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Amit S Kalgutkar

ORCID

Publication Activity (10 Years)

Years Active: 2018-2023
Publications (10 Years): 24

Top Venues

Journal of medicinal chemistry

Drug metabolism and disposition: the biological fate of chemicals

Chemical research in toxicology

Drug metabolism reviews

Pfizer Global Research and Development

Virginia Tech (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Pfizer Global Research and Development Sep 13o 1999

United States

Research Fellow :: Medicine Design

Education History

Virginia Tech Aug 27o 1988 - Apr 1o 1993

United States

PHD :: Chemistry

Publications

Rachel J Roth Flach, Eliza Bollinger, Allan R Reyes, Brigitte Laforest, Bethany L Kormos, Shenping Liu, Matthew R Reese, Luis A Martinez Alsina, Leanne Buzon, Yuan Zhang, Bruce Bechle, Amy Rosado, Parag V Sahasrabudhe, John Knafels, Samit K Bhattacharya, Kiyoyuki Omoto, John C Stansfield, Liam D Hurley, LouJin Song, Lina Luo, Susanne B Breitkopf, Mara Monetti, Teresa Cunio, Brendan Tierney, Frank J Geoly, Jake Delmore, C Parker Siddall, Liang Xue, Ka N Yip, Amit S Kalgutkar, Russell A Miller, Bei B Zhang, Kevin J Filipski
Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels. Nature communications 14 (1) (2023)
Raman Sharma, Matthew S Dowling, Kentaro Futatsugi, Amit S Kalgutkar
Mitigating a Bioactivation Liability with an Azetidine-Based Inhibitor of Diacylglycerol Acyltransferase 2 (DGAT2) En Route to the Discovery of the Clinical Candidate Ervogastat. Chemical research in toxicology (2023)
Siennah R Greenfield, Heather Eng, Qingyi Yang, Chunyang Guo, Laura J Byrnes, Alyssa L Dantonio, Graham M West, Li Di, Amit S Kalgutkar
Species differences in plasma protein binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease inhibitor nirmatrelvir. Xenobiotica; the fate of foreign compounds in biological systems (2023)
Shuai Wang, Upendra A Argikar, Lionel Cheruzel, Sungjoon Cho, Rachel D Crouch, Deepika Dhaware, Carley J S Heck, Kevin M Johnson, Amit S Kalgutkar, Lloyd King, Joyce Liu, Bin Ma, Hlaing Holly Maw, Grover P Miller, Herana Kamal Seneviratne, Ryan H Takahashi, Cong Wei, S Cyrus Khojasteh
Bioactivation and reactivity research advances - 2022 year in review‡. Drug metabolism reviews (2023)
Kentaro Futatsugi, Shawn Cabral, Daniel W Kung, Kim Huard, Esther C Y Lee, Markus Boehm, Jonathan Bauman, Ronald W Clark, Steven B Coffey, Collin Crowley, Anne-Marie Dechert-Schmitt, Matthew S Dowling, Robert Dullea, James R Gosset, Amit S Kalgutkar, Kou Kou, Qifang Li, Yajing Lian, Paula M Loria, Allyn T Londregan, Mark Niosi, Christine Orozco, John C Pettersen, Jeffrey A Pfefferkorn, Jana Polivkova, Trenton T Ross, Raman Sharma, Ingrid A Stock, Gregory Tesz, Hanna Wisniewska, Bryan Goodwin, David A Price
Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis. Journal of medicinal chemistry 65 (22) (2022)
Heather Eng, Alyssa L Dantonio, Eugene P Kadar, R Scott Obach, Li Di, Jian Lin, Nandini C Patel, Britton Boras, Gregory S Walker, Jonathan J Novak, Emi Kimoto, Ravi Shankar P Singh, Amit S Kalgutkar
Disposition of Nirmatrelvir, an Orally Bioavailable Inhibitor of SARS-CoV-2 3C-Like Protease, across Animals and Humans. Drug metabolism and disposition: the biological fate of chemicals 50 (5) (2022)
