Heike Brötz-Oesterhelt

Publication Activity (10 Years)

Years Active: 2019-2024
Publications (10 Years): 50

Top Topics

Chronic Rhinosinusitis

Multidrug Resistant

Staphylococcus Aureus

Top Venues

ACS chemical biology

Nature microbiology

ACS infectious diseases

This page only lists publications with an associated author ORCID identifier.

Publications

Kim Lewis, Richard E Lee, Heike Brötz-Oesterhelt, Sebastian Hiller, Marina V Rodnina, Tanja Schneider, Markus H Weingarth, Ingo Wohlgemuth
Sophisticated natural products as antibiotics. Nature 632 (8023) (2024)
Gabriel Castro-Falcón, Jan Straetener, Jan Bornikoel, Daniela Reimer, Trevor N Purdy, Anne Berscheid, Florence M Schempp, Dennis Y Liu, Roger G Linington, Heike Brötz-Oesterhelt, Chambers C Hughes
Antibacterial Marinopyrroles and Pseudilins Act as Protonophores. ACS chemical biology 19 (3) (2024)
Gabriel Castro-Falcón, Jan Straetener, Jan Bornikoel, Daniela Reimer, Trevor N Purdy, Anne Berscheid, Florence M Schempp, Dennis Y Liu, Roger G Linington, Heike Brötz-Oesterhelt, Chambers C Hughes
Antibacterial Marinopyrroles and Pseudilins Act as Protonophores. ACS chemical biology 19 (3) (2024)
Philipp Peslalz, Andreas Vorbach, Anton Bleisch, Elisa Liberini, Frank Kraus, Flavia Izzo, Heike Brötz-Oesterhelt, Friedrich Götz, Bernd Plietker
Chemical Predictive Modelling and Natural Product-based Divergent Synthesis - Design of Type B PPAPs with Nanomolar Activities against MRSA. Chemistry (Weinheim an der Bergstrasse, Germany) (2024)
Kevin Christopher Ludwig, Jan-Samuel Puls, Cruz L Matos de Opitz, Paolo Innocenti, Jan-Martin Daniel, Jan Bornikoel, Melina Arts, Sebastian Krannich, Jan Straetener, Dominik Brajtenbach, Beate Henrichfreise, Peter Sass, Anna Mueller, Nathaniel I Martin, Heike Brötz-Oesterhelt, Ulrich Kubitscheck, Fabian Grein, Tanja Schneider
The Dual Mode of Antibacterial Action of the Synthetic Small Molecule DCAP Involves Lipid II Binding. Journal of the American Chemical Society (2024)
Kirsten Leeten, Nicolas Jacques, Lidia Alejo Esquembre, Dana C Schneider, Jan Straetener, Camilla Henriksen, Lucia Musumeci, Florence Putters, Sofia Melo, Elena Sánchez-López, Martin Giera, Noémie Penoy, Géraldine Piel, Olivier Verlaine, Ana Amoroso, Bernard Joris, Christoph J Slavetinsky, Eric Goffin, Bernard Pirotte, Dorte Frees, Heike Brötz-Oesterhelt, Patrizio Lancellotti, Cécile Oury
Ticagrelor alters the membrane of Staphylococcus aureus and enhances the activity of vancomycin and daptomycin without eliciting cross-resistance. mBio (2024)
Philipp Peslalz, Andreas Vorbach, Anton Bleisch, Elisa Liberini, Frank Kraus, Flavia Izzo, Heike Brötz-Oesterhelt, Friedrich Götz, Bernd Plietker
Chemical Predictive Modelling and Natural Product-based Divergent Synthesis - Design of Type B PPAPs with Nanomolar Activities against MRSA. Chemistry (Weinheim an der Bergstrasse, Germany) 30 (46) (2024)
Gabriel Castro-Falcón, Jan Straetener, Jan Bornikoel, Daniela Reimer, Trevor N Purdy, Anne Berscheid, Florence M Schempp, Dennis Y Liu, Roger G Linington, Heike Brötz-Oesterhelt, Chambers C Hughes
