Ralph S Baric (Ralph Baric)

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 168

Top Venues

Nature communications

Science translational medicine

Journal of virology

Viruses

University of North Carolina at Chapel Hill

University of North Carolina at Chapel Hill (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of North Carolina at Chapel Hill

United States

Professor :: Epidemiology

Education History

University of North Carolina at Chapel Hill Apr 01 1986

United States

PHD :: Epidemiology

Publications

Rúbens Prince Dos Santos Alves, Julia Timis, Robyn Miller, Kristen Valentine, Paolla Beatriz Almeida Pinto, Andrew Gonzalez, Jose Angel Regla-Nava, Erin Maule, Michael N Nguyen, Norazizah Shafee, Sara Landeras-Bueno, Eduardo Olmedillas, Brett Laffey, Katarzyna Dobaczewska, Zbigniew Mikulski, Sara McArdle, Sarah R Leist, Kenneth Kim, Ralph S Baric, Erica Ollmann Saphire, Annie Elong Ngono, Sujan Shresta
Human coronavirus OC43-elicited CD4 + T cells protect against SARS-CoV-2 in HLA transgenic mice. Nature communications 15 (1) (2024)
Marta C Cruz Cisneros, Elizabeth J Anderson, Brea K Hampton, Breantié Parotti, Sanjay Sarkar, Sharon Taft-Benz, Timothy A Bell, Matthew Blanchard, Jacob A Dillard, Kenneth H Dinnon, Pablo Hock, Sarah R Leist, Emily A Madden, Ginger D Shaw, Ande West, Ralph S Baric, Victoria K Baxter, Fernando Pardo-Manuel de Villena, Mark T Heise, Martin T Ferris
Host Genetic Variation Impacts SARS-CoV-2 Vaccination Response in the Diversity Outbred Mouse Population. Vaccines 12 (1) (2024)
Jimin Lee, Cameron Stewart, Alexandra Schaefer, Elizabeth M Leaf, Young-Jun Park, Daniel Asarnow, John M Powers, Catherine Treichel, Kaitlin R Sprouse, Davide Corti, Ralph S Baric, Neil P King, David J Veesler
A broadly generalizable stabilization strategy for sarbecovirus fusion machinery vaccines. Nature communications 15 (1) (2024)
Jacob A Dillard, Sharon A Taft-Benz, Audrey C Knight, Elizabeth J Anderson, Katia D Pressey, Breantié Parotti, Sabian A Martinez, Jennifer L Diaz, Sanjay Sarkar, Emily A Madden, Gabriela De la Cruz, Lily E Adams, Kenneth H Dinnon, Sarah R Leist, David R Martinez, Alexandra Schaefer, John M Powers, Boyd L Yount, Izabella N Castillo, Noah L Morales, Jane Burdick, Mia Katrina D Evangelista, Lauren M Ralph, Nicholas C Pankow, Colton L Linnertz, Premkumar Lakshmanane, Stephanie A Montgomery, Martin T Ferris, Ralph S Baric, Victoria K Baxter, Mark T Heise
Adjuvant-dependent impact of inactivated SARS-CoV-2 vaccines during heterologous infection by a SARS-related coronavirus. Nature communications 15 (1) (2024)
Amie J Eisfeld, Lindsey N Anderson, Shufang Fan, Kevin B Walters, Peter J Halfmann, Danielle Westhoff Smith, Larissa B Thackray, Qing Tan, Amy C Sims, Vineet D Menachery, Alexandra Schaefer, Timothy P Sheahan, Adam S Cockrell, Kelly G Stratton, Bobbie-Jo M Webb-Robertson, Jennifer E Kyle, Kristin E Burnum-Johnson, Young-Mo Kim, Carrie D Nicora, Zuleyma Peralta, Alhaji U N'jai, Foday Sahr, Harm van Bakel, Michael S Diamond, Ralph S Baric, Thomas O Metz, Richard D Smith, Yoshihiro Kawaoka, Katrina M Waters
A compendium of multi-omics data illuminating host responses to lethal human virus infections. Scientific data 11 (1) (2024)
Michael L Mallory, Jennifer E Munt, Tara M Narowski, Izabella Castillo, Edwing Cuadra, Nora Pisanic, Paul A Fields, John M Powers, Alexandria L Dickson, Rohan Harris, Richard Wargowsky, Seamus Moran, Ahmed Allabban, Kristin Raphel, Timothy A McCaffrey, James D D Brien, Christopher D Heaney, John E Lafleur, Ralph S Baric, Lakshmanane Premkumar
COVID-19 point-of-care tests can identify low-antibody individuals: In-depth immunoanalysis of boosting benefits in a healthy cohort. Science advances 10 (24) (2024)
Rúbens Prince Dos Santos Alves, Julia Timis, Robyn Miller, Kristen Valentine, Paolla Beatriz Almeida Pinto, Andrew Gonzalez, Jose Angel Regla-Nava, Erin Maule, Michael N Nguyen, Norazizah Shafee, Sara Landeras-Bueno, Eduardo Olmedillas, Brett Laffey, Katarzyna Dobaczewska, Zbigniew Mikulski, Sara McArdle, Sarah R Leist, Kenneth Kim, Ralph S Baric, Erica Ollmann Saphire, Annie Elong Ngono, Sujan Shresta
Human coronavirus OC43-elicited CD4 + T cells protect against SARS-CoV-2 in HLA transgenic mice. Nature communications 15 (1) (2024)
Amie J Eisfeld, Lindsey N Anderson, Shufang Fan, Kevin B Walters, Peter J Halfmann, Danielle Westhoff Smith, Larissa B Thackray, Qing Tan, Amy C Sims, Vineet D Menachery, Alexandra Schaefer, Timothy P Sheahan, Adam S Cockrell, Kelly G Stratton, Bobbie-Jo M Webb-Robertson, Jennifer E Kyle, Kristin E Burnum-Johnson, Young-Mo Kim, Carrie D Nicora, Zuleyma Peralta, Alhaji U N'jai, Foday Sahr, Harm van Bakel, Michael S Diamond, Ralph S Baric, Thomas O Metz, Richard D Smith, Yoshihiro Kawaoka, Katrina M Waters
A compendium of multi-omics data illuminating host responses to lethal human virus infections. Scientific data 11 (1) (2024)
Marta C Cruz Cisneros, Elizabeth J Anderson, Brea K Hampton, Breantié Parotti, Sanjay Sarkar, Sharon Taft-Benz, Timothy A Bell, Matthew Blanchard, Jacob A Dillard, Kenneth H Dinnon, Pablo Hock, Sarah R Leist, Emily A Madden, Ginger D Shaw, Ande West, Ralph S Baric, Victoria K Baxter, Fernando Pardo-Manuel de Villena, Mark T Heise, Martin T Ferris
Host Genetic Variation Impacts SARS-CoV-2 Vaccination Response in the Diversity Outbred Mouse Population. Vaccines 12 (1) (2024)
Adrianus C M Boon, Traci L Bricker, Ethan J Fritch, Sarah R Leist, Kendra Gully, Ralph S Baric, Rachel L Graham, Brigid V Troan, Matthew Mahoney, James W Janetka
Efficacy of Host Cell Serine Protease Inhibitor MM3122 against SARS-CoV-2 for Treatment and Prevention of COVID-19. bioRxiv : the preprint server for biology (2024)
Michael L Mallory, Jennifer E Munt, Tara M Narowski, Izabella Castillo, Edwing Cuadra, Nora Pisanic, Paul A Fields, John M Powers, Alexandria L Dickson, Rohan Harris, Richard Wargowsky, Seamus Moran, Ahmed Allabban, Kristin Raphel, Timothy A McCaffrey, James D D Brien, Christopher D Heaney, John E Lafleur, Ralph S Baric, Lakshmanane Premkumar
COVID-19 point-of-care tests can identify low-antibody individuals: In-depth immunoanalysis of boosting benefits in a healthy cohort. Science advances 10 (24) (2024)
Adrianus C M Boon, Traci L Bricker, Ethan J Fritch, Sarah R Leist, Kendra Gully, Ralph S Baric, Rachel L Graham, Brigid V Troan, Matthew Mahoney, James W Janetka
