Kenneth A Jacobson

Scopus Author ID Loop profile ORCID

Publication Activity (10 Years)

Years Active: 2015-2024
Publications (10 Years): 131

Top Venues

Journal of medicinal chemistry

Molecular pharmacology

ACS pharmacology & translational science

British journal of pharmacology

National Institutes of Health

This page only lists publications with an associated author ORCID identifier.

Affiliation History

National Institutes of Health

United States

Senior Investigator :: National Institute of Diabetes & DIgestive & Kidney Diseases

Publications

Gibae Kim, Dnyandev B Jarhad, Grim Lee, Gyudong Kim, Xiyan Hou, Jinha Yu, Chang Soo Lee, Eugene Warnick, Zhan-Guo Gao, Sang Yeop Ahn, Dongik Kwak, Kichul Park, Summer Dabin Lee, Tae-Uk Park, So-Young Jung, Jong Hyun Lee, Jong-Ryoul Choi, Myeongjoong Kim, Donghyun Kim, Bongtae Kim, Kenneth A Jacobson, Lak Shin Jeong
Structural Modification and Biological Evaluation of 2,8-Disubstituted Adenine and Its Nucleosides as A 2A Adenosine Receptor Antagonists: Exploring the Roles of Ribose at Adenosine Receptors. Journal of medicinal chemistry 67 (12) (2024)
Dilip K Tosh, Matteo Pavan, Chunxia Cronin, Eline Pottie, Tina C Wan, Eric Chen, Sarah A Lewicki, Ryan G Campbell, Zhan-Guo Gao, John A Auchampach, Christophe Pol Stove, Bruce T Liang, Kenneth A Jacobson
2-Substituted (N)-Methanocarba A 3 Adenosine Receptor Agonists: In Silico, In Vitro, and In Vivo Characterization. ACS pharmacology & translational science 7 (7) (2024)
Balaram Pradhan, Matteo Pavan, Courtney L Fisher, Veronica Salmaso, Tina C Wan, Robert F Keyes, Noah Rollison, R Rama Suresh, T Santhosh Kumar, Zhan-Guo Gao, Brian C Smith, John A Auchampach, Kenneth A Jacobson
Lipid Trolling to Optimize A 3 Adenosine Receptor-Positive Allosteric Modulators (PAMs). Journal of medicinal chemistry 67 (14) (2024)
Gibae Kim, Xiyan Hou, Woong Sub Byun, Gyudong Kim, Dnyandev B Jarhad, Grim Lee, Young Eum Hyun, Jinha Yu, Chang Soo Lee, Shuhao Qu, Eugene Warnick, Zhan-Guo Gao, Ji Yong Kim, Seunghee Ji, Hyunwoo Shin, Jong-Ryoul Choi, Kenneth A Jacobson, Hyuk Woo Lee, Sang-Kook Lee, Lak Shin Jeong
Correction to "Structure-Activity Relationship of Truncated 2,8-Disubstituted-Adenosine Derivatives as Dual A 2A /A 3 Adenosine Receptor Antagonists and Their Cancer Immunotherapeutic Activity". Journal of medicinal chemistry 67 (3) (2024)
Courtney L Fisher, Matteo Pavan, Veronica Salmaso, Robert F Keyes, Tina C Wan, Balaram Pradhan, Zhan-Guo Gao, Brian C Smith, Kenneth A Jacobson, John A Auchampach
Extrahelical Binding Site for a 1 H -Imidazo[4,5-c]quinolin-4-amine A 3 Adenosine Receptor Positive Allosteric Modulator on Helix 8 and Distal Portions of Transmembrane Domains 1 and 7. Molecular pharmacology 105 (3) (2024)
Paola Oliva, Asmita Pramanik, Young-Hwan Jung, Sarah A Lewicki, Jamie M Mwendwa, Jong Hwan Park, Kenneth A Jacobson
Functionalized Congeners of 2 H -Chromene P2Y 6 Receptor Antagonists. Cells 13 (16) (2024)
Courtney L Fisher, Matteo Pavan, Veronica Salmaso, Robert F Keyes, Tina C Wan, Balaram Pradhan, Zhan-Guo Gao, Brian C Smith, Kenneth A Jacobson, John A Auchampach
Extrahelical binding site for a 1 H -imidazo[4,5-c]quinolin-4-amine A 3 adenosine receptor positive allosteric modulator on helix 8 and distal portions of transmembrane domains 1 and 7. Molecular pharmacology (2024)
Paola Oliva, Asmita Pramanik, Young-Hwan Jung, Sarah A Lewicki, Jamie M Mwendwa, Jong Hwan Park, Kenneth A Jacobson
Functionalized Congeners of 2 H -Chromene P2Y 6 Receptor Antagonists. Cells 13 (16) (2024)
Dushyant Kumar Srivastava, Vikas Navratna, Dilip K Tosh, Audrey Chinn, Md Fulbabu Sk, Emad Tajkhorshid, Kenneth A Jacobson, Eric Gouaux
Structure of the human dopamine transporter and mechanisms of inhibition. Nature (2024)
Paola Oliva, Asmita Pramanik, Young-Hwan Jung, Sarah A Lewicki, Jamie M Mwendwa, Jong Hwan Park, Kenneth A Jacobson
Functionalized Congeners of 2 H -Chromene P2Y 6 Receptor Antagonists. Cells 13 (16) (2024)
Courtney L Fisher, Matteo Pavan, Veronica Salmaso, Robert F Keyes, Tina C Wan, Balaram Pradhan, Zhan-Guo Gao, Brian C Smith, Kenneth A Jacobson, John A Auchampach
Extrahelical binding site for a 1 H -imidazo[4,5-c]quinolin-4-amine A 3 adenosine receptor positive allosteric modulator on helix 8 and distal portions of transmembrane domains 1 and 7. Molecular pharmacology (2024)
Gibae Kim, Dnyandev B Jarhad, Grim Lee, Gyudong Kim, Xiyan Hou, Jinha Yu, Chang Soo Lee, Eugene Warnick, Zhan-Guo Gao, Sang Yeop Ahn, Dongik Kwak, Kichul Park, Summer Dabin Lee, Tae-Uk Park, So-Young Jung, Jong Hyun Lee, Jong-Ryoul Choi, Myeongjoong Kim, Donghyun Kim, Bongtae Kim, Kenneth A Jacobson, Lak Shin Jeong
Structural Modification and Biological Evaluation of 2,8-Disubstituted Adenine and Its Nucleosides as A 2A Adenosine Receptor Antagonists: Exploring the Roles of Ribose at Adenosine Receptors. Journal of medicinal chemistry 67 (12) (2024)
Gibae Kim, Dnyandev B Jarhad, Grim Lee, Gyudong Kim, Xiyan Hou, Jinha Yu, Chang Soo Lee, Eugene Warnick, Zhan-Guo Gao, Sang Yeop Ahn, Dongik Kwak, Kichul Park, Summer Dabin Lee, Tae-Uk Park, So-Young Jung, Jong Hyun Lee, Jong-Ryoul Choi, Myeongjoong Kim, Donghyun Kim, Bongtae Kim, Kenneth A Jacobson, Lak Shin Jeong
Structural Modification and Biological Evaluation of 2,8-Disubstituted Adenine and Its Nucleosides as A 2A Adenosine Receptor Antagonists: Exploring the Roles of Ribose at Adenosine Receptors. Journal of medicinal chemistry (2024)
Balaram Pradhan, Matteo Pavan, Courtney L Fisher, Veronica Salmaso, Tina C Wan, Robert F Keyes, Noah Rollison, R Rama Suresh, T Santhosh Kumar, Zhan-Guo Gao, Brian C Smith, John A Auchampach, Kenneth A Jacobson
