Chun-Wa Chung

ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 33

Top Venues

Journal of medicinal chemistry

ACS chemical biology

Angewandte Chemie (International ed. in English)

Journal of proteome research

This page only lists publications with an associated author ORCID identifier.

Publications

David J Hirst, Paul Bamborough, Niam Al-Mahdi, Davina C Angell, Heather A Barnett, Andrew Baxter, Rino A Bit, Jack A Brown, Chun-Wa Chung, Peter D Craggs, Robert P Davis, Emmanuel H Demont, Alan Ferrie, Laurie J Gordon, Isobel Harada, Tim C T Ho, Ian D Holyer, Edward Hooper-Greenhill, Katherine L Jones, Matthew J Lindon, Cerys Lovatt, David Lugo, Claire Maller, Grant McGonagle, Cassie Messenger, Darren J Mitchell, David D Pascoe, Vipulkumar K Patel, Christopher Patten, Darren L Poole, Rishi R Shah, Inmaculada Rioja, Kayleigh A J Stafford, Daniel Tape, Simon Taylor, Natalie H Theodoulou, Laura Tomlinson, Ian D Wall, Christopher R Wellaway, Gemma White, Rab K Prinjha, Philip G Humphreys
Structure- and Property-Based Optimization of Efficient Pan-Bromodomain and Extra Terminal Inhibitors to Identify Oral and Intravenous Candidate I-BET787. Journal of medicinal chemistry (2024)
David J Hirst, Paul Bamborough, Niam Al-Mahdi, Davina C Angell, Heather A Barnett, Andrew Baxter, Rino A Bit, Jack A Brown, Chun-Wa Chung, Peter D Craggs, Robert P Davis, Emmanuel H Demont, Alan Ferrie, Laurie J Gordon, Isobel Harada, Tim C T Ho, Ian D Holyer, Edward Hooper-Greenhill, Katherine L Jones, Matthew J Lindon, Cerys Lovatt, David Lugo, Claire Maller, Grant McGonagle, Cassie Messenger, Darren J Mitchell, David D Pascoe, Vipulkumar K Patel, Christopher Patten, Darren L Poole, Rishi R Shah, Inmaculada Rioja, Kayleigh A J Stafford, Daniel Tape, Simon Taylor, Natalie H Theodoulou, Laura Tomlinson, Ian D Wall, Christopher R Wellaway, Gemma White, Rab K Prinjha, Philip G Humphreys
Structure- and Property-Based Optimization of Efficient Pan-Bromodomain and Extra Terminal Inhibitors to Identify Oral and Intravenous Candidate I-BET787. Journal of medicinal chemistry 67 (12) (2024)
David J Hirst, Paul Bamborough, Niam Al-Mahdi, Davina C Angell, Heather A Barnett, Andrew Baxter, Rino A Bit, Jack A Brown, Chun-Wa Chung, Peter D Craggs, Robert P Davis, Emmanuel H Demont, Alan Ferrie, Laurie J Gordon, Isobel Harada, Tim C T Ho, Ian D Holyer, Edward Hooper-Greenhill, Katherine L Jones, Matthew J Lindon, Cerys Lovatt, David Lugo, Claire Maller, Grant McGonagle, Cassie Messenger, Darren J Mitchell, David D Pascoe, Vipulkumar K Patel, Christopher Patten, Darren L Poole, Rishi R Shah, Inmaculada Rioja, Kayleigh A J Stafford, Daniel Tape, Simon Taylor, Natalie H Theodoulou, Laura Tomlinson, Ian D Wall, Christopher R Wellaway, Gemma White, Rab K Prinjha, Philip G Humphreys
Structure- and Property-Based Optimization of Efficient Pan-Bromodomain and Extra Terminal Inhibitors to Identify Oral and Intravenous Candidate I-BET787. Journal of medicinal chemistry 67 (12) (2024)
Arron Aatkar, Aini Vuorinen, Oliver E Longfield, Katharine Gilbert, Rachel Peltier-Heap, Craig D Wagner, Francesca Zappacosta, Katrin Rittinger, Chun-Wa Chung, David House, Nicholas C O Tomkinson, Jacob T Bush
Efficient Ligand Discovery Using Sulfur(VI) Fluoride Reactive Fragments. ACS chemical biology (2023)
Arron Aatkar, Aini Vuorinen, Oliver E Longfield, Katharine Gilbert, Rachel Peltier-Heap, Craig D Wagner, Francesca Zappacosta, Katrin Rittinger, Chun-Wa Chung, David House, Nicholas C O Tomkinson, Jacob T Bush
