John C Vederas (J C Vederas)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 31

Top Venues

Organic letters

Nature communications

RSC medicinal chemistry

Journal of medicinal chemistry

University of Alberta

Massachusetts Institute of Technology (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Alberta Jul 01 1987

Canada

Professor :: Chemistry Department

University of Alberta Jul 01 1982 - Jun 30 1987

Canada

Associate Professor :: Chemistry Department

University of Alberta Jul 01 1977 - Jun 30 1982

Canada

Assistant Professor :: Chemistry Department

Education History

Massachusetts Institute of Technology Sep 01 1969 - Sep 01 1973

United States

PHD :: Chemistry Department

Stanford University Sep 01 1965 - Jun 01 1969

United States

BSC :: Chemistry Department

Publications

Pu Chen, Tayla J Van Oers, Elena Arutyunova, Conrad Fischer, Chaoxiang Wang, Tess Lamer, Marco J van Belkum, Howard S Young, John C Vederas, Mary Joanne Lemieux
A Structural Comparison of Oral SARS-CoV-2 Drug Candidate Ibuzatrelvir Complexed with the Main Protease (M pro ) of SARS-CoV-2 and MERS-CoV. JACS Au 4 (8) (2024)
Moonhyuk Kwon, Connor L Hodgins, Eman M Salama, Kayla R Dias, Aalap Parikh, Ashlyn V Mackey, Karizza F Catenza, John C Vederas, Dae-Kyun Ro
New insights into natural rubber biosynthesis from rubber-deficient lettuce mutants expressing goldenrod or guayule cis-prenyltransferase. The New phytologist (2023)
Elena Arutyunova, Alexandr Belovodskiy, Pu Chen, Muhammad Bashir Khan, Michael Joyce, Holly Saffran, Jimmy Lu, Zoe Turner, Bing Bai, Tess Lamer, Howard S Young, John C Vederas, D Lorne Tyrrell, Mary Joanne Lemieux, James A Nieman
The Effect of Deuteration and Homologation of the Lactam Ring of Nirmatrelvir on Its Biochemical Properties and Oxidative Metabolism. ACS bio & med chem Au 3 (6) (2023)
Tayla J Van Oers, Alexia Piercey, Alexandr Belovodskiy, Béla Reiz, Bethan L Donnelly, Wayne Vuong, Mary Joanne Lemieux, James A Nieman, Karine Auclair, John C Vederas
Deuteration for Metabolic Stabilization of SARS-CoV-2 Inhibitors GC373 and Nirmatrelvir. Organic letters (2023)
Jeffrey Y-K Wong, Arunika I Ekanayake, Serhii Kharchenko, Steven E Kirberger, Ryan Qiu, Payam Kelich, Susmita Sarkar, Jianqian Li, Kleinberg X Fernandez, Edgar R Alvizo-Paez, Jiayuan Miao, Shiva Kalhor-Monfared, J Dwyer John, Hongsuk Kang, Hwanho Choi, John M Nuss, John C Vederas, Yu-Shan Lin, Matthew Scott Macauley, Lela Vukovic, William C K Pomerantz, Ratmir Derda
Genetically encoded discovery of perfluoroaryl macrocycles that bind to albumin and exhibit extended circulation in vivo. Nature communications 14 (1) (2023)
Jeffrey Y-K Wong, Arunika I Ekanayake, Serhii Kharchenko, Steven E Kirberger, Ryan Qiu, Payam Kelich, Susmita Sarkar, Jiaqian Li, Kleinberg X Fernandez, Edgar R Alvizo-Paez, Jiayuan Miao, Shiva Kalhor-Monfared, J Dwyer John, Hongsuk Kang, Hwanho Choi, John M Nuss, John C Vederas, Yu-Shan Lin, Matthew Scott Macauley, Lela Vukovic, William C K Pomerantz, Ratmir Derda
Author Correction: Genetically encoded discovery of perfluoroaryl macrocycles that bind to albumin and exhibit extended circulation in vivo. Nature communications 14 (1) (2023)
Sizhu Amelia Chen, Elena Arutyunova, Jimmy Lu, Muhammad Bashir Khan, Wioletta Rut, Mikolaj Zmudzinski, Shima Shahbaz, Jegan Iyyathurai, Eman W Moussa, Zoe Turner, Bing Bai, Tess Lamer, James A Nieman, John C Vederas, Olivier Julien, Marcin Dra G, Shokrollah Elahi, Howard S Young, Mary Joanne Lemieux
SARS-CoV-2 M pro Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals. ACS central science 9 (4) (2023)
Sizhu Amelia Chen, Elena Arutyunova, Jimmy Lu, Muhammad Bashir Khan, Wioletta Rut, Mikolaj Zmudzinski, Shima Shahbaz, Jegan Iyyathurai, Eman W Moussa, Zoe Turner, Bing Bai, Tess Lamer, James A Nieman, John C Vederas, Olivier Julien, Marcin Dra G, Shokrollah Elahi, Howard S Young, Mary Joanne Lemieux
