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Jan Kihlberg

ORCID

Publication Activity (10 Years)

Years Active: 2017-2023
Publications (10 Years): 33

Top Venues

Journal of medicinal chemistry

Journal of chemical information and modeling

Chemistry (Weinheim an der Bergstrasse, Germany)

ACS chemical biology

Uppsala Universitet

Lunds Universitet Tekniska Högskola (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Uppsala Universitet Jul 1o 2013

Sweden

Professor :: Chemistry - BMC

Education History

Lunds Universitet Tekniska Högskola - Dec 5o 1988

Sweden

PHD :: Organic Chemistry

Publications

Vasanthanathan Poongavanam, Florian Kölling, Anja Giese, Andreas H Göller, Lutz Lehmann, Daniel Meibom, Jan Kihlberg
Predictive Modeling of PROTAC Cell Permeability with Machine Learning. ACS omega 8 (6) (2023)
Mike Aoun, Ana Oliveira-Coelho, Alexander Krämer, Amit Saxena, Pierre Sabatier, Christian Michel Beusch, Erik Lönnblom, Manman Geng, Nhu-Nguyen Do, Zhongwei Xu, Jingdian Zhang, Yibo He, Laura Romero-Castillo, Hassan Abolhassani, Bingze Xu, Johan Viljanen, Joanna Rorbach, Gonzalo Fernandez Lahore, Inger Gjertsson, Alf Kastbom, Christopher Sjöwall, Jan Kihlberg, Roman A Zubarev, Harald Burkhardt, Rickard Holmdahl
Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice. The Journal of experimental medicine 220 (11) (2023)
Fabio Begnini, Stefan Geschwindner, Patrik Johansson, Lisa Wissler, Richard J Lewis, Emma Danelius, Andreas Luttens, Pierre Matricon, Jens Carlsson, Stijn Lenders, Beate König, Anna Friedel, Peter Sjö, Stefan Schiesser, Jan Kihlberg
Correction to "Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction". Journal of medicinal chemistry (2023)
Fabio Begnini, Stefan Geschwindner, Patrik Johansson, Lisa Wissler, Richard J Lewis, Emma Danelius, Andreas Luttens, Pierre Matricon, Jens Carlsson, Stijn Lenders, Beate König, Anna Friedel, Peter Sjö, Stefan Schiesser, Jan Kihlberg
Correction to "Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction". Journal of medicinal chemistry 66 (3) (2023)
Vasanthanathan Poongavanam, Florian Kölling, Anja Giese, Andreas H Göller, Lutz Lehmann, Daniel Meibom, Jan Kihlberg
Predictive Modeling of PROTAC Cell Permeability with Machine Learning. ACS omega 8 (6) (2023)
Fabio Begnini, Stefan Geschwindner, Patrik Johansson, Lisa Wissler, Richard J Lewis, Emma Danelius, Andreas Luttens, Pierre Matricon, Jens Carlsson, Stijn Lenders, Beate König, Anna Friedel, Peter Sjö, Stefan Schiesser, Jan Kihlberg
Correction to "Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction". Journal of medicinal chemistry 66 (3) (2023)
Diego Garcia Jimenez, Vasanthanathan Poongavanam, Jan Kihlberg
Macrocycles in Drug Discovery─Learning from the Past for the Future. Journal of medicinal chemistry (2023)
Vasanthanathan Poongavanam, Yoseph Atilaw, Stephan Siegel, Anja Giese, Lutz Lehmann, Daniel Meibom, Máté Erdélyi, Jan Kihlberg
Linker-Dependent Folding Rationalizes PROTAC Cell Permeability. Journal of medicinal chemistry 65 (19) (2022)
Daniel Sethio, Vasanthanathan Poongavanam, Ruisheng Xiong, Mohit Tyagi, Duc Duy Vo, Roland Lindh, Jan Kihlberg