Efficient Ligand Discovery Using Sulfur(VI) Fluoride Reactive Fragments. ACS chemical biology (2023)
Erin Bradley, Lucia Fusani, Chun-Wa Chung, Peter D Craggs, Emmanuel H Demont, Philip G Humphreys, Darren J Mitchell, Alex Phillipou, Inmaculada Rioja, Rishi R Shah, Christopher R Wellaway, Rab K Prinjha, David S Palmer, William J Kerr, Marc Reid, Ian D Wall, Rosa Cookson
Structure-Guided Design of a Domain-Selective Bromodomain and Extra Terminal N-Terminal Bromodomain Chemical Probe. Journal of medicinal chemistry (2023)
Oliver M Crook, Nathan Gittens, Chun-Wa Chung, Charlotte M Deane
A Functional Bayesian Model for Hydrogen-Deuterium Exchange Mass Spectrometry. Journal of proteome research (2023)
Paul Bamborough, Chun-Wa Chung, Nicole C Goodwin, Darren J Mitchell, Christopher E Neipp, Alex Phillipou, Alex G S Preston, Rab K Prinjha, Peter E Soden, Robert J Watson, Emmanuel H Demont
Design and Characterization of 1,3-Dihydro-2 H -benzo[ d ]azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors. ACS medicinal chemistry letters 14 (9) (2023)
Arron Aatkar, Aini Vuorinen, Oliver E Longfield, Katharine Gilbert, Rachel Peltier-Heap, Craig D Wagner, Francesca Zappacosta, Katrin Rittinger, Chun-Wa Chung, David House, Nicholas C O Tomkinson, Jacob T Bush
Efficient Ligand Discovery Using Sulfur(VI) Fluoride Reactive Fragments. ACS chemical biology (2023)
Arron Aatkar, Aini Vuorinen, Oliver E Longfield, Katharine Gilbert, Rachel Peltier-Heap, Craig D Wagner, Francesca Zappacosta, Katrin Rittinger, Chun-Wa Chung, David House, Nicholas C O Tomkinson, Jacob T Bush
Efficient Ligand Discovery Using Sulfur(VI) Fluoride Reactive Fragments. ACS chemical biology (2023)
Philip G Humphreys, Stephen J Atkinson, Paul Bamborough, Rino A Bit, Chun-Wa Chung, Peter D Craggs, Leanne Cutler, Rob Davis, Alan Ferrie, GangLi Gong, Laurie J Gordon, Matthew Gray, Lee A Harrison, Thomas G Hayhow, Andrea Haynes, Nick Henley, David J Hirst, Ian D Holyer, Matthew J Lindon, Cerys Lovatt, David Lugo, Scott McCleary, Judit Molnar, Qendresa Osmani, Chris Patten, Alex G S Preston, Inmaculada Rioja, Jonathan T Seal, Nicholas Smithers, Fenglai Sun, Dalin Tang, Simon Taylor, Natalie H Theodoulou, Clare Thomas, Robert J Watson, Christopher R Wellaway, Linrong Zhu, Nicholas C O Tomkinson, Rab K Prinjha
Design, Synthesis, and Characterization of I-BET567, a Pan-Bromodomain and Extra Terminal (BET) Bromodomain Oral Candidate. Journal of medicinal chemistry 65 (3) (2022)
Philip G Humphreys, Niall A Anderson, Paul Bamborough, Andrew Baxter, Chun-Wa Chung, Rosa Cookson, Peter D Craggs, Toryn Dalton, Julie C L Fournier, Laurie J Gordon, Heather F Gray, Matthew W Gray, Richard Gregory, David J Hirst, Craig J Jamieson, Katherine L Jones, Hripsimee Kessedjian, David Lugo, Grant McGonagle, Vipulkumar K Patel, Christopher Patten, Darren L Poole, Rab K Prinjha, Cesar Ramirez-Molina, Inmaculada Rioja, Gail Seal, Kayleigh A J Stafford, Rishi R Shah, Daniel Tape, Natalie H Theodoulou, Laura Tomlinson, Sabri Ukuser, Ian D Wall, Natalie Wellaway, Gemma White
Identification and Optimization of a Ligand-Efficient Benzoazepinone Bromodomain and Extra Terminal (BET) Family Acetyl-Lysine Mimetic into the Oral Candidate Quality Molecule I-BET432. Journal of medicinal chemistry 65 (22) (2022)
Oliver M Crook, Chun-Wa Chung, Charlotte M Deane
Challenges and Opportunities for Bayesian Statistics in Proteomics. Journal of proteome research 21 (4) (2022)