SARS-CoV-2 M pro Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals. ACS central science 9 (4) (2023)
Elena Arutyunova, Alexandr Belovodskiy, Pu Chen, Muhammad Bashir Khan, Michael Joyce, Holly Saffran, Jimmy Lu, Zoe Turner, Bing Bai, Tess Lamer, Howard S Young, John C Vederas, D Lorne Tyrrell, Mary Joanne Lemieux, James A Nieman
The Effect of Deuteration and Homologation of the Lactam Ring of Nirmatrelvir on Its Biochemical Properties and Oxidative Metabolism. ACS bio & med chem Au 3 (6) (2023)
Kleinberg X Fernandez, Stanley Pokorny, Guncha Ishangulyyeva, Aziz Ullah, Silvia I Todorova, Nadir Erbilgin, Allan L Carroll, John C Vederas
Beauveria bassiana exhibits strong virulence against Dendroctonus ponderosae in greenhouse and field experiments. Applied microbiology and biotechnology (2023)
Tess Lamer, Marco J van Belkum, Anjalee Wijewardane, Sorina Chiorean, Leah A Martin-Visscher, John C Vederas
SPI "sandwich": Combined SUMO-Peptide-Intein expression system and isolation procedure for improved stability and yield of peptides. Protein science : a publication of the Protein Society 31 (5) (2022)
Daniel B Engelhardt, Bethan L Donnelly, Jonathan Beadle, Marco J van Belkum, John C Vederas
Ring-opening reactions for the solid-phase synthesis of nisin lipopeptide analogues. Organic & biomolecular chemistry 20 (45) (2022)
Yu-Ting Hsiao, Jonathan Beadle, Cameron Pascoe, Ritesh Annadate, John C Vederas
Decarboxylative Radical Addition to Methylideneoxazolidinones for Stereocontrolled Synthesis of Selectively Protected Diamino Diacids. Organic letters 23 (18) (2021)
Bing Bai, Alexandr Belovodskiy, Mostofa Hena, Appan Srinivas Kandadai, Michael A Joyce, Holly A Saffran, Justin A Shields, Muhammad Bashir Khan, Elena Arutyunova, Jimmy Lu, Sardeev K Bajwa, Darren Hockman, Conrad Fischer, Tess Lamer, Wayne Vuong, Marco J van Belkum, Zhengxian Gu, Fusen Lin, Yanhua Du, Jia Xu, Mohammad Rahim, Howard S Young, John C Vederas, D Lorne Tyrrell, Mary Joanne Lemieux, James A Nieman
Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and in Vitro Biological Stability. Journal of medicinal chemistry (2021)
Bing Bai, Elena Arutyunova, Muhammad Bashir Khan, Jimmy Lu, Michael A Joyce, Holly A Saffran, Justin A Shields, Appan Srinivas Kandadai, Alexandr Belovodskiy, Mostofa Hena, Wayne Vuong, Tess Lamer, Howard S Young, John C Vederas, D Lorne Tyrrell, Mary Joanne Lemieux, James A Nieman
Peptidomimetic nitrile warheads as SARS-CoV-2 3CL protease inhibitors. RSC medicinal chemistry 12 (10) (2021)
Cameron A Pascoe, Daniel B Engelhardt, Albert Remus R Rosana, Marco J van Belkum, John C Vederas
Methylene Analogues of Neopetrosiamide as Potential Antimetastatic Agents: Solid-Supported Syntheses Using Diamino Diacids for Pre-Stapling of Peptides with Multiple Disulfides. Organic letters 23 (23) (2021)
Albert Remus R Rosana, Stanley Pokorny, Jennifer G Klutsch, Cherry Ibarra-Romero, Randy Sanichar, Daniel B Engelhardt, Marco J van Belkum, Nadir Erbilgin, Joerg Bohlmann, Allan L Carroll, John C Vederas
Selection of entomopathogenic fungus Beauveria bassiana (Deuteromycotina: Hyphomycetes) for the biocontrol of Dendroctonus ponderosae (Coleoptera: Curculionidae, Scolytinae) in Western Canada. Applied microbiology and biotechnology 105 (6) (2021)
Wayne Vuong, John C Vederas
Improved Synthesis of a Cyclic Glutamine Analogue Used in Antiviral Agents Targeting 3C and 3CL Proteases Including SARS-CoV-2 Mpro. The Journal of organic chemistry 86 (18) (2021)
Kleinberg X Fernandez, Conrad Fischer, Jennie Vu, Mahmoud Gheblawi, Wang Wang, Samantha Gottschalk, Xavier Iturrioz, Catherine Llorens-Cortés, Gavin Y Oudit, John C Vederas