Lipid Trolling to Optimize A 3 Adenosine Receptor-Positive Allosteric Modulators (PAMs). Journal of medicinal chemistry 67 (14) (2024)
Gibae Kim, Xiyan Hou, Woong Sub Byun, Gyudong Kim, Dnyandev B Jarhad, Grim Lee, Young Eum Hyun, Jinha Yu, Chang Soo Lee, Shuhao Qu, Eugene Warnick, Zhan-Guo Gao, Ji Yong Kim, Seunghee Ji, Hyunwoo Shin, Jong-Ryoul Choi, Kenneth A Jacobson, Hyuk Woo Lee, Sang-Kook Lee, Lak Shin Jeong
Correction to "Structure-Activity Relationship of Truncated 2,8-Disubstituted-Adenosine Derivatives as Dual A 2A /A 3 Adenosine Receptor Antagonists and Their Cancer Immunotherapeutic Activity". Journal of medicinal chemistry (2024)
Courtney L Fisher, Matteo Pavan, Veronica Salmaso, Robert F Keyes, Tina C Wan, Balaram Pradhan, Zhan-Guo Gao, Brian C Smith, Kenneth A Jacobson, John A Auchampach
Extrahelical Binding Site for a 1 H -Imidazo[4,5-c]quinolin-4-amine A 3 Adenosine Receptor Positive Allosteric Modulator on Helix 8 and Distal Portions of Transmembrane Domains 1 and 7. Molecular pharmacology 105 (3) (2024)
Courtney L Fisher, Matteo Pavan, Veronica Salmaso, Robert F Keyes, Tina C Wan, Balaram Pradhan, Zhan-Guo Gao, Brian C Smith, Kenneth A Jacobson, John A Auchampach
Extrahelical Binding Site for a 1 H -Imidazo[4,5-c]quinolin-4-amine A 3 Adenosine Receptor Positive Allosteric Modulator on Helix 8 and Distal Portions of Transmembrane Domains 1 and 7. Molecular pharmacology 105 (3) (2024)
Gibae Kim, Dnyandev B Jarhad, Grim Lee, Gyudong Kim, Xiyan Hou, Jinha Yu, Chang Soo Lee, Eugene Warnick, Zhan-Guo Gao, Sang Yeop Ahn, Dongik Kwak, Kichul Park, Summer Dabin Lee, Tae-Uk Park, So-Young Jung, Jong Hyun Lee, Jong-Ryoul Choi, Myeongjoong Kim, Donghyun Kim, Bongtae Kim, Kenneth A Jacobson, Lak Shin Jeong
Structural Modification and Biological Evaluation of 2,8-Disubstituted Adenine and Its Nucleosides as A 2A Adenosine Receptor Antagonists: Exploring the Roles of Ribose at Adenosine Receptors. Journal of medicinal chemistry 67 (12) (2024)
Balaram Pradhan, Matteo Pavan, Courtney L Fisher, Veronica Salmaso, Tina C Wan, Robert F Keyes, Noah Rollison, R Rama Suresh, T Santhosh Kumar, Zhan-Guo Gao, Brian C Smith, John A Auchampach, Kenneth A Jacobson
Lipid Trolling to Optimize A 3 Adenosine Receptor-Positive Allosteric Modulators (PAMs). Journal of medicinal chemistry 67 (14) (2024)
Dushyant Kumar Srivastava, Vikas Navratna, Dilip K Tosh, Audrey Chinn, Md Fulbabu Sk, Emad Tajkhorshid, Kenneth A Jacobson, Eric Gouaux
Structure of the human dopamine transporter and mechanisms of inhibition. Nature 632 (8025) (2024)
Anwesha Ghosh, Leonor Ribeiro-Rodrigues, Gabriele Ruffolo, Veronica Alfano, Cátia Domingos, Nádia Rei, Dilip K Tosh, Diogo M Rombo, Tatiana P Morais, Cláudia A Valente, Sara Xapelli, Beatriz Bordadágua, Alexandre Rainha-Campos, Carla Bentes, Eleonora Aronica, Maria José Diógenes, Sandra H Vaz, Joaquim A Ribeiro, Eleonora Palma, Kenneth A Jacobson, Ana M Sebastião
Selective modulation of epileptic tissue by an adenosine A 3 receptor-activating drug. British journal of pharmacology (2024)
Dushyant Kumar Srivastava, Vikas Navratna, Dilip K Tosh, Audrey Chinn, Md Fulbabu Sk, Emad Tajkhorshid, Kenneth A Jacobson, Eric Gouaux
Structure of the human dopamine transporter and mechanisms of inhibition. Nature 632 (8025) (2024)
Gibae Kim, Xiyan Hou, Woong Sub Byun, Gyudong Kim, Dnyandev B Jarhad, Grim Lee, Young Eum Hyun, Jinha Yu, Chang Soo Lee, Shuhao Qu, Eugene Warnick, Zhan-Guo Gao, Ji Yong Kim, Seunghee Ji, Hyunwoo Shin, Jong-Ryoul Choi, Kenneth A Jacobson, Hyuk Woo Lee, Sang-Kook Lee, Lak Shin Jeong
Correction to "Structure-Activity Relationship of Truncated 2,8-Disubstituted-Adenosine Derivatives as Dual A 2A /A 3 Adenosine Receptor Antagonists and Their Cancer Immunotherapeutic Activity". Journal of medicinal chemistry 67 (3) (2024)
Mojtaba Rostamighadi, Arezou Kamelshahroudi, Vanessa Pitsitikas, Kenneth A Jacobson, Reza Salavati
Pilot-Scale Screening of Clinically Approved Drugs to Identify Uridine Insertion/Deletion RNA Editing Inhibitors in Trypanosoma brucei . ACS infectious diseases (2024)
Zhan-Guo Gao, Mansour Haddad, Kenneth A Jacobson
A 2B adenosine receptor signaling and regulation. Purinergic signalling (2024)
Courtney L Fisher, Matteo Pavan, Veronica Salmaso, Robert F Keyes, Tina C Wan, Balaram Pradhan, Zhan-Guo Gao, Brian C Smith, Kenneth A Jacobson, John A Auchampach
Extrahelical Binding Site for a 1 H -Imidazo[4,5-c]quinolin-4-amine A 3 Adenosine Receptor Positive Allosteric Modulator on Helix 8 and Distal Portions of Transmembrane Domains 1 and 7. Molecular pharmacology 105 (3) (2024)
Balaram Pradhan, Matteo Pavan, Courtney L Fisher, Veronica Salmaso, Tina C Wan, Robert F Keyes, Noah Rollison, R Rama Suresh, T Santhosh Kumar, Zhan-Guo Gao, Brian C Smith, John A Auchampach, Kenneth A Jacobson
Lipid Trolling to Optimize A 3 Adenosine Receptor-Positive Allosteric Modulators (PAMs). Journal of medicinal chemistry (2024)
Matthew R Sapio, Ellen S Staedtler, Diana M King, Dragan Maric, Jahandar Jahanipour, Andre Ghetti, Kenneth A Jacobson, Andrew J Mannes, Michael J Iadarola
Analgesic candidate adenosine A3 receptors are expressed by perineuronal peripheral macrophages in human dorsal root ganglion and spinal cord microglia. Pain (2024)
Dilip K Tosh, Matteo Pavan, Chunxia Cronin, Eline Pottie, Tina C Wan, Eric Chen, Sarah A Lewicki, Ryan G Campbell, Zhan-Guo Gao, John A Auchampach, Christophe Pol Stove, Bruce T Liang, Kenneth A Jacobson
