Sheena McGowan

ResearcherID Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 30

Top Venues

Journal of medicinal chemistry

eLife

mBio

ChemMedChem

Monash University

Monash University (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Monash University Sep 16 2015

Australia

Laboratory Head / Senior Lecturer :: Microbiology

Monash University Jan 01 2011 - Sep 15 2015

Australia

ARC Future Fellow / Laboratory Head :: Biochemistry and Molecular Biology

Monash University Feb 01 2004 - Dec 30 2010

Australia

Postdoctoral researcher :: Biochemistry and Molecular Biology

Education History

Monash University Feb 01 2000 - Feb 26 2004

Australia

PHD :: Microbiology

Monash University Mar 01 1996 - Nov 01 2000

Australia

BSC :: Majors: Microbiology/Immunology

Publications

Rebecca C S Edgar, Tess R Malcolm, Ghizal Siddiqui, Carlo Giannangelo, Natalie A Counihan, Matthew Challis, Sandra Duffy, Mrittika Chowdhury, Jutta Marfurt, Madeline Dans, Grennady Wirjanata, Rintis Noviyanti, Kajal Daware, Chathura D Suraweera, Ric N Price, Sergio Wittlin, Vicky Marie Avery, Nyssa Drinkwater, Susan A Charman, Darren John Creek, Tania F de Koning-Ward, Peter J Scammells, Sheena McGowan
On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity. mBio 15 (6) (2024)
Darren John Creek, Carlo Giannangelo, Matthew Challis, Ghizal Siddiqui, Rebecca Edgar, Tess Malcolm, Chaille Webb, Nyssa Drinkwater, Natalie Vinh, Christopher MacRaild, Natalie Counihan, Sandra Duffy, Sergio Wittlin, Shane M Devine, Vicky Avery, Tania de Koning-Ward, Peter Scammells, Sheena McGowan
Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy. Research square (2024)
Carlo Giannangelo, Matthew P Challis, Ghizal Siddiqui, Rebecca Edgar, Tess R Malcolm, Chaille T Webb, Nyssa Drinkwater, Natalie Vinh, Christopher Macraild, Natalie A Counihan, Sandra Duffy, Sergio Wittlin, Shane M Devine, Vicky M Avery, Tania De Koning-Ward, Peter Scammells, Sheena McGowan, Darren John Creek
Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy. eLife 13 (2024)
Darren John Creek, Carlo Giannangelo, Matthew Challis, Ghizal Siddiqui, Rebecca Edgar, Tess Malcolm, Chaille Webb, Nyssa Drinkwater, Natalie Vinh, Christopher MacRaild, Natalie Counihan, Sandra Duffy, Sergio Wittlin, Shane M Devine, Vicky Avery, Tania de Koning-Ward, Peter Scammells, Sheena McGowan
Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy. Research square (2024)
Milena M Awad, Chathura D Suraweera, Callum J Vidor, Auberon Y Ye-Lin, Galain C Williams, Steven J Mileto, Christopher K Barlow, Sheena McGowan, Dena Lyras
A Clostridioides difficile endolysin modulates toxin secretion without cell lysis. Communications biology 7 (1) (2024)
Milena M Awad, Chathura D Suraweera, Callum J Vidor, Auberon Y Ye-Lin, Galain C Williams, Steven J Mileto, Christopher K Barlow, Sheena McGowan, Dena Lyras
A Clostridioides difficile endolysin modulates toxin secretion without cell lysis. Communications biology 7 (1) (2024)
Rebecca C S Edgar, Tess R Malcolm, Ghizal Siddiqui, Carlo Giannangelo, Natalie A Counihan, Matthew Challis, Sandra Duffy, Mrittika Chowdhury, Jutta Marfurt, Madeline Dans, Grennady Wirjanata, Rintis Noviyanti, Kajal Daware, Chathura D Suraweera, Ric N Price, Sergio Wittlin, Vicky Marie Avery, Nyssa Drinkwater, Susan A Charman, Darren John Creek, Tania F de Koning-Ward, Peter J Scammells, Sheena McGowan
On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity. mBio 15 (6) (2024)
Carlo Giannangelo, Matthew P Challis, Ghizal Siddiqui, Rebecca Edgar, Tess R Malcolm, Chaille T Webb, Nyssa Drinkwater, Natalie Vinh, Christopher Macraild, Natalie A Counihan, Sandra Duffy, Sergio Wittlin, Shane M Devine, Vicky M Avery, Tania De Koning-Ward, Peter Scammells, Sheena McGowan, Darren John Creek
Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy. eLife 13 (2024)
Rebecca C S Edgar, Tess R Malcolm, Ghizal Siddiqui, Carlo Giannangelo, Natalie A Counihan, Matthew Challis, Sandra Duffy, Mrittika Chowdhury, Jutta Marfurt, Madeline Dans, Grennady Wirjanata, Rintis Noviyanti, Kajal Daware, Chathura D Suraweera, Ric N Price, Sergio Wittlin, Vicky Marie Avery, Nyssa Drinkwater, Susan A Charman, Darren John Creek, Tania F de Koning-Ward, Peter J Scammells, Sheena McGowan
On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity. mBio 15 (6) (2024)
Carlo Giannangelo, Matthew P Challis, Ghizal Siddiqui, Rebecca Edgar, Tess R Malcolm, Chaille T Webb, Nyssa Drinkwater, Natalie Vinh, Christopher Macraild, Natalie A Counihan, Sandra Duffy, Sergio Wittlin, Shane M Devine, Vicky M Avery, Tania De Koning-Ward, Peter Scammells, Sheena McGowan, Darren John Creek
Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy. eLife 13 (2024)
Rebecca C S Edgar, Tess R Malcolm, Ghizal Siddiqui, Carlo Giannangelo, Natalie A Counihan, Matthew Challis, Sandra Duffy, Mrittika Chowdhury, Jutta Marfurt, Madeline Dans, Grennady Wirjanata, Rintis Noviyanti, Kajal Daware, Chathura D Suraweera, Ric N Price, Sergio Wittlin, Vicky Marie Avery, Nyssa Drinkwater, Susan A Charman, Darren John Creek, Tania F de Koning-Ward, Peter J Scammells, Sheena McGowan
On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity. mBio (2024)
Carlo Giannangelo, Matthew P Challis, Ghizal Siddiqui, Rebecca Edgar, Tess R Malcolm, Chaille T Webb, Nyssa Drinkwater, Natalie Vinh, Christopher Macraild, Natalie A Counihan, Sandra Duffy, Sergio Wittlin, Shane M Devine, Vicky M Avery, Tania De Koning-Ward, Peter Scammells, Sheena McGowan, Darren John Creek
Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy. eLife 13 (2024)
Wendy Y Cun, Clara E Bate, Yogitha N Srikhanta, Melanie L Hutton, Chaille T Webb, Sarah A Revitt-Mills, Dena Lyras, Sheena McGowan, Hai-Bo Yu, Paul A Keller, Stephen G Pyne
Design, Synthesis, and Evaluation of Cephamycin-Based Antisporulation Agents targeting Clostridioides difficile . Journal of medicinal chemistry 67 (1) (2023)
Wendy Y Cun, Clara E Bate, Yogitha N Srikhanta, Melanie L Hutton, Chaille T Webb, Sarah A Revitt-Mills, Dena Lyras, Sheena McGowan, Hai-Bo Yu, Paul A Keller, Stephen G Pyne
Design, Synthesis, and Evaluation of Cephamycin-Based Antisporulation Agents targeting Clostridioides difficile . Journal of medicinal chemistry 67 (1) (2023)
Wendy Y Cun, Clara E Bate, Yogitha N Srikhanta, Melanie L Hutton, Chaille T Webb, Sarah A Revitt-Mills, Dena Lyras, Sheena McGowan, Hai-Bo Yu, Paul A Keller, Stephen G Pyne
Design, Synthesis, and Evaluation of Cephamycin-Based Antisporulation Agents targeting Clostridioides difficile . Journal of medicinal chemistry 67 (1) (2023)
Wendy Y Cun, Clara E Bate, Yogitha N Srikhanta, Melanie L Hutton, Chaille T Webb, Sarah A Revitt-Mills, Dena Lyras, Sheena McGowan, Hai-Bo Yu, Paul A Keller, Stephen G Pyne
Design, Synthesis, and Evaluation of Cephamycin-Based Antisporulation Agents targeting Clostridioides difficile . Journal of medicinal chemistry (2023)
Rebecca C S Edgar, Ghizal Siddiqui, Katheryn Hjerrild, Tess R Malcolm, Natalie B Vinh, Chaille T Webb, Clare Holmes, Christopher A MacRaild, Hope C Chernih, Willy W Suen, Natalie A Counihan, Darren John Creek, Peter J Scammells, Sheena McGowan, Tania F de Koning-Ward
Genetic and chemical validation of Plasmodium falciparum aminopeptidase Pf A-M17 as a drug target in the hemoglobin digestion pathway. eLife 11 (2022)
