Emmanuel H Demont

ORCID

Publication Activity (10 Years)

Years Active: 2020-2021
Publications (10 Years): 13

Top Venues

Journal of medicinal chemistry

Science (New York, N.Y.)

ACS medicinal chemistry letters

GlaxoSmithKline Research and Development

This page only lists publications with an associated author ORCID identifier.

Affiliation History

GlaxoSmithKline Research and Development Oct 01 2001

United Kingdom

Section Head :: Medicinal Chemistry

Publications

Simon C C Lucas, Stephen J Atkinson, Chun-Wa Chung, Rob Davis, Laurie Gordon, Paola Grandi, James J R Gray, Thomas Grimes, Alexander Phillipou, Alex G S Preston, Rab K Prinjha, Inmaculada Rioja, Simon Taylor, Nicholas C O Tomkinson, Ian Wall, Robert J Watson, James Woolven, Emmanuel H Demont
Optimization of a Series of 2,3-Dihydrobenzofurans as Highly Potent, Second Bromodomain (BD2)-Selective, Bromo and Extra-Terminal Domain (BET) Inhibitors. Journal of medicinal chemistry 64 (15) (2021)
Michael A Clegg, Natalie H Theodoulou, Paul Bamborough, Chun-Wa Chung, Peter D Craggs, Emmanuel H Demont, Laurie J Gordon, Gemma M Liwicki, Alex Phillipou, Nicholas C O Tomkinson, Rab K Prinjha, Philip G Humphreys
Optimization of Naphthyridones into Selective TATA-Binding Protein Associated Factor 1 (TAF1) Bromodomain Inhibitors. ACS medicinal chemistry letters 12 (8) (2021)
Francesco Rianjongdee, Stephen J Atkinson, Chun-Wa Chung, Paola Grandi, James R J Gray, Laura J Kaushansky, Patricia Medeiros, Cassie Messenger, Alex Phillipou, Alex G S Preston, Rab K Prinjha, Inmaculada Rioja, Alexander Lee Satz, Simon Taylor, Ian D Wall, Robert J Watson, Gang Yao, Emmanuel H Demont
Discovery of a Highly Selective BET BD2 Inhibitor from a DNA-Encoded Library Technology Screening Hit. Journal of medicinal chemistry 64 (15) (2021)
Katherine L Jones, Dominic M Beaumont, Sharon G Bernard, Rino A Bit, Simon P Campbell, Chun-Wa Chung, Leanne Cutler, Emmanuel H Demont, Kate Dennis, Laurie Gordon, James R Gray, Michael V Haase, Antonia J Lewis, Scott McCleary, Darren J Mitchell, Susanne M Moore, Nigel Parr, Olivia J Robb, Nicholas Smithers, Peter E Soden, Colin J Suckling, Simon Taylor, Ann L Walker, Robert J Watson, Rab K Prinjha
Discovery of a Novel Bromodomain and Extra Terminal Domain (BET) Protein Inhibitor, I-BET282E, Suitable for Clinical Progression. Journal of medicinal chemistry 64 (16) (2021)
Lee A Harrison, Stephen J Atkinson, Anna Bassil, Chun-Wa Chung, Paola Grandi, James R J Gray, Etienne Levernier, Antonia Lewis, David Lugo, Cassie Messenger, Anne-Marie Michon, Darren J Mitchell, Alex G S Preston, Rab K Prinjha, Inmaculada Rioja, Jonathan T Seal, Simon Taylor, Ian D Wall, Robert J Watson, James M Woolven, Emmanuel H Demont
Identification of a Series of N-Methylpyridine-2-carboxamides as Potent and Selective Inhibitors of the Second Bromodomain (BD2) of the Bromo and Extra Terminal Domain (BET) Proteins. Journal of medicinal chemistry 64 (15) (2021)
Jonathan T Seal, Stephen J Atkinson, Paul Bamborough, Anna Bassil, Chun-Wa Chung, James Foley, Laurie Gordon, Paola Grandi, James R J Gray, Lee A Harrison, Ryan G Kruger, Jeanne J Matteo, Michael T McCabe, Cassie Messenger, Darren Mitchell, Alex Phillipou, Alex G S Preston, Rab K Prinjha, Francesco Rianjongdee, Inmaculada Rioja, Simon Taylor, Ian D Wall, Robert J Watson, James M Woolven, Anastasia Wyce, Xi-Ping Zhang, Emmanuel H Demont
Fragment-based Scaffold Hopping: Identification of Potent, Selective, and Highly Soluble Bromo and Extra Terminal Domain (BET) Second Bromodomain (BD2) Inhibitors. Journal of medicinal chemistry 64 (15) (2021)