Antibacterial Marinopyrroles and Pseudilins Act as Protonophores. ACS chemical biology (2024)
Anne Berscheid, Jan Straetener, Nadine A Schilling, Dominik Ruppelt, Martin C Konnerth, Birgit Schittek, Bernhard Krismer, Andreas Peschel, Claudia Steinem, Stephanie Grond, Heike Brötz-Oesterhelt
The microbiome-derived antibacterial lugdunin acts as a cation ionophore in synergy with host peptides. mBio (2024)
Benjamin O Torres Salazar, Taulant Dema, Nadine A Schilling, Daniela Janek, Jan Bornikoel, Anne Berscheid, Ahmed M A Elsherbini, Sophia Krauss, Simon J Jaag, Michael Lämmerhofer, Min Li, Norah Alqahtani, Malcolm J Horsburgh, Tilmann Weber, José Manuel Beltrán-Beleña, Heike Brötz-Oesterhelt, Stephanie Grond, Bernhard Krismer, Andreas Peschel
Author Correction: Commensal production of a broad-spectrum and short-lived antimicrobial peptide polyene eliminates nasal Staphylococcus aureus. Nature microbiology (2024)
Kim Lewis, Richard E Lee, Heike Brötz-Oesterhelt, Sebastian Hiller, Marina V Rodnina, Tanja Schneider, Markus H Weingarth, Ingo Wohlgemuth
Sophisticated natural products as antibiotics. Nature 632 (8023) (2024)
Gabriel Castro-Falcón, Jan Straetener, Jan Bornikoel, Daniela Reimer, Trevor N Purdy, Anne Berscheid, Florence M Schempp, Dennis Y Liu, Roger G Linington, Heike Brötz-Oesterhelt, Chambers C Hughes
Antibacterial Marinopyrroles and Pseudilins Act as Protonophores. ACS chemical biology 19 (3) (2024)
Gabriel Castro-Falcón, Jan Straetener, Jan Bornikoel, Daniela Reimer, Trevor N Purdy, Anne Berscheid, Florence M Schempp, Dennis Y Liu, Roger G Linington, Heike Brötz-Oesterhelt, Chambers C Hughes
Antibacterial Marinopyrroles and Pseudilins Act as Protonophores. ACS chemical biology 19 (3) (2024)
Gabriel Castro-Falcón, Jan Straetener, Jan Bornikoel, Daniela Reimer, Trevor N Purdy, Anne Berscheid, Florence M Schempp, Dennis Y Liu, Roger G Linington, Heike Brötz-Oesterhelt, Chambers C Hughes
Antibacterial Marinopyrroles and Pseudilins Act as Protonophores. ACS chemical biology 19 (3) (2024)
Gabriel Castro-Falcón, Jan Straetener, Jan Bornikoel, Daniela Reimer, Trevor N Purdy, Anne Berscheid, Florence M Schempp, Dennis Y Liu, Roger G Linington, Heike Brötz-Oesterhelt, Chambers C Hughes
Antibacterial Marinopyrroles and Pseudilins Act as Protonophores. ACS chemical biology 19 (3) (2024)
Stefan Pan, Aaron A Jensen, Nicholas A Wood, Beate Henrichfreise, Heike Brötz-Oesterhelt, Derek J Fisher, Peter Sass, Scot P Ouellette
Molecular Characterization of the ClpC AAA+ ATPase in the Biology of Chlamydia trachomatis. mBio (2023)
Raoul Walther, Linda M Westermann, Sheiliza Carmali, Sophie E Jackson, Heike Brötz-Oesterhelt, David R Spring
Identification of macrocyclic peptides which activate bacterial cylindrical proteases. RSC medicinal chemistry 14 (6) (2023)
Benjamin O Torres Salazar, Taulant Dema, Nadine A Schilling, Daniela Janek, Jan Bornikoel, Anne Berscheid, Ahmed M A Elsherbini, Sophia Krauss, Simon J Jaag, Michael Lämmerhofer, Min Li, Norah Alqahtani, Malcolm J Horsburgh, Tilmann Weber, José Manuel Beltrán-Beleña, Heike Brötz-Oesterhelt, Stephanie Grond, Bernhard Krismer, Andreas Peschel