Efficacy of host cell serine protease inhibitor MM3122 against SARS-CoV-2 for treatment and prevention of COVID-19. Journal of virology 98 (5) (2024)
Adrianus C M Boon, Traci L Bricker, Ethan J Fritch, Sarah R Leist, Kendra Gully, Ralph S Baric, Rachel L Graham, Brigid V Troan, Matthew Mahoney, James W Janetka
Efficacy of host cell serine protease inhibitor MM3122 against SARS-CoV-2 for treatment and prevention of COVID-19. Journal of virology (2024)
Jacob A Dillard, Sharon A Taft-Benz, Audrey C Knight, Elizabeth J Anderson, Katia D Pressey, Breantié Parotti, Sabian A Martinez, Jennifer L Diaz, Sanjay Sarkar, Emily A Madden, Gabriela De la Cruz, Lily E Adams, Kenneth H Dinnon, Sarah R Leist, David R Martinez, Alexandra Schaefer, John M Powers, Boyd L Yount, Izabella N Castillo, Noah L Morales, Jane Burdick, Mia Katrina D Evangelista, Lauren M Ralph, Nicholas C Pankow, Colton L Linnertz, Premkumar Lakshmanane, Stephanie A Montgomery, Martin T Ferris, Ralph S Baric, Victoria K Baxter, Mark T Heise
Adjuvant-dependent impact of inactivated SARS-CoV-2 vaccines during heterologous infection by a SARS-related coronavirus. Nature communications 15 (1) (2024)
Jimin Lee, Cameron Stewart, Alexandra Schaefer, Elizabeth M Leaf, Young-Jun Park, Daniel Asarnow, John M Powers, Catherine Treichel, Kaitlin R Sprouse, Davide Corti, Ralph S Baric, Neil P King, David J Veesler
A broadly generalizable stabilization strategy for sarbecovirus fusion machinery vaccines. Nature communications 15 (1) (2024)
Adrianus C M Boon, Traci L Bricker, Ethan J Fritch, Sarah R Leist, Kendra Gully, Ralph S Baric, Rachel L Graham, Brigid V Troan, Matthew Mahoney, James W Janetka
Efficacy of host cell serine protease inhibitor MM3122 against SARS-CoV-2 for treatment and prevention of COVID-19. Journal of virology 98 (5) (2024)
David R Martinez, Fernando R Moreira, Nicholas J Catanzaro, Meghan V Diefenbacher, Mark R Zweigart, Kendra L Gully, Gabriela de la Cruz, Ariane J Brown, Lily E Adams, Boyd Yount, Thomas J Baric, Michael L Mallory, Helen Conrad, Samantha R May, Stephanie Dong, D Trevor Scobey, Cameron Nguyen, Stephanie A Montgomery, Jason K Perry, Darius Babusis, Kimberly T Barrett, Anh-Hoa Nguyen, Anh-Quan Nguyen, Rao Kalla, Roy Bannister, Joy Y Feng, Tomas Cihlar, Ralph S Baric, Richard L Mackman, John P Bilello, Alexandra Schaefer, Timothy P Sheahan
The oral nucleoside prodrug GS-5245 is efficacious against SARS-CoV-2 and other endemic, epidemic, and enzootic coronaviruses. Science translational medicine 16 (748) (2024)
Xiang Liu, Wern Hann Ng, Eva Zusinaite, Joseph R Freitas, Adam Taylor, Venugopal Yerragunta, Shukra Madhaha Aavula, Sambaiah Gorriparthi, Santhakumar Ponsekaran, Rama Lakshmi Bonda, Priyanka Mani, Sridevi V Nimmagadda, Sainan Wang, Laura Sandra Lello, Ali Zaid, Ujjwal Dua, Sharon A Taft-Benz, Elizabeth J Anderson, Victoria K Baxter, Sanjay Sarkar, Zheng L Ling, Thomas Myles Ashhurst, Samuel M S Cheng, Priyabrata Pattnaik, Anand Kumar Kanakasapapathy, Ralph S Baric, Felicity Jane Burt, Joseph S Malik Peiris, Mark T Heise, Nicholas Jonathan Cole King, Andres Merits, Rajendra Lingala, Suresh Mahalingam
A single-dose intranasal live-attenuated codon deoptimized vaccine provides broad protection against SARS-CoV-2 and its variants. Nature communications 15 (1) (2024)
Adrianus C M Boon, Traci L Bricker, Ethan J Fritch, Sarah R Leist, Kendra Gully, Ralph S Baric, Rachel L Graham, Brigid V Troan, Matthew Mahoney, James W Janetka
Efficacy of host cell serine protease inhibitor MM3122 against SARS-CoV-2 for treatment and prevention of COVID-19. Journal of virology (2024)
Marta C Cruz Cisneros, Elizabeth J Anderson, Brea K Hampton, Breantié Parotti, Sanjay Sarkar, Sharon Taft-Benz, Timothy A Bell, Matthew Blanchard, Jacob A Dillard, Kenneth H Dinnon, Pablo Hock, Sarah R Leist, Emily A Madden, Ginger D Shaw, Ande West, Ralph S Baric, Victoria K Baxter, Fernando Pardo-Manuel de Villena, Mark T Heise, Martin T Ferris
Host Genetic Variation Impacts SARS-CoV-2 Vaccination Response in the Diversity Outbred Mouse Population. Vaccines 12 (1) (2024)
David R Martinez, Fernando R Moreira, Nicholas J Catanzaro, Meghan V Diefenbacher, Mark R Zweigart, Kendra L Gully, Gabriela de la Cruz, Ariane J Brown, Lily E Adams, Boyd Yount, Thomas J Baric, Michael L Mallory, Helen Conrad, Samantha R May, Stephanie Dong, D Trevor Scobey, Cameron Nguyen, Stephanie A Montgomery, Jason K Perry, Darius Babusis, Kimberly T Barrett, Anh-Hoa Nguyen, Anh-Quan Nguyen, Rao Kalla, Roy Bannister, Joy Y Feng, Tomas Cihlar, Ralph S Baric, Richard L Mackman, John P Bilello, Alexandra Schaefer, Timothy P Sheahan
The oral nucleoside prodrug GS-5245 is efficacious against SARS-CoV-2 and other endemic, epidemic, and enzootic coronaviruses. Science translational medicine 16 (748) (2024)
Ching-Lin Hsieh, Sarah R Leist, Emily Happy Miller, Ling Zhou, John M Powers, Alexandra L Tse, Albert Wang, Ande West, Mark R Zweigart, Jonathan C Schisler, Rohit K Jangra, Kartik Chandran, Ralph S Baric, Jason S Mclellan
Prefusion-stabilized SARS-CoV-2 S2-only antigen provides protection against SARS-CoV-2 challenge. Nature communications 15 (1) (2024)
Adrianus C M Boon, Traci L Bricker, Ethan J Fritch, Sarah R Leist, Kendra Gully, Ralph S Baric, Rachel L Graham, Brigid V Troan, Matthew Mahoney, James W Janetka
Efficacy of Host Cell Serine Protease Inhibitor MM3122 against SARS-CoV-2 for Treatment and Prevention of COVID-19. bioRxiv : the preprint server for biology (2024)
Adrianus C M Boon, Traci L Bricker, Ethan J Fritch, Sarah R Leist, Kendra Gully, Ralph S Baric, Rachel L Graham, Brigid V Troan, Matthew Mahoney, James W Janetka
Efficacy of host cell serine protease inhibitor MM3122 against SARS-CoV-2 for treatment and prevention of COVID-19. Journal of virology 98 (5) (2024)
Jimin Lee, Cameron Stewart, Alexandra Schaefer, Elizabeth M Leaf, Young-Jun Park, Daniel Asarnow, John M Powers, Catherine Treichel, Kaitlin R Sprouse, Davide Corti, Ralph S Baric, Neil P King, David J Veesler
A broadly generalizable stabilization strategy for sarbecovirus fusion machinery vaccines. Nature communications 15 (1) (2024)
Ching-Lin Hsieh, Sarah R Leist, Emily Happy Miller, Ling Zhou, John M Powers, Alexandra L Tse, Albert Wang, Ande West, Mark R Zweigart, Jonathan C Schisler, Rohit K Jangra, Kartik Chandran, Ralph S Baric, Jason S Mclellan