2-Substituted (N)-Methanocarba A 3 Adenosine Receptor Agonists: In Silico, In Vitro, and In Vivo Characterization. ACS pharmacology & translational science 7 (7) (2024)
Gibae Kim, Dnyandev B Jarhad, Grim Lee, Gyudong Kim, Xiyan Hou, Jinha Yu, Chang Soo Lee, Eugene Warnick, Zhan-Guo Gao, Sang Yeop Ahn, Dongik Kwak, Kichul Park, Summer Dabin Lee, Tae-Uk Park, So-Young Jung, Jong Hyun Lee, Jong-Ryoul Choi, Myeongjoong Kim, Donghyun Kim, Bongtae Kim, Kenneth A Jacobson, Lak Shin Jeong
Structural Modification and Biological Evaluation of 2,8-Disubstituted Adenine and Its Nucleosides as A 2A Adenosine Receptor Antagonists: Exploring the Roles of Ribose at Adenosine Receptors. Journal of medicinal chemistry 67 (12) (2024)
Dushyant Kumar Srivastava, Vikas Navratna, Dilip K Tosh, Audrey Chinn, Md Fulbabu Sk, Emad Tajkhorshid, Kenneth A Jacobson, Eric Gouaux
Structure of the human dopamine transporter and mechanisms of inhibition. Nature 632 (8025) (2024)
Dushyant Kumar Srivastava, Vikas Navratna, Dilip K Tosh, Audrey Chinn, Md Fulbabu Sk, Emad Tajkhorshid, Kenneth A Jacobson, Eric Gouaux
Structure of the human dopamine transporter and mechanisms of inhibition. Nature 632 (8025) (2024)
Dushyant Kumar Srivastava, Vikas Navratna, Dilip K Tosh, Audrey Chinn, Md Fulbabu Sk, Emad Tajkhorshid, Kenneth A Jacobson, Eric Gouaux
Structure of the human dopamine transporter and mechanisms of inhibition. Nature 632 (8025) (2024)
Dushyant Kumar Srivastava, Vikas Navratna, Dilip K Tosh, Audrey Chinn, Md Fulbabu Sk, Emad Tajkhorshid, Kenneth A Jacobson, Eric Gouaux
Structure of the human dopamine transporter and mechanisms of inhibition. Nature (2024)
Courtney L Fisher, Matteo Pavan, Veronica Salmaso, Robert F Keyes, Tina C Wan, Balaram Pradhan, Zhan-Guo Gao, Brian C Smith, Kenneth A Jacobson, John A Auchampach
Extrahelical binding site for a 1 H -imidazo[4,5-c]quinolin-4-amine A 3 adenosine receptor positive allosteric modulator on helix 8 and distal portions of transmembrane domains 1 and 7. Molecular pharmacology (2024)
Courtney L Fisher, Matteo Pavan, Veronica Salmaso, Robert F Keyes, Tina C Wan, Balaram Pradhan, Zhan-Guo Gao, Brian C Smith, Kenneth A Jacobson, John A Auchampach
Extrahelical Binding Site for a 1 H -Imidazo[4,5-c]quinolin-4-amine A 3 Adenosine Receptor Positive Allosteric Modulator on Helix 8 and Distal Portions of Transmembrane Domains 1 and 7. Molecular pharmacology 105 (3) (2024)
Stephen P H Alexander, Arthur Christopoulos, Anthony P Davenport, Eamonn Kelly, Alistair A Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Jamie A Davies, Maria Pia Abbracchio, George Abraham, Alexander Agoulnik, Wayne Alexander, Khaled Al-Hosaini, Magnus Bäck, Jillian G Baker, Nicholas M Barnes, Ross A D Bathgate, Jean-Martin Beaulieu, Annette G Beck-Sickinger, Maik Behrens, Kenneth E Bernstein, Bernhard Bettler, Nigel J M Birdsall, Victoria A Blaho, Francois Boulay, Corinne Bousquet, Hans Bräuner-Osborne, Geoffrey Burnstock, Girolamo Caló, Justo P Castaño, Kevin J Catt, Stefania Ceruti, Paul L Chazot, Nan Chiang, Bice Chini, Jerold Chun, Antonia Cianciulli, Olivier Civelli, Lucie H Clapp, Réjean Couture, Helen M Cox, Zsolt Csaba, Claes Dahlgren, Gordon Dent, Steven D Douglas, Pascal Dournaud, Satoru Eguchi, Emanuel Escher, Edward J Filardo, Tung Fong, Marta Fumagalli, Raul R Gainetdinov, Michael L Garelja, Marc de Gasparo, Craig Gerard, Marvin Gershengorn, Fernand Gobeil, Theodore L Goodfriend, Cyril Goudet, Lukas Grätz, Karen J Gregory, Andrew L Gundlach, Jörg Hamann, Julien Hanson, Richard L Hauger, Debbie L Hay, Akos Heinemann, Deron Raymond Herr, Morley D Hollenberg, Nicholas D Holliday, Mastgugu Horiuchi, Daniel Hoyer, László Hunyady, Ahsan Husain, Adriaan P IJzerman, Tadashi Inagami, Kenneth A Jacobson, Robert T Jensen, Ralf Jockers, Deepa Jonnalagadda, Sadashiva S Karnik, Klemens Kaupmann, Jacqueline Kemp, Charles Kennedy, Hirotaka Mizuno, Takio Kitazawa, Pawel Kozielewicz, Hans-Jürgen Kreienkamp, Jyrki P Kukkonen, Tobias Langenhan, Dan Larhammar, Katie Leach, Davide Lecca, John D Lee, Susan E Leeman, Jérôme Leprince, Xaria X Li, Stephen J Lolait, Amelie Lupp, Robyn Macrae, Janet J Maguire, Davide Malfacini, Jean Mazella, Craig A McArdle, Shlomo Melmed, Martin Christian Michel, Laurence J Miller, Vincenzo Mitolo, Bernard Mouillac, Christa Elisabeth Müller, Philip M Murphy, Jean-Louis Nahon, Tony Ngo, Xavier Norel, Duuamene Nyimanu, Anne-Marie O'Carroll, Stefan Offermanns, Maria Antonietta Panaro, Marc Parmentier, Roger G Pertwee, Jean-Philippe Pin, Eric R Prossnitz, Mark Quinn, Rithwik Ramachandran, Manisha Ray, Rainer K Reinscheid, Philippe Rondard, Gianenrico Rovati, Chiara Ruzza, Gareth John Sanger, Torsten Schöneberg, Gunnar Schulte, Stefan Schulz, Deborah L Segaloff, Charles N Serhan, Khuraijam Dhanachandra Singh, Craig M Smith, Leigh A Stoddart, Yukihiko Sugimoto, Roger J Summers, Valerie P Tan, David M Thal, Walter Wally Thomas, Pieter B M W M Timmermans, Kalyan Tirupula, Lawrence Toll, Giovanni Tulipano, Hamiyet Unal, Thomas Unger, Celine Valant, Patrick Vanderheyden, David Vaudry, Hubert Vaudry, Jean-Pierre Vilardaga, Christopher S Walker, Ji Ming Wang, Donald T Ward, Hans-Jürgen Wester, Gary B Willars, Tom Lloyd Williams, Trent M Woodruff, Chengcan Yao, Richard D Ye
The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors. British journal of pharmacology (2023)
Gibae Kim, Xiyan Hou, Woong Sub Byun, Gyudong Kim, Dnyandev B Jarhad, Grim Lee, Young Eum Hyun, Jinha Yu, Chang Soo Lee, Shuhao Qu, Eugene Warnick, Zhan-Guo Gao, Ji Yong Kim, Seunghee Ji, Hyunwoo Shin, Jong-Ryoul Choi, Kenneth A Jacobson, Hyuk Woo Lee, Sang-Kook Lee, Lak Shin Jeong