Commensal production of a broad-spectrum and short-lived antimicrobial peptide polyene eliminates nasal Staphylococcus aureus. Nature microbiology 9 (1) (2023)
Benjamin O Torres Salazar, Taulant Dema, Nadine A Schilling, Daniela Janek, Jan Bornikoel, Anne Berscheid, Ahmed M A Elsherbini, Sophia Krauss, Simon J Jaag, Michael Lämmerhofer, Min Li, Norah Alqahtani, Malcolm J Horsburgh, Tilmann Weber, José Manuel Beltrán-Beleña, Heike Brötz-Oesterhelt, Stephanie Grond, Bernhard Krismer, Andreas Peschel
Commensal production of a broad-spectrum and short-lived antimicrobial peptide polyene eliminates nasal Staphylococcus aureus. Nature microbiology 9 (1) (2023)
Benjamin O Torres Salazar, Taulant Dema, Nadine A Schilling, Daniela Janek, Jan Bornikoel, Anne Berscheid, Ahmed M A Elsherbini, Sophia Krauss, Simon J Jaag, Michael Lämmerhofer, Min Li, Norah Alqahtani, Malcolm J Horsburgh, Tilmann Weber, José Manuel Beltrán-Beleña, Heike Brötz-Oesterhelt, Stephanie Grond, Bernhard Krismer, Andreas Peschel
Commensal production of a broad-spectrum and short-lived antimicrobial peptide polyene eliminates nasal Staphylococcus aureus. Nature microbiology 9 (1) (2023)
Martina Bianchi, Mathias Winterhalter, Theresa Anisja Harbig, Daniel Hörömpöli, Ishan Ghai, Kay Nieselt, Heike Brötz-Oesterhelt, Christoph Mayer, Marina Borisova
Fosfomycin Uptake in Escherichia coli Is Mediated by the Outer-Membrane Porins OmpF, OmpC, and LamB. ACS infectious diseases 10 (1) (2023)
Isabel V L Wilkinson, Gabriel Castro-Falcón, Maria C Roda-Serrat, Trevor N Purdy, Jan Straetener, Melanie M Brauny, Lisa Maier, Heike Brötz-Oesterhelt, Lars Porskjær Christensen, Stephan A Sieber, Chambers C Hughes
The Cyanobacterial "Nutraceutical" Phycocyanobilin Inhibits Cysteine Protease Legumain. Chembiochem : a European journal of chemical biology 24 (5) (2023)
Hamada Saad, Thomas Majer, Keshab Bhattarai, Sarah Lampe, Dinh T Nguyen, Markus Kramer, Jan Straetener, Heike Brötz-Oesterhelt, Douglas A Mitchell, Harald Gross
Bioinformatics-guided discovery of biaryl-linked lasso peptides. Chemical science 14 (45) (2023)
Isabel V L Wilkinson, Gabriel Castro-Falcón, Maria C Roda-Serrat, Trevor N Purdy, Jan Straetener, Melanie M Brauny, Lisa Maier, Heike Brötz-Oesterhelt, Lars Porskjær Christensen, Stephan A Sieber, Chambers C Hughes
The Cyanobacterial "Nutraceutical" Phycocyanobilin Inhibits Cysteine Protease Legumain. Chembiochem : a European journal of chemical biology 24 (5) (2023)
Benjamin O Torres Salazar, Taulant Dema, Nadine A Schilling, Daniela Janek, Jan Bornikoel, Anne Berscheid, Ahmed M A Elsherbini, Sophia Krauss, Simon J Jaag, Michael Lämmerhofer, Min Li, Norah Alqahtani, Malcolm J Horsburgh, Tilmann Weber, José Manuel Beltrán-Beleña, Heike Brötz-Oesterhelt, Stephanie Grond, Bernhard Krismer, Andreas Peschel
Commensal production of a broad-spectrum and short-lived antimicrobial peptide polyene eliminates nasal Staphylococcus aureus. Nature microbiology 9 (1) (2023)