Krista L Dobo, Michelle O Kenyon, Olivier Dirat, Maria Engel, Andrew Fleetwood, Matthew Martin, Susan Mattano, Alyssa Musso, James Christopher McWilliams, Alexandros Papanikolaou, Patricia Parris, Jessica Whritenour, Shu Yu, Amit S Kalgutkar
Practical and Science-Based Strategy for Establishing Acceptable Intakes for Drug Product N -Nitrosamine Impurities. Chemical research in toxicology 35 (3) (2022)
David A Griffith, David J Edmonds, Jean-Philippe Fortin, Amit S Kalgutkar, J Brent Kuzmiski, Paula M Loria, Aditi R Saxena, Scott W Bagley, Clare Buckeridge, John M Curto, David R Derksen, João M Dias, Matthew C Griffor, Seungil Han, V Margaret Jackson, Margaret S Landis, Daniel Lettiere, Chris Limberakis, Yuhang Liu, Alan M Mathiowetz, Jayesh C Patel, David W Piotrowski, David A Price, Roger B Ruggeri, David A Tess
A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor. Journal of medicinal chemistry 65 (12) (2022)
S Cyrus Khojasteh, Upendra A Argikar, Sungjoon Cho, Rachel D Crouch, Carley J S Heck, Kevin M Johnson, Amit S Kalgutkar, Lloyd King, Hlaing Holly Maw, Herana Kamal Seneviratne, Shuai Wang, Cong Wei, Donglu Zhang, Klarissa D Jackson
Biotransformation novel advances - 2021 year in review. Drug metabolism reviews 54 (3) (2022)
Ravi Shankar P Singh, Gregory S Walker, Eugene P Kadar, Loretta M Cox, Heather Eng, Raman Sharma, Arthur J Bergman, Lien Van Eyck, Frances Hackman, Sima S Toussi, Amit S Kalgutkar, R Scott Obach
Metabolism and Excretion of Nirmatrelvir in Humans Using Quantitative Fluorine Nuclear Magnetic Resonance Spectroscopy: A Novel Approach for Accelerating Drug Development. Clinical pharmacology and therapeutics 112 (6) (2022)
Yan Weng, Kari R Fonseca, Yi-An Bi, Sumathy Mathialagan, Keith Riccardi, Elaine Tseng, Andrew J Bessire, Matthew A Cerny, David A Tess, A David Rodrigues, Amit S Kalgutkar, John E Litchfield, Li Di, Manthena V S Varma
Transporter-Enzyme Interplay in the Pharmacokinetics of PF-06835919, A First-in-class Ketohexokinase Inhibitor for Metabolic Disorders and Non-alcoholic Fatty Liver Disease . Drug metabolism and disposition: the biological fate of chemicals (2022)
Sarah C Shuck, Amit S Kalgutkar, Charles G Knutson, Yinsheng Wang, Shana J Sturla
Chemical Research in Toxicology at 35: Recognizing the Impact of Professor Larry Marnett. Chemical research in toxicology 35 (2) (2022)
Tim F Ryder, Arthur Bergman, Amanda King-Ahmad, Neeta B Amin, Manjinder S Lall, T Eric Ballard, Amit S Kalgutkar
Pharmacokinetics, mass balance, metabolism, and excretion of the liver-targeted acetyl-CoA carboxylase inhibitor PF-05221304 (clesacostat) in humans. Xenobiotica; the fate of foreign compounds in biological systems 52 (3) (2022)
David J Ponting, Krista L Dobo, Michelle O Kenyon, Amit S Kalgutkar
Strategies for Assessing Acceptable Intakes for Novel N -Nitrosamines Derived from Active Pharmaceutical Ingredients. Journal of medicinal chemistry 65 (23) (2022)
S Cyrus Khojasteh, Upendra A Argikar, James P Driscoll, Carley J S Heck, Lloyd King, Klarissa D Jackson, Wenying Jian, Amit S Kalgutkar, Grover P Miller, Valerie M Kramlinger, Ivonne M C M Rietjens, Aaron M Teitelbaum, Kai Wang, Cong Wei
Novel advances in biotransformation and bioactivation research - 2020 year in review. Drug metabolism reviews 53 (3) (2021)
