R Scott Obach

Publication Activity (10 Years)

Years Active: 2018-2022
Publications (10 Years): 9

Top Topics

Alcohol Use Disorder

Respiratory Syndrome Coronavirus

Induced Pluripotent Stem Cells

Top Venues

Drug metabolism and disposition: the biological fate of chemicals

Chemical research in toxicology

Clinical pharmacology and therapeutics

Journal of medicinal chemistry

This page only lists publications with an associated author ORCID identifier.

Publications

Heather Eng, Alyssa L Dantonio, Eugene P Kadar, R Scott Obach, Li Di, Jian Lin, Nandini C Patel, Britton Boras, Gregory S Walker, Jonathan J Novak, Emi Kimito, Ravi Shankar Prasad Singh, Amit S Kalgutkar
Disposition of Nirmatrelvir, an Orally Bioavailable Inhibitor of SARS-CoV-2 3C-Like Protease, across Animals and Humans. Drug metabolism and disposition: the biological fate of chemicals 50 (5) (2022)
Ravi Shankar Prasad Singh, Gregory S Walker, Eugene P Kadar, Loretta M Cox, Heather Eng, Raman Sharma, Arthur J Bergman, Lien Van Eyck, Frances Hackman, Sima S Toussi, Amit S Kalgutkar, R Scott Obach
Metabolism and Excretion of Nirmatrelvir in Humans Using Quantitative Fluorine Nuclear Magnetic Resonance Spectroscopy: A Novel Approach for Accelerating Drug Development. Clinical pharmacology and therapeutics 112 (6) (2022)
Elaine Tseng, Heather Eng, Jian Lin, Matthew A Cerny, David A Tess, Theunis C Goosen, R Scott Obach
Static and Dynamic Projections of Drug-Drug Interactions Caused by Cytochrome P450 3A Time-Dependent Inhibitors Measured in Human Liver Microsomes and Hepatocytes. Drug metabolism and disposition: the biological fate of chemicals 49 (10) (2021)
Britton Boras, Rhys M Jones, Brandon J Anson, Dan Arenson, Lisa Aschenbrenner, Malina A Bakowski, Nathan Beutler, Joseph Binder, Emily Chen, Heather Eng, Holly Hammond, Jennifer Hammond, Robert E Haupt, Robert L Hoffman, Eugene P Kadar, Rob Kania, Emi Kimito, Melanie G Kirkpatrick, Lorraine Lanyon, Emma K Lendy, Jonathan R Lillis, James Logue, Suman A Luthra, Chunlong Ma, Stephen W Mason, Marisa E McGrath, Stephen Noell, R Scott Obach, Matthew N O'Brien Laramy, Rebecca O'Connor, Kevin Ogilvie, Dafydd R Owen, Martin Pettersson, Matthew R Reese, Thomas F Rogers, Michelle I Rossulek, Jean G Sathish, Norimitsu Shirai, Claire M Steppan, Martyn Ticehurst, Lawrence W Updyke, Stuart Weston, Yuao Zhu, Jun Wang, Arnab K Chatterjee, Andrew D Mesecar, Matthew B Frieman, Annaliesa S Anderson, Charlotte Allerton
Discovery of a Novel Inhibitor of Coronavirus 3CL Protease for the Potential Treatment of COVID-19. bioRxiv : the preprint server for biology (2021)
Heather Eng, Elaine Tseng, Matthew A Cerny, Theunis C Goosen, R Scott Obach
Cytochrome P450 3A Time-Dependent Inhibition Assays Are Too Sensitive for Identification of Drugs Causing Clinically Significant Drug-Drug Interactions: A Comparison of Human Liver Microsomes and Hepatocytes and Definition of Boundaries for Inactivation Rate Constants. Drug metabolism and disposition: the biological fate of chemicals 49 (6) (2021)
Sravani Adusumalli, Rohitash Jamwal, R Scott Obach, Tim F Ryder, Lorenzo Leggio, Fatemeh Akhlaghi
Role of Molybdenum-Containing Enzymes in the Biotransformation of the Novel Ghrelin Receptor Inverse Agonist PF-5190457: A Reverse Translational Bed-to-Bench Approach. Drug metabolism and disposition: the biological fate of chemicals 47 (8) (2019)
Changhua Ji, Mausumee Guha, Xu Zhu, Jessica Whritenour, Michelle Hemkens, Susanna Tse, Gregory S Walker, Ellen Evans, Nasir K Khan, Martin B Finkelstein, Ernesto Callegari, R Scott Obach
Enzalutamide and Apalutamide: In Vitro Chemical Reactivity Studies and Activity in a Mouse Drug Allergy Model. Chemical research in toxicology 33 (1) (2019)
R Scott Obach, Gregory S Walker, Raman Sharma, Stephen Jenkinson, Tuan P Tran, Antonia F Stepan
Lead Diversification at the Nanomole Scale Using Liver Microsomes and Quantitative Nuclear Magnetic Resonance Spectroscopy: Application to Phosphodiesterase 2 Inhibitors. Journal of medicinal chemistry 61 (8) (2018)
Franco Lombardo, Giuliano Berellini, R Scott Obach
Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds. Drug metabolism and disposition: the biological fate of chemicals 46 (11) (2018)