Structure-Activity Relationship of Truncated 2,8-Disubstituted-Adenosine Derivatives as Dual A 2A /A 3 Adenosine Receptor Antagonists and Their Cancer Immunotherapeutic Activity. Journal of medicinal chemistry (2023)
Federica Cherchi, Martina Venturini, Giada Magni, Mirko Scortichini, Kenneth A Jacobson, Anna Maria Pugliese, Elisabetta Coppi
Covalently Binding Adenosine A 3 Receptor Agonist ICBM Irreversibly Reduces Voltage-Gated Ca 2+ Currents in Dorsal Root Ganglion Neurons. Purinergic signalling (2023)
Simon Krols, Federica Matteucci, Kristof Van Hecke, Guy Caljon, Kenneth A Jacobson, Serge Van Calenbergh
Dual N 6 /C7-Substituted 7-Deazapurine and Tricyclic Ribonucleosides with Affinity for G Protein-Coupled Receptors. ACS medicinal chemistry letters 15 (1) (2023)
Stephen P H Alexander, Arthur Christopoulos, Anthony P Davenport, Eamonn Kelly, Alistair A Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Jamie A Davies, Maria Pia Abbracchio, George Abraham, Alexander Agoulnik, Wayne Alexander, Khaled Al-Hosaini, Magnus Bäck, Jillian G Baker, Nicholas M Barnes, Ross A D Bathgate, Jean-Martin Beaulieu, Annette G Beck-Sickinger, Maik Behrens, Kenneth E Bernstein, Bernhard Bettler, Nigel J M Birdsall, Victoria A Blaho, Francois Boulay, Corinne Bousquet, Hans Bräuner-Osborne, Geoffrey Burnstock, Girolamo Caló, Justo P Castaño, Kevin J Catt, Stefania Ceruti, Paul L Chazot, Nan Chiang, Bice Chini, Jerold Chun, Antonia Cianciulli, Olivier Civelli, Lucie H Clapp, Réjean Couture, Helen M Cox, Zsolt Csaba, Claes Dahlgren, Gordon Dent, Steven D Douglas, Pascal Dournaud, Satoru Eguchi, Emanuel Escher, Edward J Filardo, Tung Fong, Marta Fumagalli, Raul R Gainetdinov, Michael L Garelja, Marc de Gasparo, Craig Gerard, Marvin Gershengorn, Fernand Gobeil, Theodore L Goodfriend, Cyril Goudet, Lukas Grätz, Karen J Gregory, Andrew L Gundlach, Jörg Hamann, Julien Hanson, Richard L Hauger, Debbie L Hay, Akos Heinemann, Deron Raymond Herr, Morley D Hollenberg, Nicholas D Holliday, Mastgugu Horiuchi, Daniel Hoyer, László Hunyady, Ahsan Husain, Adriaan P IJzerman, Tadashi Inagami, Kenneth A Jacobson, Robert T Jensen, Ralf Jockers, Deepa Jonnalagadda, Sadashiva S Karnik, Klemens Kaupmann, Jacqueline Kemp, Charles Kennedy, Hirotaka Mizuno, Takio Kitazawa, Pawel Kozielewicz, Hans-Jürgen Kreienkamp, Jyrki P Kukkonen, Tobias Langenhan, Dan Larhammar, Katie Leach, Davide Lecca, John D Lee, Susan E Leeman, Jérôme Leprince, Xaria X Li, Stephen J Lolait, Amelie Lupp, Robyn Macrae, Janet J Maguire, Davide Malfacini, Jean Mazella, Craig A McArdle, Shlomo Melmed, Martin Christian Michel, Laurence J Miller, Vincenzo Mitolo, Bernard Mouillac, Christa Elisabeth Müller, Philip M Murphy, Jean-Louis Nahon, Tony Ngo, Xavier Norel, Duuamene Nyimanu, Anne-Marie O'Carroll, Stefan Offermanns, Maria Antonietta Panaro, Marc Parmentier, Roger G Pertwee, Jean-Philippe Pin, Eric R Prossnitz, Mark Quinn, Rithwik Ramachandran, Manisha Ray, Rainer K Reinscheid, Philippe Rondard, Gianenrico Rovati, Chiara Ruzza, Gareth John Sanger, Torsten Schöneberg, Gunnar Schulte, Stefan Schulz, Deborah L Segaloff, Charles N Serhan, Khuraijam Dhanachandra Singh, Craig M Smith, Leigh A Stoddart, Yukihiko Sugimoto, Roger J Summers, Valerie P Tan, David M Thal, Walter Wally Thomas, Pieter B M W M Timmermans, Kalyan Tirupula, Lawrence Toll, Giovanni Tulipano, Hamiyet Unal, Thomas Unger, Celine Valant, Patrick Vanderheyden, David Vaudry, Hubert Vaudry, Jean-Pierre Vilardaga, Christopher S Walker, Ji Ming Wang, Donald T Ward, Hans-Jürgen Wester, Gary B Willars, Tom Lloyd Williams, Trent M Woodruff, Chengcan Yao, Richard D Ye
The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors. British journal of pharmacology (2023)
Naveen Thakur, Arka P Ray, Liam Sharp, Beining Jin, Alexander Duong, Niloofar Gopal Pour, Samuel Obeng, Anuradha V Wijesekara, Zhan-Guo Gao, Christopher R McCurdy, Kenneth A Jacobson, Edward Lyman, Matthew T Eddy
Anionic phospholipids control mechanisms of GPCR-G protein recognition. Nature communications 14 (1) (2023)
Naveen Thakur, Arka P Ray, Liam Sharp, Beining Jin, Alexander Duong, Niloofar Gopal Pour, Samuel Obeng, Anuradha V Wijesekara, Zhan-Guo Gao, Christopher R McCurdy, Kenneth A Jacobson, Edward Lyman, Matthew T Eddy
Anionic phospholipids control mechanisms of GPCR-G protein recognition. Nature communications 14 (1) (2023)
Naveen Thakur, Arka P Ray, Liam Sharp, Beining Jin, Alexander Duong, Niloofar Gopal Pour, Samuel Obeng, Anuradha V Wijesekara, Zhan-Guo Gao, Christopher R McCurdy, Kenneth A Jacobson, Edward Lyman, Matthew T Eddy
Anionic phospholipids control mechanisms of GPCR-G protein recognition. Nature communications 14 (1) (2023)
Naveen Thakur, Arka Prabha Ray, Edward Lyman, Zhan-Guo Gao, Kenneth A Jacobson, Matthew T Eddy
Membrane Mimetic-Dependence of GPCR Energy Landscapes. bioRxiv : the preprint server for biology (2023)
Jung-Eun Park, Klara Kirsch, Hobin Lee, Paola Oliva, Jong Il Ahn, Harsha Ravishankar, Yan Zeng, Stephen D Fox, Samuel A Kirby, Pooja Badhwar, Thorkell Andresson, Kenneth A Jacobson, Kyung S Lee
Specific inhibition of an anticancer target, polo-like kinase 1, by allosterically dismantling its mechanism of substrate recognition. Proceedings of the National Academy of Sciences of the United States of America 120 (35) (2023)
Naveen Thakur, Arka P Ray, Liam Sharp, Beining Jin, Alexander Duong, Niloofar Gopal Pour, Samuel Obeng, Anuradha V Wijesekara, Zhan-Guo Gao, Christopher R McCurdy, Kenneth A Jacobson, Edward Lyman, Matthew T Eddy