Helen E Aylott, Stephen J Atkinson, Paul Bamborough, Anna Bassil, Chun-Wa Chung, Laurie Gordon, Paola Grandi, James R J Gray, Lee A Harrison, Thomas G Hayhow, Cassie Messenger, Darren Mitchell, Alexander Phillipou, Alex G S Preston, Rab K Prinjha, Francesco Rianjongdee, Inmaculada Rioja, Jonathan T Seal, Ian D Wall, Robert J Watson, James M Woolven, Emmanuel H Demont
Template-Hopping Approach Leads to Potent, Selective, and Highly Soluble Bromo and Extraterminal Domain (BET) Second Bromodomain (BD2) Inhibitors. Journal of medicinal chemistry 64 (6) (2021)
Alex G S Preston, Stephen J Atkinson, Paul Bamborough, Chun-Wa Chung, Peter D Craggs, Laurie Gordon, Paola Grandi, James R J Gray, Emma J Jones, Matthew Lindon, Anne-Marie Michon, Darren J Mitchell, Rab K Prinjha, Francesco Rianjongdee, Inmaculada Rioja, Jonathan T Seal, Simon Taylor, Ian Wall, Robert J Watson, James Woolven, Emmanuel H Demont
Design and Synthesis of a Highly Selective and In Vivo-Capable Inhibitor of the Second Bromodomain of the Bromodomain and Extra Terminal Domain Family of Proteins. Journal of medicinal chemistry 63 (17) (2020)
Christopher R Wellaway, Paul Bamborough, Sharon G Bernard, Chun-Wa Chung, Peter D Craggs, Leanne Cutler, Emmanuel H Demont, John P Evans, Laurie Gordon, Bhumika Karamshi, Antonia J Lewis, Matthew J Lindon, Darren J Mitchell, Inmaculada Rioja, Peter E Soden, Simon Taylor, Robert J Watson, Rob Willis, James M Woolven, Beata S Wyspiańska, William J Kerr, Rab K Prinjha
Structure-Based Design of a Bromodomain and Extraterminal Domain (BET) Inhibitor Selective for the N-Terminal Bromodomains That Retains an Anti-inflammatory and Antiproliferative Phenotype. Journal of medicinal chemistry 63 (17) (2020)
Simon C C Lucas, Stephen J Atkinson, Paul Bamborough, Heather Barnett, Chun-Wa Chung, Laurie Gordon, Darren J Mitchell, Alexander Phillipou, Rab K Prinjha, Robert J Sheppard, Nicholas C O Tomkinson, Robert J Watson, Emmanuel H Demont
Optimization of Potent ATAD2 and CECR2 Bromodomain Inhibitors with an Atypical Binding Mode. Journal of medicinal chemistry 63 (10) (2020)
Jonathan T Seal, Stephen J Atkinson, Helen Aylott, Paul Bamborough, Chun-Wa Chung, Royston C B Copley, Laurie Gordon, Paola Grandi, James R J Gray, Lee A Harrison, Thomas G Hayhow, Matthew Lindon, Cassie Messenger, Anne-Marie Michon, Darren Mitchell, Alex G S Preston, Rab K Prinjha, Inmaculada Rioja, Simon Taylor, Ian D Wall, Robert J Watson, James M Woolven, Emmanuel H Demont
The Optimization of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2) Inhibitor. Journal of medicinal chemistry 63 (17) (2020)
Robert J Watson, Paul Bamborough, Heather Barnett, Chun-Wa Chung, Rob Davis, Laurie Gordon, Paola Grandi, Massimo Petretich, Alex Phillipou, Rab K Prinjha, Inmaculada Rioja, Peter Soden, Thilo Werner, Emmanuel H Demont
GSK789: A Selective Inhibitor of the First Bromodomains (BD1) of the Bromo and Extra Terminal Domain (BET) Proteins. Journal of medicinal chemistry 63 (17) (2020)
Omer Gilan, Inmaculada Rioja, Kathy Knezevic, Matthew J Bell, Miriam M Yeung, Nicola R Harker, Enid Y N Lam, Chun-Wa Chung, Paul Bamborough, Massimo Petretich, Marjeta Urh, Stephen J Atkinson, Anna K Bassil, Emma J Roberts, Dane Vassiliadis, Marian L Burr, Alex G S Preston, Christopher R Wellaway, Thilo Werner, James R Gray, Anne-Marie Michon, Thomas Gobbetti, Vinod Kumar, Peter E Soden, Andrea Haynes, Johanna Vappiani, David F Tough, Simon J Taylor, Sarah-Jane Dawson, Marcus Bantscheff, Matthew Lindon, Gerard Drewes, Emmanuel H Demont, Danette L Daniels, Paola Grandi, Rabinder K Prinjha, Mark A Dawson
Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation. Science (New York, N.Y.) 368 (6489) (2020)

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Publication Activity (10 Years)

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Emmanuel H Demont