Richard L Mackman (Richard Mackman)

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 14

Top Venues

Journal of medicinal chemistry

Science translational medicine

The Journal of organic chemistry

ACS medicinal chemistry letters

This page only lists publications with an associated author ORCID identifier.

Publications

Dustin S Siegel, Hon C Hui, Jared Pitts, Meghan S Vermillion, Kazuya Ishida, Davin Rautiola, Michael Keeney, Hammad Irshad, Lijun Zhang, Kwon Chun, Gregory Chin, Bindu Goyal, Edward Doerffler, Hai Yang, Michael O Clarke, Chris Palmiotti, Arya Vijjapurapu, Nicholas C Riola, Kirsten Stray, Eisuke Murakami, Bin Ma, Ting Wang, Xiaofeng Zhao, Yili Xu, Gary Lee, Bruno Marchand, Minji Seung, Arabinda Nayak, Adrian Tomkinson, Nani Kadrichu, Scott Ellis, Ona Barauskas, Joy Y Feng, Jason K Perry, Michel Perron, John P Bilello, Philip J Kuehl, Raju Subramanian, Tomas Cihlar, Richard L Mackman
Discovery of GS-7682, a Novel 4'-Cyano-Modified C -Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys. Journal of medicinal chemistry 67 (15) (2024)
Dustin S Siegel, Hon C Hui, Jared Pitts, Meghan S Vermillion, Kazuya Ishida, Davin Rautiola, Michael Keeney, Hammad Irshad, Lijun Zhang, Kwon Chun, Gregory Chin, Bindu Goyal, Edward Doerffler, Hai Yang, Michael O Clarke, Chris Palmiotti, Arya Vijjapurapu, Nicholas C Riola, Kirsten Stray, Eisuke Murakami, Bin Ma, Ting Wang, Xiaofeng Zhao, Yili Xu, Gary Lee, Bruno Marchand, Minji Seung, Arabinda Nayak, Adrian Tomkinson, Nani Kadrichu, Scott Ellis, Ona Barauskas, Joy Y Feng, Jason K Perry, Michel Perron, John P Bilello, Philip J Kuehl, Raju Subramanian, Tomas Cihlar, Richard L Mackman
Discovery of GS-7682, a Novel 4'-Cyano-Modified C -Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys. Journal of medicinal chemistry 67 (15) (2024)
Dustin S Siegel, Hon C Hui, Jared Pitts, Meghan S Vermillion, Kazuya Ishida, Davin Rautiola, Michael Keeney, Hammad Irshad, Lijun Zhang, Kwon Chun, Gregory Chin, Bindu Goyal, Edward Doerffler, Hai Yang, Michael O Clarke, Chris Palmiotti, Arya Vijjapurapu, Nicholas C Riola, Kirsten Stray, Eisuke Murakami, Bin Ma, Ting Wang, Xiaofeng Zhao, Yili Xu, Gary Lee, Bruno Marchand, Minji Seung, Arabinda Nayak, Adrian Tomkinson, Nani Kadrichu, Scott Ellis, Ona Barauskas, Joy Y Feng, Jason K Perry, Michel Perron, John P Bilello, Philip J Kuehl, Raju Subramanian, Tomas Cihlar, Richard L Mackman
Discovery of GS-7682, a Novel 4'-Cyano-Modified C -Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys. Journal of medicinal chemistry (2024)
Richard L Mackman, Rao V Kalla, Darius Babusis, Jared Pitts, Kimberly T Barrett, Kwon Chun, Venice Du Pont, Lauren Rodriguez, Jasmine Moshiri, Yili Xu, Michael Lee, Gary Lee, Blake Bleier, Anh-Quan Nguyen, B Michael O'Keefe, Andrea Ambrosi, Meredith Cook, Joy Yu, Kassibla Elodie Dempah, Elaine Bunyan, Nicholas C Riola, Xianghan Lu, Renmeng Liu, Ashley Davie, Tien-Ying Hsiang, Justin Dearing, Meghan Vermillion, Michael Gale, Anita Niedziela-Majka, Joy Y Feng, Charlotte Hedskog, John P Bilello, Raju Subramanian, Tomas Cihlar
Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 That Exhibits Antiviral Efficacy in SARS-CoV-2-Infected African Green Monkeys. Journal of medicinal chemistry (2023)
Richard L Mackman
Phosphoramidate Prodrugs Continue to Deliver, The Journey of Remdesivir (GS-5734) from RSV to SARS-CoV-2. ACS medicinal chemistry letters 13 (3) (2022)
Meghan S Vermillion, Eisuke Murakami, Bin Ma, Jared Pitts, Adrian Tomkinson, Davin Rautiola, Darius Babusis, Hammad Irshad, Dustin Seigel, Cynthia Kim, Xiaofeng Zhao, Congrong Niu, Jesse Yang, Andrew Gigliotti, Nani Kadrichu, John P Bilello, Scott Ellis, Roy Bannister, Raju Subramanian, Bill Smith, Richard L Mackman, William A Lee, Philip J Kuehl, Jim Hartke, Tomas Cihlar, Danielle P Porter
Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection. Science translational medicine 14 (633) (2022)
Alexandra Schaefer, David R Martinez, John J Won, Rita M Meganck, Fernando R Moreira, Ariane J Brown, Kendra L Gully, Mark R Zweigart, William S Conrad, Samantha R May, Stephanie Dong, Rao Kalla, Kwon Chun, Venice Du Pont, Darius Babusis, Jennifer Tang, Eisuke Murakami, Raju Subramanian, Kimberly T Barrett, Blake J Bleier, Roy Bannister, Joy Y Feng, John P Bilello, Tomas Cihlar, Richard L Mackman, Stephanie A Montgomery, Ralph S Baric, Timothy P Sheahan
