Paul Bamborough

ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 23

Top Venues

Journal of medicinal chemistry

ACS medicinal chemistry letters

Angewandte Chemie (International ed. in English)

Science (New York, N.Y.)

This page only lists publications with an associated author ORCID identifier.

Publications

David J Hirst, Paul Bamborough, Niam Al-Mahdi, Davina C Angell, Heather A Barnett, Andrew Baxter, Rino A Bit, Jack A Brown, Chun-Wa Chung, Peter D Craggs, Robert P Davis, Emmanuel H Demont, Alan Ferrie, Laurie J Gordon, Isobel Harada, Tim C T Ho, Ian D Holyer, Edward Hooper-Greenhill, Katherine L Jones, Matthew J Lindon, Cerys Lovatt, David Lugo, Claire Maller, Grant McGonagle, Cassie Messenger, Darren J Mitchell, David D Pascoe, Vipulkumar K Patel, Christopher Patten, Darren L Poole, Rishi R Shah, Inmaculada Rioja, Kayleigh A J Stafford, Daniel Tape, Simon Taylor, Natalie H Theodoulou, Laura Tomlinson, Ian D Wall, Christopher R Wellaway, Gemma White, Rab K Prinjha, Philip G Humphreys
Structure- and Property-Based Optimization of Efficient Pan-Bromodomain and Extra Terminal Inhibitors to Identify Oral and Intravenous Candidate I-BET787. Journal of medicinal chemistry (2024)
David J Hirst, Paul Bamborough, Niam Al-Mahdi, Davina C Angell, Heather A Barnett, Andrew Baxter, Rino A Bit, Jack A Brown, Chun-Wa Chung, Peter D Craggs, Robert P Davis, Emmanuel H Demont, Alan Ferrie, Laurie J Gordon, Isobel Harada, Tim C T Ho, Ian D Holyer, Edward Hooper-Greenhill, Katherine L Jones, Matthew J Lindon, Cerys Lovatt, David Lugo, Claire Maller, Grant McGonagle, Cassie Messenger, Darren J Mitchell, David D Pascoe, Vipulkumar K Patel, Christopher Patten, Darren L Poole, Rishi R Shah, Inmaculada Rioja, Kayleigh A J Stafford, Daniel Tape, Simon Taylor, Natalie H Theodoulou, Laura Tomlinson, Ian D Wall, Christopher R Wellaway, Gemma White, Rab K Prinjha, Philip G Humphreys
Structure- and Property-Based Optimization of Efficient Pan-Bromodomain and Extra Terminal Inhibitors to Identify Oral and Intravenous Candidate I-BET787. Journal of medicinal chemistry 67 (12) (2024)
David J Hirst, Paul Bamborough, Niam Al-Mahdi, Davina C Angell, Heather A Barnett, Andrew Baxter, Rino A Bit, Jack A Brown, Chun-Wa Chung, Peter D Craggs, Robert P Davis, Emmanuel H Demont, Alan Ferrie, Laurie J Gordon, Isobel Harada, Tim C T Ho, Ian D Holyer, Edward Hooper-Greenhill, Katherine L Jones, Matthew J Lindon, Cerys Lovatt, David Lugo, Claire Maller, Grant McGonagle, Cassie Messenger, Darren J Mitchell, David D Pascoe, Vipulkumar K Patel, Christopher Patten, Darren L Poole, Rishi R Shah, Inmaculada Rioja, Kayleigh A J Stafford, Daniel Tape, Simon Taylor, Natalie H Theodoulou, Laura Tomlinson, Ian D Wall, Christopher R Wellaway, Gemma White, Rab K Prinjha, Philip G Humphreys
Structure- and Property-Based Optimization of Efficient Pan-Bromodomain and Extra Terminal Inhibitors to Identify Oral and Intravenous Candidate I-BET787. Journal of medicinal chemistry 67 (12) (2024)
Paul Bamborough, Chun-Wa Chung, Nicole C Goodwin, Darren J Mitchell, Christopher E Neipp, Alex Phillipou, Alex G S Preston, Rab K Prinjha, Peter E Soden, Robert J Watson, Emmanuel H Demont
Design and Characterization of 1,3-Dihydro-2 H -benzo[ d ]azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors. ACS medicinal chemistry letters 14 (9) (2023)
