Radim Nencka

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 30

Top Topics

Acute Myeloid Leukemia

Structural Basis

Allogeneic Hematopoietic Stem Cell Transplantation

Respiratory Syndrome Coronavirus

Top Venues

Journal of medicinal chemistry

Nature communications

Beilstein journal of organic chemistry

Cancer research

This page only lists publications with an associated author ORCID identifier.

Publications

Luca Julianna Tóth, Kateřina Krejčová, Milan Dejmek, Eva Žilecká, Blanka Klepetářová, Lenka Poštová Slavětínská, Evzen Boura, Radim Nencka
Novel analogues of a nonnucleoside SARS-CoV-2 RdRp inhibitor as potential antivirotics. Beilstein journal of organic chemistry 20 (2024)
Hugo Kocek, Dominika Chalupská, Milan Dejmek, Alexandra Dvořáková, Michala Zgarbová, Michal Šála, Karel Chalupský, Petra Krafčíková, Tomáš Otava, Matúš Drexler, Eliška Procházková, Blanka Klepetářová, Milan Štefek, Ján Kozic, Helena Mertlíková-Kaiserová, Evzen Boura, Jan Weber, Radim Nencka
Discovery of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides. RSC medicinal chemistry (2024)
Hugo Kocek, Dominika Chalupská, Milan Dejmek, Alexandra Dvořáková, Michala Zgarbová, Michal Šála, Karel Chalupský, Petra Krafčíková, Tomáš Otava, Matúš Drexler, Eliška Procházková, Blanka Klepetářová, Milan Štefek, Ján Kozic, Helena Mertlíková-Kaiserová, Evzen Boura, Jan Weber, Radim Nencka
Discovery of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides. RSC medicinal chemistry (2024)
Luca Julianna Tóth, Kateřina Krejčová, Milan Dejmek, Eva Žilecká, Blanka Klepetářová, Lenka Poštová Slavětínská, Evzen Boura, Radim Nencka
Novel analogues of a nonnucleoside SARS-CoV-2 RdRp inhibitor as potential antivirotics. Beilstein journal of organic chemistry 20 (2024)
Jan Šilhán, Martin Klima, Tomas Otava, Petr Skvara, Dominika Chalupska, Karel Chalupsky, Jan Kozic, Radim Nencka, Evzen Boura
Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase. Nature communications 14 (1) (2023)
Ivana Mejdrová, Jan Dušek, Kryštof Škach, Alžbeta Stefela, Josef Skoda, Karel Chalupský, Klára Dohnalová, Ivona Pavkova, Thales Kronenberger, Azam Rashidian, Lucie Smutná, Vojtěch Duchoslav, Tomas Smutny, Petr Pávek, Radim Nencka
Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2- a ]pyridine Structure. Journal of medicinal chemistry 66 (4) (2023)
Milan Štefek, Dominika Chalupská, Karel Chalupský, Michala Zgarbová, Alexandra Dvořáková, Petra Krafčíková, Alice Shi Ming Li, Michal Šála, Milan Dejmek, Tomáš Otava, Ema Chaloupecká, Jaroslav Kozák, Ján Kozic, Masoud Vedadi, Jan Weber, Helena Mertlíková-Kaiserová, Radim Nencka
Rational Design of Highly Potent SARS-CoV-2 nsp14 Methyltransferase Inhibitors. ACS omega 8 (30) (2023)
Jan Šilhán, Martin Klima, Tomas Otava, Petr Skvara, Dominika Chalupska, Karel Chalupsky, Jan Kozic, Radim Nencka, Evzen Boura
Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase. Nature communications 14 (1) (2023)
Ivana Mejdrová, Jan Dušek, Kryštof Škach, Alžbeta Stefela, Josef Skoda, Karel Chalupský, Klára Dohnalová, Ivona Pavkova, Thales Kronenberger, Azam Rashidian, Lucie Smutná, Vojtěch Duchoslav, Tomas Smutny, Petr Pávek, Radim Nencka
Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2- a ]pyridine Structure. Journal of medicinal chemistry 66 (4) (2023)
Jan Šilhán, Martin Klima, Tomas Otava, Petr Skvara, Dominika Chalupska, Karel Chalupsky, Jan Kozic, Radim Nencka, Evzen Boura
Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase. Nature communications 14 (1) (2023)
Ivana Mejdrová, Jan Dušek, Kryštof Škach, Alžbeta Stefela, Josef Skoda, Karel Chalupský, Klára Dohnalová, Ivona Pavkova, Thales Kronenberger, Azam Rashidian, Lucie Smutná, Vojtěch Duchoslav, Tomas Smutny, Petr Pávek, Radim Nencka
Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2- a ]pyridine Structure. Journal of medicinal chemistry 66 (4) (2023)
Ivana Mejdrová, Jan Dušek, Kryštof Škach, Alžbeta Stefela, Josef Skoda, Karel Chalupský, Klára Dohnalová, Ivona Pavkova, Thales Kronenberger, Azam Rashidian, Lucie Smutná, Vojtěch Duchoslav, Tomas Smutny, Petr Pávek, Radim Nencka
Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2- a ]pyridine Structure. Journal of medicinal chemistry 66 (4) (2023)
Jan Šilhán, Martin Klima, Tomas Otava, Petr Skvara, Dominika Chalupska, Karel Chalupsky, Jan Kozic, Radim Nencka, Evzen Boura
Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase. Nature communications 14 (1) (2023)
Jan Šilhán, Martin Klima, Tomas Otava, Petr Skvara, Dominika Chalupska, Karel Chalupsky, Jan Kozic, Radim Nencka, Evzen Boura
Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase. Nature communications 14 (1) (2023)
Ivana Mejdrová, Jan Dušek, Kryštof Škach, Alžbeta Stefela, Josef Skoda, Karel Chalupský, Klára Dohnalová, Ivona Pavkova, Thales Kronenberger, Azam Rashidian, Lucie Smutná, Vojtěch Duchoslav, Tomas Smutny, Petr Pávek, Radim Nencka
Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2- a ]pyridine Structure. Journal of medicinal chemistry (2023)
Ivana Mejdrová, Jan Dušek, Kryštof Škach, Alžbeta Stefela, Josef Skoda, Karel Chalupský, Klára Dohnalová, Ivona Pavkova, Thales Kronenberger, Azam Rashidian, Lucie Smutná, Vojtěch Duchoslav, Tomas Smutny, Petr Pávek, Radim Nencka
Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2- a ]pyridine Structure. Journal of medicinal chemistry 66 (4) (2023)
Courtney Chambers, Katerina Cermakova, Yuen San Chan, Kristen J Kurtz, Katharina Wohlan, Andrew Henry Lewis, Christiana Wang, Anh Pham, Milan Dejmek, Michal Šála, Mario Loeza Cabrera, Rogelio Aguilar, Radim Nencka, H Daniel Lacorazza, Rachel E Rau, H Courtney Hodges
SWI/SNF blockade disrupts PU.1-directed enhancer programs in normal hematopoietic cells and acute myeloid leukemia. Cancer research (2023)
Jan Šilhán, Martin Klima, Tomas Otava, Petr Skvara, Dominika Chalupska, Karel Chalupsky, Jan Kozic, Radim Nencka, Evzen Boura
Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase. Nature communications 14 (1) (2023)
Jan Šilhán, Martin Klima, Tomas Otava, Petr Skvara, Dominika Chalupska, Karel Chalupsky, Jan Kozic, Radim Nencka, Evzen Boura
Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase. Nature communications 14 (1) (2023)
Courtney Chambers, Katerina Cermakova, Yuen San Chan, Kristen J Kurtz, Katharina Wohlan, Andrew Henry Lewis, Christiana Wang, Anh Pham, Milan Dejmek, Michal Šála, Mario Loeza Cabrera, Rogelio Aguilar, Radim Nencka, H Daniel Lacorazza, Rachel E Rau, H Courtney Hodges
SWI/SNF blockade disrupts PU.1-directed enhancer programs in normal hematopoietic cells and acute myeloid leukemia. Cancer research (2023)
Miroslav Smola, Ondrej Gutten, Milan Dejmek, Milan Kožíšek, Thomas Evangelidis, Zahra Aliakbar Tehrani, Barbora Novotná, Radim Nencka, Gabriel Birkuš, Lubomír Rulíšek, Evzen Boura
Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein. Angewandte Chemie (International ed. in English) 60 (18) (2021)
Tomáš Otava, Michal Šála, Fengling Li, Jindřich Fanfrlík, Kanchan Devkota, Sumera Perveen, Irene Chau, Paknoosh Pakarian, Pavel Hobza, Masoud Vedadi, Evzen Boura, Radim Nencka
The Structure-Based Design of SARS-CoV-2 nsp14 Methyltransferase Ligands Yields Nanomolar Inhibitors. ACS infectious diseases 7 (8) (2021)
Nemanja Milisavljevic, Eva Konkolová, Jaroslav Kozák, Jan Hodek, Lucia Veselovská, Veronika Sýkorová, Karel Čížek, Radek Pohl, Luděk Eyer, Pavel Svoboda, Daniel Ruzek, Jan Weber, Radim Nencka, Evzen Boura, Michal Hocek
Antiviral Activity of 7-Substituted 7-Deazapurine Ribonucleosides, Monophosphate Prodrugs, and Triphoshates against Emerging RNA Viruses. ACS infectious diseases 7 (2) (2021)
Markéta Pimková Polidarová, Petra Břehová, Martin Maxmilian Kaiser, Miroslav Smola, Martin Dračínský, Joshua Smith, Aleš Marek, Milan Dejmek, Michal Šála, Ondrej Gutten, Lubomír Rulíšek, Barbora Novotná, Andrea Brázdová, Zlatko Janeba, Radim Nencka, Evzen Boura, Ondřej Páv, Gabriel Birkuš
Synthesis and Biological Evaluation of Phosphoester and Phosphorothioate Prodrugs of STING Agonist 3',3'-c-Di(2'F,2'dAMP). Journal of medicinal chemistry 64 (11) (2021)
Michal Šála, Kristen R Hollinger, Ajit G Thomas, Ranjeet P Dash, Carolyn Tallon, Vijayabhaskar Veeravalli, Lyndah Lovell, Martin Kögler, Hubert Hřebabecký, Eliška Procházková, Ondřej Nešuta, Amanda Donoghue, Jenny Lam, Rana Rais, Camilo Rojas, Barbara S Slusher, Radim Nencka
Novel Human Neutral Sphingomyelinase 2 Inhibitors as Potential Therapeutics for Alzheimer's Disease. Journal of medicinal chemistry 63 (11) (2020)
Cemal Köprülüoğlu, Milan Dejmek, Michal Šála, Haresh Ajani, Hubert Hřebabecký, Jindřich Fanfrlík, Radek Jorda, Martin Dračínský, Eliška Procházková, Pavel Šácha, Vladimír Kryštof, Pavel Hobza, Martin Lepsik, Radim Nencka
Optimization of norbornyl-based carbocyclic nucleoside analogs as cyclin-dependent kinase 2 inhibitors. Journal of molecular recognition : JMR 33 (8) (2020)
Dhurvas Chandrasekaran Dinesh, Dominika Chalupska, Jan Silhan, Eliska Koutna, Radim Nencka, Vaclav Veverka, Evzen Boura
Structural basis of RNA recognition by the SARS-CoV-2 nucleocapsid phosphoprotein. PLoS pathogens 16 (12) (2020)
Hubert Hřebabecký, Martin Dračínský, Eliška Procházková, Michal Šála, Richard L Mackman, Radim Nencka
Control of α/β Anomer Formation by a 2',5' Bridge: Toward Nucleoside Derivatives Locked in the South Conformation. The Journal of organic chemistry 82 (21) (2018)
Jana Humpolickova, Ivana Mejdrová, Marika Matousova, Radim Nencka, Evzen Boura
Fluorescent Inhibitors as Tools To Characterize Enzymes: Case Study of the Lipid Kinase Phosphatidylinositol 4-Kinase IIIβ (PI4KB). Journal of medicinal chemistry 60 (1) (2016)
Ivana Mejdrová, Dominika Chalupská, Pavla Plačková, Christin Müller, Michal Šála, Martin Klíma, Adriana Baumlová, Hubert Hřebabecký, Eliška Procházková, Milan Dejmek, Dmytro Strunin, Jan Weber, Gary Lee, Marika Matoušová, Helena Mertlíková-Kaiserová, John Ziebuhr, Gabriel Birkus, Evzen Boura, Radim Nencka
Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase IIIβ (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology. Journal of medicinal chemistry 60 (1) (2016)