Hakon Leffler (H Leffler)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 36

Top Venues

Journal of medicinal chemistry

Cells

International journal of molecular sciences

ChemMedChem

Lunds Universitet

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Lunds Universitet

Sweden

Associate Professor - Professor :: Laboratory Medicine

UCSF

United States

Specialist - Adjunct Professor :: Psychiatry and Pharmaceutical Chemistry

University of California San Diego

United States

Visiting Scholar :: Psychiatry

Publications

Fredrik R Zetterberg, Kristoffer Peterson, Ulf J Nilsson, Kajsa Andréasson Dahlgren, Carl Diehl, Ian Holyer, Maria Håkansson, Areej Khabut, Barbro Kahl-Knutson, Hakon Leffler, Alison C MacKinnon, James A Roper, Robert J Slack, Reihaneh Zarrizi, Anders Pedersen
Discovery of the Selective and Orally Available Galectin-1 Inhibitor GB1908 as a Potential Treatment for Lung Cancer. Journal of medicinal chemistry 67 (11) (2024)
Henry Kim, Louis Kretz, Céline Ronin, Christina Starck, James A Roper, Barbro Kahl-Knutson, Kristoffer Peterson, Hakon Leffler, Ulf J Nilsson, Anders Pedersen, Fredrik R Zetterberg, Robert J Slack
Determining the Affinity and Kinetics of Small Molecule Inhibitors of Galectin-1 Using Surface Plasmon Resonance. International journal of molecular sciences 25 (12) (2024)
Henry Kim, Louis Kretz, Céline Ronin, Christina Starck, James A Roper, Barbro Kahl-Knutson, Kristoffer Peterson, Hakon Leffler, Ulf J Nilsson, Anders Pedersen, Fredrik R Zetterberg, Robert J Slack
Determining the Affinity and Kinetics of Small Molecule Inhibitors of Galectin-1 Using Surface Plasmon Resonance. International journal of molecular sciences 25 (12) (2024)
Henry Kim, Louis Kretz, Céline Ronin, Christina Starck, James A Roper, Barbro Kahl-Knutson, Kristoffer Peterson, Hakon Leffler, Ulf J Nilsson, Anders Pedersen, Fredrik R Zetterberg, Robert J Slack
Determining the Affinity and Kinetics of Small Molecule Inhibitors of Galectin-1 Using Surface Plasmon Resonance. International journal of molecular sciences 25 (12) (2024)
Sjors van Klaveren, Mujtaba Hassan, Maria Håkansson, Richard E Johnsson, Jessica Larsson, Žiga Jakopin, Marko Anderluh, Hakon Leffler, Tihomir Tomašič, Ulf J Nilsson
Galectin-8N-Selective 4-Halophenylphthalazinone-Galactals Double π-Stack in a Unique Pocket. ACS medicinal chemistry letters 15 (8) (2024)
Sjors van Klaveren, Mujtaba Hassan, Maria Håkansson, Richard E Johnsson, Jessica Larsson, Žiga Jakopin, Marko Anderluh, Hakon Leffler, Tihomir Tomašič, Ulf J Nilsson
Galectin-8N-Selective 4-Halophenylphthalazinone-Galactals Double π-Stack in a Unique Pocket. ACS medicinal chemistry letters 15 (8) (2024)
Fredrik R Zetterberg, Kristoffer Peterson, Ulf J Nilsson, Kajsa Andréasson Dahlgren, Carl Diehl, Ian Holyer, Maria Håkansson, Areej Khabut, Barbro Kahl-Knutson, Hakon Leffler, Alison C MacKinnon, James A Roper, Robert J Slack, Reihaneh Zarrizi, Anders Pedersen
Discovery of the Selective and Orally Available Galectin-1 Inhibitor GB1908 as a Potential Treatment for Lung Cancer. Journal of medicinal chemistry (2024)
Morten Aagaard Nielsen, Ditte Køster, Akul Y Mehta, Kristian Stengaard-Pedersen, Pierre Busson, Peter Junker, Kim Hørslev-Petersen, Merete Lund Hetland, Mikkel Østergaard, Malene Hvid, Hakon Leffler, Tue W Kragstrup, Richard D Cummings, Bent Winding Deleuran