Prefusion-stabilized SARS-CoV-2 S2-only antigen provides protection against SARS-CoV-2 challenge. Nature communications 15 (1) (2024)
Renee Wan Yi Chan, Michael Chi-Wai Chan, Sudhakar Agnihothram, Louisa L Y Chan, Denise I T Kuok, Joanne H M Fong, Yi Guan, Leo L M Poon, Ralph S Baric, John M Nicholls, Joseph S Malik Peiris
Erratum for Chan et al., "Tropism of and Innate Immune Responses to the Novel Human Betacoronavirus Lineage C Virus in Human Ex Vivo Respiratory Organ Cultures". Journal of virology (2024)
Jimin Lee, Cameron Stewart, Alexandra Schaefer, Elizabeth M Leaf, Young-Jun Park, Daniel Asarnow, John M Powers, Catherine Treichel, Kaitlin R Sprouse, Davide Corti, Ralph S Baric, Neil P King, David J Veesler
A broadly generalizable stabilization strategy for sarbecovirus fusion machinery vaccines. Nature communications 15 (1) (2024)
Michael H J Rhodin, Archie C Reyes, Anand Balakrishnan, Nalini Bisht, Nicole M Kelly, Joyce Sweeney Gibbons, Jonathan Lloyd, Michael Vaine, Tessa Cressey, Miranda Crepeau, Ruichao Shen, Nathan Manalo, Jonathan Castillo, Rachel E Levene, Daniel Leonard, Tianzhu Zang, Lijuan Jiang, Kellye Daniels, Robert M Cox, Carolin M Lieber, Josef D Wolf, Richard K Plemper, Sarah R Leist, Trevor Scobey, Ralph S Baric, Guoqiang Wang, Bryan Goodwin, Yat Sun Or
The small molecule inhibitor of SARS-CoV-2 3CLpro EDP-235 prevents viral replication and transmission in vivo. Nature communications 15 (1) (2024)
Xiang Liu, Wern Hann Ng, Eva Zusinaite, Joseph R Freitas, Adam Taylor, Venugopal Yerragunta, Shukra Madhaha Aavula, Sambaiah Gorriparthi, Santhakumar Ponsekaran, Rama Lakshmi Bonda, Priyanka Mani, Sridevi V Nimmagadda, Sainan Wang, Laura Sandra Lello, Ali Zaid, Ujjwal Dua, Sharon A Taft-Benz, Elizabeth J Anderson, Victoria K Baxter, Sanjay Sarkar, Zheng L Ling, Thomas Myles Ashhurst, Samuel M S Cheng, Priyabrata Pattnaik, Anand Kumar Kanakasapapathy, Ralph S Baric, Felicity Jane Burt, Joseph S Malik Peiris, Mark T Heise, Nicholas Jonathan Cole King, Andres Merits, Rajendra Lingala, Suresh Mahalingam
A single-dose intranasal live-attenuated codon deoptimized vaccine provides broad protection against SARS-CoV-2 and its variants. Nature communications 15 (1) (2024)
Amie J Eisfeld, Lindsey N Anderson, Shufang Fan, Kevin B Walters, Peter J Halfmann, Danielle Westhoff Smith, Larissa B Thackray, Qing Tan, Amy C Sims, Vineet D Menachery, Alexandra Schaefer, Timothy P Sheahan, Adam S Cockrell, Kelly G Stratton, Bobbie-Jo M Webb-Robertson, Jennifer E Kyle, Kristin E Burnum-Johnson, Young-Mo Kim, Carrie D Nicora, Zuleyma Peralta, Alhaji U N'jai, Foday Sahr, Harm van Bakel, Michael S Diamond, Ralph S Baric, Thomas O Metz, Richard D Smith, Yoshihiro Kawaoka, Katrina M Waters
A compendium of multi-omics data illuminating host responses to lethal human virus infections. Scientific data 11 (1) (2024)
Ching-Lin Hsieh, Sarah R Leist, Emily Happy Miller, Ling Zhou, John M Powers, Alexandra L Tse, Albert Wang, Ande West, Mark R Zweigart, Jonathan C Schisler, Rohit K Jangra, Kartik Chandran, Ralph S Baric, Jason S Mclellan
Prefusion-stabilized SARS-CoV-2 S2-only antigen provides protection against SARS-CoV-2 challenge. Nature communications 15 (1) (2024)
Ching-Lin Hsieh, Sarah R Leist, Emily Happy Miller, Ling Zhou, John M Powers, Alexandra L Tse, Albert Wang, Ande West, Mark R Zweigart, Jonathan C Schisler, Rohit K Jangra, Kartik Chandran, Ralph S Baric, Jason S Mclellan
Prefusion-stabilized SARS-CoV-2 S2-only antigen provides protection against SARS-CoV-2 challenge. Nature communications 15 (1) (2024)
Michael H J Rhodin, Archie C Reyes, Anand Balakrishnan, Nalini Bisht, Nicole M Kelly, Joyce Sweeney Gibbons, Jonathan Lloyd, Michael Vaine, Tessa Cressey, Miranda Crepeau, Ruichao Shen, Nathan Manalo, Jonathan Castillo, Rachel E Levene, Daniel Leonard, Tianzhu Zang, Lijuan Jiang, Kellye Daniels, Robert M Cox, Carolin M Lieber, Josef D Wolf, Richard K Plemper, Sarah R Leist, Trevor Scobey, Ralph S Baric, Guoqiang Wang, Bryan Goodwin, Yat Sun Or
The small molecule inhibitor of SARS-CoV-2 3CLpro EDP-235 prevents viral replication and transmission in vivo. Nature communications 15 (1) (2024)
Renee Wan Yi Chan, Michael Chi-Wai Chan, Sudhakar Agnihothram, Louisa L Y Chan, Denise I T Kuok, Joanne H M Fong, Yi Guan, Leo L M Poon, Ralph S Baric, John M Nicholls, Joseph S Malik Peiris
Erratum for Chan et al., "Tropism of and Innate Immune Responses to the Novel Human Betacoronavirus Lineage C Virus in Human Ex Vivo Respiratory Organ Cultures". Journal of virology 98 (4) (2024)
Marta C Cruz Cisneros, Elizabeth J Anderson, Brea K Hampton, Breantié Parotti, Sanjay Sarkar, Sharon Taft-Benz, Timothy A Bell, Matthew Blanchard, Jacob A Dillard, Kenneth H Dinnon, Pablo Hock, Sarah R Leist, Emily A Madden, Ginger D Shaw, Ande West, Ralph S Baric, Victoria K Baxter, Fernando Pardo-Manuel de Villena, Mark T Heise, Martin T Ferris
Host Genetic Variation Impacts SARS-CoV-2 Vaccination Response in the Diversity Outbred Mouse Population. Vaccines 12 (1) (2024)
Rúbens Prince Dos Santos Alves, Julia Timis, Robyn Miller, Kristen Valentine, Paolla Beatriz Almeida Pinto, Andrew Gonzalez, Jose Angel Regla-Nava, Erin Maule, Michael N Nguyen, Norazizah Shafee, Sara Landeras-Bueno, Eduardo Olmedillas, Brett Laffey, Katarzyna Dobaczewska, Zbigniew Mikulski, Sara McArdle, Sarah R Leist, Kenneth Kim, Ralph S Baric, Erica Ollmann Saphire, Annie Elong Ngono, Sujan Shresta
Human coronavirus OC43-elicited CD4 + T cells protect against SARS-CoV-2 in HLA transgenic mice. Nature communications 15 (1) (2024)
Renee Wan Yi Chan, Michael Chi-Wai Chan, Sudhakar Agnihothram, Louisa L Y Chan, Denise I T Kuok, Joanne H M Fong, Yi Guan, Leo L M Poon, Ralph S Baric, John M Nicholls, Joseph S Malik Peiris
Erratum for Chan et al., "Tropism of and Innate Immune Responses to the Novel Human Betacoronavirus Lineage C Virus in Human Ex Vivo Respiratory Organ Cultures". Journal of virology 98 (4) (2024)
Ching-Lin Hsieh, Sarah R Leist, Emily Happy Miller, Ling Zhou, John M Powers, Alexandra L Tse, Albert Wang, Ande West, Mark R Zweigart, Jonathan C Schisler, Rohit K Jangra, Kartik Chandran, Ralph S Baric, Jason S Mclellan
Prefusion-stabilized SARS-CoV-2 S2-only antigen provides protection against SARS-CoV-2 challenge. Nature communications 15 (1) (2024)
