William J Zuercher (William Zuercher)

Publication Activity (10 Years)

Years Active: 2017-2023
Publications (10 Years): 27

Top Topics

Toxoplasma Gondii

Top Venues

Journal of medicinal chemistry

Molecules (Basel, Switzerland)

The Biochemical journal

This page only lists publications with an associated author ORCID identifier.

Publications

Dana M Klug, Edwin G Tse, Daniel Gedder Silva, Yafeng Cao, Susan A Charman, Jyoti Chauhan, Elly Crighton, Maria Dichiara, Chris Drake, David Harold Drewry, Flavio da Silva Emery, Lori Ferrins, Lee M Graves, Emily Hopkins, Thomas A C Kresina, Álvaro Lorente-Macías, Benjamin G Perry, Richard Phipps, Bruno Quiroga, Antonio Quotadamo, Giada N Sabatino, Anthony Sama, Andreas G Schätzlein, Quillon J Simpson, Jonathan Steele, Julia Shanu-Wilson, Peter Sjö, Paul Stapleton, Christopher J Swain, Alexandra Vaideanu, Huanxu Xie, William J Zuercher, Matthew H Todd
Open Source Antibiotics: Simple Diarylimidazoles Are Potent against Methicillin-Resistant Staphylococcus aureus . ACS infectious diseases (2023)
Meganathan Nandakumar, Anja Ollodart, Neil Fleck, Nirav R Kapadia, Andrew Frando, Vishant Boradia, Jeffery L Smith, Junxi Chen, William J Zuercher, Timothy M Willson, Christoph Grundner
Dual Inhibition of Mycobacterium tuberculosis and the Host TGFBR1 by an Anilinoquinazoline. Journal of medicinal chemistry (2023)
Mary M Mader, Joachim Rudolph, Ingo V Hartung, David E Uehling, Paul Workman, William J Zuercher
Which Small Molecule? Selecting Chemical Probes for Use in Cancer Research and Target Validation. Cancer discovery (2023)
Deanna Marie Tiek, Beril Erdogdu, Roham Razaghi, Lu Jin, Norah Sadowski, Carla Alamillo-Ferrer, J Robert Hogg, Bassem R Haddad, David Harold Drewry, Carrow I Wells, Julie E Pickett, Xiao Song, Anshika Goenka, Bo Hu, Samuel A Goldlust, William J Zuercher, Mihaela Pertea, Winston Timp, Shi-Yuan Cheng, Rebecca B Riggins
Temozolomide-induced guanine mutations create exploitable vulnerabilities of guanine-rich DNA and RNA regions in drug-resistant gliomas. Science advances 8 (25) (2022)
Indran Mathavan, Lawrence J Liu, Sean W Robinson, Nelly El-Sakkary, Adam Jo J Elatico, Darwin Gomez, Ricky Nellas, Raymond J Owens, William J Zuercher, Iva Hopkins Navratilova, Conor R Caffrey, Konstantinos Beis
Identification of Inhibitors of the Schistosoma mansoni VKR2 Kinase Domain. ACS medicinal chemistry letters 13 (11) (2022)
Ricardo A M Serafim, Fiona J Sorrell, Benedict-Tilmann Berger, Ross J Collins, Stanley N S Vasconcelos, Katlin B Massirer, Stefan Knapp, James Bennett, Oleg Fedorov, Hitesh Patel, William J Zuercher, Jonathan M Elkins
Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold. Journal of medicinal chemistry 64 (18) (2021)
Carrow I Wells, Hassan Al-Ali, David M Andrews, Christopher R M Asquith, Alison D Axtman, Ivan Dikic, Daniel V Ebner, Peter Ettmayer, Christian Fischer, Mathias Frederiksen, Robert E Futrell, Nathanael S Gray, Stephanie B Hatch, Stefan Knapp, Ulrich Lücking, Michael Michaelides, Caitlin E Mills, Susanne Müller, Dafydd Owen, Alfredo Picado, Kumar S Saikatendu, Martin Schröder, Alexandra Stolz, Mariana Tellechea, Brandon J Turunen, Santiago Vilar, Jinhua Wang, William J Zuercher, Timothy M Willson, David Harold Drewry
The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification. International journal of molecular sciences 22 (2) (2021)