Simon C C Lucas, Stephen J Atkinson, Chun-Wa Chung, Rob Davis, Laurie Gordon, Paola Grandi, James J R Gray, Thomas Grimes, Alexander Phillipou, Alex G S Preston, Rab K Prinjha, Inmaculada Rioja, Simon Taylor, Nicholas C O Tomkinson, Ian Wall, Robert J Watson, James Woolven, Emmanuel H Demont
Optimization of a Series of 2,3-Dihydrobenzofurans as Highly Potent, Second Bromodomain (BD2)-Selective, Bromo and Extra-Terminal Domain (BET) Inhibitors. Journal of medicinal chemistry 64 (15) (2021)
Christopher R Wellaway, Ian R Baldwin, Paul Bamborough, Daniel Barker, Michelle A Bartholomew, Chun-Wa Chung, Birgit Dümpelfeld, John P Evans, Neal J Fazakerley, Paul Homes, Steven P Keeling, Xiao Q Lewell, Finlay W McNab, Joanne Morley, Deborah Needham, Margarete Neu, Antoon J M van Oosterhout, Anshu Pal, Friedrich B M Reinhard, Francesco Rianjongdee, Craig M Robertson, Paul Rowland, Rishi R Shah, Emma B Sherriff, Lisa A Sloan, Simon Teague, Daniel A Thomas, Natalie Wellaway, Justyna Wojno-Picon, James M Woolven, Diane M Coe
Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism. Journal of medicinal chemistry 65 (1) (2021)
Michael A Clegg, Natalie H Theodoulou, Paul Bamborough, Chun-Wa Chung, Peter D Craggs, Emmanuel H Demont, Laurie J Gordon, Gemma M Liwicki, Alex Phillipou, Nicholas C O Tomkinson, Rab K Prinjha, Philip G Humphreys
Optimization of Naphthyridones into Selective TATA-Binding Protein Associated Factor 1 (TAF1) Bromodomain Inhibitors. ACS medicinal chemistry letters 12 (8) (2021)
Francesco Rianjongdee, Stephen J Atkinson, Chun-Wa Chung, Paola Grandi, James R J Gray, Laura J Kaushansky, Patricia Medeiros, Cassie Messenger, Alex Phillipou, Alex G S Preston, Rab K Prinjha, Inmaculada Rioja, Alexander Lee Satz, Simon Taylor, Ian D Wall, Robert J Watson, Gang Yao, Emmanuel H Demont
Discovery of a Highly Selective BET BD2 Inhibitor from a DNA-Encoded Library Technology Screening Hit. Journal of medicinal chemistry 64 (15) (2021)
Katherine L Jones, Dominic M Beaumont, Sharon G Bernard, Rino A Bit, Simon P Campbell, Chun-Wa Chung, Leanne Cutler, Emmanuel H Demont, Kate Dennis, Laurie Gordon, James R Gray, Michael V Haase, Antonia J Lewis, Scott McCleary, Darren J Mitchell, Susanne M Moore, Nigel Parr, Olivia J Robb, Nicholas Smithers, Peter E Soden, Colin J Suckling, Simon Taylor, Ann L Walker, Robert J Watson, Rab K Prinjha
Discovery of a Novel Bromodomain and Extra Terminal Domain (BET) Protein Inhibitor, I-BET282E, Suitable for Clinical Progression. Journal of medicinal chemistry 64 (16) (2021)
Lee A Harrison, Stephen J Atkinson, Anna Bassil, Chun-Wa Chung, Paola Grandi, James R J Gray, Etienne Levernier, Antonia Lewis, David Lugo, Cassie Messenger, Anne-Marie Michon, Darren J Mitchell, Alex G S Preston, Rab K Prinjha, Inmaculada Rioja, Jonathan T Seal, Simon Taylor, Ian D Wall, Robert J Watson, James M Woolven, Emmanuel H Demont
Identification of a Series of N-Methylpyridine-2-carboxamides as Potent and Selective Inhibitors of the Second Bromodomain (BD2) of the Bromo and Extra Terminal Domain (BET) Proteins. Journal of medicinal chemistry 64 (15) (2021)
Jonathan T Seal, Stephen J Atkinson, Paul Bamborough, Anna Bassil, Chun-Wa Chung, James Foley, Laurie Gordon, Paola Grandi, James R J Gray, Lee A Harrison, Ryan G Kruger, Jeanne J Matteo, Michael T McCabe, Cassie Messenger, Darren Mitchell, Alex Phillipou, Alex G S Preston, Rab K Prinjha, Francesco Rianjongdee, Inmaculada Rioja, Simon Taylor, Ian D Wall, Robert J Watson, James M Woolven, Anastasia Wyce, Xi-Ping Zhang, Emmanuel H Demont