David R Martinez, Fernando R Moreira, Nicholas J Catanzaro, Meghan V Diefenbacher, Mark R Zweigart, Kendra L Gully, Gabriela de la Cruz, Ariane J Brown, Lily E Adams, Boyd Yount, Thomas J Baric, Michael L Mallory, Helen Conrad, Samantha R May, Stephanie Dong, D Trevor Scobey, Cameron Nguyen, Stephanie A Montgomery, Jason K Perry, Darius Babusis, Kimberly T Barrett, Anh-Hoa Nguyen, Anh-Quan Nguyen, Rao Kalla, Roy Bannister, Joy Y Feng, Tomas Cihlar, Ralph S Baric, Richard L Mackman, John P Bilello, Alexandra Schaefer, Timothy P Sheahan
The oral nucleoside prodrug GS-5245 is efficacious against SARS-CoV-2 and other endemic, epidemic, and enzootic coronaviruses. Science translational medicine 16 (748) (2024)
Michael H J Rhodin, Archie C Reyes, Anand Balakrishnan, Nalini Bisht, Nicole M Kelly, Joyce Sweeney Gibbons, Jonathan Lloyd, Michael Vaine, Tessa Cressey, Miranda Crepeau, Ruichao Shen, Nathan Manalo, Jonathan Castillo, Rachel E Levene, Daniel Leonard, Tianzhu Zang, Lijuan Jiang, Kellye Daniels, Robert M Cox, Carolin M Lieber, Josef D Wolf, Richard K Plemper, Sarah R Leist, Trevor Scobey, Ralph S Baric, Guoqiang Wang, Bryan Goodwin, Yat Sun Or
The small molecule inhibitor of SARS-CoV-2 3CLpro EDP-235 prevents viral replication and transmission in vivo. Nature communications 15 (1) (2024)
Adrianus C M Boon, Traci L Bricker, Ethan J Fritch, Sarah R Leist, Kendra Gully, Ralph S Baric, Rachel L Graham, Brigid V Troan, Matthew Mahoney, James W Janetka
Efficacy of Host Cell Serine Protease Inhibitor MM3122 against SARS-CoV-2 for Treatment and Prevention of COVID-19. bioRxiv : the preprint server for biology (2024)
David R Martinez, Fernando R Moreira, Nicholas J Catanzaro, Meghan V Diefenbacher, Mark R Zweigart, Kendra L Gully, Gabriela de la Cruz, Ariane J Brown, Lily E Adams, Boyd Yount, Thomas J Baric, Michael L Mallory, Helen Conrad, Samantha R May, Stephanie Dong, D Trevor Scobey, Cameron Nguyen, Stephanie A Montgomery, Jason K Perry, Darius Babusis, Kimberly T Barrett, Anh-Hoa Nguyen, Anh-Quan Nguyen, Rao Kalla, Roy Bannister, Joy Y Feng, Tomas Cihlar, Ralph S Baric, Richard L Mackman, John P Bilello, Alexandra Schaefer, Timothy P Sheahan
The oral nucleoside prodrug GS-5245 is efficacious against SARS-CoV-2 and other endemic, epidemic, and enzootic coronaviruses. Science translational medicine 16 (748) (2024)
Ching-Lin Hsieh, Sarah R Leist, Emily Happy Miller, Ling Zhou, John M Powers, Alexandra L Tse, Albert Wang, Ande West, Mark R Zweigart, Jonathan C Schisler, Rohit K Jangra, Kartik Chandran, Ralph S Baric, Jason S Mclellan
Prefusion-stabilized SARS-CoV-2 S2-only antigen provides protection against SARS-CoV-2 challenge. Nature communications 15 (1) (2024)
Ching-Lin Hsieh, Sarah R Leist, Emily Happy Miller, Ling Zhou, John M Powers, Alexandra L Tse, Albert Wang, Ande West, Mark R Zweigart, Jonathan C Schisler, Rohit K Jangra, Kartik Chandran, Ralph S Baric, Jason S Mclellan
Prefusion-stabilized SARS-CoV-2 S2-only antigen provides protection against SARS-CoV-2 challenge. Nature communications 15 (1) (2024)
Rúbens Prince Dos Santos Alves, Julia Timis, Robyn Miller, Kristen Valentine, Paolla Beatriz Almeida Pinto, Andrew Gonzalez, Jose Angel Regla-Nava, Erin Maule, Michael N Nguyen, Norazizah Shafee, Sara Landeras-Bueno, Eduardo Olmedillas, Brett Laffey, Katarzyna Dobaczewska, Zbigniew Mikulski, Sara McArdle, Sarah R Leist, Kenneth Kim, Ralph S Baric, Erica Ollmann Saphire, Annie Elong Ngono, Sujan Shresta
Human coronavirus OC43-elicited CD4 + T cells protect against SARS-CoV-2 in HLA transgenic mice. Nature communications 15 (1) (2024)
Jacob A Dillard, Sharon A Taft-Benz, Audrey C Knight, Elizabeth J Anderson, Katia D Pressey, Breantié Parotti, Sabian A Martinez, Jennifer L Diaz, Sanjay Sarkar, Emily A Madden, Gabriela De la Cruz, Lily E Adams, Kenneth H Dinnon, Sarah R Leist, David R Martinez, Alexandra Schaefer, John M Powers, Boyd L Yount, Izabella N Castillo, Noah L Morales, Jane Burdick, Mia Katrina D Evangelista, Lauren M Ralph, Nicholas C Pankow, Colton L Linnertz, Premkumar Lakshmanane, Stephanie A Montgomery, Martin T Ferris, Ralph S Baric, Victoria K Baxter, Mark T Heise
Adjuvant-dependent impact of inactivated SARS-CoV-2 vaccines during heterologous infection by a SARS-related coronavirus. Nature communications 15 (1) (2024)
Jacob A Dillard, Sharon A Taft-Benz, Audrey C Knight, Elizabeth J Anderson, Katia D Pressey, Breantié Parotti, Sabian A Martinez, Jennifer L Diaz, Sanjay Sarkar, Emily A Madden, Gabriela De la Cruz, Lily E Adams, Kenneth H Dinnon, Sarah R Leist, David R Martinez, Alexandra Schaefer, John M Powers, Boyd L Yount, Izabella N Castillo, Noah L Morales, Jane Burdick, Mia Katrina D Evangelista, Lauren M Ralph, Nicholas C Pankow, Colton L Linnertz, Premkumar Lakshmanane, Stephanie A Montgomery, Martin T Ferris, Ralph S Baric, Victoria K Baxter, Mark T Heise
Adjuvant-dependent impact of inactivated SARS-CoV-2 vaccines during heterologous infection by a SARS-related coronavirus. Nature communications 15 (1) (2024)
Amie J Eisfeld, Lindsey N Anderson, Shufang Fan, Kevin B Walters, Peter J Halfmann, Danielle Westhoff Smith, Larissa B Thackray, Qing Tan, Amy C Sims, Vineet D Menachery, Alexandra Schaefer, Timothy P Sheahan, Adam S Cockrell, Kelly G Stratton, Bobbie-Jo M Webb-Robertson, Jennifer E Kyle, Kristin E Burnum-Johnson, Young-Mo Kim, Carrie D Nicora, Zuleyma Peralta, Alhaji U N'jai, Foday Sahr, Harm van Bakel, Michael S Diamond, Ralph S Baric, Thomas O Metz, Richard D Smith, Yoshihiro Kawaoka, Katrina M Waters
A compendium of multi-omics data illuminating host responses to lethal human virus infections. Scientific data 11 (1) (2024)
Jacob A Dillard, Sharon A Taft-Benz, Audrey C Knight, Elizabeth J Anderson, Katia D Pressey, Breantié Parotti, Sabian A Martinez, Jennifer L Diaz, Sanjay Sarkar, Emily A Madden, Gabriela De la Cruz, Lily E Adams, Kenneth H Dinnon, Sarah R Leist, David R Martinez, Alexandra Schaefer, John M Powers, Boyd L Yount, Izabella N Castillo, Noah L Morales, Jane Burdick, Mia Katrina D Evangelista, Lauren M Ralph, Nicholas C Pankow, Colton L Linnertz, Premkumar Lakshmanane, Stephanie A Montgomery, Martin T Ferris, Ralph S Baric, Victoria K Baxter, Mark T Heise
Adjuvant-dependent impact of inactivated SARS-CoV-2 vaccines during heterologous infection by a SARS-related coronavirus. Nature communications 15 (1) (2024)