Simulation Reveals the Chameleonic Behavior of Macrocycles. Journal of chemical information and modeling 63 (1) (2022)
Daniel Sethio, Vasanthanathan Poongavanam, Ruisheng Xiong, Mohit Tyagi, Duc Duy Vo, Roland Lindh, Jan Kihlberg
Simulation Reveals the Chameleonic Behavior of Macrocycles. Journal of chemical information and modeling 63 (1) (2022)
Daniel Sethio, Vasanthanathan Poongavanam, Ruisheng Xiong, Mohit Tyagi, Duc Duy Vo, Roland Lindh, Jan Kihlberg
Simulation Reveals the Chameleonic Behavior of Macrocycles. Journal of chemical information and modeling 63 (1) (2022)
Daniel Sethio, Vasanthanathan Poongavanam, Ruisheng Xiong, Mohit Tyagi, Duc Duy Vo, Roland Lindh, Jan Kihlberg
Simulation Reveals the Chameleonic Behavior of Macrocycles. Journal of chemical information and modeling (2022)
Daniel Sethio, Vasanthanathan Poongavanam, Ruisheng Xiong, Mohit Tyagi, Duc Duy Vo, Roland Lindh, Jan Kihlberg
Simulation Reveals the Chameleonic Behavior of Macrocycles. Journal of chemical information and modeling 63 (1) (2022)
Daniel Sethio, Vasanthanathan Poongavanam, Ruisheng Xiong, Mohit Tyagi, Duc Duy Vo, Roland Lindh, Jan Kihlberg
Simulation Reveals the Chameleonic Behavior of Macrocycles. Journal of chemical information and modeling 63 (1) (2022)
Andreas Luttens, Hjalmar Gullberg, Eldar Abdurakhmanov, Duy Duc Vo, Dario Akaberi, Vladimir O Talibov, Natalia Nekhotiaeva, Laura Vangeel, Steven De Jonghe, Dirk Jochmans, Janina Krambrich, Ali Tas, Bo Lundgren, Ylva Gravenfors, Alexander J Craig, Yoseph Atilaw, Anja Sandström, Lindon W K Moodie, Åke Lundkvist, Martijn J van Hemert, Johan Neyts, Johan Lennerstrand, Jan Kihlberg, Kristian Sandberg, U Helena Danielson, Jens Carlsson
Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses. Journal of the American Chemical Society 144 (7) (2022)
Fabio Begnini, Stefan Geschwindner, Patrik Johansson, Lisa Wissler, Richard J Lewis, Emma Danelius, Andreas Luttens, Pierre Matricon, Jens Carlsson, Stijn Lenders, Beate König, Anna Friedel, Peter Sjö, Stefan Schiesser, Jan Kihlberg
Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction. Journal of medicinal chemistry 65 (4) (2022)
Fabio Begnini, Vasanthanathan Poongavanam, Yoseph Atilaw, Máté Erdélyi, Stefan Schiesser, Jan Kihlberg
Cell Permeability of Isomeric Macrocycles: Predictions and NMR Studies. ACS medicinal chemistry letters 12 (6) (2021)
Pierre Matricon, Duc Duy Vo, Zhan-Guo Gao, Jan Kihlberg, Kenneth A Jacobson, Jens Carlsson
Fragment-based design of selective GPCR ligands guided by free energy simulations. Chemical communications (Cambridge, England) 57 (92) (2021)
Vasanthanathan Poongavanam, Jan Kihlberg
PROTAC cell permeability and oral bioavailability: a journey into uncharted territory. Future medicinal chemistry (2021)
Jonathan Bogaerts, Yoseph Atilaw, Stefan Peintner, Roy Aerts, Jan Kihlberg, Christian Johannessen, Máté Erdélyi
Employing complementary spectroscopies to study the conformations of an epimeric pair of side-chain stapled peptides in aqueous solution. RSC advances 11 (7) (2021)
Johan Viljanen, Erik Lönnblom, Changrong Ge, Jie Yang, Lei Cheng, Silvia Aldi, Weiwei Cai, Alf Kastbom, Christopher Sjöwall, Inger Gjertsson, Rikard Holmdahl, Jan Kihlberg