Benjamin O Torres Salazar, Taulant Dema, Nadine A Schilling, Daniela Janek, Jan Bornikoel, Anne Berscheid, Ahmed M A Elsherbini, Sophia Krauss, Simon J Jaag, Michael Lämmerhofer, Min Li, Norah Alqahtani, Malcolm J Horsburgh, Tilmann Weber, José Manuel Beltrán-Beleña, Heike Brötz-Oesterhelt, Stephanie Grond, Bernhard Krismer, Andreas Peschel
Commensal production of a broad-spectrum and short-lived antimicrobial peptide polyene eliminates nasal Staphylococcus aureus. Nature microbiology (2023)
Martina Bianchi, Mathias Winterhalter, Theresa Anisja Harbig, Daniel Hörömpöli, Ishan Ghai, Kay Nieselt, Heike Brötz-Oesterhelt, Christoph Mayer, Marina Borisova
Fosfomycin Uptake in Escherichia coli Is Mediated by the Outer-Membrane Porins OmpF, OmpC, and LamB. ACS infectious diseases 10 (1) (2023)
Raoul Walther, Linda M Westermann, Sheiliza Carmali, Sophie E Jackson, Heike Brötz-Oesterhelt, David R Spring
Identification of macrocyclic peptides which activate bacterial cylindrical proteases. RSC medicinal chemistry 14 (6) (2023)
Martina Bianchi, Mathias Winterhalter, Theresa Anisja Harbig, Daniel Hörömpöli, Ishan Ghai, Kay Nieselt, Heike Brötz-Oesterhelt, Christoph Mayer, Marina Borisova
Fosfomycin Uptake in Escherichia coli Is Mediated by the Outer-Membrane Porins OmpF, OmpC, and LamB. ACS infectious diseases (2023)
Martina Bianchi, Mathias Winterhalter, Theresa Anisja Harbig, Daniel Hörömpöli, Ishan Ghai, Kay Nieselt, Heike Brötz-Oesterhelt, Christoph Mayer, Marina Borisova
Fosfomycin Uptake in Escherichia coli Is Mediated by the Outer-Membrane Porins OmpF, OmpC, and LamB. ACS infectious diseases 10 (1) (2023)
Isabel V L Wilkinson, Gabriel Castro-Falcón, Maria C Roda-Serrat, Trevor N Purdy, Jan Straetener, Melanie M Brauny, Lisa Maier, Heike Brötz-Oesterhelt, Lars Porskjær Christensen, Stephan A Sieber, Chambers C Hughes
The Cyanobacterial "Nutraceutical" Phycocyanobilin Inhibits Cysteine Protease Legumain. Chembiochem : a European journal of chemical biology 24 (5) (2023)
Benjamin O Torres Salazar, Taulant Dema, Nadine A Schilling, Daniela Janek, Jan Bornikoel, Anne Berscheid, Ahmed M A Elsherbini, Sophia Krauss, Simon J Jaag, Michael Lämmerhofer, Min Li, Norah Alqahtani, Malcolm J Horsburgh, Tilmann Weber, José Manuel Beltrán-Beleña, Heike Brötz-Oesterhelt, Stephanie Grond, Bernhard Krismer, Andreas Peschel
Commensal production of a broad-spectrum and short-lived antimicrobial peptide polyene eliminates nasal Staphylococcus aureus. Nature microbiology 9 (1) (2023)
Benjamin O Torres Salazar, Taulant Dema, Nadine A Schilling, Daniela Janek, Jan Bornikoel, Anne Berscheid, Ahmed M A Elsherbini, Sophia Krauss, Simon J Jaag, Michael Lämmerhofer, Min Li, Norah Alqahtani, Malcolm J Horsburgh, Tilmann Weber, José Manuel Beltrán-Beleña, Heike Brötz-Oesterhelt, Stephanie Grond, Bernhard Krismer, Andreas Peschel
Commensal production of a broad-spectrum and short-lived antimicrobial peptide polyene eliminates nasal Staphylococcus aureus. Nature microbiology 9 (1) (2023)