Anionic Phospholipids Control Mechanisms of GPCR-G Protein Recognition. bioRxiv : the preprint server for biology (2023)
Dilip K Tosh, Courtney L Fisher, Veronica Salmaso, Tina C Wan, Ryan G Campbell, Eric Chen, Zhan-Guo Gao, John A Auchampach, Kenneth A Jacobson
First Potent Macrocyclic A 3 Adenosine Receptor Agonists Reveal G-Protein and β-Arrestin2 Signaling Preferences. ACS pharmacology & translational science 6 (9) (2023)
Paola Oliva, R Rama Suresh, Silvia Pasquini, Veronica Salmaso, Edward J Will, Dilip K Tosh, Zhan-Guo Gao, Naili Liu, Oksana Gavrilova, Fabrizio Vincenzi, Katia Varani, Kenneth A Jacobson
2-Amino-5-arylethynyl-thiophen-3-yl-(phenyl)methanones as A 1 Adenosine Receptor Positive Allosteric Modulators. ACS medicinal chemistry letters 14 (12) (2023)
Jung-Eun Park, Hobin Lee, Paola Oliva, Klara Kirsch, Bora Kim, Jong Il Ahn, Celeste N Alverez, Snehal Gaikwad, Kristopher W Krausz, Robert O'Connor, Ganesha Rai, Anton Simeonov, Beverly A Mock, Frank J Gonzalez, Kyung S Lee, Kenneth A Jacobson
Structural Optimization and Anticancer Activity of Polo-like Kinase 1 (Plk1) Polo-Box Domain (PBD) Inhibitors and Their Prodrugs. ACS pharmacology & translational science 6 (3) (2023)
Naveen Thakur, Arka P Ray, Liam Sharp, Beining Jin, Alexander Duong, Niloofar Gopal Pour, Samuel Obeng, Anuradha V Wijesekara, Zhan-Guo Gao, Christopher R McCurdy, Kenneth A Jacobson, Edward Lyman, Matthew T Eddy
Anionic phospholipids control mechanisms of GPCR-G protein recognition. Nature communications 14 (1) (2023)
Eline Pottie, R Rama Suresh, Kenneth A Jacobson, Christophe Pol Stove
Assay-Dependent Inverse Agonism at the A 3 Adenosine Receptor: When Neutral Is Not Neutral. ACS pharmacology & translational science 6 (9) (2023)
Abigail M Schwarz, Attila Keresztes, Thai Bui, Ryan J Hecksel, Adrian Peña, Brianna Lent, Zhan-Guo Gao, Martín Gamez-Rivera, Caleb A Seekins, Kerry Chou, Taylor L Appel, Kenneth A Jacobson, Fahad A Al-Obeidi, John M Streicher
Terpenes from Cannabis sativa Induce Antinociception in Mouse Chronic Neuropathic Pain via Activation of Spinal Cord Adenosine A 2A Receptors. bioRxiv : the preprint server for biology (2023)
Stephen P H Alexander, Arthur Christopoulos, Anthony P Davenport, Eamonn Kelly, Alistair A Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Jamie A Davies, Maria Pia Abbracchio, George Abraham, Alexander Agoulnik, Wayne Alexander, Khaled Al-Hosaini, Magnus Bäck, Jillian G Baker, Nicholas M Barnes, Ross A D Bathgate, Jean-Martin Beaulieu, Annette G Beck-Sickinger, Maik Behrens, Kenneth E Bernstein, Bernhard Bettler, Nigel J M Birdsall, Victoria A Blaho, Francois Boulay, Corinne Bousquet, Hans Bräuner-Osborne, Geoffrey Burnstock, Girolamo Caló, Justo P Castaño, Kevin J Catt, Stefania Ceruti, Paul L Chazot, Nan Chiang, Bice Chini, Jerold Chun, Antonia Cianciulli, Olivier Civelli, Lucie H Clapp, Réjean Couture, Helen M Cox, Zsolt Csaba, Claes Dahlgren, Gordon Dent, Steven D Douglas, Pascal Dournaud, Satoru Eguchi, Emanuel Escher, Edward J Filardo, Tung Fong, Marta Fumagalli, Raul R Gainetdinov, Michael L Garelja, Marc de Gasparo, Craig Gerard, Marvin Gershengorn, Fernand Gobeil, Theodore L Goodfriend, Cyril Goudet, Lukas Grätz, Karen J Gregory, Andrew L Gundlach, Jörg Hamann, Julien Hanson, Richard L Hauger, Debbie L Hay, Akos Heinemann, Deron Raymond Herr, Morley D Hollenberg, Nicholas D Holliday, Mastgugu Horiuchi, Daniel Hoyer, László Hunyady, Ahsan Husain, Adriaan P IJzerman, Tadashi Inagami, Kenneth A Jacobson, Robert T Jensen, Ralf Jockers, Deepa Jonnalagadda, Sadashiva S Karnik, Klemens Kaupmann, Jacqueline Kemp, Charles Kennedy, Hirotaka Mizuno, Takio Kitazawa, Pawel Kozielewicz, Hans-Jürgen Kreienkamp, Jyrki P Kukkonen, Tobias Langenhan, Dan Larhammar, Katie Leach, Davide Lecca, John D Lee, Susan E Leeman, Jérôme Leprince, Xaria X Li, Stephen J Lolait, Amelie Lupp, Robyn Macrae, Janet J Maguire, Davide Malfacini, Jean Mazella, Craig A McArdle, Shlomo Melmed, Martin Christian Michel, Laurence J Miller, Vincenzo Mitolo, Bernard Mouillac, Christa Elisabeth Müller, Philip M Murphy, Jean-Louis Nahon, Tony Ngo, Xavier Norel, Duuamene Nyimanu, Anne-Marie O'Carroll, Stefan Offermanns, Maria Antonietta Panaro, Marc Parmentier, Roger G Pertwee, Jean-Philippe Pin, Eric R Prossnitz, Mark Quinn, Rithwik Ramachandran, Manisha Ray, Rainer K Reinscheid, Philippe Rondard, Gianenrico Rovati, Chiara Ruzza, Gareth John Sanger, Torsten Schöneberg, Gunnar Schulte, Stefan Schulz, Deborah L Segaloff, Charles N Serhan, Khuraijam Dhanachandra Singh, Craig M Smith, Leigh A Stoddart, Yukihiko Sugimoto, Roger J Summers, Valerie P Tan, David M Thal, Walter Wally Thomas, Pieter B M W M Timmermans, Kalyan Tirupula, Lawrence Toll, Giovanni Tulipano, Hamiyet Unal, Thomas Unger, Celine Valant, Patrick Vanderheyden, David Vaudry, Hubert Vaudry, Jean-Pierre Vilardaga, Christopher S Walker, Ji Ming Wang, Donald T Ward, Hans-Jürgen Wester, Gary B Willars, Tom Lloyd Williams, Trent M Woodruff, Chengcan Yao, Richard D Ye
The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors. British journal of pharmacology (2023)
Simon Krols, Federica Matteucci, Kristof Van Hecke, Guy Caljon, Kenneth A Jacobson, Serge Van Calenbergh
Dual N 6 /C7-Substituted 7-Deazapurine and Tricyclic Ribonucleosides with Affinity for G Protein-Coupled Receptors. ACS medicinal chemistry letters 15 (1) (2023)
Hai-Jun Zhang, Michał Ociepa, Molhm Nassir, Bin Zheng, Sarah A Lewicki, Veronica Salmaso, Helay Baburi, Jessica Nagel, Salahuddin Mirza, Beatriz Bueschbell, Haneen Al-Hroub, Olga Perzanowska, Ziqing Lin, Michael A Schmidt, Martin D Eastgate, Kenneth A Jacobson, Christa Elisabeth Müller, Joanna Kowalska, Jacek Jemielity, Phil S Baran