Synthesis of an Array of Triple-Helical Peptides from Type II Collagen for Multiplex Analysis of Autoantibodies in Rheumatoid Arthritis. ACS chemical biology 15 (9) (2020)
Fabio Begnini, Vasanthanathan Poongavanam, Björn Over, Marie Castaldo, Stefan Geschwindner, Patrik Johansson, Mohit Tyagi, Christian Tyrchan, Lisa Wissler, Peter Sjö, Stefan Schiesser, Jan Kihlberg
Mining Natural Products for Macrocycles to Drug Difficult Targets. Journal of medicinal chemistry 64 (2) (2020)
Flavio Ballante, Axel Rudling, Alexey Zeifman, Andreas Luttens, Duy Duc Vo, John J Irwin, Jan Kihlberg, Jose Brea, Maria Isabel Loza, Jens Carlsson
Docking Finds GPCR Ligands in Dark Chemical Matter. Journal of medicinal chemistry 63 (2) (2020)
Emma Danelius, Vasanthanathan Poongavanam, Stefan Peintner, Lianne H E Wieske, Máté Erdélyi, Jan Kihlberg
Solution Conformations Explain the Chameleonic Behaviour of Macrocyclic Drugs. Chemistry (Weinheim an der Bergstrasse, Germany) 26 (23) (2020)
Johan Viljanen, Erik Lönnblom, Changrong Ge, Jie Yang, Lei Cheng, Silvia Aldi, Weiwei Cai, Alf Kastbom, Christopher Sjöwall, Gregg B Fields, Inger Gjertsson, Rikard Holmdahl, Jan Kihlberg
Correction to Synthesis of an Array of Triple-Helical Peptides from Type II Collagen for Multiplex Analysis of Autoantibodies in Rheumatoid Arthritis. ACS chemical biology 15 (11) (2020)
Giulia Caron, Jan Kihlberg, Giuseppe Ermondi
Intramolecular hydrogen bonding: An opportunity for improved design in medicinal chemistry. Medicinal research reviews 39 (5) (2019)
Mohit Tyagi, Fabio Begnini, Vasanthanathan Poongavanam, Bradley C Doak, Jan Kihlberg
Drug Syntheses Beyond the Rule of 5. Chemistry (Weinheim an der Bergstrasse, Germany) 26 (1) (2019)
Derar Al-Smadi, Thilak Reddy Enugala, Vadim Kessler, Anil Ranu Mhashal, Shina Caroline Lynn Kamerlin, Jan Kihlberg, Thomas Norberg, Mikael Widersten
Chemical and Biochemical Approaches for the Synthesis of Substituted Dihydroxybutanones and Di- and Tri-Hydroxypentanones. The Journal of organic chemistry 84 (11) (2019)
Matteo Rossi Sebastiano, Bradley C Doak, Maria Backlund, Vasanthanathan Poongavanam, Björn Over, Giuseppe Ermondi, Giulia Caron, Pär Matsson, Jan Kihlberg
Impact of Dynamically Exposed Polarity on Permeability and Solubility of Chameleonic Drugs Beyond the Rule of 5. Journal of medicinal chemistry 61 (9) (2018)
Bradley C Doak, Jan Kihlberg
Cyclophilin Succumbs to a Macrocyclic Chameleon. Journal of medicinal chemistry 61 (21) (2018)
Cecilia Lindgren, Mohit Tyagi, Johan Viljanen, Johannes Toms, Changrong Ge, Naru Zhang, Rikard Holmdahl, Jan Kihlberg, Anna Linusson
Dynamics Determine Signaling in a Multicomponent System Associated with Rheumatoid Arthritis. Journal of medicinal chemistry 61 (11) (2018)
Mohit Tyagi, Vasanthanathan Poongavanam, Marika Lindhagen, Anna Pettersen, Peter Sjö, Stefan Schiesser, Jan Kihlberg
Toward the Design of Molecular Chameleons: Flexible Shielding of an Amide Bond Enhances Macrocycle Cell Permeability. Organic letters 20 (18) (2018)
Pär Matsson, Jan Kihlberg
How Big Is Too Big for Cell Permeability? Journal of medicinal chemistry 60 (5) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Jan Kihlberg