Ricardo A M Serafim, Jonathan M Elkins, William J Zuercher, Stefan A Laufer, Alexander Titz
Chemical Probes for Understudied Kinases: Challenges and Opportunities. Journal of medicinal chemistry (2021)
Ami Ketley, Marzena Wojciechowska, Sonja Ghidelli-Disse, Paul Bamborough, Tushar K Ghosh, Marta Lopez Morato, Saam Sedehizadeh, Naveed Altaf Malik, Zhenzhi Tang, Paulina Powalowska, Matthew K Tanner, Rudolf Billeter-Clark, Rebecca C Trueman, Philippine C Geiszler, Alessandra Agostini, Othman Othman, Markus Boesche, Marcus Bantscheff, Martin Rüdiger, Danuta E Mossakowska, David Harold Drewry, William J Zuercher, Charles A Thornton, Gerard Drewes, Iain Uings, Christopher J Hayes, J David Brook
CDK12 inhibition reduces abnormalities in cells from patients with myotonic dystrophy and in a mouse model. Science translational medicine 12 (541) (2021)
Alfredo Picado, Apirat Chaikuad, Carrow I Wells, Safal Shrestha, William J Zuercher, Julie E Pickett, Frank E Kwarcinski, Parvathi Sinha, Chandi S de Silva, Reena Zutshi, Shubin Liu, Natarajan Kannan, Stefan Knapp, David Harold Drewry, Timothy M Willson
A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation. Journal of medicinal chemistry 63 (23) (2020)
Alice L Herneisen, Saima M Sidik, Benedikt M Markus, David Harold Drewry, William J Zuercher, Sebastian Lourido
Identifying the Target of an Antiparasitic Compound in Toxoplasma Using Thermal Proteome Profiling. ACS chemical biology 15 (7) (2020)
Christopher R M Asquith, Tuomo Laitinen, Carrow I Wells, Graham J Tizzard, William J Zuercher
New Insights into 4-Anilinoquinazolines as Inhibitors of Cardiac Troponin I-Interacting Kinase (TNNi3K). Molecules (Basel, Switzerland) 25 (7) (2020)
Christopher R M Asquith, Tuomo Laitinen, James M Bennett, Carrow I Wells, Jonathan M Elkins, William J Zuercher, Graham J Tizzard, Antti Poso
Design and Analysis of the 4-Anilinoquin(az)oline Kinase Inhibition Profiles of GAK/SLK/STK10 Using Quantitative Structure-Activity Relationships. ChemMedChem 15 (1) (2019)
Cunyu Zhang, Katrina L Creech, William J Zuercher, Timothy M Willson
Gram-scale synthesis of FICZ, a photoreactive endogenous ligand of the aryl hydrocarbon receptor. Scientific reports 9 (1) (2019)
Christopher R M Asquith, Benedict-Tilman Berger, Jing Wan, James M Bennett, Stephen J Capuzzi, Daniel J Crona, David Harold Drewry, Michael P East, Jonathan M Elkins, Oleg Fedorov, Paulo H Godoi, Debra M Hunter, Stefan Knapp, Susanne Müller, Chad D Torrice, Carrow I Wells, H Shelton Earp, Timothy M Willson, William J Zuercher
SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK). Journal of medicinal chemistry 62 (5) (2019)
Christopher R M Asquith, Kaleb M Naegeli, Michael P East, Tuomo Laitinen, Tammy M Havener, Carrow I Wells, Gary L Johnson, David Harold Drewry, William J Zuercher, David C Morris
Design of a Cyclin G Associated Kinase (GAK)/Epidermal Growth Factor Receptor (EGFR) Inhibitor Set to Interrogate the Relationship of EGFR and GAK in Chordoma. Journal of medicinal chemistry 62 (9) (2019)
Luigi Racioppi, Erik Russell Nelson, Wei Huang, Debarati Mukherjee, Scott A Lawrence, William Lento, Anna Maria Masci, Yiquin Jiao, Sunghee Park, Brian York, Yaping Liu, Amy E Baek, David Harold Drewry, William J Zuercher, Francesca Romana Bertani, Luca Businaro, Joseph Geradts, Allison Hall, Anthony R Means, Nelson Chao, Ching-Yi Chang, Donald P McDonnell
CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer. Nature communications 10 (1) (2019)
