuang Li, Somnath Mukherjee, Dhabaleswar Patra, Chun-Liang Chen, Thomas Klose, Xin-Qiu Yao, Anthony A Kossiakoff, Leifu Chang, Philip C Andrews, John Joseph Grubb Tesmer
Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1. Nature 595 (7868) (2021)
Rachel A Rowlands, Qiuyan Chen, Renee A Bouley, Larisa V Avramova, John Joseph Grubb Tesmer, Andrew D White
Generation of Highly Selective, Potent, and Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors. Journal of medicinal chemistry 64 (1) (2021)
Kelly A Manthei, Dhabaleswar Patra, Christopher J Wilson, Maria V Fawaz, Lolita Piersimoni, Jenny Capua Shenkar, Wenmin Yuan, Philip C Andrews, John R Engen, Anna A Schwendeman, Melanie D Ohi, John Joseph Grubb Tesmer
Structural analysis of lecithin:cholesterol acyltransferase bound to high density lipoprotein particles. Communications biology 3 (1) (2020)
Jennifer N Cash, Naincy R Chandan, Alan Y Hsu, Prateek V Sharma, Qing Deng, Alan V Smrcka, John Joseph Grubb Tesmer
Discovery of Small Molecules That Target the Phosphatidylinositol (3,4,5) Trisphosphate (PIP3)-Dependent Rac Exchanger 1 (P-Rex1) PIP3-Binding Site and Inhibit P-Rex1-Dependent Functions in Neutrophils. Molecular pharmacology 97 (3) (2020)
Renee A Bouley, Zara Y Weinberg, Helen V Waldschmidt, Yu-Chen Yen, Scott D Larsen, Manojkumar A Puthenveedu, John Joseph Grubb Tesmer
A New Paroxetine-Based GRK2 Inhibitor Reduces Internalization of the μ-Opioid Receptor. Molecular pharmacology 97 (6) (2020)
Sandeep K Ravala, Jesse B Hopkins, Caroline B Plescia, Samantha R Allgood, Madison A Kane, Jennifer N Cash, Robert V Stahelin, John Joseph Grubb Tesmer
The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding. The Journal of biological chemistry 295 (36) (2020)
Helen V Waldschmidt, Kristoff T Homan, Marilyn C Cato, Osvaldo Cruz-Rodríguez, Alessandro Cannavo, Michael W Wilson, Jianliang Song, Joseph Y Cheung, Walter J Koch, John Joseph Grubb Tesmer, Scott D Larsen
Correction to "Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine". Journal of medicinal chemistry 62 (12) (2019)
Tyler S Beyett, Amy E Fraley, Emily Labudde, Dhabaleswar Patra, Ryan C Coleman, Akito Eguchi, Alisa Glukhova, Qiuyan Chen, Robert M Williams, Walter J Koch, David H Sherman, John Joseph Grubb Tesmer
Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe. Proceedings of the National Academy of Sciences of the United States of America 116 (32) (2019)
Jennifer N Cash, Sarah Urata, Sheng Li, Sandeep K Ravala, Larisa V Avramova, Michael D Shost, Jorge Silvio Gutkind, John Joseph Grubb Tesmer, Michael A Cianfrocco
Cryo-electron microscopy structure and analysis of the P-Rex1-Gβγ signaling scaffold. Science advances 5 (10) (2019)
Maria V Fawaz, Sang Yeop Kim, Dan Li, Ran Ming, Ziyun Xia, Karl Olsen, Irina D Pogozheva, John Joseph Grubb Tesmer, Anna A Schwendeman
Phospholipid Component Defines Pharmacokinetic and Pharmacodynamic Properties of Synthetic High-Density Lipoproteins. The Journal of pharmacology and experimental therapeutics 372 (2) (2019)
Sumit J Bandekar, Nadia Arang, Ena S Tully, Brittany A Tang, Brenna L Barton, Sheng Li, Jorge Silvio Gutkind, John Joseph Grubb Tesmer
Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential. Science signaling 12 (569) (2019)
Vania Hinkovska-Galcheva, Robert Kelly, Kelly A Manthei, Renee Bouley, Wenmin Yuan, Anna Schwendeman, John Joseph Grubb Tesmer, James A Shayman
Determinants of pH profile and acyl chain selectivity in lysosomal phospholipase A2. Journal of lipid research 59 (7) (2018)
Kelly A Manthei, Shyh-Ming Yang, Bolormaa Baljinnyam, Louise Chang, Alisa Glukhova, Wenmin Yuan, Lita A Freeman, David J Maloney, Anna Schwendeman, Alan T Remaley, Ajit Jadhav, John Joseph Grubb Tesmer
Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol. eLife 7 (2018)

John Joseph Grubb Tesmer.css-eqlu8i{font-size:small;padding-left:4px;} (John Jg Tesmer, John J G Tesmer)

Publication Activity (10 Years)

Top Topics

Top Venues

John Joseph Grubb Tesmer (John Jg Tesmer, John J G Tesmer)