Fragment-based Scaffold Hopping: Identification of Potent, Selective, and Highly Soluble Bromo and Extra Terminal Domain (BET) Second Bromodomain (BD2) Inhibitors. Journal of medicinal chemistry 64 (15) (2021)
Julien C Vantourout, Andrew M Mason, Josephine Yuen, Graham L Simpson, Ghotas Evindar, Letian Kuai, Michael Hobbs, Emma Edgar, Saul Needle, Xiaopeng Bai, Steve Wilson, Paul Scott-Stevens, William Traylen, Kim Lambert, Neil Young, Shenaz Bunally, Scott G Summerfield, Richard Snell, Rakesh Lad, Eric Shi, Steven Skinner, Lisa Shewchuk, Allan J B Watson, Chun-Wa Chung, Sandeep Pal, Dennis A Holt, Lara S Kallander, Joanne Prendergast, Katrina Rivera, David G Washburn, Mark R Harpel, Christopher Arico-Muendel, Albert Isidro-Llobet
In Vivo Half-Life Extension of BMP1/TLL Metalloproteinase Inhibitors Using Small-Molecule Human Serum Albumin Binders. Bioconjugate chemistry 32 (2) (2021)
Helen E Aylott, Stephen J Atkinson, Paul Bamborough, Anna Bassil, Chun-Wa Chung, Laurie Gordon, Paola Grandi, James R J Gray, Lee A Harrison, Thomas G Hayhow, Cassie Messenger, Darren Mitchell, Alexander Phillipou, Alex G S Preston, Rab K Prinjha, Francesco Rianjongdee, Inmaculada Rioja, Jonathan T Seal, Ian D Wall, Robert J Watson, James M Woolven, Emmanuel H Demont
Template-Hopping Approach Leads to Potent, Selective, and Highly Soluble Bromo and Extraterminal Domain (BET) Second Bromodomain (BD2) Inhibitors. Journal of medicinal chemistry 64 (6) (2021)
Cynthia Tallant, Paul Bamborough, Chun-Wa Chung, Francisco Javier Gamo, Robert Kirkpatrick, Chris Larminie, J Julio Martin, Rab Prinjha, Inmaculada Rioja, Daniel F Simola, Raquel Gabarró, Felix Calderon
Expanding Bromodomain Targeting into Neglected Parasitic Diseases. ACS infectious diseases 7 (11) (2021)
Robert P Law, Joao Nunes, Chun-Wa Chung, Marcus Bantscheff, Karol Buda, Han Dai, John P Evans, Adam Flinders, Diana Klimaszewska, Antonia J Lewis, Marcel Muelbaier, Paul Scott-Stevens, Peter Stacey, Christopher J Tame, Gillian F Watt, Nico Zinn, Markus A Queisser, John D Harling, Andrew B Benowitz
Discovery and Characterisation of Highly Cooperative FAK-Degrading PROTACs. Angewandte Chemie (International ed. in English) 60 (43) (2021)
Alex G S Preston, Stephen J Atkinson, Paul Bamborough, Chun-Wa Chung, Peter D Craggs, Laurie Gordon, Paola Grandi, James R J Gray, Emma J Jones, Matthew Lindon, Anne-Marie Michon, Darren J Mitchell, Rab K Prinjha, Francesco Rianjongdee, Inmaculada Rioja, Jonathan T Seal, Simon Taylor, Ian Wall, Robert J Watson, James Woolven, Emmanuel H Demont
Design and Synthesis of a Highly Selective and In Vivo-Capable Inhibitor of the Second Bromodomain of the Bromodomain and Extra Terminal Domain Family of Proteins. Journal of medicinal chemistry 63 (17) (2020)
Christopher R Wellaway, Paul Bamborough, Sharon G Bernard, Chun-Wa Chung, Peter D Craggs, Leanne Cutler, Emmanuel H Demont, John P Evans, Laurie Gordon, Bhumika Karamshi, Antonia J Lewis, Matthew J Lindon, Darren J Mitchell, Inmaculada Rioja, Peter E Soden, Simon Taylor, Robert J Watson, Rob Willis, James M Woolven, Beata S Wyspiańska, William J Kerr, Rab K Prinjha
Structure-Based Design of a Bromodomain and Extraterminal Domain (BET) Inhibitor Selective for the N-Terminal Bromodomains That Retains an Anti-inflammatory and Antiproliferative Phenotype. Journal of medicinal chemistry 63 (17) (2020)