Philip G Humphreys, Stephen J Atkinson, Paul Bamborough, Rino A Bit, Chun-Wa Chung, Peter D Craggs, Leanne Cutler, Rob Davis, Alan Ferrie, GangLi Gong, Laurie J Gordon, Matthew Gray, Lee A Harrison, Thomas G Hayhow, Andrea Haynes, Nick Henley, David J Hirst, Ian D Holyer, Matthew J Lindon, Cerys Lovatt, David Lugo, Scott McCleary, Judit Molnar, Qendresa Osmani, Chris Patten, Alex G S Preston, Inmaculada Rioja, Jonathan T Seal, Nicholas Smithers, Fenglai Sun, Dalin Tang, Simon Taylor, Natalie H Theodoulou, Clare Thomas, Robert J Watson, Christopher R Wellaway, Linrong Zhu, Nicholas C O Tomkinson, Rab K Prinjha
Design, Synthesis, and Characterization of I-BET567, a Pan-Bromodomain and Extra Terminal (BET) Bromodomain Oral Candidate. Journal of medicinal chemistry 65 (3) (2022)
Philip G Humphreys, Niall A Anderson, Paul Bamborough, Andrew Baxter, Chun-Wa Chung, Rosa Cookson, Peter D Craggs, Toryn Dalton, Julie C L Fournier, Laurie J Gordon, Heather F Gray, Matthew W Gray, Richard Gregory, David J Hirst, Craig J Jamieson, Katherine L Jones, Hripsimee Kessedjian, David Lugo, Grant McGonagle, Vipulkumar K Patel, Christopher Patten, Darren L Poole, Rab K Prinjha, Cesar Ramirez-Molina, Inmaculada Rioja, Gail Seal, Kayleigh A J Stafford, Rishi R Shah, Daniel Tape, Natalie H Theodoulou, Laura Tomlinson, Sabri Ukuser, Ian D Wall, Natalie Wellaway, Gemma White
Identification and Optimization of a Ligand-Efficient Benzoazepinone Bromodomain and Extra Terminal (BET) Family Acetyl-Lysine Mimetic into the Oral Candidate Quality Molecule I-BET432. Journal of medicinal chemistry 65 (22) (2022)
Christopher R Wellaway, Ian R Baldwin, Paul Bamborough, Daniel Barker, Michelle A Bartholomew, Chun-Wa Chung, Birgit Dümpelfeld, John P Evans, Neal J Fazakerley, Paul Homes, Steven P Keeling, Xiao Q Lewell, Finlay W McNab, Joanne Morley, Deborah Needham, Margarete Neu, Antoon J M van Oosterhout, Anshu Pal, Friedrich B M Reinhard, Francesco Rianjongdee, Craig M Robertson, Paul Rowland, Rishi R Shah, Emma B Sherriff, Lisa A Sloan, Simon Teague, Daniel A Thomas, Natalie Wellaway, Justyna Wojno-Picon, James M Woolven, Diane M Coe
Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism. Journal of medicinal chemistry 65 (1) (2021)
Michael A Clegg, Natalie H Theodoulou, Paul Bamborough, Chun-Wa Chung, Peter D Craggs, Emmanuel H Demont, Laurie J Gordon, Gemma M Liwicki, Alex Phillipou, Nicholas C O Tomkinson, Rab K Prinjha, Philip G Humphreys
Optimization of Naphthyridones into Selective TATA-Binding Protein Associated Factor 1 (TAF1) Bromodomain Inhibitors. ACS medicinal chemistry letters 12 (8) (2021)
Jonathan T Seal, Stephen J Atkinson, Paul Bamborough, Anna Bassil, Chun-Wa Chung, James Foley, Laurie Gordon, Paola Grandi, James R J Gray, Lee A Harrison, Ryan G Kruger, Jeanne J Matteo, Michael T McCabe, Cassie Messenger, Darren Mitchell, Alex Phillipou, Alex G S Preston, Rab K Prinjha, Francesco Rianjongdee, Inmaculada Rioja, Simon Taylor, Ian D Wall, Robert J Watson, James M Woolven, Anastasia Wyce, Xi-Ping Zhang, Emmanuel H Demont
Fragment-based Scaffold Hopping: Identification of Potent, Selective, and Highly Soluble Bromo and Extra Terminal Domain (BET) Second Bromodomain (BD2) Inhibitors. Journal of medicinal chemistry 64 (15) (2021)
Ami Ketley, Marzena Wojciechowska, Sonja Ghidelli-Disse, Paul Bamborough, Tushar K Ghosh, Marta Lopez Morato, Saam Sedehizadeh, Naveed Altaf Malik, Zhenzhi Tang, Paulina Powalowska, Matthew K Tanner, Rudolf Billeter-Clark, Rebecca C Trueman, Philippine C Geiszler, Alessandra Agostini, Othman Othman, Markus Boesche, Marcus Bantscheff, Martin Rüdiger, Danuta E Mossakowska, David Harold Drewry, William J Zuercher, Charles A Thornton, Gerard Drewes, Iain Uings, Christopher J Hayes, J David Brook
