Heather Eng

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2021-2023
Publications (10 Years): 9

Top Venues

Drug metabolism and disposition: the biological fate of chemicals

Clinical pharmacology and therapeutics

Nature communications

The Journal of pharmacology and experimental therapeutics

Pfizer

The University of Toledo (BSC)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Pfizer Sep 17o 2007

United States

Senior Scientist :: PDM

Education History

The University of Toledo

United States

BSC :: Pharmacy

Publications

Siennah R Greenfield, Heather Eng, Qingyi Yang, Chunyang Guo, Laura J Byrnes, Alyssa L Dantonio, Graham M West, Li Di, Amit S Kalgutkar
Species differences in plasma protein binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease inhibitor nirmatrelvir. Xenobiotica; the fate of foreign compounds in biological systems (2023)
Heather Eng, Alyssa L Dantonio, Eugene P Kadar, R Scott Obach, Li Di, Jian Lin, Nandini C Patel, Britton Boras, Gregory S Walker, Jonathan J Novak, Emi Kimoto, Ravi Shankar P Singh, Amit S Kalgutkar
Disposition of Nirmatrelvir, an Orally Bioavailable Inhibitor of SARS-CoV-2 3C-Like Protease, across Animals and Humans. Drug metabolism and disposition: the biological fate of chemicals 50 (5) (2022)
Angela C Doran, Woodrow Burchett, Connor Landers, Gabrielle M Gualtieri, Amanda Balesano, Heather Eng, Alyssa L Dantonio, Theunis C Goosen, R Scott Obach
Defining the Selectivity of Chemical Inhibitors Used for Cytochrome P450 Reaction Phenotyping: Overcoming Selectivity Limitations with a Six-Parameter Inhibition Curve-Fitting Approach. Drug metabolism and disposition: the biological fate of chemicals (2022)
Ravi Shankar P Singh, Gregory S Walker, Eugene P Kadar, Loretta M Cox, Heather Eng, Raman Sharma, Arthur J Bergman, Lien Van Eyck, Frances Hackman, Sima S Toussi, Amit S Kalgutkar, R Scott Obach
Metabolism and Excretion of Nirmatrelvir in Humans Using Quantitative Fluorine Nuclear Magnetic Resonance Spectroscopy: A Novel Approach for Accelerating Drug Development. Clinical pharmacology and therapeutics 112 (6) (2022)
Elaine Tseng, Heather Eng, Jian Lin, Matthew A Cerny, David A Tess, Theunis C Goosen, R Scott Obach
Static and Dynamic Projections of Drug-Drug Interactions Caused by Cytochrome P450 3A Time-Dependent Inhibitors Measured in Human Liver Microsomes and Hepatocytes. Drug metabolism and disposition: the biological fate of chemicals 49 (10) (2021)
Britton Boras, Rhys M Jones, Brandon J Anson, Dan Arenson, Lisa Aschenbrenner, Malina A Bakowski, Nathan Beutler, Joseph Binder, Emily Chen, Heather Eng, Holly Hammond, Jennifer Hammond, Robert E Haupt, Robert L Hoffman, Eugene P Kadar, Rob Kania, Emi Kimoto, Melanie G Kirkpatrick, Lorraine Lanyon, Emma K Lendy, Jonathan R Lillis, James P Logue, Suman A Luthra, Chunlong Ma, Stephen W Mason, Marisa E McGrath, Stephen Noell, R Scott Obach, Matthew N O' Brien, Rebecca O'Connor, Kevin Ogilvie, Dafydd Owen, Martin Pettersson, Matthew R Reese, Thomas F Rogers, Romel Rosales, Michelle I Rossulek, Jean G Sathish, Norimitsu Shirai, Claire Steppan, Martyn Ticehurst, Lawrence W Updyke, Stuart M Weston, Yuao Zhu, Kris M White, Adolfo García-Sastre, Jun Wang, Arnab K Chatterjee, Andrew D Mesecar, Matthew B Friemann, Annaliesa S Anderson, Charlotte Allerton
Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19. Nature communications 12 (1) (2021)
Britton Boras, Rhys M Jones, Brandon J Anson, Dan Arenson, Lisa Aschenbrenner, Malina A Bakowski, Nathan Beutler, Joseph Binder, Emily Chen, Heather Eng, Holly Hammond, Jennifer Hammond, Robert E Haupt, Robert L Hoffman, Eugene P Kadar, Rob Kania, Emi Kimoto, Melanie G Kirkpatrick, Lorraine Lanyon, Emma K Lendy, Jonathan R Lillis, James Logue, Suman A Luthra, Chunlong Ma, Stephen W Mason, Marisa E McGrath, Stephen Noell, R Scott Obach, Matthew N O'Brien Laramy, Rebecca O'Connor, Kevin Ogilvie, Dafydd R Owen, Martin Pettersson, Matthew R Reese, Thomas F Rogers, Michelle I Rossulek, Jean G Sathish, Norimitsu Shirai, Claire Steppan, Martyn Ticehurst, Lawrence W Updyke, Stuart Weston, Yuao Zhu, Jun Wang, Arnab K Chatterjee, Andrew D Mesecar, Matthew B Frieman, Annaliesa S Anderson, Charlotte Allerton
Discovery of a Novel Inhibitor of Coronavirus 3CL Protease for the Potential Treatment of COVID-19. bioRxiv : the preprint server for biology (2021)
Heather Eng, Yi-An Bi, Mark A West, Sangwoo Ryu, Emi Yamaguchi, Rachel E Kosa, David A Tess, David A Griffith, John Litchfield, Amit S Kalgutkar, Manthena V S Varma
Organic Anion-Transporting Polypeptide 1B1/1B3-Mediated Hepatic Uptake Determines the Pharmacokinetics of Large Lipophilic Acids: In Vitro-In Vivo Evaluation in Cynomolgus Monkey. The Journal of pharmacology and experimental therapeutics 377 (1) (2021)
Heather Eng, Elaine Tseng, Matthew A Cerny, Theunis C Goosen, R Scott Obach
Cytochrome P450 3A Time-Dependent Inhibition Assays Are Too Sensitive for Identification of Drugs Causing Clinically Significant Drug-Drug Interactions: A Comparison of Human Liver Microsomes and Hepatocytes and Definition of Boundaries for Inactivation Rate Constants. Drug metabolism and disposition: the biological fate of chemicals 49 (6) (2021)

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Publication Activity (10 Years)

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Heather Eng