Manthena V S Varma (Manthena V Varma)

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 30

Top Topics

Chronic Kidney Disease

Endothelial Cells

Top Venues

Clinical pharmacology and therapeutics

Drug metabolism and disposition: the biological fate of chemicals

The Journal of pharmacology and experimental therapeutics

Molecular pharmaceutics

This page only lists publications with an associated author ORCID identifier.

Publications

Yi-An Bi, Samantha Jordan, Amanda King-Ahmad, Mark A West, Manthena V S Varma
Mechanistic Determinants of Daprodustat Drug-Drug Interactions and Pharmacokinetics in Hepatic Dysfunction and Chronic Kidney Disease: Significance of OATP1B-CYP2C8 Interplay. Clinical pharmacology and therapeutics (2024)
Yi-An Bi, Samantha Jordan, Amanda King-Ahmad, Mark A West, Manthena V S Varma
Mechanistic Determinants of Daprodustat Drug-Drug Interactions and Pharmacokinetics in Hepatic Dysfunction and Chronic Kidney Disease: Significance of OATP1B-CYP2C8 Interplay. Clinical pharmacology and therapeutics 115 (6) (2024)
Yi-An Bi, Samantha Jordan, Amanda King-Ahmad, Mark A West, Manthena V S Varma
Mechanistic Determinants of Daprodustat Drug-Drug Interactions and Pharmacokinetics in Hepatic Dysfunction and Chronic Kidney Disease: Significance of OATP1B-CYP2C8 Interplay. Clinical pharmacology and therapeutics 115 (6) (2024)
Yi-An Bi, Samantha Jordan, Amanda King-Ahmad, Mark A West, Emi Yamaguchi, Sangwoo Ryu, Sumathy Mathialagan, David A Tess, Manthena V S Varma
Low molecular weight acids and OATP1B mediated hepatic clearance: In vitro and in vivo evaluation using novel hypoxia-inducible factor prolyl hydroxylase inhibitors (Dustats) . Drug metabolism and disposition: the biological fate of chemicals (2024)
Sumathy Mathialagan, Git Chung, Keith Pye, A David Rodrigues, Manthena V S Varma, Colin Brown
Significance of organic anion transporter 2 and organic cation transporter 2 in creatinine clearance: Mechanistic evaluation using freshly-prepared human primary renal proximal tubule cells . The Journal of pharmacology and experimental therapeutics (2023)
Ryota Kikuchi, Paresh P Chothe, Xiaoyan Chu, Felix Huth, Kazuya Ishida, Naoki Ishiguro, Rongrong Jiang, Hong Shen, Simone H Stahl, Manthena V S Varma, Marie-Emilie Willemin, Bridget L Morse
Utilization of OATP1B Biomarker Coproporphyrin-I to Guide Drug-Drug Interaction Risk Assessment: Evaluation by the Pharmaceutical Industry. Clinical pharmacology and therapeutics (2023)
Maciej J Zamek-Gliszczynski, Vishal Sangha, Hong Shen, Bo Feng, Matthias B Wittwer, Manthena V S Varma, Xiaomin Liang, Yuichi Sugiyama, Lei Zhang, Reina Bendayan, null null
Transporters in Drug Development: International Transporter Consortium Update on Emerging Transporters of Clinical Importance. Clinical pharmacology and therapeutics 112 (3) (2022)
Jian Lin, Emi Kimito, Shinji Yamazaki, Manoli Vourvahis, Arthur Bergman, A David Rodrigues, Chester Costales, Rui Li, Manthena V S Varma
Effect of Hepatic Impairment on OATP1B Activity: Quantitative Pharmacokinetic Analysis of Endogenous Biomarker and Substrate Drugs. Clinical pharmacology and therapeutics (2022)
Sangwoo Ryu, Nathaniel Woody, George Chang, Sumathy Mathialagan, Manthena V S Varma
Identification of Organic Anion Transporter 2 Inhibitors: Screening, Structure-Based Analysis, and Clinical Drug Interaction Risk Assessment. Journal of medicinal chemistry 65 (21) (2022)
Jian Lin, Emi Kimito, Shinji Yamazaki, Manoli Vourvahis, Arthur Bergman, A David Rodrigues, Chester Costales, Rui Li, Manthena V S Varma