Tess R Malcolm, Karolina W Swiderska, Brooke K Hayes, Chaille T Webb, Marcin Drag, Nyssa Drinkwater, Sheena McGowan
Mapping the substrate specificity of the Plasmodium M1 and M17 aminopeptidases. The Biochemical journal 478 (13) (2021)
Sebastian S Broendum, Daniel E Williams, Brooke K Hayes, Felix Kraus, James Fodor, Ben E Clifton, Anne Geert Volbeda, Jeroen D C Codee, Blake T Riley, Nyssa Drinkwater, Kylie A Farrow, Kirill Tsyganov, Ryan D Heselpoth, Daniel C Nelson, Colin J Jackson, Ashley M Buckle, Sheena McGowan
High avidity drives the interaction between the streptococcal C1 phage endolysin, PlyC, with the cell surface carbohydrates of Group A Streptococcus. Molecular microbiology 116 (2) (2021)
Jisook Lee, Nyssa Drinkwater, Sheena McGowan, Peter J Scammells
A Structure-Activity Relationship Study of Novel Hydroxamic Acid Inhibitors around the S1 Subsite of Human Aminopeptidase N. ChemMedChem 16 (1) (2020)
Emilia M Marijanovic, James Fodor, Blake T Riley, Benjamin Thomas Porebski, Mauricio G S Costa, Itamar Kass, David E Hoke, Sheena McGowan, Ashley M Buckle
Reactive centre loop dynamics and serpin specificity. Scientific reports 9 (1) (2019)
Mansura Akter, Nyssa Drinkwater, Shane M Devine, Simon C Drew, Bankala Krishnarjuna, Cael O Debono, Geqing Wang, Martin J Scanlon, Peter J Scammells, Sheena McGowan, Christopher A MacRaild, Raymond S Norton
Identification of the Binding Site of Apical Membrane Antigen 1 (AMA1) Inhibitors Using a Paramagnetic Probe. ChemMedChem 14 (5) (2019)
Natalie B Vinh, Nyssa Drinkwater, Tess R Malcolm, Michael Kassiou, Leonardo Lucantoni, Peter M Grin, Georgina S Butler, Sandra Duffy, Christopher M Overall, Vicky M Avery, Peter J Scammells, Sheena McGowan
Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases. Journal of medicinal chemistry 62 (2) (2019)
Jisook Lee, Natalie B Vinh, Nyssa Drinkwater, Wei Yang, Komagal Kannan Sivaraman, Luke S Schembri, Michelle Gazdik, Peter M Grin, Georgina S Butler, Christopher M Overall, Susan A Charman, Sheena McGowan, Peter J Scammells
Novel Human Aminopeptidase N Inhibitors: Discovery and Optimization of Subsite Binding Interactions. Journal of medicinal chemistry 62 (15) (2019)
Blake T Riley, David E Hoke, Sheena McGowan, Ashley M Buckle
Crystal structure of the inhibitor-free form of the serine protease kallikrein-4. Acta crystallographica. Section F, Structural biology communications 75 (Pt 8) (2019)
Yogitha N Srikhanta, Melanie L Hutton, Milena M Awad, Nyssa Drinkwater, Julie Singleton, Sophie L Day, Bliss A Cunningham, Sheena McGowan, Dena Lyras
Cephamycins inhibit pathogen sporulation and effectively treat recurrent Clostridioides difficile infection. Nature microbiology 4 (12) (2019)
Rebecca Rabi, Sarah Larcombe, Rommel A Mathias, Sheena McGowan, Milena Awad, Dena Lyras
Clostridium sordellii outer spore proteins maintain spore structural integrity and promote bacterial clearance from the gastrointestinal tract. PLoS pathogens 14 (4) (2018)
Wei Yang, Blake T Riley, Xiangyun Lei, Benjamin T Porebski, Itamar Kass, Ashley M Buckle, Sheena McGowan
Mapping the Pathway and Dynamics of Bestatin Inhibition of the Plasmodium falciparum M1 Aminopeptidase PfA-M1. ChemMedChem 13 (23) (2018)
Wei Yang, Blake T Riley, Xiangyun Lei, Benjamin T Porebski, Itamar Kass, Ashley M Buckle, Sheena McGowan
Generation of AMBER force field parameters for zinc centres of M1 and M17 family aminopeptidases. Journal of biomolecular structure & dynamics 36 (10) (2017)
Nyssa Drinkwater, Jisook Lee, Wei Yang, Tess R Malcolm, Sheena McGowan
M1 aminopeptidases as drug targets: broad applications or therapeutic niche? The FEBS journal 284 (10) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Sheena McGowan