Larissa M Podust

Publication Activity (10 Years)

Years Active: 2017-2023
Publications (10 Years): 10

Top Topics

Molecular Dynamics Simulations

Trypanosoma Cruzi

Protein Protein

Top Venues

PLoS neglected tropical diseases

Journal of medicinal chemistry

The Journal of biological chemistry

This page only lists publications with an associated author ORCID identifier.

Publications

Vandna Sharma, Valentina Noemi Madia, Valeria Tudino, Jennifer V Nguyen, Anjan Debnath, Antonella Messore, Davide Ialongo, Elisa Patacchini, Irene Palenca, Silvia Basili Franzin, Luisa Seguella, Giuseppe Esposito, Rita Petrucci, Paola Di Matteo, Martina Bortolami, Francesco Saccoliti, Roberto Di Santo, Luigi Scipione, Roberta Costi, Larissa M Podust
Miconazole-like Scaffold is a Promising Lead for Naegleria fowleri -Specific CYP51 Inhibitors. Journal of medicinal chemistry (2023)
Elany Barbosa da Silva, Vandna Sharma, Lilian Hernandez-Alvarez, Arthur H Tang, Alexander Stoye, Anthony J O'Donoghue, William H Gerwick, Richard J Payne, James H McKerrow, Larissa M Podust
Intramolecular Interactions Enhance the Potency of Gallinamide A Analogues against Trypanosoma cruzi . Journal of medicinal chemistry 65 (5) (2022)
Karin Nienhaus, Vandna Sharma, Gerd Ulrich Nienhaus, Larissa M Podust
Homodimerization Counteracts the Detrimental Effect of Nitrogenous Heme Ligands on the Enzymatic Activity of Acanthamoeba castellanii CYP51. Biochemistry 61 (13) (2022)
Lucianna H Santos, Thales Kronenberger, Renata G Almeida, Elany Barbosa da Silva, Rafael E O Rocha, Joyce C Oliveira, Luiza V Barreto, Danielle Skinner, Pavla Fajtová, Miriam A Giardini, Brendon Woodworth, Conner Bardine, André L Lourenço, Charles S Craik, Antti Poso, Larissa M Podust, James H McKerrow, Jair Lage Siqueira-Neto, Anthony J O'Donoghue, Eufrânio N da Silva Júnior, Rafaela Salgado Ferreira
Structure-Based Identification of Naphthoquinones and Derivatives as Novel Inhibitors of Main Protease M pro and Papain-like Protease PL pro of SARS-CoV-2. Journal of chemical information and modeling (2022)
Joshua C Corpuz, Ashay Patel, Tony D Davis, Larissa M Podust, James Andrew McCammon, Michael D Burkart
Essential Role of Loop Dynamics in Type II NRPS Biomolecular Recognition. ACS chemical biology 17 (10) (2022)
Vandna Sharma, Brian Shing, Lilian Hernandez-Alvarez, Anjan Debnath, Larissa M Podust
Domain-Swap Dimerization of Acanthamoeba castellanii CYP51 and a Unique Mechanism of Inactivation by Isavuconazole. Molecular pharmacology 98 (6) (2020)
Matthew D DeMars, Nathan L Samora, Song Yang, Marc Garcia-Borràs, Jacob N Sanders, Kendall N Houk, Larissa M Podust, David H Sherman
Exploring the molecular basis for substrate specificity in homologous macrolide biosynthetic cytochromes P450. The Journal of biological chemistry 294 (44) (2019)
Wenxu Zhou, Anjan Debnath, Gareth Jennings, Hye Jee Hahn, Boden H Vanderloop, Minu Chaudhuri, W David Nes, Larissa M Podust
Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri. PLoS pathogens 14 (9) (2018)
Anjan Debnath, Claudia M Calvet, Gareth Jennings, Wenxu Zhou, Alexander Aksenov, Madeline R Luth, Ruben Abagyan, W David Nes, James H McKerrow, Larissa M Podust
CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM). PLoS neglected tropical diseases 11 (12) (2017)
Claudia Magalhaes Calvet, Jun Yong Choi, Diane Thomas, Brian Suzuki, Ken Hirata, Sharon Lostracco-Johnson, Liliane Batista de Mesquita, Alanderson Nogueira, Marcelo Meuser-Batista, Tatiana Araujo Silva, Jair Lage Siqueira-Neto, William R Roush, Mirian Claudia de Souza Pereira, James H McKerrow, Larissa M Podust
4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection. PLoS neglected tropical diseases 11 (12) (2017)