Adrianus C M Boon, Traci L Bricker, Ethan J Fritch, Sarah R Leist, Kendra Gully, Ralph S Baric, Rachel L Graham, Brigid V Troan, Matthew Mahoney, James W Janetka
Efficacy of host cell serine protease inhibitor MM3122 against SARS-CoV-2 for treatment and prevention of COVID-19. Journal of virology 98 (5) (2024)
Yixuan J Hou, Shiho Chiba, Sarah R Leist, Rita M Meganck, David R Martinez, Alexandra Schaefer, Nicholas J Catanzaro, Vishwaraj Sontake, Ande West, Catlin E Edwards, Boyd Yount, Rhianna E Lee-Ferris, Samuel C Gallant, Seth J Zost, John Powers, Lily E Adams, Edgar F Kong, Melissa D Mattocks, Aleksandra Tata, Scott H Randell, Purushothama Rao Tata, Peter J Halfmann, James E Crowe, Yoshihiro Kawaoka, Ralph S Baric
Host range, transmissibility and antigenicity of a pangolin coronavirus. Nature microbiology (2023)
Geoffrey B Hutchinson, Olubukola M Abiona, Cynthia T Ziwawo, Anne P Werner, Daniel Ellis, Yaroslav Tsybovsky, Sarah R Leist, Charis Palandjian, Ande West, Ethan J Fritch, Nianshuang Wang, Daniel Wrapp, Seyhan Boyoglu-Barnum, George Ueda, Julien S Baker, Masaru Kanekiyo, Jason S Mclellan, Ralph S Baric, Neil P King, Barney S Graham, Kizzmekia S Corbett-Helaire
Nanoparticle display of prefusion coronavirus spike elicits S1-focused cross-reactive antibody response against diverse coronavirus subgenera. Nature communications 14 (1) (2023)
Calvin J Kuo, Shannon Choi, Vincent van Unen, Huimin Zhang, Arjun Rustagi, Samira Alwahabi, António Santos, Joshua E Chan, Brandon Lam, Daniel Solis, Jordan Mah, Katharina Röeltgen, Winston Trope, Alexander Guh-Siesel, Zhongqi Lin, Aimee Beck, Caitlin E Edwards, Venkata Vamsee Aditya Mallajosyula, Brock Martin, James C Y Dunn, Joseph B Shrager, Ralph S Baric, Benjamin A Pinsky, Scott D Boyd, Catherine A Blish, Mark M Davis
Organoid modeling of lung-resident immune responses to SARS-CoV-2 infection. Research square (2023)
Mark Heise, Jacob A Dillard, Sharon Taft-Benz, Audrey Knight, Elizabeth J Anderson, Katia Pressey, Breantié Parotti, Sabian Martinez, Jennifer L Diaz, Sanjay Sarkar, Emily Madden, Gabriela De la Cruz, Lily Adams, Kenneth Dinnon Iii, Sarah R Leist, David Martinez, Alexandra Schaefer, John Powers, Boyd Yount, Izabella Castillo, Noah Morales, Jane Burdick, Mia Katrina Evangelista, Lauren Ralph, Nicholas Pankow, Colton Linnertz, Prem Lakshmanane, Stephanie Montgomery, Martin Ferris, Ralph S Baric, Victoria K Baxter
Adjuvant-dependent effects on the safety and efficacy of inactivated SARS-CoV-2 vaccines during heterologous infection by a SARS-related coronavirus. Research square (2023)
Deanna R Zhu, Alecia J Rajesh, Rita M Meganck, Ellen F Young, Jennifer E Munt, Victor L Tse, Boyd Yount, Helen Conrad, Laura White, Sandra Henein, Aravinda M DeSilva, Ralph S Baric
Dengue virus 4/2 envelope domain chimeric virus panel maps type-specific responses against dengue serotype 2. mBio (2023)
Calvin J Kuo, Shannon Choi, Vincent van Unen, Huimin Zhang, Arjun Rustagi, Samira Alwahabi, António Santos, Joshua E Chan, Brandon Lam, Daniel Solis, Jordan Mah, Katharina Röeltgen, Winston Trope, Alexander Guh-Siesel, Zhongqi Lin, Aimee Beck, Caitlin E Edwards, Venkata Vamsee Aditya Mallajosyula, Brock Martin, James C Y Dunn, Joseph B Shrager, Ralph S Baric, Benjamin A Pinsky, Scott D Boyd, Catherine A Blish, Mark M Davis
Organoid modeling of lung-resident immune responses to SARS-CoV-2 infection. Research square (2023)
Yupeng Feng, Meng Yuan, John M Powers, Mengyun Hu, Jennifer E Munt, Prabhu S Arunachalam, Sarah R Leist, Lorenza Bellusci, Junghyun Kim, Kaitlin R Sprouse, Lily E Adams, Sumana Sundaramurthy, Xueyong Zhu, Lisa M Shirreff, Michael L Mallory, Trevor D Scobey, Alberto C Moreno, Derek T O'Hagan, Harry Kleanthous, François J Villinger, David J Veesler, Neil P King, Mehul S Suthar, Surender Khurana, Ralph S Baric, Ian A Wilson, Bali Pulendran
Broadly neutralizing antibodies against sarbecoviruses generated by immunization of macaques with an AS03-adjuvanted COVID-19 vaccine. Science translational medicine 15 (695) (2023)
Linhui Hao, Tien-Ying Hsiang, Ronit R Dalmat, Renee C Ireton, Jennifer F Morton, Caleb Stokes, Jason Netland, Malika Hale, Chris Thouvenel, Anna Wald, Nicholas M Franko, Kristen Huden, Helen Y Chu, Alex Sigal, Alexander L Greninger, Sasha W Tiles, Lynn K Barrett, Wesley C Van Voorhis, Jennifer Munt, Trevor Scobey, Ralph S Baric, David J Rawlings, Marion Pepper, Paul K Drain, Michael Gale
Dynamics of SARS-CoV-2 VOC Neutralization and Novel mAb Reveal Protection against Omicron. Viruses 15 (2) (2023)
Alex J Guseman, Linda J Rennick, Sham Nambulli, Chandra N Roy, David R Martinez, Darian T Yang, Fatema Bhinderwala, Sandra Vergara, Alexandra Schaefer, Ralph S Baric, Zandrea Ambrose, W Paul Duprex, Angela M Gronenborn
Targeting spike glycans to inhibit SARS-CoV2 viral entry. Proceedings of the National Academy of Sciences of the United States of America 120 (38) (2023)
Robert L Atmar, Khalil Ettayebi, Sasirekha Ramani, Frederick H Neill, Lisa C Lindesmith, Ralph S Baric, Amanda Brinkman, Ralph Braun, James Sherwood, Mary K Estes
A Bivalent Human Norovirus Vaccine Induces Homotypic and Heterotypic Neutralizing Antibodies. The Journal of infectious diseases (2023)
Kan Li, Richard H C Huntwork, Gillian Q Horn, Milite Abraha, Kathryn M Hastie, Haoyang Li, Vamseedhar Rayaprolu, Eduardo Olmedillas, Elizabeth Feeney, Kenneth Cronin, Sharon L Schendel, Mark Heise, Daniel Bedinger, Melissa D Mattocks, Ralph S Baric, S Munir Alam, Erica Ollmann Saphire, Georgia D Tomaras, S Moses Dennison
Cryptic-site-specific antibodies to the SARS-CoV-2 receptor binding domain can retain functional binding affinity to spike variants. Journal of virology (2023)
Alena Janda Markmann, D Ryan Bhowmik, Baowei Jiang, Michael Van Hoy, Frank Wang, Yixuan J Hou, Ralph S Baric, Aravinda M de Silva, Luther A Bartelt
A semi-quantitative, rapid, point of care SARS-CoV-2 serologic assay predicts neutralizing antibody levels. bioRxiv : the preprint server for biology (2023)
Audrey Lee, Katharine A Floyd, Shengyang Wu, Zhouqing Fang, Tze Kai Tan, Heather M Froggatt, John M Powers, Sarah R Leist, Kendra L Gully, Miranda L Hubbard, Chunfeng Li, Harold Hui, David Scoville, Alistaire D Ruggiero, Yan Liang, Anna Pavenko, Victor Lujan, Ralph S Baric, Garry P Nolan, Prabhu S Arunachalam, Mehul S Suthar, Bali Pulendran