Metabolically stable apelin-analogues, incorporating cyclohexylalanine and homoarginine, as potent apelin receptor activators. RSC medicinal chemistry 12 (8) (2021)
Wayne Vuong, Muhammad Bashir Khan, Conrad Fischer, Elena Arutyunova, Tess Lamer, Justin A Shields, Holly A Saffran, Ryan T McKay, Marco J van Belkum, Michael A Joyce, Howard S Young, D Lorne J Tyrrell, John C Vederas, Mary Joanne Lemieux
Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication. Nature communications 11 (1) (2020)
Wayne Vuong, Muhammad Bashir Khan, Conrad Fischer, Elena Arutyunova, Tess Lamer, Justin A Shields, Holly A Saffran, Ryan T McKay, Marco J van Belkum, Michael A Joyce, Howard S Young, D Lorne J Tyrrell, John C Vederas, Mary Joanne Lemieux
Author Correction: Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication. Nature communications 11 (1) (2020)
Isaac Antwi, Sorina Chiorean, Marco J van Belkum, John C Vederas
Unveiling the active isomer of cycloalanopine, a cyclic opine from Lactobacillus rhamnosus LS8, through synthesis and analog production. RSC medicinal chemistry 11 (4) (2020)
Conrad Fischer, Tess Lamer, Kleinberg Fernandez, Mahmoud Gheblawi, Wang Wang, Cameron Pascoe, Gareth Lambkin, Xavier Iturrioz, Catherine Llorens-Cortes, Gavin Y Oudit, John C Vederas
Optimizing PEG-Extended Apelin Analogues as Cardioprotective Drug Leads: Importance of the KFRR Motif and Aromatic Head Group for Improved Physiological Activity. Journal of medicinal chemistry 63 (20) (2020)
Samara Pinto Custodio Bernardo, Albert Remus R Rosana, Adriane Nunes de Souza, Sorina Chiorean, Meire Lelis Leal Martins, John C Vederas
Draft Genome Sequence of the Thermophilic Bacterium Bacillus licheniformis SMIA-2, an Antimicrobial- and Thermostable Enzyme-Producing Isolate from Brazilian Soil. Microbiology resource announcements 9 (17) (2020)
Sorina Chiorean, Isaac Antwi, Daniel W Carney, Ioli Kotsogianni, Andrew M Giltrap, Francesca M Alexander, Stephen A Cochrane, Richard J Payne, Nathaniel I Martin, Antoine Henninot, John C Vederas
Dissecting the Binding Interactions of Teixobactin with the Bacterial Cell-Wall Precursor Lipid II. Chembiochem : a European journal of chemical biology 21 (6) (2019)
Wayne Vuong, Fabricio Mosquera-Guagua, Randy Sanichar, Tyler R McDonald, Oliver P Ernst, Lei Wang, John C Vederas
Synthesis of Chiral Spin-Labeled Amino Acids. Organic letters 21 (24) (2019)
Conrad Fischer, Moonhyuk Kwon, Dae-Kun Ro, Marco J van Belkum, John C Vederas
Isolation, expression and biochemical characterization of recombinant hyoscyamine-6β-hydroxylase from Brugmansia sanguinea - tuning the scopolamine production. MedChemComm 9 (5) (2018)
K M Towle, John C Vederas
Structural features of many circular and leaderless bacteriocins are similar to those in saposins and saposin-like peptides. MedChemComm 8 (2) (2017)
Randy Sanichar, John C Vederas
One-Step Transformation of Coenzyme A into Analogues by Transamidation. Organic letters 19 (8) (2017)
Alireza Bakhtiary, Stephen A Cochrane, Pascal Mercier, Ryan T McKay, Mark Miskolzie, Clarissa S Sit, John C Vederas
Insights into the Mechanism of Action of the Two-Peptide Lantibiotic Lacticin 3147. Journal of the American Chemical Society 139 (49) (2017)
Shaun M K McKinnie, Wang Wang, Conrad Fischer, Tyler McDonald, Kevin R Kalin, Xavier Iturrioz, Catherine Llorens-Cortes, Gavin Y Oudit, John C Vederas
Synthetic Modification within the "RPRL" Region of Apelin Peptides: Impact on Cardiovascular Activity and Stability to Neprilysin and Plasma Degradation. Journal of medicinal chemistry 60 (14) (2017)

John C Vederas.css-eqlu8i{font-size:small;padding-left:4px;} (J C Vederas)

Publication Activity (10 Years)

Top Topics

Top Venues

John C Vederas (J C Vederas)