Martina Bianchi, Mathias Winterhalter, Theresa Anisja Harbig, Daniel Hörömpöli, Ishan Ghai, Kay Nieselt, Heike Brötz-Oesterhelt, Christoph Mayer, Marina Borisova
Fosfomycin Uptake in Escherichia coli Is Mediated by the Outer-Membrane Porins OmpF, OmpC, and LamB. ACS infectious diseases 10 (1) (2023)
Martina Bianchi, Mathias Winterhalter, Theresa Anisja Harbig, Daniel Hörömpöli, Ishan Ghai, Kay Nieselt, Heike Brötz-Oesterhelt, Christoph Mayer, Marina Borisova
Fosfomycin Uptake in Escherichia coli Is Mediated by the Outer-Membrane Porins OmpF, OmpC, and LamB. ACS infectious diseases 10 (1) (2023)
Philipp Peslalz, Mark Grieshober, Frank Kraus, Anton Bleisch, Flavia Izzo, Dajana Lichtenstein, Helen Hammer, Andreas Vorbach, Kyoko Momoi, Ulrich M Zanger, Heike Brötz-Oesterhelt, Albert Braeuning, Bernd Plietker, Steffen Stenger
Unnatural Endotype B PPAPs as Novel Compounds with Activity against Mycobacterium tuberculosis . Journal of medicinal chemistry (2023)
Isabel V L Wilkinson, Gabriel Castro-Falcón, Maria C Roda-Serrat, Trevor N Purdy, Jan Straetener, Melanie M Brauny, Lisa Maier, Heike Brötz-Oesterhelt, Lars Porskjær Christensen, Stephan A Sieber, Chambers C Hughes
The Cyanobacterial "Nutraceutical" Phycocyanobilin Inhibits Cysteine Protease Legumain. Chembiochem : a European journal of chemical biology (2022)
Houchao Xu, Anne Wochele, Minghe Luo, Gregor Schnakenburg, Yuhui Sun, Heike Brötz-Oesterhelt, Jeroen S Dickschat
Synthesis of tryptophan-dehydrobutyrine diketopiperazine and biological activity of hangtaimycin and its co-metabolites. Beilstein journal of organic chemistry 18 (2022)
Laura Reinhardt, Dhana Thomy, Markus Lakemeyer, Linda Maria Westermann, Joaquin Ortega, Stephan A Sieber, Peter Sass, Heike Brötz-Oesterhelt
Antibiotic Acyldepsipeptides Stimulate the Streptomyces Clp-ATPase/ClpP Complex for Accelerated Proteolysis. mBio (2022)
Sofia S Mendes, Joana Marques, Edit Mesterházy, Jan Straetener, Melina Arts, Teresa Pissarro, Jorgina Reginold, Anne Berscheid, Jan Bornikoel, Robert M Kluj, Christoph Mayer, Filipp Oesterhelt, Sofia Friães, Beatriz Royo, Tanja Schneider, Heike Brötz-Oesterhelt, Carlos C Romão, Lígia M Saraiva
Synergetic Antimicrobial Activity and Mechanism of Clotrimazole-Linked CO-Releasing Molecules. ACS bio & med chem Au 2 (4) (2022)
Lei Zhang, Lidia Alejo Esquembre, Shu-Ning Xia, Filipp Oesterhelt, Chambers C Hughes, Heike Brötz-Oesterhelt, Robin Teufel
Antibacterial Synnepyrroles from Human-Associated Nocardiopsis sp. Show Protonophore Activity and Disrupt the Bacterial Cytoplasmic Membrane. ACS chemical biology 17 (10) (2022)
Raphael Reher, Allegra T Aron, Pavla Fajtová, Paolo Stincone, Berenike Wagner, Alicia I Pérez-Lorente, Chenxi Liu, Ido Y Ben Shalom, Wout Bittremieux, Mingxun Wang, Kyowon Jeong, Marie L Matos-Hernández, Kelsey L Alexander, Eduardo J E Caro-Diaz, C Benjamin Naman, J H William Scanlan, Phil M M Hochban, Wibke E Diederich, Carlos Molina-Santiago, Diego Romero, Khaled A Selim, Peter Sass, Heike Brötz-Oesterhelt, Chambers C Hughes, Pieter C Dorrestein, Anthony J O'Donoghue, William H Gerwick, Daniel Petras