María Ayelén Carabajal, Christopher R M Asquith, Tuomo Laitinen, Graham J Tizzard, Lucía Yim, Analía Rial, José A Chabalgoity, William J Zuercher, Eleonora García Véscovi
Quinazoline-Based Antivirulence Compounds Selectively Target Salmonella PhoP/PhoQ Signal Transduction System. Antimicrobial agents and chemotherapy 64 (1) (2019)
Christopher R M Asquith, James M Bennett, Lianyong Su, Tuomo Laitinen, Jonathan M Elkins, Julie E Pickett, Carrow I Wells, Zengbiao Li, Timothy M Willson, William J Zuercher
Towards the Development of an In vivo Chemical Probe for Cyclin G Associated Kinase (GAK). Molecules (Basel, Switzerland) 24 (22) (2019)
William T Barker, Ansley M Nemeth, Sara M Brackett, Akash K Basak, Courtney E Chandler, Leigh A Jania, William J Zuercher, Roberta J Melander, Beverly H Koller, Robert K Ernst, Roberta J Melander
Repurposing Eukaryotic Kinase Inhibitors as Colistin Adjuvants in Gram-Negative Bacteria. ACS infectious diseases 5 (10) (2019)
Nathan Wlodarchak, Nathan Teachout, Jeffrey Beczkiewicz, Rebecca Procknow, Adam J Schaenzer, Kenneth Satyshur, Martin Pavelka, William J Zuercher, David Drewry, John-Demian Sauer, Robert Striker
In Silico Screen and Structural Analysis Identifies Bacterial Kinase Inhibitors which Act with β-Lactams To Inhibit Mycobacterial Growth. Molecular pharmaceutics 15 (11) (2018)
Blair L Strang, Christopher R M Asquith, Hanan F Moshrif, Catherine M-K Ho, William J Zuercher, Hassan Al-Ali
Identification of lead anti-human cytomegalovirus compounds targeting MAP4K4 via machine learning analysis of kinase inhibitor screening data. PloS one 13 (7) (2018)
Christopher R M Asquith, Paulo H C Godoi, Rafael M Couñago, Tuomo Laitinen, John W Scott, Christopher G Langendorf, Jonathan S Oakhill, David H Drewry, William J Zuercher, Panayiotis A Koutentis, Timothy M Willson, Andreas S Kalogirou
1,2,6-Thiadiazinones as Novel Narrow Spectrum Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) Inhibitors. Molecules (Basel, Switzerland) 23 (5) (2018)
Daniel M Foulkes, Dominic P Byrne, Wayland Yeung, Safal Shrestha, Fiona P Bailey, Samantha Ferries, Claire E Eyers, Karen Keeshan, Carrow I Wells, David Harold Drewry, William J Zuercher, Natarajan Kannan, Patrick A Eyers
Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells. Science signaling 11 (549) (2018)
Dominic P Byrne, Yong Li, Krithika Ramakrishnan, Igor L Barsukov, Edwin Alexander Yates, Claire E Eyers, Dulcé Papy-Garcia, Sandrine Chantepie, Vijayakanth Pagadala, Jian Liu, Carrow I Wells, David Harold Drewry, William J Zuercher, Neil G Berry, David G Fernig, Patrick A Eyers
New tools for carbohydrate sulfation analysis: heparan sulfate 2-O-sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors. The Biochemical journal 475 (15) (2018)
Dominic P Byrne, Yong Li, Pawin Ngamlert, Krithika Ramakrishnan, Claire E Eyers, Carrow I Wells, David Harold Drewry, William J Zuercher, Neil G Berry, David G Fernig, Patrick A Eyers
New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors. The Biochemical journal 475 (15) (2018)
Christopher R M Asquith, Tuomo Laitinen, James M Bennett, Paulo H Godoi, Michael P East, Graham J Tizzard, Lee M Graves, Gary L Johnson, Ronna E Dornsife, Carrow I Wells, Jonathan M Elkins, Timothy M Willson, William J Zuercher
Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase. ChemMedChem 13 (1) (2017)