Stereocontrolled access to thioisosteres of nucleoside di- and triphosphates. Nature chemistry (2023)
Naveen Thakur, Arka P Ray, Liam Sharp, Beining Jin, Alexander Duong, Niloofar Gopal Pour, Samuel Obeng, Anuradha V Wijesekara, Zhan-Guo Gao, Christopher R McCurdy, Kenneth A Jacobson, Edward Lyman, Matthew T Eddy
Anionic Phospholipids Control Mechanisms of GPCR-G Protein Recognition. bioRxiv : the preprint server for biology (2023)
Naveen Thakur, Arka P Ray, Liam Sharp, Beining Jin, Alexander Duong, Niloofar Gopal Pour, Samuel Obeng, Anuradha V Wijesekara, Zhan-Guo Gao, Christopher R McCurdy, Kenneth A Jacobson, Edward Lyman, Matthew T Eddy
Anionic Phospholipids Control Mechanisms of GPCR-G Protein Recognition. bioRxiv : the preprint server for biology (2023)
Paola Oliva, R Rama Suresh, Silvia Pasquini, Veronica Salmaso, Edward J Will, Dilip K Tosh, Zhan-Guo Gao, Naili Liu, Oksana Gavrilova, Fabrizio Vincenzi, Katia Varani, Kenneth A Jacobson
2-Amino-5-arylethynyl-thiophen-3-yl-(phenyl)methanones as A 1 Adenosine Receptor Positive Allosteric Modulators. ACS medicinal chemistry letters 14 (12) (2023)
Zhiwei Wen, Asmita Pramanik, Sarah A Lewicki, Young-Hwan Jung, Zhan-Guo Gao, John C R Randle, Chunxia Cronin, Zhoumou Chen, Luigino A Giancotti, Gregory S Whitehead, Bruce T Liang, Sylvie Breton, Daniela Salvemini, Donald N Cook, Kenneth A Jacobson
Alicyclic Ring Size Variation of 4-Phenyl-2-naphthoic Acid Derivatives as P2Y 14 Receptor Antagonists. Journal of medicinal chemistry (2023)
Paola Oliva, R Rama Suresh, Silvia Pasquini, Veronica Salmaso, Edward J Will, Dilip K Tosh, Zhan-Guo Gao, Naili Liu, Oksana Gavrilova, Fabrizio Vincenzi, Katia Varani, Kenneth A Jacobson
2-Amino-5-arylethynyl-thiophen-3-yl-(phenyl)methanones as A 1 Adenosine Receptor Positive Allosteric Modulators. ACS medicinal chemistry letters 14 (12) (2023)
Naveen Thakur, Arka P Ray, Liam Sharp, Beining Jin, Alexander Duong, Niloofar Gopal Pour, Samuel Obeng, Anuradha V Wijesekara, Zhan-Guo Gao, Christopher R McCurdy, Kenneth A Jacobson, Edward Lyman, Matthew T Eddy
Anionic phospholipids control mechanisms of GPCR-G protein recognition. Nature communications 14 (1) (2023)
Simon Krols, Federica Matteucci, Kristof Van Hecke, Guy Caljon, Kenneth A Jacobson, Serge Van Calenbergh
Dual N 6 /C7-Substituted 7-Deazapurine and Tricyclic Ribonucleosides with Affinity for G Protein-Coupled Receptors. ACS medicinal chemistry letters 15 (1) (2023)
Jung-Eun Park, Hobin Lee, Paola Oliva, Klara Kirsch, Bora Kim, Jong Il Ahn, Celeste N Alverez, Snehal Gaikwad, Kristopher W Krausz, Robert O'Connor, Ganesha Rai, Anton Simeonov, Beverly A Mock, Frank J Gonzalez, Kyung S Lee, Kenneth A Jacobson
Structural Optimization and Anticancer Activity of Polo-like Kinase 1 (Plk1) Polo-Box Domain (PBD) Inhibitors and Their Prodrugs. ACS pharmacology & translational science 6 (3) (2023)
Gregory S Whitehead, Tadeusz P Karcz, Dilip K Tosh, Young-Hwan Jung, Zhiwei Wen, Ryan G Campbell, Varun Gopinatth, Zhan-Guo Gao, Kenneth A Jacobson, Donald N Cook
Effects of Purinergic Receptor Deletion or Pharmacologic Modulation on Pulmonary Inflammation in Mice. ACS pharmacology & translational science 5 (10) (2022)
Lucas B Fallot, R Rama Suresh, Courtney L Fisher, Veronica Salmaso, Robert D O'Connor, Noy Kaufman, Zhan-Guo Gao, John A Auchampach, Kenneth A Jacobson
Structure-Activity Studies of 1 H -Imidazo[4,5- c ]quinolin-4-amine Derivatives as A 3 Adenosine Receptor Positive Allosteric Modulators. Journal of medicinal chemistry 65 (22) (2022)
Kiran S Toti, Ryan G Campbell, Hobin Lee, Veronica Salmaso, R Rama Suresh, Zhan-Guo Gao, Kenneth A Jacobson
Fluorescent A 2A and A 3 adenosine receptor antagonists as flow cytometry probes. Purinergic signalling (2022)
Kiran S Toti, John R Jimah, Veronica Salmaso, Jenny E Hinshaw, Kenneth A Jacobson
Synthesis and Effect of Conformationally Locked Carbocyclic Guanine Nucleotides on Dynamin. Biomolecules 12 (4) (2022)
Anna Shiriaeva, Daejin Park, Gyudong Kim, Yoonji Lee, Xiyan Hou, Dnyandev B Jarhad, Gibae Kim, Jinha Yu, Young Eum Hyun, Woomi Kim, Zhan-Guo Gao, Kenneth A Jacobson, Gye Won Han, Raymond C Stevens, Lak Shin Jeong, Sun Choi, Vadim Cherezov
GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for the A 2A Adenosine Receptor. Journal of medicinal chemistry 65 (17) (2022)
Kiran S Toti, Rajkumar Verma, Michael J McGonnigle, Daylin Gamiotea Turro, Zhiwei Wen, Sarah A Lewicki, Bruce T Liang, Kenneth A Jacobson
Structure-Activity Relationship and Neuroprotective Activity of 1,5-Dihydro-2 H -naphtho[1,2- b ][1,4]diazepine-2,4(3 H )-diones as P2X4 Receptor Antagonists. Journal of medicinal chemistry 65 (20) (2022)
Mirko Scortichini, Riham Mohammed Idris, Susanne Moschütz, Antje Keim, Veronica Salmaso, Clemens Dobelmann, Paola Oliva, Karolina Losenkova, Heikki Irjala, Samuli Vaittinen, Jouko Sandholm, Gennady G Yegutkin, Norbert Sträter, Anna Junker, Christa Elisabeth Müller, Kenneth A Jacobson
Structure-Activity Relationship of 3-Methylcytidine-5'-α,β-methylenediphosphates as CD73 Inhibitors. Journal of medicinal chemistry 65 (3) (2022)
Courtney L Fisher, Lucas B Fallot, Tina C Wan, Robert F Keyes, R Rama Suresh, Amy C Rothwell, Zhan-Guo Gao, John D McCorvy, Brian C Smith, Kenneth A Jacobson, John A Auchampach
Characterization of Dual-Acting A 3 Adenosine Receptor Positive Allosteric Modulators That Preferentially Enhance Adenosine-Induced Gα i3 and Gα oA Isoprotein Activation. ACS pharmacology & translational science 5 (8) (2022)