Native metabolomics identifies the rivulariapeptolide family of protease inhibitors. Nature communications 13 (1) (2022)
Niraj Aryal, Junhong Chen, Keshab Bhattarai, Oliver Hennrich, Ira Handayani, Markus Kramer, Jan Straetener, Tatjana Wommer, Anne Berscheid, Silke Peter, Norbert Reiling, Heike Brötz-Oesterhelt, Christian Geibel, Michael Lämmerhofer, Yvonne Mast, Harald Gross
High Plasticity of the Amicetin Biosynthetic Pathway in Streptomyces sp. SHP 22-7 Led to the Discovery of Streptcytosine P and Cytosaminomycins F and G and Facilitated the Production of 12F-Plicacetin. Journal of natural products 85 (3) (2022)
Alina Dietrich, Ursula Steffens, Mike Gajdiss, Anna-Lena Boschert, Jana Katharina Dröge, Christiane Szekat, Peter Sass, Imran T Malik, Jan Bornikoel, Laura Reinke, Boris Maček, Mirita Franz-Wachtel, Kay Nieselt, Theresa Harbig, Kirstin Scherlach, Heike Brötz-Oesterhelt, Christian Hertweck, Hans-Georg Sahl, Gabriele Bierbaum
Cervimycin-Resistant Staphylococcus aureus Strains Display Vancomycin-Intermediate Resistant Phenotypes. Microbiology spectrum 10 (5) (2022)
Daniel Hörömpöli, Catherine Ciglia, Karl-Heinz Glüsenkamp, Lars Ole Haustedt, Hildegard Falkenstein-Paul, Gerd Bendas, Anne Berscheid, Heike Brötz-Oesterhelt
The Antibiotic Negamycin Crosses the Bacterial Cytoplasmic Membrane by Multiple Routes. Antimicrobial agents and chemotherapy 65 (4) (2021)
Simon Heilbronner, Bernhard Krismer, Heike Brötz-Oesterhelt, Andreas Peschel
The microbiome-shaping roles of bacteriocins. Nature reviews. Microbiology 19 (11) (2021)
Louis Koeninger, Lisa Osbelt, Anne Berscheid, Judith Wendler, Jürgen Berger, Katharina Hipp, Till R Lesker, Marina C Pils, Nisar P Malek, Benjamin A H Jensen, Heike Brötz-Oesterhelt, Till Strowig, null Jan Wehkamp
Curbing gastrointestinal infections by defensin fragment modifications without harming commensal microbiota. Communications biology 4 (1) (2021)
Andri Frediansyah, Jan Straetener, Heike Brötz-Oesterhelt, Harald Gross
Massiliamide, a cyclic tetrapeptide with potent tyrosinase inhibitory properties from the Gram-negative bacterium Massilia albidiflava DSM 17472T. The Journal of antibiotics 74 (4) (2020)
Jayesh Arun Bafna, Eulàlia Sans-Serramitjana, Silvia Acosta-Gutiérrez, Igor V Bodrenko, Daniel Hörömpöli, Anne Berscheid, Heike Brötz-Oesterhelt, Mathias Winterhalter, Matteo Ceccarelli
Kanamycin Uptake into Escherichia coli Is Facilitated by OmpF and OmpC Porin Channels Located in the Outer Membrane. ACS infectious diseases 6 (7) (2020)
Nadine A Schilling, Anne Berscheid, Johannes Schumacher, Julian S Saur, Martin C Konnerth, Sebastian N Wirtz, José Manuel Beltrán-Beleña, Alexander Zipperer, Bernhard Krismer, Andreas Peschel, Hubert Kalbacher, Heike Brötz-Oesterhelt, Claudia Steinem, Stephanie Grond
Synthetic Lugdunin Analogues Reveal Essential Structural Motifs for Antimicrobial Action and Proton Translocation Capability. Angewandte Chemie (International ed. in English) 58 (27) (2019)