Michelle L Halls

Loop profile ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 12

Top Venues

Science signaling

British journal of pharmacology

Nature structural & molecular biology

The Journal of biological chemistry

Monash Institute of Pharmaceutical Sciences

Monash University (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Monash Institute of Pharmaceutical Sciences

Australia

NHMRC RD Wright Fellow :: Drug Discovery Biology Theme

Monash Institute of Pharmaceutical Sciences

Australia

NHMRC CJ Martin Fellow :: Drug Discovery Biology Theme

University of Cambridge

United Kingdom

NHMRC CJ Martin Fellow :: Pharmacology

Education History

Monash University

Australia

PHD :: Pharmacology

Monash University

Australia

BSC

Monash University

Australia

BSC

Publications

Michelle L Halls
Illuminating GPCR trafficking. Nature chemical biology (2024)
Anh T N Nguyen, Diep T N Nguyen, Huan Yee Koh, Jason Toskov, William MacLean, Andrew Xu, Daokun Zhang, Geoffrey I Webb, Lauren T May, Michelle L Halls
The application of artificial intelligence to accelerate GPCR drug discovery. British journal of pharmacology (2023)
Alastair C Keen, Manuela Jörg, Michelle L Halls
The application of targeted protein degradation technologies to G protein-coupled receptors. British journal of pharmacology (2023)
Yong-Gang Chang, Christopher J Lupton, Charles Bayly-Jones, Alastair C Keen, Laura D'Andrea, Christina M Lucato, Joel Ricky Steele, Hari Venugopal, Ralf Bernd Schittenhelm, James C Whisstock, Michelle L Halls, Andrew M Ellisdon
Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism. Nature structural & molecular biology 29 (8) (2022)
Christopher J Lupton, Charles Bayly-Jones, Laura D'Andrea, Cheng Huang, Ralf Bernd Schittenhelm, Hari Venugopal, James C Whisstock, Michelle L Halls, Andrew M Ellisdon
The cryo-EM structure of the human neurofibromin dimer reveals the molecular basis for neurofibromatosis type 1. Nature structural & molecular biology 28 (12) (2021)
Nestor N Jimenez-Vargas, Jing Gong, Matthew J Wisdom, Dane D Jensen, Rocco Latorre, Alan Hegron, Shavonne Teng, Jesse J DiCello, Pradeep Rajasekhar, Nicholas A Veldhuis, Simona E Carbone, Yang Yu, Cintya Lopez-Lopez, Josue Jaramillo-Polanco, Meritxell Canals, David E Reed, Alan E Lomax, Brian L Schmidt, Kam W Leong, Stephen J Vanner, Michelle L Halls, Nigel W Bunnett, Daniel P Poole
Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain. Proceedings of the National Academy of Sciences of the United States of America 117 (26) (2020)
Alexander Gillis, Arisbel B Gondin, Andrea Kliewer, Julie Sanchez, Herman D Lim, Claudia Alamein, Preeti Manandhar, Marina J Santiago, Sebastian Fritzwanker, Frank Schmiedel, Timothy A Katte, Tristan A Reekie, Natasha L Grimsey, Michael Kassiou, Barrie Kellam, Cornelius Krasel, Michelle L Halls, Mark Connor, J Robert Lane, Stefan Schulz, Macdonald J Christie, Meritxell Canals
Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists. Science signaling 13 (625) (2020)
Srgjan Civciristov, Michelle L Halls
Signalling in response to sub-picomolar concentrations of active compounds: Pushing the boundaries of GPCR sensitivity. British journal of pharmacology 176 (14) (2019)
Srgjan Civciristov, Cheng Huang, Bonan Liu, Elsa A Marquez, Arisbel B Gondin, Ralf Bernd Schittenhelm, Andrew M Ellisdon, Meritxell Canals, Michelle L Halls
Ligand-dependent spatiotemporal signaling profiles of the μ-opioid receptor are controlled by distinct protein-interaction networks. The Journal of biological chemistry 294 (44) (2019)
Elke Miess, Arisbel B Gondin, Arsalan Yousuf, Ralph Steinborn, Nadja Mösslein, Yunshi Yang, Martin Göldner, Julia G Ruland, Moritz Bünemann, Cornelius Krasel, Macdonald J Christie, Michelle L Halls, Stefan Schulz, Meritxell Canals
Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitization. Science signaling 11 (539) (2018)
Dane D Jensen, TinaMarie Lieu, Michelle L Halls, Nicholas A Veldhuis, Wendy L Imlach, Quynh N Mai, Daniel P Poole, Tim Quach, Luigi Aurelio, Joshua W Conner, Carmen Klein Herenbrink, Nicholas Barlow, Jamie S Simpson, Martin J Scanlon, Bimbil Graham, Adam McCluskey, Phillip J Robinson, Virginie Escriou, Romina Nassini, Serena Materazzi, Pierangelo Geppetti, Gareth A Hicks, Macdonald J Christie, Christopher J H Porter, Meritxell Canals, Nigel W Bunnett
Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief. Science translational medicine 9 (392) (2018)
Srgjan Civciristov, Andrew M Ellisdon, Ryan Suderman, Cindy K Pon, Bronwyn A Evans, Oded Kleifeld, Steven J Charlton, William S Hlavacek, Meritxell Canals, Michelle L Halls
Preassembled GPCR signaling complexes mediate distinct cellular responses to ultralow ligand concentrations. Science signaling 11 (551) (2018)

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Publication Activity (10 Years)

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Michelle L Halls