Silvia Sgambellone, Silvia Marri, Stefano Catarinicchia, Alessandro Pini, Dilip K Tosh, Kenneth A Jacobson, Emanuela Masini, Daniela Salvemini, Laura Lucarini
Adenosine A 3 Receptor (A 3 AR) Agonist for the Treatment of Bleomycin-Induced Lung Fibrosis in Mice. International journal of molecular sciences 23 (21) (2022)
Ida C Schiller, Kenneth A Jacobson, Zhiwei Wen, Aparna Malisetty, Günther Schmalzing, Fritz Markwardt
Dihydropyridines Potentiate ATP-Induced Currents Mediated by the Full-Length Human P2X5 Receptor. Molecules (Basel, Switzerland) 27 (6) (2022)
Zhiwei Wen, Veronica Salmaso, Young-Hwan Jung, Ngan B Phung, Varun Gopinatth, Qasim Shah, Alexandra T Patterson, John C R Randle, Zhoumou Chen, Daniela Salvemini, David I Lieberman, Gregory S Whitehead, Tadeusz P Karcz, Donald N Cook, Kenneth A Jacobson
Bridged Piperidine Analogues of a High Affinity Naphthalene-Based P2Y 14 R Antagonist. Journal of medicinal chemistry 65 (4) (2022)
R Rama Suresh, Zhan-Guo Gao, Veronica Salmaso, Eric Chen, Ryan G Campbell, Russell B Poe, Theodore E Liston, Kenneth A Jacobson
Selective A 3 Adenosine Receptor Antagonist Radioligand for Human and Rodent Species. ACS medicinal chemistry letters 13 (4) (2022)
Stefania Merighi, Pier Andrea Borea, Katia Varani, Fabrizio Vincenzi, Alessia Travagli, Manuela Nigro, Silvia Pasquini, R Rama Suresh, Sung Won Kim, Nora D Volkow, Kenneth A Jacobson, Stefania Gessi
Pathophysiological Role and Medicinal Chemistry of A 2A Adenosine Receptor Antagonists in Alzheimer's Disease. Molecules (Basel, Switzerland) 27 (9) (2022)
Jan Phillip Lemmerhirt, Andreas Isaak, Rongfang Liu, Max Kock, Constantin Gabriel Daniliuc, Kenneth A Jacobson, Laura H Heitman, Anna Junker
Development of Bicyclo[3.1.0]hexane-Based A 3 Receptor Ligands: Closing the Gaps in the Structure-Affinity Relationships. Molecules (Basel, Switzerland) 27 (7) (2022)
Heather Leduc-Pessah, Cynthia Xu, Churmy Y Fan, Rebecca Dalgarno, Yuta Kohro, Sydney Sparanese, Nikita N Burke, Kenneth A Jacobson, Christophe Altier, Daniela Salvemini, Tuan Trang
Spinal A3 adenosine receptor activation acutely restores morphine antinociception in opioid tolerant male rats. Journal of neuroscience research (2021)
Stephen P H Alexander, Arthur Christopoulos, Anthony P Davenport, Eamonn Kelly, Alistair A Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Christopher Southan, Jamie A Davies, Maria Pia Abbracchio, Wayne Alexander, Khaled Al-Hosaini, Magnus Bäck, Nicholas M Barnes, Ross A D Bathgate, Jean-Martin Beaulieu, Kenneth E Bernstein, Bernhard Bettler, Nigel J M Birdsall, Victoria A Blaho, Francois Boulay, Corinne Bousquet, Hans Bräuner-Osborne, Geoffrey Burnstock, Girolamo Caló, Justo P Castaño, Kevin J Catt, Stefania Ceruti, Paul L Chazot, Nan Chiang, Bice Chini, Jerold Chun, Antonia Cianciulli, Olivier Civelli, Lucie H Clapp, Réjean Couture, Zsolt Csaba, Claes Dahlgren, Gordon Dent, Khuraijam Dhanachandra Singh, Steven D Douglas, Pascal Dournaud, Satoru Eguchi, Emanuel Escher, Edward J Filardo, Tung Fong, Marta Fumagalli, Raul R Gainetdinov, Marc de Gasparo, Craig Gerard, Marvin Gershengorn, Fernand Gobeil, Theodore L Goodfriend, Cyril Goudet, Karen J Gregory, Andrew L Gundlach, Jörg Hamann, Julien Hanson, Richard L Hauger, Debbie L Hay, Akos Heinemann, Morley D Hollenberg, Nicholas D Holliday, Mastgugu Horiuchi, Daniel Hoyer, László Hunyady, Ahsan Husain, Adriaan P IJzerman, Tadashi Inagami, Kenneth A Jacobson, Robert T Jensen, Ralf Jockers, Deepa Jonnalagadda, Sadashiva S Karnik, Klemens Kaupmann, Jacqueline Kemp, Charles Kennedy, Hirotaka Mizuno, Takio Kitazawa, Pawel Kozielewicz, Hans-Jürgen Kreienkamp, Jyrki P Kukkonen, Tobias Langenhan, Katie Leach, Davide Lecca, John D Lee, Susan E Leeman, Jérôme Leprince, Xaria X Li, Tom Lloyd Williams, Stephen J Lolait, Amelie Lupp, Robyn Macrae, Janet J Maguire, Jean Mazella, Craig A McArdle, Shlomo Melmed, Martin Christian Michel, Laurence J Miller, Vincenzo Mitolo, Bernard Mouillac, Christa Elisabeth Müller, Philip Murphy, Jean-Louis Nahon, Tony Ngo, Xavier Norel, Duuamene Nyimanu, Anne-Marie O'Carroll, Stefan Offermanns, Maria Antonietta Panaro, Marc Parmentier, Roger G Pertwee, Jean-Philippe Pin, Eric R Prossnitz, Mark Quinn, Rithwik Ramachandran, Manisha Ray, Rainer K Reinscheid, Philippe Rondard, Gianenrico Rovati, Chiara Ruzza, Gareth John Sanger, Torsten Schöneberg, Gunnar Schulte, Stefan Schulz, Deborah L Segaloff, Charles N Serhan, Leigh A Stoddart, Yukihiko Sugimoto, Roger J Summers, Valerie P Tan, David M Thal, Walter Wally Thomas, Pieter B M W M Timmermans, Kalyan Tirupula, Giovanni Tulipano, Hamiyet Unal, Thomas Unger, Celine Valant, Patrick Vanderheyden, David Vaudry, Hubert Vaudry, Jean-Pierre Vilardaga, Christopher S Walker, Ji Ming Wang, Donald T Ward, Hans-Jürgen Wester, Gary B Willars, Trent M Woodruff, Chengcan Yao, Richard D Ye
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors. British journal of pharmacology (2021)
Héctor Godoy-Marín, Romain Duroux, Kenneth A Jacobson, Concepció Soler, Hildegard Colino-Lage, Veronica Jiménez-Sábado, José Montiel, Leif Hove-Madsen, Francisco Ciruela
Adenosine A2A Receptors Are Upregulated in Peripheral Blood Mononuclear Cells from Atrial Fibrillation Patients. International journal of molecular sciences 22 (7) (2021)
R Rama Suresh, Russell B Poe, Baorui Lin, Kexin Lv, Ryan G Campbell, Zhan-Guo Gao, Theodore E Liston, Kiran S Toti, Kenneth A Jacobson
Convergent synthesis of 2-thioether-substituted ( N )-methanocarba-adenosines as purine receptor agonists. RSC advances 11 (44) (2021)
Kenneth A Jacobson, Veronica Salmaso, R Rama Suresh, Dilip K Tosh