BCG vaccination stimulates integrated organ immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance. Nature immunology (2023)
Ellen F Young, Boyd Yount, Petraleigh Pantoja, Sandra Henein, Rita M Meganck, Jennifer McBride, Jennifer E Munt, Thomas J Baric, Deanna Zhu, Trevor Scobey, Stephanie Dong, Longping V Tse, Melween I Martinez, Armando G Burgos, Rachel L Graham, Laura White, Aravinda DeSilva, Carlos A A Sariol, Ralph S Baric
A live dengue virus vaccine carrying a chimeric envelope glycoprotein elicits dual DENV2-DENV4 serotype-specific immunity. Nature communications 14 (1) (2023)
Ellen F Young, Boyd Yount, Petraleigh Pantoja, Sandra Henein, Rita M Meganck, Jennifer McBride, Jennifer E Munt, Thomas J Baric, Deanna Zhu, Trevor Scobey, Stephanie Dong, Longping V Tse, Melween I Martinez, Armando G Burgos, Rachel L Graham, Laura White, Aravinda DeSilva, Carlos A A Sariol, Ralph S Baric
A live dengue virus vaccine carrying a chimeric envelope glycoprotein elicits dual DENV2-DENV4 serotype-specific immunity. Nature communications 14 (1) (2023)
A Brenda Kapingidza, Daniel J Marston, Caitlin Harris, Daniel Wrapp, Kaitlyn Winters, Dieter Mielke, Lu Xiaozhi, Qi Yin, Andrew Foulger, Rob Parks, Maggie Barr, Amanda Newman, Alexandra Schaefer, Amanda Eaton, Justine Mae Flores, Austin Harner, Nicholas J Catanzaro, Michael L Mallory, Melissa D Mattocks, Christopher Beverly, Brianna Rhodes, Katayoun Mansouri, Elizabeth Van Itallie, Pranay Vure, Brooke Dunn, Taylor Keyes, Sherry Stanfield-Oakley, Christopher W Woods, Elizabeth A Petzold, Emmanuel B Walter, Kevin Wiehe, Robert J Edwards, David C Montefiori, Guido Ferrari, Ralph S Baric, Derek W Cain, Kevin O Saunders, Barton F Haynes, Mihai L Azoitei
Engineered immunogens to elicit antibodies against conserved coronavirus epitopes. Nature communications 14 (1) (2023)
Linhui Hao, Tien-Ying Hsiang, Ronit R Dalmat, Renee C Ireton, Jennifer F Morton, Caleb Stokes, Jason Netland, Malika Hale, Chris Thouvenel, Anna Wald, Nicholas M Franko, Kristen Huden, Helen Y Chu, Alex Sigal, Alexander L Greninger, Sasha W Tiles, Lynn K Barrett, Wesley C Van Voorhis, Jennifer Munt, Trevor Scobey, Ralph S Baric, David J Rawlings, Marion Pepper, Paul K Drain, Michael Gale
Dynamics of SARS-CoV-2 VOC Neutralization and Novel mAb Reveal Protection against Omicron. Viruses 15 (2) (2023)
Yupeng Feng, Meng Yuan, John M Powers, Mengyun Hu, Jennifer E Munt, Prabhu S Arunachalam, Sarah R Leist, Lorenza Bellusci, Junghyun Kim, Kaitlin R Sprouse, Lily E Adams, Sumana Sundaramurthy, Xueyong Zhu, Lisa M Shirreff, Michael L Mallory, Trevor D Scobey, Alberto C Moreno, Derek T O'Hagan, Harry Kleanthous, François J Villinger, David J Veesler, Neil P King, Mehul S Suthar, Surender Khurana, Ralph S Baric, Ian A Wilson, Bali Pulendran
Broadly neutralizing antibodies against sarbecoviruses generated by immunization of macaques with an AS03-adjuvanted COVID-19 vaccine. Science translational medicine 15 (695) (2023)
Longping V Tse, Yixuan J Hou, Elizabeth McFadden, Rhianna E Lee-Ferris, Trevor D Scobey, Sarah R Leist, David R Martinez, Rita M Meganck, Alexandra Schaefer, Boyd L Yount, Teresa M Mascenik, John M Powers, Scott H Randell, Yi Zhang, Lingshu Wang, John Mascola, Jason S Mclellan, Ralph S Baric
A MERS-CoV antibody neutralizes a pre-emerging group 2c bat coronavirus. Science translational medicine 15 (715) (2023)
Linhui Hao, Tien-Ying Hsiang, Ronit R Dalmat, Renee C Ireton, Jennifer F Morton, Caleb Stokes, Jason Netland, Malika Hale, Chris Thouvenel, Anna Wald, Nicholas M Franko, Kristen Huden, Helen Y Chu, Alex Sigal, Alexander L Greninger, Sasha W Tiles, Lynn K Barrett, Wesley C Van Voorhis, Jennifer Munt, Trevor Scobey, Ralph S Baric, David J Rawlings, Marion Pepper, Paul K Drain, Michael Gale
Dynamics of SARS-CoV-2 VOC Neutralization and Novel mAb Reveal Protection against Omicron. Viruses 15 (2) (2023)
Narayanappa Amruta, Saifudeen Ismael, Sarah R Leist, Timothy E Gressett, Akhilesh Srivastava, Kenneth H Dinnon, Elizabeth B Engler-Chiurazzi, Nicholas J Maness, Xuebin Qin, Jay K Kolls, Ralph S Baric, Gregory Bix
Mouse Adapted SARS-CoV-2 (MA10) Viral Infection Induces Neuroinflammation in Standard Laboratory Mice. Viruses 15 (1) (2022)
Cesar A Lopez, Clark H Cunningham, Sierra Pugh, Katerina Brandt, Usaphea P Vanna, Matthew J Delacruz, Quique Guerra, D Ryan Bhowmik, Samuel J Goldstein, Yixuan J Hou, Margaret Gearhart, Christine Wiethorn, Candace Pope, Carolyn Amditis, Kathryn Pruitt, Cinthia Newberry-Dillon, John L Schmitz, Lakshmanane Premkumar, Adaora A Adimora, Ralph S Baric, Michael Emch, Ross M Boyce, Allison E Aiello, Bailey K Fosdick, Daniel B Larremore, Aravinda M de Silva, Jonathan J Juliano, Alena Janda Markmann
Ethnoracial Disparities in SARS-CoV-2 Seroprevalence in a Large Cohort of Individuals in Central North Carolina from April to December 2020. mSphere 7 (3) (2022)
Scott B Biering, Francielle Tramontini Gomes de Sousa, Laurentia V Tjang, Felix Pahmeier, Chi Zhu, Richard Ruan, Sophie F Blanc, Trishna S Patel, Caroline M Worthington, Dustin R Glasner, Bryan Castillo-Rojas, Venice Servellita, Nicholas T N Lo, Marcus P Wong, Colin M Warnes, Daniel R Sandoval, Thomas Mandel Clausen, Yale A Santos, Douglas M Fox, Victoria Ortega, Anders M Näär, Ralph S Baric, Sarah A Stanley, Hector C Aguilar, Jeffrey D Esko, Charles Y Chiu, John E Pak, P Robert Beatty, Eva Harris
SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling. Nature communications 13 (1) (2022)
Scott B Biering, Francielle Tramontini Gomes de Sousa, Laurentia V Tjang, Felix Pahmeier, Chi Zhu, Richard Ruan, Sophie F Blanc, Trishna S Patel, Caroline M Worthington, Dustin R Glasner, Bryan Castillo-Rojas, Venice Servellita, Nicholas T N Lo, Marcus P Wong, Colin M Warnes, Daniel R Sandoval, Thomas Mandel Clausen, Yale A Santos, Douglas M Fox, Victoria Ortega, Anders M Näär, Ralph S Baric, Sarah A Stanley, Hector C Aguilar, Jeffrey D Esko, Charles Y Chiu, John E Pak, P Robert Beatty, Eva Harris
SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling. Nature communications 13 (1) (2022)
Luther A Bartelt, Alena Janda Markmann, Bridget Nelson, Jessica Keys, Heather Root, Heather I Henderson, JoAnn Kuruc, Caroline Baker, D Ryan Bhowmik, Yixuan J Hou, Lakshmanane Premkumar, Caleb Cornaby, John L Schmitz, Susan Weiss, Yara Park, Ralph S Baric, Aravinda M de Silva, Anne Lachiewicz, Sonia Napravnik, David Van Duin, David M Margolis