Effect of hepatic impairment on OATP1B activity: Quantitative pharmacokinetic analysis of endogenous biomarker and substrate drugs. Clinical pharmacology and therapeutics (2022)
Manthena V S Varma
Clinical Relevance of Organic Anion Transporting Polypeptide 1B-Mediated Hepatic Uptake for High-Permeability Drugs: A Perspective. Clinical pharmacology and therapeutics 112 (3) (2022)
Yan Weng, Kari R Fonseca, Yi-An Bi, Sumathy Mathialagan, Keith Riccardi, Elaine Tseng, Andrew J Bessire, Matthew A Cerny, David A Tess, A David Rodrigues, Amit S Kalgutkar, John E Litchfield, Li Di, Manthena V S Varma
Transporter-Enzyme Interplay in the Pharmacokinetics of PF-06835919, A First-in-class Ketohexokinase Inhibitor for Metabolic Disorders and Non-alcoholic Fatty Liver Disease . Drug metabolism and disposition: the biological fate of chemicals (2022)
Xiaoyan Chu, Bhagwat Prasad, Sibylle Neuhoff, Kenta Yoshida, James Steven Leeder, Dwaipayan Mukherjee, Kunal S Taskar, Manthena V S Varma, Xinyuan Zhang, Xinning Yang, Aleksandra Galetin
Clinical Implications of Altered Drug Transporter Abundance/Function and PBPK Modeling in Specific Populations: An ITC Perspective. Clinical pharmacology and therapeutics 112 (3) (2022)
Heather Eng, Yi-An Bi, Mark A West, Sangwoo Ryu, Emi Yamaguchi, Rachel E Kosa, David A Tess, David A Griffith, John Litchfield, Amit S Kalgutkar, Manthena V S Varma
Organic Anion-Transporting Polypeptide 1B1/1B3-Mediated Hepatic Uptake Determines the Pharmacokinetics of Large Lipophilic Acids: In Vitro-In Vivo Evaluation in Cynomolgus Monkey. The Journal of pharmacology and experimental therapeutics 377 (1) (2021)
Chester Costales, Jian Lin, Emi Kimito, Shinji Yamazaki, James R Gosset, A David Rodrigues, Sarah Lazzaro, Mark A West, Michael West, Manthena V S Varma
Quantitative prediction of breast cancer resistant protein mediated drug-drug interactions using physiologically-based pharmacokinetic modeling. CPT: pharmacometrics & systems pharmacology 10 (9) (2021)
Aditya R Kumar, Bhagwat Prasad, Deepak Kumar Bhatt, Sumathy Mathialagan, Manthena V S Varma, Jashvant D Unadkat
In Vivo-to-In Vitro Extrapolation of Transporter-Mediated Renal Clearance: Relative Expression Factor Versus Relative Activity Factor Approach. Drug metabolism and disposition: the biological fate of chemicals 49 (6) (2021)
Kim Huard, Aaron C Smith, Gregg Cappon, Robert L Dow, David J Edmonds, Ayman El-Kattan, William P Esler, Dilinie P Fernando, David A Griffith, Amit S Kalgutkar, Trenton T Ross, Scott W Bagley, David Beebe, Yi-An Bi, Shawn Cabral, Collin Crowley, Shawn D Doran, Matthew S Dowling, Spiros Liras, Vincent Mascitti, Mark Niosi, Jeffrey A Pfefferkorn, Jana Polivkova, Cathy Préville, David A Price, Andre Shavnya, Norimitsu Shirai, Andrew H Smith, James R Southers, David A Tess, Benjamin A Thuma, Manthena V S Varma, Xiaojing Yang
Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting. Journal of medicinal chemistry 63 (19) (2020)
Stefanus J Steyn, Manthena V S Varma
Cytochrome-P450-Mediated Drug-Drug Interactions of Substrate Drugs: Assessing Clinical Risk Based on Molecular Properties and an Extended Clearance Classification System. Molecular pharmaceutics 17 (8) (2020)
Yi-An Bi, Sangwoo Ryu, David A Tess, A David Rodrigues, Manthena V S Varma
Effect of Human Plasma on Hepatic Uptake of Organic Anion-Transporting Polypeptide 1B Substrates: Studies Using Transfected Cells and Primary Human Hepatocytes. Drug metabolism and disposition: the biological fate of chemicals 49 (1) (2020)