Expanding the repertoire of methanocarba nucleosides from purinergic signaling to diverse targets. RSC medicinal chemistry 12 (11) (2021)
Hongseok Choi, Kenneth A Jacobson, Jinha Yu, Lak Shin Jeong
Design and Synthesis of 2,6-Disubstituted-4'-Selenoadenosine-5'-N,N-Dimethyluronamide Derivatives as Human A3 Adenosine Receptor Antagonists. Pharmaceuticals (Basel, Switzerland) 14 (4) (2021)
Min Guo, Abolghasem 'Gus' Bakhoda, Zhan-Guo Gao, Joseph M Ramsey, Yang Li, Kelly A O'Conor, Andrew C Kelleher, Seth M Eisenberg, Yeona Kang, Xuefeng Yan, Cameron Javdan, Joanna S Fowler, Kenner C Rice, Jacob M Hooker, Kenneth A Jacobson, Sung Won Kim, Nora D Volkow
Discovery of Highly Potent Adenosine A1 Receptor Agonists: Targeting Positron Emission Tomography Probes. ACS chemical neuroscience 12 (18) (2021)
Young-Hwan Jung, Veronica Salmaso, Zhiwei Wen, John M Bennett, Ngan B Phung, David I Lieberman, Varun Gopinatth, John C R Randle, Zhoumou Chen, Daniela Salvemini, Tadeusz P Karcz, Donald N Cook, Kenneth A Jacobson
Structure-Activity Relationship of Heterocyclic P2Y14 Receptor Antagonists: Removal of the Zwitterionic Character with Piperidine Bioisosteres. Journal of medicinal chemistry 64 (8) (2021)
Pierre Matricon, Duc Duy Vo, Zhan-Guo Gao, Jan Kihlberg, Kenneth A Jacobson, Jens Carlsson
Fragment-based design of selective GPCR ligands guided by free energy simulations. Chemical communications (Cambridge, England) 57 (92) (2021)
Elisabetta Coppi, Federica Cherchi, Elena Lucarini, Carla Ghelardini, Felicita Pedata, Kenneth A Jacobson, Di Cesare Mannelli Lorenzo, Anna Maria Pugliese, Daniela Salvemini
Uncovering the Mechanisms of Adenosine Receptor-Mediated Pain Control: Focus on the A3 Receptor Subtype. International journal of molecular sciences 22 (15) (2021)
Zhan-Guo Gao, R Rama Suresh, Kenneth A Jacobson
Pharmacological characterization of DPTN and other selective A3 adenosine receptor antagonists. Purinergic signalling (2021)
Yoonji Lee, Xiyan Hou, Jin Hee Lee, Akshata Nayak, Varughese Alexander, Pankaz K Sharma, Hyerim Chang, Khai Phan, Zhan-Guo Gao, Kenneth A Jacobson, Sun Choi, Lak Shin Jeong
Subtle Chemical Changes Cross the Boundary between Agonist and Antagonist: New A3 Adenosine Receptor Homology Models and Structural Network Analysis Can Predict This Boundary. Journal of medicinal chemistry 64 (17) (2021)
Shanu Jain, Sai P Pydi, Kiran S Toti, Bernard Robaye, Marco Idzko, Oksana Gavrilova, Jürgen Wess, Kenneth A Jacobson
Lack of adipocyte purinergic P2Y6 receptor greatly improves whole body glucose homeostasis. Proceedings of the National Academy of Sciences of the United States of America 117 (48) (2020)
Veronica Salmaso, Kenneth A Jacobson
Purinergic Signaling: Impact of GPCR Structures on Rational Drug Design. ChemMedChem 15 (21) (2020)
Celeste N Alverez, Jung-Eun Park, Kiran S Toti, Yangliu Xia, Kristopher W Krausz, Ganesha Rai, Jeong Kyu Bang, Frank J Gonzalez, Kenneth A Jacobson, Kyung S Lee
Identification of a New Heterocyclic Scaffold for Inhibitors of the Polo-Box Domain of Polo-like Kinase 1. Journal of medicinal chemistry 63 (22) (2020)
Haley S Province, Cuiying Xiao, Allison S Mogul, Ankita Sahoo, Kenneth A Jacobson, Ramón A Piñol, Oksana Gavrilova, Marc L Reitman
Activation of neuronal adenosine A1 receptors causes hypothermia through central and peripheral mechanisms. PloS one 15 (12) (2020)
Seungchan An, Gyudong Kim, Hyun Jin Kim, Sungjin Ahn, Hyun Young Kim, Hyejin Ko, Young Eum Hyun, Mai Nguyen, Juri Jeong, Zijing Liu, Jinhe Han, Hongseok Choi, Jinha Yu, Ji Won Kim, Hyuk Woo Lee, Kenneth A Jacobson, Won Jea Cho, Young-Mi Kim, Keon Wook Kang, Minsoo Noh, Lak Shin Jeong
Discovery and Structure-Activity Relationships of Novel Template, Truncated 1'-Homologated Adenosine Derivatives as Pure Dual PPARγ/δ Modulators. Journal of medicinal chemistry 63 (24) (2020)
Timothy M Doyle, Tally M Largent-Milnes, Zhoumou Chen, Vasiliki Staikopoulos, Emanuela Esposito, Rebecca Dalgarno, Churmy Fan, Dilip K Tosh, Salvatore Cuzzocrea, Kenneth A Jacobson, Tuan Trang, Mark R Hutchinson, Gary J Bennett, Todd W Vanderah, Daniela Salvemini
Chronic Morphine-Induced Changes in Signaling at the A3 Adenosine Receptor Contribute to Morphine-Induced Hyperalgesia, Tolerance, and Withdrawal. The Journal of pharmacology and experimental therapeutics 374 (2) (2020)
Yan Lu, Shanshan Qin, Bingjie Zhang, Antao Dai, Xiaoqing Cai, Mengna Ma, Zhan-Guo Gao, Dehua Yang, Raymond C Stevens, Kenneth A Jacobson, Ming-Wei Wang, Wenqing Shui
Correction to Accelerating the Throughput of Affinity Mass Spectrometry-Based Ligand Screening toward a G Protein-Coupled Receptor. Analytical chemistry 92 (6) (2020)
Pierre Matricon, R Rama Suresh, Zhan-Guo Gao, Nicolas Panel, Kenneth A Jacobson, Jens Carlsson
Ligand design by targeting a binding site water. Chemical science 12 (3) (2020)
Kenneth A Jacobson, Zhan-Guo Gao, Pierre Matricon, Matthew T Eddy, Jens Carlsson
Adenosine A2A receptor antagonists: from caffeine to selective non-xanthines. British journal of pharmacology (2020)
Dilip K Tosh, Veronica Salmaso, Harsha Rao, Amelia Bitant, Courtney L Fisher, David I Lieberman, Helmut Vorbrüggen, Marc L Reitman, Oksana Gavrilova, Zhan-Guo Gao, John A Auchampach, Kenneth A Jacobson
Truncated (N)-Methanocarba Nucleosides as Partial Agonists at Mouse and Human A3 Adenosine Receptors: Affinity Enhancement by N6-(2-Phenylethyl) Substitution. Journal of medicinal chemistry 63 (8) (2020)

Kenneth A Jacobson.css-eqlu8i{font-size:small;padding-left:4px;}

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Kenneth A Jacobson