Outcomes of Convalescent Plasma with Defined High versus Lower Neutralizing Antibody Titers against SARS-CoV-2 among Hospitalized Patients: CoronaVirus Inactivating Plasma (CoVIP) Study. mBio 13 (5) (2022)
Laura J Stevens, Andrea J Pruijssers, Hery W Lee, Calvin J Gordon, Egor P Tchesnokov, Jennifer Gribble, Amelia S George, Tia M Hughes, Xiaotao Lu, Jiani Li, Jason K Perry, Danielle P Porter, Tomas Cihlar, Timothy P Sheahan, Ralph S Baric, Matthias Götte, Mark R Denison
Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms. Science translational medicine 14 (656) (2022)
Aled Morgan Edwards, Ralph S Baric, Erica Ollmann Saphire, Jeffrey B Ulmer
Stopping pandemics before they start: Lessons learned from SARS-CoV-2. Science (New York, N.Y.) 375 (6585) (2022)
Lisa C Lindesmith, Florencia A T Boshier, Paul D Brewer-Jensen, Sunando Roy, Veronica Costantini, Michael L Mallory, Mark Zweigart, Samantha R May, Helen Conrad, Kathleen M O'Reilly, Daniel Kelly, Cristina C Celma, Stuart Beard, Rachel Williams, Helena J Tutill, Sylvia Becker Dreps, Filemón Bucardo, David J Allen, Jan Vinjé, Richard A Goldstein, Judith Breuer, Ralph S Baric
Immune Imprinting Drives Human Norovirus Potential for Global Spread. mBio 13 (5) (2022)
Longping V Tse, Rita M Meganck, Stephanie Dong, Lily E Adams, Laura J White, Michael L Mallory, Ramesh Jadi, Aravinda M de Silva, Ralph S Baric
Generation of Mature DENVs via Genetic Modification and Directed Evolution. mBio 13 (3) (2022)
Scott B Biering, Francielle Tramontini Gomes de Sousa, Laurentia V Tjang, Felix Pahmeier, Chi Zhu, Richard Ruan, Sophie F Blanc, Trishna S Patel, Caroline M Worthington, Dustin R Glasner, Bryan Castillo-Rojas, Venice Servellita, Nicholas T N Lo, Marcus P Wong, Colin M Warnes, Daniel R Sandoval, Thomas Mandel Clausen, Yale A Santos, Douglas M Fox, Victoria Ortega, Anders M Näär, Ralph S Baric, Sarah A Stanley, Hector C Aguilar, Jeffrey D Esko, Charles Y Chiu, John E Pak, P Robert Beatty, Eva Harris
SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling. Nature communications 13 (1) (2022)
Scott B Biering, Francielle Tramontini Gomes de Sousa, Laurentia V Tjang, Felix Pahmeier, Chi Zhu, Richard Ruan, Sophie F Blanc, Trishna S Patel, Caroline M Worthington, Dustin R Glasner, Bryan Castillo-Rojas, Venice Servellita, Nicholas T N Lo, Marcus P Wong, Colin M Warnes, Daniel R Sandoval, Thomas Mandel Clausen, Yale A Santos, Douglas M Fox, Victoria Ortega, Anders M Näär, Ralph S Baric, Sarah A Stanley, Hector C Aguilar, Jeffrey D Esko, Charles Y Chiu, John E Pak, P Robert Beatty, Eva Harris
SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling. Nature communications 13 (1) (2022)
Scott B Biering, Sylvia A Sarnik, Eleanor Wang, James R Zengel, Sarah R Leist, Alexandra Schaefer, Varun Sathyan, Padraig Hawkins, Kenichi Okuda, Cyrus Tau, Aditya R Jangid, Connor V Duffy, Jin Wei, Rodney C Gilmore, Mia Madel Alfajaro, Madison S Strine, Xammy Nguyenla, Erik Van Dis, Carmelle Catamura, Livia H Yamashiro, Julia A Belk, Adam Begeman, Jessica C Stark, D Judy Shon, Douglas M Fox, Shahrzad Ezzatpour, Emily Huang, Nico Olegario, Arjun Rustagi, Allison S Volmer, Alessandra Livraghi-Butrico, Eddie Wehri, Richard R Behringer, Dong-Joo Cheon, Julia Schaletzky, Hector C Aguilar, Andreas S Puschnik, Brian Button, Benjamin A Pinsky, Catherine A Blish, Ralph S Baric, Wanda K O'Neal, Carolyn R Bertozzi, Craig B Wilen, Richard C Boucher, Jan E Carette, Sarah A Stanley, Eva Harris, Silvana Konermann, Patrick D Hsu
Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection. Nature genetics 54 (8) (2022)
Yunlong Shi, Ari Zeida, Caitlin E Edwards, Michael L Mallory, Santiago Sastre, Matías R Machado, Raymond J Pickles, Ling Fu, Keke Liu, Jing Yang, Ralph S Baric, Richard C Boucher, Rafael Radi, Kate S Carroll
Thiol-based chemical probes exhibit antiviral activity against SARS-CoV-2 via allosteric disulfide disruption in the spike glycoprotein. Proceedings of the National Academy of Sciences of the United States of America 119 (6) (2022)
Cameron Bradley Morrison, Caitlin E Edwards, Kendall M Shaffer, Kenza C Araba, Jason A Wykoff, Danielle R Williams, Takanori Asakura, Hong Dang, Lisa C Morton, Rodney C Gilmore, Wanda K O'Neal, Richard C Boucher, Ralph S Baric, Camille Ehre
SARS-CoV-2 infection of airway cells causes intense viral and cell shedding, two spreading mechanisms affected by IL-13. Proceedings of the National Academy of Sciences of the United States of America 119 (16) (2022)
Scott B Biering, Francielle Tramontini Gomes de Sousa, Laurentia V Tjang, Felix Pahmeier, Chi Zhu, Richard Ruan, Sophie F Blanc, Trishna S Patel, Caroline M Worthington, Dustin R Glasner, Bryan Castillo-Rojas, Venice Servellita, Nicholas T N Lo, Marcus P Wong, Colin M Warnes, Daniel R Sandoval, Thomas Mandel Clausen, Yale A Santos, Douglas M Fox, Victoria Ortega, Anders M Näär, Ralph S Baric, Sarah A Stanley, Hector C Aguilar, Jeffrey D Esko, Charles Y Chiu, John E Pak, P Robert Beatty, Eva Harris
SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling. Nature communications 13 (1) (2022)
Longping V Tse, Rita M Meganck, Kenza C Araba, Boyd L Yount, Kendall M Shaffer, Yixuan J Hou, Jennifer E Munt, Lily E Adams, Jason A Wykoff, Jeremy M Morowitz, Stephanie Dong, Scott T Magness, William F Marzluff, Liara M Gonzalez, Camille Ehre, Ralph S Baric
Genomewide CRISPR knockout screen identified PLAC8 as an essential factor for SADS-CoVs infection. Proceedings of the National Academy of Sciences of the United States of America 119 (18) (2022)
Scott B Biering, Francielle Tramontini Gomes de Sousa, Laurentia V Tjang, Felix Pahmeier, Chi Zhu, Richard Ruan, Sophie F Blanc, Trishna S Patel, Caroline M Worthington, Dustin R Glasner, Bryan Castillo-Rojas, Venice Servellita, Nicholas T N Lo, Marcus P Wong, Colin M Warnes, Daniel R Sandoval, Thomas Mandel Clausen, Yale A Santos, Douglas M Fox, Victoria Ortega, Anders M Näär, Ralph S Baric, Sarah A Stanley, Hector C Aguilar, Jeffrey D Esko, Charles Y Chiu, John E Pak, P Robert Beatty, Eva Harris
SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling. Nature communications 13 (1) (2022)