Therapeutic treatment with an oral prodrug of the remdesivir parental nucleoside is protective against SARS-CoV-2 pathogenesis in mice. Science translational medicine 14 (643) (2022)
Richard L Mackman, Hon C Hui, Michel Perron, Eisuke Murakami, Christopher Palmiotti, Gary Lee, Kirsten Stray, Lijun Zhang, Bindu Goyal, Kwon Chun, Daniel Byun, Dustin Siegel, Scott Simonovich, Venice Du Pont, Jared Pitts, Darius Babusis, Arya Vijjapurapu, Xianghan Lu, Cynthia Kim, Xiaofeng Zhao, Julie Chan, Bin Ma, Diane Lye, Adelle Vandersteen, Sarah Wortman, Kimberly T Barrett, Maria Toteva, Robert Jordan, Raju Subramanian, John P Bilello, Tomas Cihlar
Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine C-Nucleoside Leading to the Discovery of Remdesivir (GS-5734) as a Potent Inhibitor of Respiratory Syncytial Virus with Efficacy in the African Green Monkey Model of RSV. Journal of medicinal chemistry 64 (8) (2021)
Richard L Mackman, Michael Mish, Gregory Chin, Jason K Perry, Todd Appleby, Vangelis Aktoudianakis, Sammy Metobo, Peter Pyun, Congrong Niu, Stephane Daffis, Helen Yu, Jim Zheng, Armando G Villasenor, Jeff Zablocki, Jason Chamberlain, Haolun Jin, Gary Lee, Kimberley Suekawa-Pirrone, Rex Santos, William E Delaney, Simon P Fletcher
Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B. Journal of medicinal chemistry 63 (18) (2020)
Timothy P Sheahan, Amy C Sims, Rachel L Graham, Vineet D Menachery, Lisa E Gralinski, James B Case, Sarah R Leist, Krzysztof Pyrc, Joy Y Feng, Iva Trantcheva, Roy Bannister, Yeojin Park, Darius Babusis, Michael O Clarke, Richard L Mackman, Jamie E Spahn, Christopher A Palmiotti, Dustin Siegel, Adrian S Ray, Tomas Cihlar, Robert Jordan, Mark R Denison, Ralph S Baric
Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses. Science translational medicine 9 (396) (2018)
Hubert Hřebabecký, Martin Dračínský, Eliška Procházková, Michal Šála, Richard L Mackman, Radim Nencka
Control of α/β Anomer Formation by a 2',5' Bridge: Toward Nucleoside Derivatives Locked in the South Conformation. The Journal of organic chemistry 82 (21) (2018)
Richard L Mackman, Victoria A Steadman, David K Dean, Petr Jansa, Karine G Poullennec, Todd Appleby, Carol Austin, Caroline A Blakemore, Ruby Cai, Carina Cannizzaro, Gregory Chin, Jean-Yves C Chiva, Neil A Dunbar, Hans Fliri, Adrian J Highton, Hon Hui, Mingzhe Ji, Haolun Jin, Kapil Karki, Andrew J Keats, Linos Lazarides, Yu-Jen Lee, Albert Liclican, Michael Mish, Bernard Murray, Simon B Pettit, Peter Pyun, Michael Sangi, Rex Santos, Jonathan Sanvoisin, Uli Schmitz, Adam Schrier, Dustin Siegel, David Sperandio, George Stepan, Yang Tian, Gregory M Watt, Hai Yang, Brian E Schultz
Discovery of a Potent and Orally Bioavailable Cyclophilin Inhibitor Derived from the Sanglifehrin Macrocycle. Journal of medicinal chemistry 61 (21) (2018)
Victoria A Steadman, Simon B Pettit, Karine G Poullennec, Linos Lazarides, Andrew J Keats, David K Dean, Steven J Stanway, Carol A Austin, Jonathan A Sanvoisin, Gregory M Watt, Hans G Fliri, Albert C Liclican, Debi Jin, Melanie H Wong, Stephanie A Leavitt, Yu-Jen Lee, Yang Tian, Christian R Frey, Todd C Appleby, Uli Schmitz, Petr Jansa, Richard L Mackman, Brian E Schultz
Discovery of Potent Cyclophilin Inhibitors Based on the Structural Simplification of Sanglifehrin A. Journal of medicinal chemistry 60 (3) (2017)
Dustin Siegel, Hon C Hui, Edward Doerffler, Michael O Clarke, Kwon Chun, Lijun Zhang, Sean Neville, Ernest Carra, Willard Lew, Bruce Ross, Queenie Wang, Lydia Wolfe, Robert Jordan, Veronica Soloveva, John Knox, Jason Perry, Michel Perron, Kirsten M Stray, Ona Barauskas, Joy Y Feng, Yili Xu, Gary Lee, Arnold L Rheingold, Adrian S Ray, Roy Bannister, Robert Strickley, Swami Swaminathan, William A Lee, Sina Bavari, Tomas Cihlar, Michael K Lo, Travis K Warren, Richard L Mackman
Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. Journal of medicinal chemistry 60 (5) (2017)

Richard L Mackman.css-eqlu8i{font-size:small;padding-left:4px;} (Richard Mackman)

Publication Activity (10 Years)

Top Topics

Top Venues

Richard L Mackman (Richard Mackman)