David A Tess, Heather Eng, Amit S Kalgutkar, John Litchfield, David J Edmonds, David A Griffith, Manthena V S Varma
Predicting the Human Hepatic Clearance of Acidic and Zwitterionic Drugs. Journal of medicinal chemistry 63 (20) (2020)
Yi-An Bi, Chester Costales, Sumathy Mathialagan, Mark West, Soraya Eatemadpour, Sarah Lazzaro, Laurie Tylaska, Renato Scialis, Hui Zhang, John Umland, Emi Kimito, David A Tess, Bo Feng, Larry M Tremaine, Manthena V S Varma, A David Rodrigues
Quantitative Contribution of Six Major Transporters to the Hepatic Uptake of Drugs: "SLC-Phenotyping" Using Primary Human Hepatocytes. The Journal of pharmacology and experimental therapeutics 370 (1) (2019)
Anna Vildhede, Emi Kimoto, Ryan M Pelis, A David Rodrigues, Manthena V S Varma
Quantitative Proteomics and Mechanistic Modeling of Transporter-Mediated Disposition in Nonalcoholic Fatty Liver Disease. Clinical pharmacology and therapeutics 107 (5) (2019)
A David Rodrigues, Yurong Lai, Hong Shen, Manthena V S Varma, Andrew Rowland, Stefan Oswald
Induction of Human Intestinal and Hepatic Organic Anion Transporting Polypeptides: Where Is the Evidence for Its Relevance in Drug-Drug Interactions? Drug metabolism and disposition: the biological fate of chemicals 48 (3) (2019)
Arthur Bergman, Yi-An Bi, Sumathy Mathialagan, John Litchfield, David J Kazierad, Jeffrey A Pfefferkorn, Manthena V S Varma
Effect of Hepatic Organic Anion-Transporting Polypeptide 1B Inhibition and Chronic Kidney Disease on the Pharmacokinetics of a Liver-Targeted Glucokinase Activator: A Model-Based Evaluation. Clinical pharmacology and therapeutics 106 (4) (2019)
Manthena V S Varma, Yi-An Bi, Sarah Lazzaro, Mark West
Clopidogrel as a Perpetrator of Drug-Drug Interactions: A Challenge for Quantitative Predictions? Clinical pharmacology and therapeutics 105 (6) (2019)
Emi Kimito, Manoli Vourvahis, Renato J Scialis, Heather Eng, A David Rodrigues, Manthena V S Varma
Mechanistic Evaluation of the Complex Drug-Drug Interactions of Maraviroc: Contribution of Cytochrome P450 3A, P-Glycoprotein and Organic Anion Transporting Polypeptide 1B1. Drug metabolism and disposition: the biological fate of chemicals 47 (5) (2019)
Yi-An Bi, Jian Lin, Sumathy Mathialagan, Laurie Tylaska, Ernesto Callegari, A David Rodrigues, Manthena V S Varma
Role of Hepatic Organic Anion Transporter 2 in the Pharmacokinetics of R- and S-Warfarin: In Vitro Studies and Mechanistic Evaluation. Molecular pharmaceutics 15 (3) (2018)
Emi Kimoto, Sumathy Mathialagan, Laurie Tylaska, Mark Niosi, Jian Lin, Anthony A Carlo, David A Tess, Manthena V S Varma
Organic Anion Transporter 2-Mediated Hepatic Uptake Contributes to the Clearance of High-Permeability-Low-Molecular-Weight Acid and Zwitterion Drugs: Evaluation Using 25 Drugs. The Journal of pharmacology and experimental therapeutics 367 (2) (2018)
Anna Vildhede, Emi Kimoto, A David Rodrigues, Manthena V S Varma
Quantification of Hepatic Organic Anion Transport Proteins OAT2 and OAT7 in Human Liver Tissue and Primary Hepatocytes. Molecular pharmaceutics 15 (8) (2018)
Rachel E Kosa, Sarah Lazzaro, Yi-An Bi, Brendan Tierney, Dana Gates, Sweta Modi, Chester Costales, A David Rodrigues, Larry M Tremaine, Manthena V S Varma
Simultaneous Assessment of Transporter-Mediated Drug-Drug Interactions Using a Probe Drug Cocktail in Cynomolgus Monkey. Drug metabolism and disposition: the biological fate of chemicals 46 (8) (2018)