Increased Galectin-9 Levels Correlate with Disease Activity in Patients with DMARD-Naïve Rheumatoid Arthritis and Modulate the Secretion of MCP-1 and IL-6 from Synovial Fibroblasts. Cells 12 (2) (2023)
Morten Aagaard Nielsen, Ditte Køster, Akul Y Mehta, Kristian Stengaard-Pedersen, Pierre Busson, Peter Junker, Kim Hørslev-Petersen, Merete Lund Hetland, Mikkel Østergaard, Malene Hvid, Hakon Leffler, Tue W Kragstrup, Richard D Cummings, Bent Winding Deleuran
Increased Galectin-9 Levels Correlate with Disease Activity in Patients with DMARD-Naïve Rheumatoid Arthritis and Modulate the Secretion of MCP-1 and IL-6 from Synovial Fibroblasts. Cells 12 (2) (2023)
Morten Aagaard Nielsen, Ditte Køster, Akul Y Mehta, Kristian Stengaard-Pedersen, Pierre Busson, Peter Junker, Kim Hørslev-Petersen, Merete Lund Hetland, Mikkel Østergaard, Malene Hvid, Hakon Leffler, Tue W Kragstrup, Richard D Cummings, Bent Winding Deleuran
Increased Galectin-9 Levels Correlate with Disease Activity in Patients with DMARD-Naïve Rheumatoid Arthritis and Modulate the Secretion of MCP-1 and IL-6 from Synovial Fibroblasts. Cells 12 (2) (2023)
Mukul Mahanti, Kumar Bhaskar Pal, Rohit Kumar, Markus Schulze, Hakon Leffler, Derek T Logan, Ulf J Nilsson
Ligand Sulfur Oxidation State Progressively Alters Galectin-3-Ligand Complex Conformations To Induce Affinity-Influencing Hydrogen Bonds. Journal of medicinal chemistry (2023)
Fredrik R Zetterberg, Carl Diehl, Maria Håkansson, Barbro Kahl-Knutson, Hakon Leffler, Ulf J Nilsson, Kristoffer Peterson, James A Roper, Robert J Slack
Discovery of Selective and Orally Available Galectin-1 Inhibitors. Journal of medicinal chemistry (2023)
Morten Aagaard Nielsen, Ditte Køster, Akul Y Mehta, Kristian Stengaard-Pedersen, Pierre Busson, Peter Junker, Kim Hørslev-Petersen, Merete Lund Hetland, Mikkel Østergaard, Malene Hvid, Hakon Leffler, Tue W Kragstrup, Richard D Cummings, Bent Winding Deleuran
Increased Galectin-9 Levels Correlate with Disease Activity in Patients with DMARD-Naïve Rheumatoid Arthritis and Modulate the Secretion of MCP-1 and IL-6 from Synovial Fibroblasts. Cells 12 (2) (2023)
Morten Aagaard Nielsen, Ditte Køster, Akul Y Mehta, Kristian Stengaard-Pedersen, Pierre Busson, Peter Junker, Kim Hørslev-Petersen, Merete Lund Hetland, Mikkel Østergaard, Malene Hvid, Hakon Leffler, Tue W Kragstrup, Richard D Cummings, Bent Winding Deleuran
Increased Galectin-9 Levels Correlate with Disease Activity in Patients with DMARD-Naïve Rheumatoid Arthritis and Modulate the Secretion of MCP-1 and IL-6 from Synovial Fibroblasts. Cells 12 (2) (2023)
László Lázár, Anastasia S Tsagkarakou, George Stravodimos, George Kontopidis, Hakon Leffler, Ulf J Nilsson, László Somsák, Demetrios D Leonidas
Strong Binding of C -Glycosylic1,2-Thiodisaccharides to Galectin-3─Enthalpy-Driven Affinity Enhancement by Water-Mediated Hydrogen Bonds. Journal of medicinal chemistry (2023)
Felix Tobola, Martin Lepsik, Syeda Rehana Zia, Hakon Leffler, Ulf J Nilsson, Nina Persson, Anne Imberty, Birgit Wiltschi
Engineering the Ligand Specificity of the Human Galectin-1 by Incorporation of Tryptophan Analogues. Chembiochem : a European journal of chemical biology 23 (5) (2022)