Simon C C Lucas, Stephen J Atkinson, Paul Bamborough, Heather Barnett, Chun-Wa Chung, Laurie Gordon, Darren J Mitchell, Alexander Phillipou, Rab K Prinjha, Robert J Sheppard, Nicholas C O Tomkinson, Robert J Watson, Emmanuel H Demont
Optimization of Potent ATAD2 and CECR2 Bromodomain Inhibitors with an Atypical Binding Mode. Journal of medicinal chemistry 63 (10) (2020)
Michael A Clegg, Paul Bamborough, Chun-Wa Chung, Peter D Craggs, Laurie Gordon, Paola Grandi, Melanie Leveridge, Matthew Lindon, Gemma M Liwicki, Anne-Marie Michon, Judit Molnar, Inmaculada Rioja, Peter E Soden, Natalie H Theodoulou, Thilo Werner, Nicholas C O Tomkinson, Rab K Prinjha, Philip G Humphreys
Application of Atypical Acetyl-lysine Methyl Mimetics in the Development of Selective Inhibitors of the Bromodomain-Containing Protein 7 (BRD7)/Bromodomain-Containing Protein 9 (BRD9) Bromodomains. Journal of medicinal chemistry 63 (11) (2020)
Jonathan T Seal, Stephen J Atkinson, Helen Aylott, Paul Bamborough, Chun-Wa Chung, Royston C B Copley, Laurie Gordon, Paola Grandi, James R J Gray, Lee A Harrison, Thomas G Hayhow, Matthew Lindon, Cassie Messenger, Anne-Marie Michon, Darren Mitchell, Alex G S Preston, Rab K Prinjha, Inmaculada Rioja, Simon Taylor, Ian D Wall, Robert J Watson, James M Woolven, Emmanuel H Demont
The Optimization of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2) Inhibitor. Journal of medicinal chemistry 63 (17) (2020)
Robert J Watson, Paul Bamborough, Heather Barnett, Chun-Wa Chung, Rob Davis, Laurie Gordon, Paola Grandi, Massimo Petretich, Alex Phillipou, Rab K Prinjha, Inmaculada Rioja, Peter Soden, Thilo Werner, Emmanuel H Demont
GSK789: A Selective Inhibitor of the First Bromodomains (BD1) of the Bromo and Extra Terminal Domain (BET) Proteins. Journal of medicinal chemistry 63 (17) (2020)
Chun-Wa Chung, Han Dai, Esther Fernandez, Christopher P Tinworth, Ian Churcher, Jenni Cryan, Jane Denyer, John D Harling, Agnieszka Konopacka, Markus A Queisser, Christopher J Tame, Gillian Watt, Fan Jiang, Dongming Qian, Andrew B Benowitz
Structural Insights into PROTAC-Mediated Degradation of Bcl-xL. ACS chemical biology 15 (9) (2020)
Omer Gilan, Inmaculada Rioja, Kathy Knezevic, Matthew J Bell, Miriam M Yeung, Nicola R Harker, Enid Y N Lam, Chun-Wa Chung, Paul Bamborough, Massimo Petretich, Marjeta Urh, Stephen J Atkinson, Anna K Bassil, Emma J Roberts, Dane Vassiliadis, Marian L Burr, Alex G S Preston, Christopher R Wellaway, Thilo Werner, James R Gray, Anne-Marie Michon, Thomas Gobbetti, Vinod Kumar, Peter E Soden, Andrea Haynes, Johanna Vappiani, David F Tough, Simon J Taylor, Sarah-Jane Dawson, Marcus Bantscheff, Matthew Lindon, Gerard Drewes, Emmanuel H Demont, Danette L Daniels, Paola Grandi, Rabinder K Prinjha, Mark A Dawson
Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation. Science (New York, N.Y.) 368 (6489) (2020)
Paul Bamborough, Chun-Wa Chung, Emmanuel H Demont, Rebecca C Furze, Andrew J Bannister, Ka Hing Che, Hawa Diallo, Clement Douault, Paola Grandi, Tony Kouzarides, Anne-Marie Michon, Darren J Mitchell, Rabinder K Prinjha, Christina Rau, Samuel Robson, Robert J Sheppard, Richard Upton, Robert J Watson
A Chemical Probe for the ATAD2 Bromodomain. Angewandte Chemie (International ed. in English) 55 (38) (2016)

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Publication Activity (10 Years)

Top Topics

Top Venues

Chun-Wa Chung