CDK12 inhibition reduces abnormalities in cells from patients with myotonic dystrophy and in a mouse model. Science translational medicine 12 (541) (2021)
Helen E Aylott, Stephen J Atkinson, Paul Bamborough, Anna Bassil, Chun-Wa Chung, Laurie Gordon, Paola Grandi, James R J Gray, Lee A Harrison, Thomas G Hayhow, Cassie Messenger, Darren Mitchell, Alexander Phillipou, Alex G S Preston, Rab K Prinjha, Francesco Rianjongdee, Inmaculada Rioja, Jonathan T Seal, Ian D Wall, Robert J Watson, James M Woolven, Emmanuel H Demont
Template-Hopping Approach Leads to Potent, Selective, and Highly Soluble Bromo and Extraterminal Domain (BET) Second Bromodomain (BD2) Inhibitors. Journal of medicinal chemistry 64 (6) (2021)
Cynthia Tallant, Paul Bamborough, Chun-Wa Chung, Francisco Javier Gamo, Robert Kirkpatrick, Chris Larminie, J Julio Martin, Rab Prinjha, Inmaculada Rioja, Daniel F Simola, Raquel Gabarró, Felix Calderon
Expanding Bromodomain Targeting into Neglected Parasitic Diseases. ACS infectious diseases 7 (11) (2021)
Alex G S Preston, Stephen J Atkinson, Paul Bamborough, Chun-Wa Chung, Peter D Craggs, Laurie Gordon, Paola Grandi, James R J Gray, Emma J Jones, Matthew Lindon, Anne-Marie Michon, Darren J Mitchell, Rab K Prinjha, Francesco Rianjongdee, Inmaculada Rioja, Jonathan T Seal, Simon Taylor, Ian Wall, Robert J Watson, James Woolven, Emmanuel H Demont
Design and Synthesis of a Highly Selective and In Vivo-Capable Inhibitor of the Second Bromodomain of the Bromodomain and Extra Terminal Domain Family of Proteins. Journal of medicinal chemistry 63 (17) (2020)
Christopher R Wellaway, Paul Bamborough, Sharon G Bernard, Chun-Wa Chung, Peter D Craggs, Leanne Cutler, Emmanuel H Demont, John P Evans, Laurie Gordon, Bhumika Karamshi, Antonia J Lewis, Matthew J Lindon, Darren J Mitchell, Inmaculada Rioja, Peter E Soden, Simon Taylor, Robert J Watson, Rob Willis, James M Woolven, Beata S Wyspiańska, William J Kerr, Rab K Prinjha
Structure-Based Design of a Bromodomain and Extraterminal Domain (BET) Inhibitor Selective for the N-Terminal Bromodomains That Retains an Anti-inflammatory and Antiproliferative Phenotype. Journal of medicinal chemistry 63 (17) (2020)
Simon C C Lucas, Stephen J Atkinson, Paul Bamborough, Heather Barnett, Chun-Wa Chung, Laurie Gordon, Darren J Mitchell, Alexander Phillipou, Rab K Prinjha, Robert J Sheppard, Nicholas C O Tomkinson, Robert J Watson, Emmanuel H Demont
Optimization of Potent ATAD2 and CECR2 Bromodomain Inhibitors with an Atypical Binding Mode. Journal of medicinal chemistry 63 (10) (2020)
Michael A Clegg, Paul Bamborough, Chun-Wa Chung, Peter D Craggs, Laurie Gordon, Paola Grandi, Melanie Leveridge, Matthew Lindon, Gemma M Liwicki, Anne-Marie Michon, Judit Molnar, Inmaculada Rioja, Peter E Soden, Natalie H Theodoulou, Thilo Werner, Nicholas C O Tomkinson, Rab K Prinjha, Philip G Humphreys
Application of Atypical Acetyl-lysine Methyl Mimetics in the Development of Selective Inhibitors of the Bromodomain-Containing Protein 7 (BRD7)/Bromodomain-Containing Protein 9 (BRD9) Bromodomains. Journal of medicinal chemistry 63 (11) (2020)
Jonathan T Seal, Stephen J Atkinson, Helen Aylott, Paul Bamborough, Chun-Wa Chung, Royston C B Copley, Laurie Gordon, Paola Grandi, James R J Gray, Lee A Harrison, Thomas G Hayhow, Matthew Lindon, Cassie Messenger, Anne-Marie Michon, Darren Mitchell, Alex G S Preston, Rab K Prinjha, Inmaculada Rioja, Simon Taylor, Ian D Wall, Robert J Watson, James M Woolven, Emmanuel H Demont