Khuchtumur Bum-Erdene, Patrick M Collins, Matthew W Hugo, Somayeh S Tarighat, Fei Fei, Chandan Kishor, Hakon Leffler, Ulf J Nilsson, John Groffen, I Darren Grice, Nora Heisterkamp, Helen Blanchard
Novel Selective Galectin-3 Antagonists Are Cytotoxic to Acute Lymphoblastic Leukemia. Journal of medicinal chemistry 65 (8) (2022)
Fredrik R Zetterberg, Alison MacKinnon, Thomas Brimert, Lise Gravelle, Richard E Johnsson, Barbro Kahl-Knutson, Hakon Leffler, Ulf J Nilsson, Anders Pedersen, Kristoffer Peterson, James A Roper, Hans Schambye, Robert J Slack, Susan Tantawi
Discovery and Optimization of the First Highly Effective and Orally Available Galectin-3 Inhibitors for Treatment of Fibrotic Disease. Journal of medicinal chemistry 65 (19) (2022)
Dharma Pally, Mallar Banerjee, Shahid Hussain, Rekha V Kumar, Alexandra Petersson, Ebba Rosendal, Ludvig Gunnarsson, Kristoffer Peterson, Hakon Leffler, Ulf J Nilsson, Ramray Bhat
Galectin-9 Signaling Drives Breast Cancer Invasion through Extracellular Matrix. ACS chemical biology 17 (6) (2022)
Benedetta Girardi, Martina Manna, Sjors Van Klaveren, Tihomir Tomašič, Žiga Jakopin, Hakon Leffler, Ulf J Nilsson, Daniel Ricklin, Janez Mravljak, Oliver Schwardt, Marko Anderluh
Selective Monovalent Galectin-8 Ligands Based on 3-Lactoylgalactoside. ChemMedChem (2021)
Johan Wallerstein, Vilhelm Ekberg, Majda Misini Ignjatović, Rohit Kumar, Octav Caldararu, Kristoffer Peterson, Sven Wernersson, Ulrika Brath, Hakon Leffler, Esko Oksanen, Derek T Logan, Ulf J Nilsson, Ulf Ryde, Mikael Akke
Entropy-Entropy Compensation between the Protein, Ligand, and Solvent Degrees of Freedom Fine-Tunes Affinity in Ligand Binding to Galectin-3C. JACS Au 1 (4) (2021)
Lucía Sanjurjo, Iris A Schulkens, Pauline Touarin, Roy Heusschen, Ed Aanhane, Kitty C M Castricum, Tanja D De Gruijl, Ulf J Nilsson, Hakon Leffler, Arjan W Griffioen, Latifa Elantak, Rory R Koenen, Victor L J L Thijssen
Chemokines modulate glycan binding and the immunoregulatory activity of galectins. Communications biology 4 (1) (2021)
Mujtaba Hassan, Floriane Baussière, Samo Guzelj, Anders P Sundin, Maria Håkansson, Rebeka Kovačič, Hakon Leffler, Tihomir Tomašič, Marko Anderluh, Žiga Jakopin, Ulf J Nilsson
Structure-Guided Design of d-Galactal Derivatives with High Affinity and Selectivity for the Galectin-8 N-Terminal Domain. ACS medicinal chemistry letters 12 (11) (2021)
Klas Erik Bratteby, Edvard Torkelsson, Elina Tampio L'Estrade, Kristoffer Peterson, Vladimir Shalgunov, Mengfei Xiong, Hakon Leffler, Fredrik R Zetterberg, Tomas G Olsson, Nic Gillings, Ulf J Nilsson, Matthias Manfred Herth, Maria Erlandsson
In Vivo Veritas: 18F-Radiolabeled Glycomimetics Allow Insights into the Pharmacological Fate of Galectin-3 Inhibitors. Journal of medicinal chemistry 63 (2) (2020)
Alexander Dahlqvist, Axel Furevi, Niklas Warlin, Hakon Leffler, Ulf J Nilsson
Stereo- and regioselective hydroboration of 1-exo-methylene pyranoses: discovery of aryltriazolylmethyl C-galactopyranosides as selective galectin-1 inhibitors. Beilstein journal of organic chemistry 15 (2019)
Lynda Vuong, Eleni Kouverianou, Claire M Rooney, Brian J McHugh, Sarah E M Howie, Christopher D Gregory, Stuart J Forbes, Neil Cowan Henderson, Fredrik R Zetterberg, Ulf J Nilsson, Hakon Leffler, Paul Ford, Anders Pedersen, Lise Gravelle, Susan Tantawi, Hans Schambye, Tariq Sethi, Alison C MacKinnon