Heather Eng, Yi-An Bi, Mark A West, Sangwoo Ryu, Emi Yamaguchi, Rachel E Kosa, David A Tess, David A Griffith, John Litchfield, Amit S Kalgutkar, Manthena V S Varma
Organic Anion-Transporting Polypeptide 1B1/1B3-Mediated Hepatic Uptake Determines the Pharmacokinetics of Large Lipophilic Acids: In Vitro-In Vivo Evaluation in Cynomolgus Monkey. The Journal of pharmacology and experimental therapeutics 377 (1) (2021)
Valerie M Kramlinger, Deepak Dalvie, Carley J S Heck, Amit S Kalgutkar, James O'Neill, Dian Su, Aaron M Teitelbaum, Rheem A Totah
Future of Biotransformation Science in the Pharmaceutical Industry. Drug metabolism and disposition: the biological fate of chemicals 50 (3) (2021)
Kim Huard, Aaron C Smith, Gregg Cappon, Robert L Dow, David J Edmonds, Ayman El-Kattan, William P Esler, Dilinie P Fernando, David A Griffith, Amit S Kalgutkar, Trenton T Ross, Scott W Bagley, David Beebe, Yi-An Bi, Shawn Cabral, Collin Crowley, Shawn D Doran, Matthew S Dowling, Spiros Liras, Vincent Mascitti, Mark Niosi, Jeffrey A Pfefferkorn, Jana Polivkova, Cathy Préville, David A Price, Andre Shavnya, Norimitsu Shirai, Andrew H Smith, James R Southers, David A Tess, Benjamin A Thuma, Manthena V S Varma, Xiaojing Yang
Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting. Journal of medicinal chemistry 63 (19) (2020)
Kentaro Futatsugi, Aaron C Smith, Meihua Tu, Brian Raymer, Kay Ahn, Steven B Coffey, Matthew S Dowling, Dilinie P Fernando, Jemy A Gutierrez, Kim Huard, Jayasankar Jasti, Amit S Kalgutkar, John D Knafels, Jayvardhan Pandit, Kevin D Parris, Sylvie Perez, Jeffrey A Pfefferkorn, David A Price, Tim Ryder, Andre Shavnya, Ingrid A Stock, Andy S Tsai, Gregory J Tesz, Benjamin A Thuma, Yan Weng, Hanna M Wisniewska, Gang Xing, Jun Zhou, Thomas V Magee
Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose. Journal of medicinal chemistry 63 (22) (2020)
Matthew A Cerny, Amit S Kalgutkar, R Scott Obach, Raman Sharma, Douglas K Spracklin, Gregory S Walker
Effective Application of Metabolite Profiling in Drug Design and Discovery. Journal of medicinal chemistry 63 (12) (2020)
David A Tess, Heather Eng, Amit S Kalgutkar, John Litchfield, David J Edmonds, David A Griffith, Manthena V S Varma
Predicting the Human Hepatic Clearance of Acidic and Zwitterionic Drugs. Journal of medicinal chemistry 63 (20) (2020)
Amit S Kalgutkar
Designing around Structural Alerts in Drug Discovery. Journal of medicinal chemistry 63 (12) (2019)
Tim F Ryder, Matthew F Calabrese, Gregory S Walker, Kimberly O Cameron, Allan R Reyes, Kris A Borzilleri, Jake Delmore, Russell Miller, Ravi G Kurumbail, Jessica Ward, Daniel W Kung, Janice A Brown, David J Edmonds, Heather Eng, Angela C Wolford, Amit S Kalgutkar
Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK). Journal of medicinal chemistry 61 (16) (2018)
Kimberly Lapham, Jian Lin, Jonathan Novak, Christine Orozco, Mark Niosi, Li Di, Theunis C Goosen, Sangwoo Ryu, Keith Riccardi, Heather Eng, Kimberly O Cameron, Amit S Kalgutkar
6-Chloro-5-[4-(1-Hydroxycyclobutyl)Phenyl]-1H-Indole-3-Carboxylic Acid is a Highly Selective Substrate for Glucuronidation by UGT1A1, Relative to β-Estradiol. Drug metabolism and disposition: the biological fate of chemicals 46 (12) (2018)

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Publication Activity (10 Years)

Top Topics

Top Venues

Amit S Kalgutkar