The Optimization of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2) Inhibitor. Journal of medicinal chemistry 63 (17) (2020)
Christopher R Wellaway, Dominique Amans, Paul Bamborough, Heather Barnett, Rino A Bit, Jack A Brown, Neil R Carlson, Chun-Wa Chung, Anthony W J Cooper, Peter D Craggs, Robert P Davis, Tony W Dean, John P Evans, Laurie Gordon, Isobel L Harada, David J Hirst, Philip G Humphreys, Katherine L Jones, Antonia J Lewis, Matthew J Lindon, Dave Lugo, Mahnoor Mahmood, Scott McCleary, Patricia Medeiros, Darren J Mitchell, Michael O'Sullivan, Armelle Le Gall, Vipulkumar K Patel, Chris Patten, Darren L Poole, Rishi R Shah, Jane E Smith, Kayleigh A J Stafford, Pamela J Thomas, Mythily Vimal, Ian D Wall, Robert J Watson, Natalie Wellaway, Gang Yao, Rab K Prinjha
Discovery of a Bromodomain and Extraterminal Inhibitor with a Low Predicted Human Dose through Synergistic Use of Encoded Library Technology and Fragment Screening. Journal of medicinal chemistry 63 (2) (2020)
Robert J Watson, Paul Bamborough, Heather Barnett, Chun-Wa Chung, Rob Davis, Laurie Gordon, Paola Grandi, Massimo Petretich, Alex Phillipou, Rab K Prinjha, Inmaculada Rioja, Peter Soden, Thilo Werner, Emmanuel H Demont
GSK789: A Selective Inhibitor of the First Bromodomains (BD1) of the Bromo and Extra Terminal Domain (BET) Proteins. Journal of medicinal chemistry 63 (17) (2020)
Omer Gilan, Inmaculada Rioja, Kathy Knezevic, Matthew J Bell, Miriam M Yeung, Nicola R Harker, Enid Y N Lam, Chun-Wa Chung, Paul Bamborough, Massimo Petretich, Marjeta Urh, Stephen J Atkinson, Anna K Bassil, Emma J Roberts, Dane Vassiliadis, Marian L Burr, Alex G S Preston, Christopher R Wellaway, Thilo Werner, James R Gray, Anne-Marie Michon, Thomas Gobbetti, Vinod Kumar, Peter E Soden, Andrea Haynes, Johanna Vappiani, David F Tough, Simon J Taylor, Sarah-Jane Dawson, Marcus Bantscheff, Matthew Lindon, Gerard Drewes, Emmanuel H Demont, Danette L Daniels, Paola Grandi, Rabinder K Prinjha, Mark A Dawson
Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation. Science (New York, N.Y.) 368 (6489) (2020)
Paul Bamborough, Chun-Wa Chung, Emmanuel H Demont, Angela M Bridges, Peter D Craggs, David P Dixon, Peter Francis, Rebecca C Furze, Paola Grandi, Emma J Jones, Bhumika Karamshi, Kelly Locke, Simon C C Lucas, Anne-Marie Michon, Darren J Mitchell, Peter Pogány, Rab K Prinjha, Christina Rau, Ana Maria Roa, Andrew D Roberts, Robert J Sheppard, Robert J Watson
A Qualified Success: Discovery of a New Series of ATAD2 Bromodomain Inhibitors with a Novel Binding Mode Using High-Throughput Screening and Hit Qualification. Journal of medicinal chemistry 62 (16) (2019)
Paul Bamborough, Chun-Wa Chung, Rebecca C Furze, Paola Grandi, Anne-Marie Michon, Robert J Watson, Darren J Mitchell, Heather Barnett, Rab K Prinjha, Christina Rau, Robert J Sheppard, Thilo Werner, Emmanuel H Demont
Aiming to Miss a Moving Target: Bromo and Extra Terminal Domain (BET) Selectivity in Constrained ATAD2 Inhibitors. Journal of medicinal chemistry 61 (18) (2018)
Paul Bamborough, Chun-Wa Chung, Emmanuel H Demont, Rebecca C Furze, Andrew J Bannister, Ka Hing Che, Hawa Diallo, Clement Douault, Paola Grandi, Tony Kouzarides, Anne-Marie Michon, Darren J Mitchell, Rabinder K Prinjha, Christina Rau, Samuel Robson, Robert J Sheppard, Richard Upton, Robert J Watson
A Chemical Probe for the ATAD2 Bromodomain. Angewandte Chemie (International ed. in English) 55 (38) (2016)

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Publication Activity (10 Years)

Top Topics

Top Venues

Paul Bamborough