An Orally Active Galectin-3 Antagonist Inhibits Lung Adenocarcinoma Growth and Augments Response to PD-L1 Blockade. Cancer research 79 (7) (2019)
Ž Bojić-Trbojević, M Jovanović Krivokuća, A Vilotić, N Kolundžić, I Stefanoska, Fredrik R Zetterberg, Ulf J Nilsson, Hakon Leffler, Lj Vićovac
Human trophoblast requires galectin-3 for cell migration and invasion. Scientific reports 9 (1) (2019)
John Stegmayr, Fredrik R Zetterberg, Michael C Carlsson, Xiaoli Huang, Gunjan Sharma, Barbro Kahl-Knutson, Hans Schambye, Ulf J Nilsson, Stina Oredsson, Hakon Leffler
Extracellular and intracellular small-molecule galectin-3 inhibitors. Scientific reports 9 (1) (2019)
Maria Luisa Verteramo, Olof Stenström, Majda Misini Ignjatović, Octav Caldararu, Martin A Olsson, Francesco Manzoni, Hakon Leffler, Esko Oksanen, Derek T Logan, Ulf J Nilsson, Ulf Ryde, Mikael Akke
Interplay between Conformational Entropy and Solvation Entropy in Protein-Ligand Binding. Journal of the American Chemical Society 141 (5) (2019)
Kumar Bhaskar Pal, Mukul Mahanti, Hakon Leffler, Ulf J Nilsson
A Galactoside-Binding Protein Tricked into Binding Unnatural Pyranose Derivatives: 3-Deoxy-3-Methyl-Gulosides Selectively Inhibit Galectin-1. International journal of molecular sciences 20 (15) (2019)
Rohit Kumar, Majda Misini Ignjatović, Kristoffer Peterson, Martin Olsson, Hakon Leffler, Ulf Ryde, Ulf J Nilsson, Derek T Logan
Structure and Energetics of Ligand-Fluorine Interactions with Galectin-3 Backbone and Side-Chain Amides: Insight into Solvation Effects and Multipolar Interactions. ChemMedChem 14 (16) (2019)
Fredrik R Zetterberg, Kristoffer Peterson, Richard E Johnsson, Thomas Brimert, Maria Håkansson, Derek T Logan, Hakon Leffler, Ulf J Nilsson
Monosaccharide Derivatives with Low-Nanomolar Lectin Affinity and High Selectivity Based on Combined Fluorine-Amide, Phenyl-Arginine, Sulfur-π, and Halogen Bond Interactions. ChemMedChem 13 (2) (2018)
Kristoffer Peterson, Patrick M Collins, Xiaoli Huang, Barbro Kahl-Knutsson, Sofia Essén, Fredrik R Zetterberg, Stina Oredsson, Hakon Leffler, Helen Blanchard, Ulf J Nilsson
Aromatic heterocycle galectin-1 interactions for selective single-digit nM affinity ligands. RSC advances 8 (44) (2018)
Jérémy Magescas, Lucie Sengmanivong, Amandine Viau, Adeline Mayeux, Tien Dang, Martine Burtin, Ulf J Nilsson, Hakon Leffler, Françoise Poirier, Fabiola Terzi, Delphine Delacour
Spindle pole cohesion requires glycosylation-mediated localization of NuMA. Scientific reports 7 (1) (2017)
A-L Noresson, O Aurelius, C T Öberg, O Engström, A P Sundin, M Håkansson, Olof Stenström, M Akke, Derek T Logan, Hakon Leffler, Ulf J Nilsson
Designing interactions by control of protein-ligand complex conformation: tuning arginine-arene interaction geometry for enhanced electrostatic protein-ligand interactions. Chemical science 9 (4) (2017)
John Stegmayr, Adriana Lepur, Barbro Kahl-Knutson, Matilde Aguilar-Moncayo, Anatole A Klyosov, Robert A Field, Stina Oredsson, Ulf J Nilsson, Hakon Leffler
Low or No Inhibitory Potency of the Canonical Galectin Carbohydrate-binding Site by Pectins and Galactomannans. The Journal of biological chemistry 291 (25) (2016)

Hakon Leffler.css-eqlu8i{font-size:small;padding-left:4px;} (H Leffler)

Publication Activity (10 Years)

Top Topics

Top Venues

Hakon Leffler (H Leffler)