Kenneth H Dinnon Iii, Sarah R Leist, Kenichi Okuda, Hong Dang, Ethan J Fritch, Kendra L Gully, Gabriela de la Cruz, Mia D Evangelista, Takanori Asakura, Rodney C Gilmore, Padraig Hawkins, Satoko Nakano, Ande West, Alexandra Schaefer, Lisa E Gralinski, Jamie L Everman, Satria P Sajuthi, Mark R Zweigart, Stephanie Dong, Jennifer McBride, Michelle R Cooley, Jesse B Hines, Miriya K Love, Steve D Groshong, Alison VanSchoiack, Stefan-Laural J Phelan, Yan Liang, Tyler Hether, Michael Leon, Ross E Zumwalt, Lisa M Barton, Eric J Duval, Sanjay Mukhopadhyay, Edana Stroberg, Alain Borczuk, Leigh B Thorne, Muthu K Sakthivel, Yueh Z Lee, James S Hagood, Jason R Mock, Max A Seibold, Wanda K O'Neal, Stephanie A Montgomery, Richard C Boucher, Ralph S Baric
SARS-CoV-2 infection produces chronic pulmonary epithelial and immune cell dysfunction with fibrosis in mice. Science translational medicine 14 (664) (2022)
William A Fischer, Joseph J Eron, Wayne Holman, Myron S Cohen, Lei Fang, Laura J Szewczyk, Timothy P Sheahan, Ralph S Baric, Katie R Mollan, Cameron R Wolfe, Elizabeth R Duke, Masoud M Azizad, Katyna Borroto-Esoda, David Alain Wohl, Robert W Coombs, Amy James Loftis, Paul Alabanza, Felicia Lipansky, Wendy P Painter
A phase 2a clinical trial of molnupiravir in patients with COVID-19 shows accelerated SARS-CoV-2 RNA clearance and elimination of infectious virus. Science translational medicine 14 (628) (2022)
Scott B Biering, Francielle Tramontini Gomes de Sousa, Laurentia V Tjang, Felix Pahmeier, Chi Zhu, Richard Ruan, Sophie F Blanc, Trishna S Patel, Caroline M Worthington, Dustin R Glasner, Bryan Castillo-Rojas, Venice Servellita, Nicholas T N Lo, Marcus P Wong, Colin M Warnes, Daniel R Sandoval, Thomas Mandel Clausen, Yale A Santos, Douglas M Fox, Victoria Ortega, Anders M Näär, Ralph S Baric, Sarah A Stanley, Hector C Aguilar, Jeffrey D Esko, Charles Y Chiu, John E Pak, P Robert Beatty, Eva Harris
SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling. Nature communications 13 (1) (2022)
Matthew R Chang, Luke Tomasovic, Natalia A Kuzmina, Adam J Ronk, Patrick O Byrne, Rebecca I Johnson, Nadia Storm, Eduardo Olmedillas, Yixuan J Hou, Alexandra Schaefer, Sarah R Leist, Longping V Tse, Hanzhong Ke, Christian Coherd, Katrina Nguyen, Maliwan Kamkaew, Anna N Honko, Quan Zhu, Galit Alter, Erica Ollmann Saphire, Jason S Mclellan, Anthony Griffths, Ralph S Baric, Alexander Bukreyev, Wayne A Marasco
IgG-like bispecific antibodies with potent and synergistic neutralization against circulating SARS-CoV-2 variants of concern. Nature communications 13 (1) (2022)
Michael A Davis, Kathleen Voss, J Bryan Turnbull, Andrew T Gustin, Megan Knoll, Antonio Muruato, Tien-Ying Hsiang, Kenneth H Dinnon Iii, Sarah R Leist, Katie Nickel, Ralph S Baric, Warren Ladiges, Shreeram Akilesh, Kelly D Smith, Michael Gale
A C57BL/6 Mouse Model of SARS-CoV-2 Infection Recapitulates Age- and Sex-Based Differences in Human COVID-19 Disease and Recovery. Vaccines 11 (1) (2022)
Narayanappa Amruta, Saifudeen Ismael, Sarah R Leist, Timothy E Gressett, Akhilesh Srivastava, Kenneth H Dinnon, Elizabeth B Engler-Chiurazzi, Nicholas J Maness, Xuebin Qin, Jay K Kolls, Ralph S Baric, Gregory Bix
Mouse Adapted SARS-CoV-2 (MA10) Viral Infection Induces Neuroinflammation in Standard Laboratory Mice. Viruses 15 (1) (2022)
Alexandra Schaefer, David R Martinez, John J Won, Rita M Meganck, Fernando R Moreira, Ariane J Brown, Kendra L Gully, Mark R Zweigart, William S Conrad, Samantha R May, Stephanie Dong, Rao Kalla, Kwon Chun, Venice Du Pont, Darius Babusis, Jennifer Tang, Eisuke Murakami, Raju Subramanian, Kimberly T Barrett, Blake J Bleier, Roy Bannister, Joy Y Feng, John P Bilello, Tomas Cihlar, Richard L Mackman, Stephanie A Montgomery, Ralph S Baric, Timothy P Sheahan
Therapeutic treatment with an oral prodrug of the remdesivir parental nucleoside is protective against SARS-CoV-2 pathogenesis in mice. Science translational medicine 14 (643) (2022)
Lisa C Lindesmith, Paul D Brewer-Jensen, Michael L Mallory, Mark R Zweigart, Samantha R May, Daniel Kelly, Rachel Williams, Sylvia Becker-Dreps, Filemón Bucardo, David J Allen, Judith Breuer, Ralph S Baric
Antigenic Site Immunodominance Redirection Following Repeat Variant Exposure. Viruses 14 (6) (2022)
Narayanappa Amruta, Saifudeen Ismael, Sarah R Leist, Timothy E Gressett, Akhilesh Srivastava, Kenneth H Dinnon, Elizabeth B Engler-Chiurazzi, Nicholas J Maness, Xuebin Qin, Jay K Kolls, Ralph S Baric, Gregory Bix
Mouse Adapted SARS-CoV-2 (MA10) Viral Infection Induces Neuroinflammation in Standard Laboratory Mice. Viruses 15 (1) (2022)
Emma C Milligan, Katherine J Olstad, Caitlin A Williams, Michael L Mallory, Patricio Cano, Kaitlyn A Cross, Jennifer E Munt, Carolina Garrido, Lisa C Lindesmith, Jennifer K Watanabe, Jodie L Usachenko, Lincoln Hopkins, Ramya Immareddy, Yashavanth Shaan Lakshmanappa, Sonny R Elizaldi, Jamin W Roh, Rebecca L Sammak, Rachel E Pollard, JoAnn L Yee, Savannah Herbek, Trevor Scobey, Dieter Mielke, Genevieve G Fouda, Guido Ferrari, Hongmei Gao, Xiaoying X Shen, Pamela A Kozlowski, David Montefiori, Michael G Hudgens, Darin K Edwards, Andrea Carfi, Kizzmekia S Corbett-Helaire, Barney S Graham, Christopher B Fox, Mark Tomai, Smita S Iyer, Ralph S Baric, J Rachel Reader, Dirk P Dittmer, Koen K A Van Rompay, Sallie R Permar, Kristina De Paris
Infant rhesus macaques immunized against SARS-CoV-2 are protected against heterologous virus challenge one year later. Science translational medicine (2022)
Scott B Biering, Francielle Tramontini Gomes de Sousa, Laurentia V Tjang, Felix Pahmeier, Chi Zhu, Richard Ruan, Sophie F Blanc, Trishna S Patel, Caroline M Worthington, Dustin R Glasner, Bryan Castillo-Rojas, Venice Servellita, Nicholas T N Lo, Marcus P Wong, Colin M Warnes, Daniel R Sandoval, Thomas Mandel Clausen, Yale A Santos, Douglas M Fox, Victoria Ortega, Anders M Näär, Ralph S Baric, Sarah A Stanley, Hector C Aguilar, Jeffrey D Esko, Charles Y Chiu, John E Pak, P Robert Beatty, Eva Harris
SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling. Nature communications 13 (1) (2022)
Narayanappa Amruta, Saifudeen Ismael, Sarah R Leist, Timothy E Gressett, Akhilesh Srivastava, Kenneth H Dinnon, Elizabeth B Engler-Chiurazzi, Nicholas J Maness, Xuebin Qin, Jay K Kolls, Ralph S Baric, Gregory Bix
Mouse Adapted SARS-CoV-2 (MA10) Viral Infection Induces Neuroinflammation in Standard Laboratory Mice. Viruses 15 (1) (2022)

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Ralph S Baric (Ralph Baric)